ES8303421A1 - Un procedimiento para la preparacion de 6-alquiliden-penamas. - Google Patents

Un procedimiento para la preparacion de 6-alquiliden-penamas.

Info

Publication number
ES8303421A1
ES8303421A1 ES501645A ES501645A ES8303421A1 ES 8303421 A1 ES8303421 A1 ES 8303421A1 ES 501645 A ES501645 A ES 501645A ES 501645 A ES501645 A ES 501645A ES 8303421 A1 ES8303421 A1 ES 8303421A1
Authority
ES
Spain
Prior art keywords
formula
beta
preparation
lactam compounds
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES501645A
Other languages
English (en)
Other versions
ES501645A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES8303421A1 publication Critical patent/ES8303421A1/es
Publication of ES501645A0 publication Critical patent/ES501645A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 6-ALQUILIDEN-PENAMAS Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES O ESTERES HIDROLIZABLES ~AIN VIVO~B, DE FORMULA (I), EN LA QUE R , R Y R PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE DESHIDRATACION DE UN COMPUESTO DE FORMULA (II), EN LA QUE R ES HIDROGENO O UN GRUPO BLOQUEANTE DE CARBOXILO; Y R , R Y R TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO POR TRATAMIENTO CON UN AZODICARBOXILATO, UNA TRAIRILFOSFINA O UN TRIALQUILFOSFITO, EN UN DISOLVENTE ORGANICO APROTICO INERTE, A UNA TEMPERATURA ENTRE -20 C Y 100 C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE INFECCIONES BACTERIANAS
ES501645A 1980-04-24 1981-04-24 Un procedimiento para la preparacion de 6-alquiliden-penamas. Granted ES501645A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8013563 1980-04-24

Publications (2)

Publication Number Publication Date
ES8303421A1 true ES8303421A1 (es) 1983-02-01
ES501645A0 ES501645A0 (es) 1983-02-01

Family

ID=10512985

Family Applications (1)

Application Number Title Priority Date Filing Date
ES501645A Granted ES501645A0 (es) 1980-04-24 1981-04-24 Un procedimiento para la preparacion de 6-alquiliden-penamas.

Country Status (14)

Country Link
US (2) US4485110A (es)
EP (1) EP0041768B1 (es)
JP (1) JPH0689004B2 (es)
AU (1) AU547552B2 (es)
CA (1) CA1221356A (es)
DE (1) DE3176517D1 (es)
ES (1) ES501645A0 (es)
GR (1) GR74493B (es)
HK (1) HK93590A (es)
IE (1) IE53292B1 (es)
NZ (1) NZ196902A (es)
PT (1) PT72914B (es)
SG (1) SG75390G (es)
ZA (1) ZA812708B (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4558042A (en) * 1981-05-06 1985-12-10 Farmitalia Carlo Erba S.P.A. β-Lactam-containing antibacterial agents and β-lactamase inhibitors
JPS58198486A (ja) * 1982-05-14 1983-11-18 Sankyo Co Ltd ペネムまたはカルバペネム−３−カルボン酸誘導体およびその製法
JPS591464A (ja) * 1982-06-26 1984-01-06 Sankyo Co Ltd β−ラクタム化合物及びその製法
FI77459C (fi) * 1982-12-08 1989-03-10 Erba Farmitalia Foerfarande foer framstaellning av (5r)-penemderivat.
EP0120613A1 (en) * 1983-03-02 1984-10-03 Beecham Group Plc Penem derivatives and precursors
US4614614A (en) * 1983-03-28 1986-09-30 Ciba-Geigy Corporation Process for the manufacture of optically active azetidinones
JPS6028981A (ja) * 1983-07-27 1985-02-14 Shionogi & Co Ltd ジオキソラニルペネムカルボン酸誘導体
GB8402086D0 (en) * 1984-01-26 1984-02-29 Beecham Group Plc Compounds
FI82471C (fi) * 1984-01-26 1991-03-11 Beecham Group Plc Foerfarande foer framstaellning av farmakologiskt aktiva 6-metylenpenemderivater.
US5015473A (en) * 1984-01-30 1991-05-14 Pfizer Inc. 6-(substituted)methylenepenicillanic and 6-(substituted)hydroxymethylpenicillanic acids and derivatives thereof
US4826833A (en) * 1984-01-30 1989-05-02 Pfizer Inc. 6-(Substituted)methylene-penicillanic and 6-(substituted)hydroxymethylpenicillanic acids and derivatives thereof
US4559333A (en) * 1984-03-01 1985-12-17 Schering Corporation Hydrazone substituted penems
EP0167050A1 (en) * 1984-06-21 1986-01-08 Beecham Group Plc Clavulanate compounds, their preparation and use and intermediates thereof
WO1986000615A1 (en) * 1984-07-13 1986-01-30 Sanraku Incorporated New 2-oxoazetidines, process for the preparation and utilization thereof
GB8518421D0 (en) * 1985-07-22 1985-08-29 Beecham Group Plc Compounds
GB8518422D0 (en) * 1985-07-22 1985-08-29 Beecham Group Plc Compounds
DE3618813A1 (de) * 1986-06-04 1987-12-10 Hoechst Ag Pharmazeutische zubereitung zur behandlung bakterieller infektionen
AT392903B (de) * 1987-10-08 1991-07-10 Hoechst Ag Pharmazeutische zubereitung enthaltend ein cephalosporin und ein penemantibiotikum
ATE118215T1 (de) * 1989-09-04 1995-02-15 Beecham Group Plc Cephalosporinderivate, verfahren zu ihrer herstellung, pharmazeutische präparate und zwischenverbindungen.
GB9116236D0 (en) * 1991-07-27 1991-09-11 Smithkline Beecham Plc Novel compounds
GB9305837D0 (en) * 1993-03-20 1993-05-05 Smithkline Beecham Plc Novel compounds
US6472383B1 (en) 1994-04-25 2002-10-29 Smithkline Beecham P.L.C. Pharmaceutical formulations
CZ286898B6 (en) * 1994-04-25 2000-07-12 Smithkline Beecham Plc Pharmaceutical preparation
US5629306A (en) 1994-12-09 1997-05-13 Research Corporation Technologies, Inc. 7-alkylidene cephalosporanic acid derivatives and methods of using the same
US6407091B1 (en) 1999-04-15 2002-06-18 Research Corporation Technologies, Inc. β-lactamase inhibiting compounds
AR039774A1 (es) 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
AR039475A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
US20040132708A1 (en) * 2002-05-01 2004-07-08 Wyeth Process for preparing 6-alkylidene penem derivatives
TW200621282A (en) * 2004-08-13 2006-07-01 Wyeth Corp Stabilizing formulations
CA2616468A1 (en) * 2005-07-27 2007-03-08 Wyeth Tricyclic 6-alkylidene-penem .beta.-lactamase inhibitors and .beta.-lactam antibiotic combination: a broad spectrum antibiotic
BRPI0613927A2 (pt) * 2005-07-27 2011-02-15 Wyeth Corp uso de cefepima ou um sal farmaceuticamente aceitável desta e um composto da fórmula i ou um sal farmaceuticamente aceitável ou éster deste hidrolisável in vivo; composição; embalagem; e produto
GT200600380A (es) * 2005-08-24 2007-03-29 Proceso para la preparacion de inhibidores de beta-lactamasa
JP5276653B2 (ja) 2007-05-21 2013-08-28 ハンス・ルドルフ・プフェンドラー カルバペネム類を含む殺菌性抗ｍｒｓａ活性医薬組成物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4301074A (en) * 1977-11-17 1981-11-17 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acid
US4123539A (en) * 1977-12-29 1978-10-31 Merck & Co., Inc. 6-Ethylpenicillanic acid
EP0003960B1 (de) * 1978-02-02 1983-06-29 Ciba-Geigy Ag 6-Substituierte Thia-Azaverbindungen, ihre Herstellung und diese enthaltende pharmazeutische Präparate
US4272437A (en) * 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates
US4282150A (en) * 1978-12-18 1981-08-04 Bristol-Myers Company 2,6-Disubstituted penem compounds
GB2045236A (en) * 1979-03-26 1980-10-29 Hoechst Uk Ltd Oxapenem derivatives
JPS55153789A (en) * 1979-04-11 1980-11-29 Sankyo Co Ltd Penem-3-carboxylic acid derivative and its preparation
US4260598A (en) * 1979-10-22 1981-04-07 Pfizer Inc. Method for increasing antibacterial effectiveness of a β-lactam antibiotic
US4432970A (en) * 1979-11-23 1984-02-21 Pfizer Inc. 6-beta-Halopenicillanic acid 1,1-dioxides as beta-lactamase inhibitors

Also Published As

Publication number Publication date
PT72914A (en) 1981-05-01
DE3176517D1 (en) 1987-12-17
PT72914B (en) 1982-06-18
EP0041768A2 (en) 1981-12-16
IE810906L (en) 1981-10-24
EP0041768A3 (en) 1982-01-27
US4560550A (en) 1985-12-24
NZ196902A (en) 1984-03-30
US4485110A (en) 1984-11-27
CA1221356A (en) 1987-05-05
SG75390G (en) 1990-11-23
JPS56167689A (en) 1981-12-23
AU547552B2 (en) 1985-10-24
ZA812708B (en) 1982-04-28
HK93590A (en) 1990-11-16
AU6976281A (en) 1981-10-29
IE53292B1 (en) 1988-10-12
JPH0689004B2 (ja) 1994-11-09
ES501645A0 (es) 1983-02-01
EP0041768B1 (en) 1987-11-11
GR74493B (es) 1984-06-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19950603