RU1836371C - Способ получени производных 5,5а,6,7,8,9,9а,10-октагидропиридо (2,3- @ )-хинолина или их фармацевтически приемлемых солей - Google Patents
Способ получени производных 5,5а,6,7,8,9,9а,10-октагидропиридо (2,3- @ )-хинолина или их фармацевтически приемлемых солейInfo
- Publication number
- RU1836371C RU1836371C SU904830582A SU4830582A RU1836371C RU 1836371 C RU1836371 C RU 1836371C SU 904830582 A SU904830582 A SU 904830582A SU 4830582 A SU4830582 A SU 4830582A RU 1836371 C RU1836371 C RU 1836371C
- Authority
- RU
- Russia
- Prior art keywords
- quinoline
- pharmaceutically acceptable
- acceptable salts
- reagent
- octahydropyrido
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Использование: в качестве агонистов доламина. Сущность изобретени : продукт - производные 5,5а,6,7,8,9,9э,10-октагидро- пиридо(2,3-а)хинолина общей ф-лы 1 или 2: VN-R где X - галоид, водород или группа -NRiR2, где RI и RZ - каждый в отдельности водород, Ci-Ce-алкил, Ci-Сб-алкилфенил, или RI и R2 - вместе вз тые с атомом азота, к которому они присоединены, образуют ПИррОЛИДИН, R - С1-С4-ЗЛКИЛ, ИЛИ ИХ фармацевтически приемлемые соли. Реагент 1: соединение общей ф-лы 3 или 4 где R - Ci-d-алкил. Реагент 2- дегидратирующий галогенирующий агент, такой, как ок- сихлорид фосфора. Реагент 3: амин общей ф-лы: NHRiR2, где RI и R2 - указано выше. Услови реакции: в среде органического растворител . 2 табл. 00 со о 00 VI
Description
Таблица 1
Ингибирование сывороточного лролактина
Все соединени были введены в виде рацемической смеси.
11183637112
Таблица 2 Данные по ингибированию пролэктина соединени из уровн техники
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/383,673 US4939259A (en) | 1989-07-24 | 1989-07-24 | 2-oxo-pyrido[2,3-g]quinoline derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
RU1836371C true RU1836371C (ru) | 1993-08-23 |
Family
ID=23514174
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU904830582A RU1836371C (ru) | 1989-07-24 | 1990-07-23 | Способ получени производных 5,5а,6,7,8,9,9а,10-октагидропиридо (2,3- @ )-хинолина или их фармацевтически приемлемых солей |
Country Status (14)
Country | Link |
---|---|
US (1) | US4939259A (ru) |
EP (1) | EP0410641A3 (ru) |
JP (1) | JPH0395182A (ru) |
KR (1) | KR910002853A (ru) |
CN (1) | CN1049162A (ru) |
AU (1) | AU631228B2 (ru) |
CA (1) | CA2021314A1 (ru) |
HU (1) | HU207079B (ru) |
IE (1) | IE902674A1 (ru) |
MX (1) | MX21657A (ru) |
NZ (1) | NZ234550A (ru) |
PT (1) | PT94749A (ru) |
RU (1) | RU1836371C (ru) |
ZA (1) | ZA905618B (ru) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1300145A4 (en) * | 2000-07-04 | 2004-07-07 | Toray Industries | PREVENTIVE OR THERAPEUTIC DRUGS FOR MOOD DISORDERS OR ANXIETY DISORDERS |
DE502005005922D1 (de) * | 2005-06-21 | 2008-12-18 | Geke Technologie Gmbh | Geschoss oder gefechtskopf |
FR2936710B1 (fr) * | 2008-10-07 | 2011-01-07 | Ceva Sante Animale | Composition veterinaire antiprolactinique destinee aux ruminants |
US9018227B2 (en) * | 2010-03-19 | 2015-04-28 | Indiana State University | Nicotinic acetylcholine receptor agonists |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA995670A (en) * | 1970-10-05 | 1976-08-24 | Wilson S. Waring | Phenanthrolines and pyrido-quinolines |
US4198415A (en) * | 1979-01-22 | 1980-04-15 | Eli Lilly And Company | Prolactin inhibiting octahydro pyrazolo[3,4-g]quinolines |
US4235909A (en) * | 1979-04-19 | 1980-11-25 | Eli Lilly And Company | Octahydro-2H-pyrrolo[3,4-g]quinolines |
FR2540112B1 (fr) * | 1983-02-01 | 1986-08-29 | Sandoz Sa | Nouveaux derives de la benzo(g)quinoleine, leur preparation et leur utilisation comme medicaments |
US4501890A (en) * | 1983-09-26 | 1985-02-26 | Eli Lilly And Company | Trans-(±)-2,4,6-substituted-5,5a,6,7,8,9,9a,10-octahydro-pyrimido[4,5-g]quinolines |
US4537893A (en) * | 1984-04-27 | 1985-08-27 | Eli Lilly And Company | Octahydrothiazolo[4,5-g]quinolines and use as prolactin secretion inhibitors |
IE58695B1 (en) * | 1984-08-02 | 1993-11-03 | Lilly Co Eli | Octahydro-oxazolo [4,5-g] quinolines |
US4659832A (en) * | 1985-06-10 | 1987-04-21 | Eli Lilly And Company | Process for the preparation of octahydro-oxazolo [4,5-G]quinolines |
US4826986A (en) * | 1986-06-16 | 1989-05-02 | Eli Lilly And Company | 6-Oxo-trans-octa- and decahydroquinolines |
-
1989
- 1989-07-24 US US07/383,673 patent/US4939259A/en not_active Expired - Fee Related
-
1990
- 1990-07-17 NZ NZ234550A patent/NZ234550A/en unknown
- 1990-07-17 CA CA002021314A patent/CA2021314A1/en not_active Abandoned
- 1990-07-17 ZA ZA905618A patent/ZA905618B/xx unknown
- 1990-07-18 PT PT94749A patent/PT94749A/pt not_active Application Discontinuation
- 1990-07-19 EP EP19900307884 patent/EP0410641A3/en not_active Ceased
- 1990-07-19 MX MX2165790A patent/MX21657A/es unknown
- 1990-07-20 AU AU59184/90A patent/AU631228B2/en not_active Ceased
- 1990-07-23 CN CN90104812A patent/CN1049162A/zh active Pending
- 1990-07-23 JP JP2197596A patent/JPH0395182A/ja active Pending
- 1990-07-23 IE IE267490A patent/IE902674A1/en unknown
- 1990-07-23 KR KR1019900011149A patent/KR910002853A/ko not_active Application Discontinuation
- 1990-07-23 HU HU904584A patent/HU207079B/hu not_active IP Right Cessation
- 1990-07-23 RU SU904830582A patent/RU1836371C/ru active
Non-Patent Citations (1)
Title |
---|
I. Med. Chem. 23 (5). 481-491, 1980. * |
Also Published As
Publication number | Publication date |
---|---|
PT94749A (pt) | 1991-03-20 |
HUT54686A (en) | 1991-03-28 |
AU631228B2 (en) | 1992-11-19 |
HU904584D0 (en) | 1990-12-28 |
US4939259A (en) | 1990-07-03 |
EP0410641A3 (en) | 1991-04-17 |
ZA905618B (en) | 1992-03-25 |
JPH0395182A (ja) | 1991-04-19 |
CN1049162A (zh) | 1991-02-13 |
CA2021314A1 (en) | 1991-01-25 |
KR910002853A (ko) | 1991-02-26 |
HU207079B (en) | 1993-03-01 |
IE902674A1 (en) | 1991-02-27 |
MX21657A (es) | 1993-12-01 |
AU5918490A (en) | 1991-01-24 |
NZ234550A (en) | 1992-03-26 |
EP0410641A2 (en) | 1991-01-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU1838308C (ru) | Способ получени производных замещенного (1Н-азол-1-илметил)-бензтриазола или их фармацевтически приемлемых солей присоединени кислот | |
FI92582B (fi) | Menetelmä uusien terapeuttisesti käyttökelpoisten kinoksaliinijohdannaisten valmistamiseksi | |
CA2053253A1 (en) | New aryl-and heteroarylethenylene derivatives and process for their preparation | |
NO922185L (no) | 1-metylkarbapenemderivater, fremgangsmaate til fremstilling derav, samt anvendelse av derivatene som antibiotika | |
AU1811988A (en) | A process for the preparation of substituted indolin-2-one derivatives | |
AT379800B (de) | Verfahren zur herstellung von neuen 2-oxazetidin-derivaten | |
RU1836371C (ru) | Способ получени производных 5,5а,6,7,8,9,9а,10-октагидропиридо (2,3- @ )-хинолина или их фармацевтически приемлемых солей | |
RU94033098A (ru) | Способ производных 1-замещенного-5/4h/-тетразолинона | |
CH612427A5 (en) | Process for the preparation of heterocyclic compounds substituted by acylamino groups | |
AU5608090A (en) | Amines | |
ES2016017A6 (es) | Procedimiento para preparar derivados de acido 1,1-dioxocefem-4-carbotiolico. | |
IE820239L (en) | Carbapenem derivatives | |
AU6892681A (en) | Amino alkoxy pyrazoles | |
ES468127A1 (es) | Un procedimiento para la preparacion de nuevos derivados de pirido (2,1-b) quinazolina | |
ES8104302A1 (es) | Un procedimiento para preparar un derivado de cefema | |
GB1469197A (en) | Preparation of 1-aminoalkyl triazolobenzodiazepines | |
GB1417355A (en) | Substituted piperazine and homopiperazine derivatives | |
ES8505178A1 (es) | Procedimiento para la obtencion de derivados quinolinicos | |
CA2274530A1 (en) | Process for producing 5-arylthio imidazole derivatives | |
IE40507L (en) | Salicylamide derivatives | |
ES383905A1 (es) | Un procedimiento para la preparacion de derivados de piri- midopiridazina. | |
ES8702394A1 (es) | Procedimiento para preparar nuevos derivados de acido sulfa-moilbenzoico | |
ES8302703A1 (es) | "un procedimiento para la preparacion de fenil-quinolicidinas". | |
JPS55160769A (en) | Hydrazinophthalazine derivative | |
TH13791A (th) | อนุพันธ์ต่างๆของกรดบิวไทริค |