YU47200B - Postupak za dobijanje imidazopiridazinskih derivata - Google Patents

Postupak za dobijanje imidazopiridazinskih derivata

Info

Publication number
YU47200B
YU47200B YU156988A YU156988A YU47200B YU 47200 B YU47200 B YU 47200B YU 156988 A YU156988 A YU 156988A YU 156988 A YU156988 A YU 156988A YU 47200 B YU47200 B YU 47200B
Authority
YU
Yugoslavia
Prior art keywords
group
formula
compound
optionally substituted
alkyl
Prior art date
Application number
YU156988A
Other languages
English (en)
Other versions
YU156988A (en
Inventor
S.M. Hodgson
Original Assignee
The Wellcome Foundation Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Wellcome Foundation Limited filed Critical The Wellcome Foundation Limited
Publication of YU156988A publication Critical patent/YU156988A/xx
Publication of YU47200B publication Critical patent/YU47200B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

POSTUPAK ZA DOBIJANJE IMIDAZOPIRIDAZINSKIH DERIVATA opste formule: u kojoj R1 predstavlja opciono supstituisanu karbociklicnu aril grupu sa 6 ili 10 clanova u prstenu i koja sadrzi najmanje jedan aromatican prsten, opciono supstituisanu heterociklicnu aril grupu koja ima 5 do 10 clanova u prstenu ili opciono supstituisanu C1-10 alkil, C2-10 alkenil, C3-10 cikloalkil ili C3-10 cikloalkenil grupu; R2 predstavlja opicono supstituisanu C1-10 alkil, C2-10 alkenil, C2-10 alkinil, C3-10 cikloalkenil grupu, opciono supstituisanu karbocik-licnu aril grupu koja ima 6 do 10 clanova u prstenu i sadrzi najmanje jedan aromaticni prsten, opciono supstituisanu heterociklicnu grupu koja ima od 5 do 10 clanova u prstenu, ili opciono supstituisanu aril (C1-14) alkil grupu gde je aril deo karbociklicne ili heterociklicne grupe kao sto je ovde ranije definisano; R3 predstavlja vodonikov atom, C1-14 alkil grupu: i/ili X predstavlja atom kiseonika ili sumpora, grupu -CH2- ili grupu NR4 gde R4 predstavlja vodonikov atom ili C1-4 alkil grupu; i Y predstavlja grupu -CH2- ili -CH2CH2- ili X-Y zajedno predstavljaju grupu -CH=CH- i njihovih farmaceutski prihvatljivih soli, naznacen time, sto obuhvata: reakciju u aproticnom rastvaracu kao sto je dimetilformamid, 1,3-dimetilimidazolinon ili heksametilfosforamid na temperaturi od oko 50°C do oko 120°C, piridizinskog derivata opste formule (II) gde su R1 i X i Y kao sto je definisano za formulu (I) sa jedinjenjem opste formule (III) pricemu su R2 i R3 definisani kao u formuli (I) a Zje atom halogena, posle cega se, ukoliko se zeli i/ili ako je potrebno, dobivena jedinjenja formule (I) mogu prevesti u druga jedinjenja formule (I) pomocu: - odvajanja grupe -CO2R2 pod kiselim uslovima, opciono u prisustvu rastvaraca, i onda reakcijom sa reagensom za uvodjenje razlicite -CO2R2 grupe; - zamene esterifikujuce grupe R2 u jedinjenju formule (I) tretiran-jem pomenutog jedinjenja sa odgovarajucim alkoholom u prisustvu baze na temperaturi u intervalu 50 do 180°C; ili - alkilovanja jedinjenje u kojem je R3 vodonik tako da se obezbedi jedinjenje u kojem je R3 alkil grupa; i/ili vrsi se obrazovanje soli. Prijava sadrzi jos 6 zavisnih zahteva.
YU156988A 1987-08-15 1988-08-12 Postupak za dobijanje imidazopiridazinskih derivata YU47200B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878719368A GB8719368D0 (en) 1987-08-15 1987-08-15 Heterocyclic compounds

Publications (2)

Publication Number Publication Date
YU156988A YU156988A (en) 1990-04-30
YU47200B true YU47200B (sh) 1995-01-31

Family

ID=10622364

Family Applications (3)

Application Number Title Priority Date Filing Date
YU156988A YU47200B (sh) 1987-08-15 1988-08-12 Postupak za dobijanje imidazopiridazinskih derivata
YU202889A YU47212B (sh) 1987-08-15 1989-10-18 Postupak za dobijanje imidazopiridazinskih derivata
YU202789A YU47130B (sh) 1987-08-15 1989-10-18 Postupak za dobijanje imidazopiridazinskih derivata

Family Applications After (2)

Application Number Title Priority Date Filing Date
YU202889A YU47212B (sh) 1987-08-15 1989-10-18 Postupak za dobijanje imidazopiridazinskih derivata
YU202789A YU47130B (sh) 1987-08-15 1989-10-18 Postupak za dobijanje imidazopiridazinskih derivata

Country Status (28)

Country Link
US (5) US5091531A (sh)
EP (1) EP0305093B1 (sh)
JP (1) JPS6468375A (sh)
KR (1) KR890003764A (sh)
CN (2) CN1031532A (sh)
AP (1) AP89A (sh)
AT (1) ATE103919T1 (sh)
AU (1) AU613392B2 (sh)
CA (1) CA1336432C (sh)
DD (1) DD289529A5 (sh)
DE (1) DE3888897T2 (sh)
DK (1) DK168954B1 (sh)
ES (1) ES2063039T3 (sh)
FI (1) FI89600C (sh)
GB (1) GB8719368D0 (sh)
HU (1) HU204052B (sh)
IL (1) IL87435A (sh)
MC (1) MC1969A1 (sh)
MX (1) MX12655A (sh)
MY (1) MY103602A (sh)
NO (1) NO168305C (sh)
NZ (1) NZ225808A (sh)
PH (1) PH25741A (sh)
PL (3) PL159008B1 (sh)
PT (1) PT88260B (sh)
RU (3) RU1769759C (sh)
YU (3) YU47200B (sh)
ZA (1) ZA885996B (sh)

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GB8719368D0 (en) * 1987-08-15 1987-09-23 Wellcome Found Heterocyclic compounds
PH27291A (en) * 1989-01-31 1993-05-04 Takeda Chemical Industries Ltd Imidazolpyrimidazines their production and use
EP0440119A1 (en) * 1990-01-31 1991-08-07 Takeda Chemical Industries, Ltd. Imidazopyridazine compounds, their production and use
ATE117690T1 (de) * 1990-03-01 1995-02-15 Takeda Chemical Industries Ltd Imidazopyridazine, ihre herstellung und verwendung.
KR20010087738A (ko) * 1998-10-21 2001-09-21 다케다 야쿠힌 고교 가부시키가이샤 축합 피리다진 유도체, 이의 제조 방법 및 용도
SK18412002A3 (sk) 2000-06-30 2003-06-03 Wyeth Použitie substituovaných triazolopyrimidínových derivátov a farmaceutický prostriedok s ich obsahom
JP3767352B2 (ja) 2000-09-18 2006-04-19 トヨタ自動車株式会社 内燃機関の制御装置
US6960584B2 (en) * 2001-04-10 2005-11-01 Merck & Co., Inc. Inhibitors of Akt activity
CA2659971A1 (en) * 2006-08-04 2008-02-07 Takeda Pharmaceutical Company Limited Fused heterocyclic derivative and use thereof
CA2667487C (en) * 2006-11-06 2017-04-04 Supergen, Inc. Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors
US8431608B2 (en) 2007-08-17 2013-04-30 Icagen Inc. Heterocycles as potassium channel modulators
US8058274B2 (en) * 2007-08-17 2011-11-15 Icagen, Inc. Heterocycles as potassium channel modulators
WO2009106577A1 (en) * 2008-02-28 2009-09-03 Novartis Ag Imidazo [1,2-b] pyridazine derivatives for the treatment of c-met tyrosine kinase mediated disease
WO2009128520A1 (ja) * 2008-04-18 2009-10-22 塩野義製薬株式会社 Ｐ１３ｋ阻害活性を有する複素環化合物
UY32049A (es) * 2008-08-14 2010-03-26 Takeda Pharmaceutical Inhibidores de cmet
TW201437211A (zh) * 2013-03-01 2014-10-01 Bayer Pharma AG 經取代咪唑并嗒□

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US3809691A (en) * 1967-10-23 1974-05-07 Eastman Kodak Co Novel cyanine dyes with fused imidazolo nuclei
US3615639A (en) * 1967-10-23 1971-10-26 Eastman Kodak Co Direct positive silver halide emulsions containing dyes as electron acceptors and spectral sensitizers
DE2043811A1 (en) * 1970-09-03 1972-03-09 E.I. du Pont de Nemours and Co., Wilmington, Del. (V.StA.) Fungicidal and acaricidal alkyl 2-benzimi- - dazole carbomate derivs
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DE3423092A1 (de) * 1984-06-22 1986-01-02 Dr. Karl Thomae Gmbh, 7950 Biberach Neue 8-alkylthio-2-piperazino-pyrimido(5,4-d) pyrimidine, ihre herstellung und diese verbindungen enthaltende arzneimittel
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DE3446778A1 (de) * 1984-12-21 1986-07-03 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazoderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE3446812A1 (de) * 1984-12-21 1986-06-26 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazoderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE3527036A1 (de) * 1985-07-27 1987-02-05 Merck Patent Gmbh 6-arylalkenylpyridazinone
DE3542661A1 (de) * 1985-12-03 1987-06-04 Bayer Ag Imidazopyridazinalkensaeureamide, verfahren zu ihrer herstellung, zwischenprodukte zu ihrer herstellung
WO1989001478A1 (en) * 1987-08-07 1989-02-23 The Australian National University ARYLOXY- AND ARALKYLTHIO-IMIDAZO[1,2-b]PYRIDAZINES
WO1989001333A1 (en) * 1987-08-07 1989-02-23 The Australian National University IMIDAZO[1,2-b]PYRIDAZINES
GB8719368D0 (en) * 1987-08-15 1987-09-23 Wellcome Found Heterocyclic compounds

Also Published As

Publication number Publication date
GB8719368D0 (en) 1987-09-23
ATE103919T1 (de) 1994-04-15
PL160044B1 (pl) 1993-02-26
US5538970A (en) 1996-07-23
AP8800098A0 (en) 1988-08-01
YU47130B (sh) 1994-12-28
MX12655A (es) 1993-10-01
DD289529A5 (de) 1991-05-02
NO168305B (no) 1991-10-28
PL160045B1 (en) 1993-02-26
YU202889A (en) 1990-04-30
YU47212B (sh) 1995-01-31
DK451588D0 (da) 1988-08-12
AU613392B2 (en) 1991-08-01
MC1969A1 (fr) 1989-09-29
NO883613L (no) 1989-02-16
PH25741A (en) 1991-10-18
ES2063039T3 (es) 1995-01-01
PL159008B1 (pl) 1992-11-30
YU202789A (en) 1990-04-30
NZ225808A (en) 1991-07-26
YU156988A (en) 1990-04-30
US5091531A (en) 1992-02-25
AP89A (en) 1990-06-14
MY103602A (en) 1993-08-28
EP0305093B1 (en) 1994-04-06
FI89600B (fi) 1993-07-15
RU1836372C (ru) 1993-08-23
NO883613D0 (no) 1988-08-12
FI883758A0 (fi) 1988-08-12
PL274216A1 (en) 1989-05-02
DK168954B1 (da) 1994-07-18
NO168305C (no) 1992-02-05
HUT50473A (en) 1990-02-28
RU2017741C1 (ru) 1994-08-15
IL87435A (en) 1993-01-31
FI883758A (fi) 1989-02-16
HU204052B (en) 1991-11-28
CA1336432C (en) 1995-07-25
CN1085901A (zh) 1994-04-27
FI89600C (fi) 1993-10-25
JPS6468375A (en) 1989-03-14
EP0305093A1 (en) 1989-03-01
US5371219A (en) 1994-12-06
PT88260A (pt) 1989-09-14
US5380759A (en) 1995-01-10
DE3888897D1 (de) 1994-05-11
AU2097988A (en) 1989-02-16
PT88260B (pt) 1995-03-01
US5447956A (en) 1995-09-05
RU1769759C (ru) 1992-10-15
KR890003764A (ko) 1989-04-17
ZA885996B (en) 1990-04-25
DK451588A (da) 1989-02-16
IL87435A0 (en) 1989-01-31
CN1031532A (zh) 1989-03-08
DE3888897T2 (de) 1994-10-20

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