ES8104302A1 - Un procedimiento para preparar un derivado de cefema - Google Patents

Un procedimiento para preparar un derivado de cefema

Info

Publication number
ES8104302A1
ES8104302A1 ES488234A ES488234A ES8104302A1 ES 8104302 A1 ES8104302 A1 ES 8104302A1 ES 488234 A ES488234 A ES 488234A ES 488234 A ES488234 A ES 488234A ES 8104302 A1 ES8104302 A1 ES 8104302A1
Authority
ES
Spain
Prior art keywords
formula
triaril
procedure
phosphite
chlorine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES488234A
Other languages
English (en)
Other versions
ES488234A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21732838&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8104302(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES8104302A1 publication Critical patent/ES8104302A1/es
Publication of ES488234A0 publication Critical patent/ES488234A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/59—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L24/00—Arrangements for connecting or disconnecting semiconductor or solid-state bodies; Methods or apparatus related thereto
    • H01L24/74—Apparatus for manufacturing arrangements for connecting or disconnecting semiconductor or solid-state bodies
    • H01L24/78—Apparatus for connecting with wire connectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2224/00—Indexing scheme for arrangements for connecting or disconnecting semiconductor or solid-state bodies and methods related thereto as covered by H01L24/00
    • H01L2224/74—Apparatus for manufacturing arrangements for connecting or disconnecting semiconductor or solid-state bodies and for methods related thereto
    • H01L2224/78—Apparatus for connecting with wire connectors
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2924/00—Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H01L2924/0001—Technical content checked by a classifier
    • H01L2924/00014—Technical content checked by a classifier the subject-matter covered by the group, the symbol of which is combined with the symbol of this group, being disclosed without further technical details
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Computer Hardware Design (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Power Engineering (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE UN DERIVADO DE CEFEMA, DE FORMULA (I), EN LA QUE X ES CLORO O BROMO, R ES UN GRUPO PROTECTOR DE ACIDO CARBOXILICO, R1 ES HIDROGENO O METOXI Y R2 Y R3 PUEDEN SER, INDEPENDIENTEMENTE O CONJUNTAMENTE, UNO DE VARIOS RADICALES. EL PROCEDIMIENTO SE BASA EN LA REACCION DE UN COMPUESTO DE FORMULA (II), EN LA QUE R, R1, R2 Y R3 REPRESENTAN LO MISMO QUE EN LA FORMULA (I), CON 1,0 A 1,3 EQUIVALENTES DE UN COMPLEJO HALOGENO-FOSFITO DE TRIARILO, EN UN DISOLVENTE ORGANICO INERTE ANHIDRO. DICHO COMPLEJO SE OBTIENE <<IN SITU>> POR MEZCLA DE CANTIDADES EQUIVALENTES DE UN FOSFITO DE TRIARILO Y CLORO O BROMO EN EL DISOLVENTE CITADO. LA TEMPERATURA SE MANTIENE INFERIOR A 30GC. ESTOS COMPUESTOS TIENEN APLICACIONES CLINICAS COMO ANTIBIOTICOS. *FORMULA*
ES488234A 1979-02-01 1980-02-01 Un procedimiento para preparar un derivado de cefema Granted ES488234A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/008,647 US4226986A (en) 1979-02-01 1979-02-01 Process for halogenation of β-lactam compounds

Publications (2)

Publication Number Publication Date
ES8104302A1 true ES8104302A1 (es) 1981-04-16
ES488234A0 ES488234A0 (es) 1981-04-16

Family

ID=21732838

Family Applications (2)

Application Number Title Priority Date Filing Date
ES488234A Granted ES488234A0 (es) 1979-02-01 1980-02-01 Un procedimiento para preparar un derivado de cefema
ES495102A Expired ES8106530A1 (es) 1979-02-01 1980-09-16 Un procedimiento para la preparacion de un derivado de iminohalogenuro

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES495102A Expired ES8106530A1 (es) 1979-02-01 1980-09-16 Un procedimiento para la preparacion de un derivado de iminohalogenuro

Country Status (22)

Country Link
US (1) US4226986A (es)
EP (1) EP0014566B1 (es)
JP (1) JPS55104289A (es)
KR (2) KR830001892B1 (es)
BE (1) BE881426A (es)
BG (1) BG35896A3 (es)
CA (1) CA1150725A (es)
CH (1) CH642971A5 (es)
CS (1) CS275604B6 (es)
DE (1) DE3063395D1 (es)
ES (2) ES488234A0 (es)
FR (1) FR2447926A1 (es)
GB (1) GB2041374B (es)
HU (1) HU182065B (es)
IE (1) IE49503B1 (es)
IL (1) IL59266A (es)
IT (1) IT1130240B (es)
LU (1) LU82121A1 (es)
MX (1) MX6576E (es)
PH (2) PH14774A (es)
RO (1) RO84256B (es)
ZM (1) ZM1280A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1148938A (en) * 1979-05-08 1983-06-28 John R. Corfield Preparation of cephalosporins and intermediates employed therein
US4281117A (en) * 1980-09-04 1981-07-28 Eli Lilly And Company Process for 3-chloro cephalosporin nucleus
IN181695B (es) * 1992-08-10 1998-09-05 Ranbaxy Lab Ltd
US5604222A (en) * 1993-12-27 1997-02-18 Lupin Laboratories, Ltd. Method for the preparation of 2-chloro sulfinyl azetidinones
US5578721A (en) * 1994-07-11 1996-11-26 Lupin Laboratories Limited Process for preparation of 3-exomethylene cepham sulfoxide esters
JP6669831B2 (ja) * 2018-10-02 2020-03-18 株式会社ユニバーサルエンターテインメント 遊技機

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3925372A (en) * 1973-02-23 1975-12-09 Lilly Co Eli Alpha-aminoacyl-3-halo cephalosporins
US3962227A (en) * 1973-02-23 1976-06-08 Eli Lilly And Company 3-halo cephalosporins
GB1472869A (en) * 1975-08-11 1977-05-11 Farmaceutici Italia Intermediates for cephalosporin synthesis
IE45158B1 (en) * 1976-08-16 1982-06-30 Lilly Co Eli 3-chloro-cephem synthesis
GB1576219A (en) * 1976-12-31 1980-10-01 Connlab Holdings Ltd Thiazoleneazetidinone derivatives

Also Published As

Publication number Publication date
EP0014566A1 (en) 1980-08-20
US4226986A (en) 1980-10-07
ES495102A0 (es) 1981-08-16
MX6576E (es) 1985-07-24
CA1150725A (en) 1983-07-26
IT8019610A0 (it) 1980-01-31
DE3063395D1 (en) 1983-07-07
RO84256A (ro) 1984-05-23
KR830001906B1 (ko) 1983-09-19
JPS55104289A (en) 1980-08-09
JPH0115515B2 (es) 1989-03-17
FR2447926A1 (fr) 1980-08-29
IL59266A0 (en) 1980-05-30
FR2447926B1 (es) 1982-12-31
KR830001955A (ko) 1983-05-21
IT1130240B (it) 1986-06-11
GB2041374A (en) 1980-09-10
IE49503B1 (en) 1985-10-16
PH17758A (en) 1984-11-27
KR830001892B1 (ko) 1983-09-17
PH14774A (en) 1981-12-09
CH642971A5 (fr) 1984-05-15
RO84256B (ro) 1984-07-30
HU182065B (en) 1983-12-28
GB2041374B (en) 1983-04-13
ES8106530A1 (es) 1981-08-16
LU82121A1 (fr) 1980-04-23
ZM1280A1 (en) 1980-09-22
CS8000660A2 (en) 1991-03-12
BG35896A3 (en) 1984-07-16
BE881426A (fr) 1980-07-30
IL59266A (en) 1983-05-15
ES488234A0 (es) 1981-04-16
KR830001957A (ko) 1983-05-19
CS275604B6 (en) 1992-03-18
IE800187L (en) 1980-08-01
EP0014566B1 (en) 1983-05-25

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