WO2013131520A2 - Pressurized container containing haemostatic paste - Google Patents

Pressurized container containing haemostatic paste Download PDF

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Publication number
WO2013131520A2
WO2013131520A2 PCT/DK2013/050054 DK2013050054W WO2013131520A2 WO 2013131520 A2 WO2013131520 A2 WO 2013131520A2 DK 2013050054 W DK2013050054 W DK 2013050054W WO 2013131520 A2 WO2013131520 A2 WO 2013131520A2
Authority
WO
WIPO (PCT)
Prior art keywords
container
paste
propellant
compartment
valve
Prior art date
Application number
PCT/DK2013/050054
Other languages
English (en)
French (fr)
Other versions
WO2013131520A3 (en
Inventor
Mette Krog JENSEN
Kristian Larsen
Original Assignee
Ferrosan Medical Devices A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrosan Medical Devices A/S filed Critical Ferrosan Medical Devices A/S
Priority to CN201380012440.2A priority Critical patent/CN104159527B/zh
Priority to IN8122DEN2014 priority patent/IN2014DN08122A/en
Priority to RU2014140147A priority patent/RU2657955C2/ru
Priority to JP2014560250A priority patent/JP6241624B2/ja
Priority to US14/383,461 priority patent/US11109849B2/en
Priority to CA2865349A priority patent/CA2865349C/en
Priority to HK15105847.7A priority patent/HK1204904B/en
Priority to EP13712675.1A priority patent/EP2822474B1/en
Publication of WO2013131520A2 publication Critical patent/WO2013131520A2/en
Publication of WO2013131520A3 publication Critical patent/WO2013131520A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/00491—Surgical glue applicators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
    • A61B17/12186—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices liquid materials adapted to be injected
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14526—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons the piston being actuated by fluid pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/155—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by gas introduced into the reservoir
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
    • B65B55/02—Sterilising, e.g. of complete packages
    • B65B55/04—Sterilising wrappers or receptacles prior to, or during, packaging
    • B65B55/08—Sterilising wrappers or receptacles prior to, or during, packaging by irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00535—Surgical instruments, devices or methods pneumatically or hydraulically operated
    • A61B2017/00544—Surgical instruments, devices or methods pneumatically or hydraulically operated pneumatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M2005/14513—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons with secondary fluid driving or regulating the infusion

Definitions

  • the present invention relates to a container adapted to dispense its content under pressure.
  • the container of the present invention consists of two separate
  • the container of the present invention contains a haemostatic paste.
  • haemostatic agents provides for control of bleeding in surgical procedures.
  • Haemostatic agents, supplement pressure, ligature and other conventional methods of controlling capillary, venous and arterial bleeding are known.
  • haemostatic control different devices for application of haemostatic agents are currently on the market.
  • One such product is a pre-filled syringe applied with an applicator tip.
  • the syringe contains the haemostatic agent in paste form in a volume which allows suitable mixing of the haemostatic agent with any further agent, such as water, saline and thrombin, within the containment unit.
  • any further agent such as water, saline and thrombin
  • the design of the syringe leads to the need for applying manual pressure on the plunger located within the containment unit from behind leading to loss of some control with the direction in which the applicator tip is pointed, i.e. aiming correctly at the site of bleeding is made more difficult.
  • the user Due to the viscosity of the haemostatic paste formed in the containment unit after mixing, the user has to apply considerable force to the end of the plunger in order to empty the haemostatic paste out of the containment unit onto a site of bleeding. Because such a relative high force is needed the precision in applying the product is limited and the device has limited user-friendliness.
  • the collapsible bag type comprises a collapsible bag arrangement where the product is held in a flexible bag secured to the neck of the container with an outlet valve. The propellant is held between the bag and the container wall. Under pressure the bag collapses and extrudes the product from the outlet valve. Filling of the bags is performed under high pressure through the valve which induces phase-separation in paste products.
  • the container In the "piston" type the container is divided into two chambers by an internal piston, and product and propellant is held separately from each other with this piston. Under pressure of the propellant the piston forces the product from the container through a valve.
  • the "piston” type containers are usually used for product in liquid, fluid, paste and plastic form, such as foodstuffs (mayonnaise, whipped cream etc.), cosmetics
  • the invention relates to a device for dispensing a haemostatic paste from a container under pressure having an interior including a product compartment and a propellant compartment separated from one another and a slidable piston separating the product compartment from the propellant compartment.
  • This device provides haemostatic paste which may be administered with great precision and by use of a minimal amount of force.
  • the haemostatic paste is ready-to-use.
  • ready-to-use is intended to mean a paste that can be applied directly from the pressurized container to a subject. This does not exclude the possibility that further ingredients are mixed into the haemostatic paste after it has been expelled from the pressurized container.
  • haemostatic pastes it is necessary to store the paste separately from the propellant intended to keep the paste under pressure. To do this, the paste is kept separate from the propellant by means of a piston capable of sliding in sealed contact against the interior surface of the body of the container.
  • the invention relates to a device for dispensing a haemostatic paste from a container under pressure.
  • the present invention which makes administration of the haemostatic paste easier by use of a propellant as driving force.
  • the device of the invention is furthermore designed such that it can be pointed in all directions whilst complete emptying of the container is still possible. This is of high importance during a surgical procedure where the bleeding site may be located in difficult to reach places. As stated above previous products typically require considerable manual force for application to a bleeding site and the precise application of the haemostatic agent is difficult and requires some strength of the surgeon.
  • the device of the present invention comprises a container having an interior including a product compartment and a propellant compartment separated from one another, said container having a first end with a haemostatic paste outlet extending from the product compartment, said outlet being openable and closable.
  • a valve is located in
  • the valve may be positioned in connection with the haemostatic paste outlet to allow for flow of the haemostatic paste through the haemostatic paste outlet to the exterior of the device.
  • a slidable piston is separating the product compartment from the propellant
  • the piston may comprise a primary piston having a primary wall-engaging skirt and a secondary piston having a secondary wall-engaging skirt and between said primary and secondary pistons an interposed deformable sealant material is located.
  • said deformable material may be compressed between the primary and secondary pistons and urged against the container wall to form a seal.
  • the primary piston is preferably in frictional engagement with the wall of the contained and the secondary piston is preferably in loose fit thus to encourage compression of the interposed deformable sealant material.
  • the deformable sealant material may be any liquid or semi-solid material which is chemically compatible with the materials it will come into contact with in use.
  • Water- based materials such as aqueous gels of alginic materials are suitable, as are many organic and mineral oils, greases and waxes.
  • the sealant material may in one embodiment be selected from the group consisting of: ethylene glycol, diethylene glycol, butylene glycol, amylene glycol, glycerol, polyglycerin, glycerin, polyvinyl alcohol, silicone, acrylic resin.
  • the deformable sealant material is a gel.
  • the deformable sealant is an aqueous gel.
  • the valve used with the present invention is preferably arranged to allow easy flow of the haemostatic paste through the haemostatic paste outlet and to allow the paste to be dispensed to exit via the valve.
  • the valve may be arranged with optimized fluid passage for example by having large inlet and/or out let openings, smooth surfaces and/or a passage way through which the paste may flow without being limited by bends, protrusions etc.
  • exchangeable, bendable and/or cutable long tip of the known type are used in conjunction with Surgiflo® haemostatic paste applicators.
  • the exchangeable tip can be selected in order to allow administration of the
  • haemostatic paste in hard to reach areas to allow passage of a fluid with a specific viscosity and/or administer fluid at a specific flow rate.
  • a cutable long tip the tip can be cut to a desired length with respect to given circumstances of the administration such as viscosity of fluid (haemostatic paste), administration area etc. If the long tip is at least partly conical the tip can be cut to provide a specific diameter to the exit opening of the tip.
  • a bendable tip which holds its shape after being bent and preferably will not kink when being bend.
  • the bendable tip can be bendable in all directions.
  • the user may shape the tip to be optimized for administration of a specific fluid and/or optimized for administration of the fluid in hard to reach areas.
  • the exchangeable tip may be bent to have an optimized curvature and a cut to have a desired length by the user.
  • the tip is in one embodiment between 5-20 cm long, such as 10-20 cm long, such as 15-20 cm long. In one embodiment the tip is not bendable.
  • the device comprises a movable actuator coupled to the valving member so that actuating movement of the actuator actuates the valving member to the open position.
  • the actuator may be of a form wherein a handle part of the actuator is positioned along the side of the container in a distance and angle from the container making it easy to reach and press by the user preferably with a minimal change of hand position.
  • the actuator may preferably be arranged to require a minimum of force by the user in order to actuate the valve and administer the haemostatic paste.
  • This can for example be achieved by an actuator arrangement with a hinged lever arm transferring the force applied by the user to the movable valving member.
  • the pressure in the propellant chamber is in one embodiment in the range of 100-500 kPa at room temperature, more preferably in the range of 200-500 kPa, such as 300- 500 kPa, more preferably 400-500 kPa. In another embodiment the pressure in the propellant chamber is in the range 100-400 kPa at room temperature, such as 100-300 kPa, more preferably 100-200 kPa.
  • the propellant may be selected from the group consisting of nitrogen, oxygen, compressed air, butane, propane, chlorofluorocarbon, fluorocarbon and dimethyl ether.
  • the propellant is nitrogen, oxygen or compressed air.
  • the haemostatic paste of the present invention has a viscosity in the range of 700- 4.000 Pa-s at room temperature, such as between 1 .000-4.000 Pa-s, for example 1 .200-4.000 Pa-s, such as 1 .400-4.000 Pa-s, for example 1 .600-4.000 Pa-s, such as 1 .800-4.000 Pa-s, for example 2.000-4.000 Pa-s, such as 2.200-4.000 Pa-s, for example 2.400-4.000 Pa-s, such as 2.600-4.000 Pa-s, for example 2.800-4.000 Pa-s, such as 3.000-4.000 Pa-s, for example 3.200-4.000 Pa-s, such as 3.400-4.000 Pa-s, for example 3.600-4.000 Pa-s, such as 3.800-4000 Pa-s
  • the haemostatic paste of the present invention has a viscosity in the range 700-4.000 Pa-s, for example 700-3.800 Pa-s, such as 700-3.600 Pa-s, for example 700-3.400 Pa-s, such as 700-3.200 Pa-s, for example 700-3.000 Pa-s, such as 700-2.800 Pa-s, for example 700-2.600 Pa-s, such as 700-2.400 Pa-s, for example 700-2.200 Pa-s, such as 700-2.000 Pa-s, for example 700-1 .800 Pa-s, such as 700-1 .600 Pa-s, for example 700-1 .400 Pa-s, such as 700- 1 .200 Pa-s, for example 700-1 .000 Pa-s, such as 700-900 Pa-s, for example 700-800 Pa-s.
  • the haemostatic paste of the present invention may comprise 10-25% v/v of gelatine or collagen and a suitable liquid.
  • the suitable liquid may be selected from the group consisting of: sterile water, sterile saline and sterile PBS buffer.
  • the haemostatic paste may be combined with another active ingredient.
  • An appropriate amount of another active agent may be added to the haemostatic paste.
  • Such another active agent may be selected from the group consisting of: germicidal agent, preservative, antimicrobial agents, coagulation factors, antifibrinolytic agents, surfactants, growth factors to promote healing, calcium ions to aid coagulation, adrenaline or other substances capable of constricting blood vessels.
  • coagulation factors include coagulation factors selected from the group consisting of thrombin, fibrinogen, aprotinin, fibronectin, factor XIII, factor VII, factor VIII, and combinations thereof.
  • Such compounds may be of any mammalian origin, such as of porcine or human origin, or may be obtained by recombinant means by methods well-known to the skilled person. It will be understood that gelatine and collagen are not considered as being coagulation factors.
  • Antifibrinolytic agents may be selected from the group consisting of tranexamic acid, ⁇ - aminocaproic acid, aprotinin, pepstatin, leupeptin, antipain, chymostatin, gabexate, and mixtures thereof.
  • the antifibrinolytic agent is preferably tranexamic acid.
  • Antimicrobial agents may be selected from bactericidal or bacteriostatic agents, such as antibiotics and sulphonamides, antiviral compounds, antimycotic agents and anti- infectives.
  • Surfactants may be selected from the group consisting of anionic surfactants, cationic surfactants, non-ionic surfactants and surface active biological modifiers.
  • the composition does not contain such another active agent, i.e. said composition does not contain germicidal agent, coagulation factors, anti-fibrinolytic agents, surfactants, antimicrobial agents., preservative, growth factors, calcium ions, adrenaline and/or other substances capable of constricting blood vessels
  • All ingredients of the haemostatic paste should be able to tolerate sterilization by radiation and still keep the activity.
  • the haemostatic paste preferably has a minimum shelf-life of two years at room temperature.
  • valve In use, the valve is opened releasing the internal pressure, the propellant in the propellant chamber expands thereby forcing the secondary piston into even closer contact with the sealant which is urged outward against the container wall.
  • the primary piston advances and extrudes the product from the valve.
  • the primary and secondary piston is preferably made of a plastic material selected from the group consisting of Polyethylene (HDPE), Polystyrene, Akrylnitril-butadien-styren (ABS ), polyamide (PA), Polypropylene, and Poly Vinyl Chloride (PVC).
  • HDPE Polyethylene
  • ABS Polystyrene
  • PA polyamide
  • PVC Poly Vinyl Chloride
  • the primary and secondary piston is made of HDPE.
  • the container is made of aluminium coated on the inside with a coating.
  • a coating may be selected from the group consisting of FDA approved coatings for example, but not limited to PPG2497-303/A (PPG Industries Lackfabrik GmbH), PPG2956-401/A (PPG Industries Lackfabrik GmbH) and J3121 (Valspar).
  • the valve of the device may be fitted with an appropriate actuator.
  • the pressure needed to be exerted by the user on the actuator in order to empty the device may vary with different actuator types.
  • the device and all its components are preferably made of materials which can withstand sterilization by gamma radiation or beta radiation.
  • Said sterilization is in one embodiment performed at 10-50 kGy, more preferably at 10-40 kGy, such as 10-30 kGy, more preferably 10-20 kGy.
  • the sterilization is performed at 10-50 kGy, such at 20-50 kGy, more preferably 30-50 kGy, such as 40-50 kGy.
  • the sterilization is performed at 25-30 kGy.
  • the device of the present invention is preferably completely air and light tight. After having subjected the device to sterilization by radiation the haemostatic paste present in the product chamber is sterile and will remain so until use.
  • Fig 1 shows the overall design of the device of the invention
  • Fig 2 shows a preferred embodiment of the piston
  • Fig 3 shows an embodiment of an actuator used with the present invention.
  • the device consists of an elongate cylindrical container 1 (which may be an extruded or seamed can) having a top 2 and inturned domed base 3, the top having a neck 4 and fitted therein a valved outlet extrusion valve 5.
  • the presence of the membrane 8 is optional but, when present, it forms with the base 3 a propellant compartment 12.
  • the base 3 has a generally central hole for introduction of propellant during filling after which it is closed by a plug 13.
  • the crown of the primary piston 6 is shaped to conform generally to the internal configuration of the container top and internal parts of the valve 5 so as to maximise the amount of product which can be expelled by the piston.
  • Fig. 3 shows an embodiment of a movable actuator 4 used with the present invention.
  • the actuator comprises a lever arm 15 connected to the haemostatic paste outlet of the device 16 by hinge 17 and a lever handle 18 extending from the lever arm 15 in an angle of approximately 90 ⁇
  • the lever handle 17 is pressed towards the container 1 by a force indicated by arrow F and the valve is hereby opened allowing paste to pass from the inside of the container 1 , through the valve and out through a tip 19.
  • the force is provided by the grip of the user (not shown).
  • the lever handle 18 When the lever handle 18 is pressed by the user i.e. when the force F is applied by the user to open the valve, the lever handle is brought to a position in which it is parallel to or close to parallel to the longitudinal direction of the container. When the force is relaxed the handle moves back along the direction R. Thus, when the valve is closed the lever handle is relatively close to the container wall and is positioned in an angle which enables the user to easily change grip from holding around the container with all fingers to a grip holding around the lever handle with one or more fingers in order to apply the force F to actuate (i.e. open) the valve and administer the haemostatic paste until the force F is released.
  • the tip 19 shown in fig. 3 is slightly conical at towards the distal end 20 of the tip.
  • Cross-linked gelatine powder is mixed with a liquid such that the powder is fully wetted.
  • the paste is filled into the device of the invention through the top of the open container into the product compartment. In this way the product may be filled into the product compartment without the use of valves and without being under pressure.
  • the container is closed by attaching the valve body to the container.
  • the valve is securely sealed to the container by crimping of the valve body.
  • the propellant is filled into the propellant compartment under pressure through the opening in the propellant compartment.
  • the propellant compartment is then sealed by a plug, such as a rubber stopper.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Reproductive Health (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Toxicology (AREA)
  • Mechanical Engineering (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Materials For Medical Uses (AREA)
  • Surgical Instruments (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
PCT/DK2013/050054 2012-03-06 2013-03-05 Pressurized container containing haemostatic paste WO2013131520A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CN201380012440.2A CN104159527B (zh) 2012-03-06 2013-03-05 包含止血糊剂的压力容器
IN8122DEN2014 IN2014DN08122A (en:Method) 2012-03-06 2013-03-05
RU2014140147A RU2657955C2 (ru) 2012-03-06 2013-03-05 Контейнер под давлением, содержащий гемостатическую пасту
JP2014560250A JP6241624B2 (ja) 2012-03-06 2013-03-05 止血ペーストを収容する加圧容器
US14/383,461 US11109849B2 (en) 2012-03-06 2013-03-05 Pressurized container containing haemostatic paste
CA2865349A CA2865349C (en) 2012-03-06 2013-03-05 Pressurized container containing haemostatic paste
HK15105847.7A HK1204904B (en) 2012-03-06 2013-03-05 Pressurized container containing haemostatic paste
EP13712675.1A EP2822474B1 (en) 2012-03-06 2013-03-05 Pressurized container containing haemostatic paste

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201270099 2012-03-06
DKPA201270099 2012-03-06

Publications (2)

Publication Number Publication Date
WO2013131520A2 true WO2013131520A2 (en) 2013-09-12
WO2013131520A3 WO2013131520A3 (en) 2013-10-24

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Application Number Title Priority Date Filing Date
PCT/DK2013/050054 WO2013131520A2 (en) 2012-03-06 2013-03-05 Pressurized container containing haemostatic paste

Country Status (8)

Country Link
US (1) US11109849B2 (en:Method)
EP (1) EP2822474B1 (en:Method)
JP (1) JP6241624B2 (en:Method)
CN (1) CN104159527B (en:Method)
CA (1) CA2865349C (en:Method)
IN (1) IN2014DN08122A (en:Method)
RU (1) RU2657955C2 (en:Method)
WO (1) WO2013131520A2 (en:Method)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9265858B2 (en) 2012-06-12 2016-02-23 Ferrosan Medical Devices A/S Dry haemostatic composition
US9533069B2 (en) 2008-02-29 2017-01-03 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing
US9724078B2 (en) 2013-06-21 2017-08-08 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
US10111980B2 (en) 2013-12-11 2018-10-30 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
CN110946633A (zh) * 2019-11-26 2020-04-03 杭州电子科技大学 一种便携式快速挤出装置
US10653837B2 (en) 2014-12-24 2020-05-19 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
US10918796B2 (en) 2015-07-03 2021-02-16 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
US11046818B2 (en) 2014-10-13 2021-06-29 Ferrosan Medical Devices A/S Dry composition for use in haemostasis and wound healing
US20220143320A1 (en) * 2019-03-06 2022-05-12 Gambro Lundia Ab Device and method for the delivery of a thrombin activated fibrin sealant
US11801324B2 (en) 2018-05-09 2023-10-31 Ferrosan Medical Devices A/S Method for preparing a haemostatic composition

Families Citing this family (3)

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