WO2008114721A1 - Ｌ－グルタミン酸系アミノ酸生産微生物及びアミノ酸の製造法 - Google Patents

Ｌ－グルタミン酸系アミノ酸生産微生物及びアミノ酸の製造法 Download PDF

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Publication number
WO2008114721A1
WO2008114721A1 PCT/JP2008/054735 JP2008054735W WO2008114721A1 WO 2008114721 A1 WO2008114721 A1 WO 2008114721A1 JP 2008054735 W JP2008054735 W JP 2008054735W WO 2008114721 A1 WO2008114721 A1 WO 2008114721A1
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WO
WIPO (PCT)
Prior art keywords
amino acid
producing
production
acid
microorganism capable
Prior art date
Application number
PCT/JP2008/054735
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English (en)
French (fr)
Inventor
Seizaburo Shiraga
Noriko Murayama
Hiroshi Izui
Hisao Ito
Hisashi Yasueda
Yoshihiro Usuda
Kazuhiko Matsui
Original Assignee
Ajinomoto Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co., Inc. filed Critical Ajinomoto Co., Inc.
Priority to BRPI0808939-6A priority Critical patent/BRPI0808939B1/pt
Priority to EP08722131A priority patent/EP2133417A4/en
Publication of WO2008114721A1 publication Critical patent/WO2008114721A1/ja
Priority to US12/555,124 priority patent/US8080396B2/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/14—Glutamic acid; Glutamine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/10—Citrulline; Arginine; Ornithine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/24—Proline; Hydroxyproline; Histidine

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Ｌ－グルタミン酸、Ｌ－グルタミン、Ｌ－プロリン、Ｌ－オルニチン、Ｌ－シトルリン、Ｌ－アルギニンからなる群より選ばれる１又は２以上のアミノ酸生産能を有し、かつα－ケトグルタル酸シンターゼの活性が増大するように改変された微生物を培地で培養して、前記Ｌ－アミノ酸を該培地中又は菌体内に生成蓄積させ、該培地又は菌体よりＬ－アミノ酸を採取する。
PCT/JP2008/054735 2007-03-14 2008-03-14 Ｌ－グルタミン酸系アミノ酸生産微生物及びアミノ酸の製造法 WO2008114721A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
BRPI0808939-6A BRPI0808939B1 (pt) 2007-03-14 2008-03-14 Microorganismo, e, método para produzir ácido l-glutâmico
EP08722131A EP2133417A4 (en) 2007-03-14 2008-03-14 MICROORGANISM CAPABLE OF PRODUCING L-GLUTAMIC ACID-TYPE AMINO ACID AND PROCESS FOR PRODUCING AMINO ACID
US12/555,124 US8080396B2 (en) 2007-03-14 2009-09-08 Microorganism producing an amino acid of the L-glutamic acid family and a method for producing the amino acid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-065367 2007-03-14
JP2007065367A JP2010130899A (ja) 2007-03-14 2007-03-14 Ｌ−グルタミン酸系アミノ酸生産微生物及びアミノ酸の製造法

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/555,124 Continuation US8080396B2 (en) 2007-03-14 2009-09-08 Microorganism producing an amino acid of the L-glutamic acid family and a method for producing the amino acid

Publications (1)

Publication Number Publication Date
WO2008114721A1 true WO2008114721A1 (ja) 2008-09-25

Family

ID=39765829

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/054735 WO2008114721A1 (ja) 2007-03-14 2008-03-14 Ｌ－グルタミン酸系アミノ酸生産微生物及びアミノ酸の製造法

Country Status (7)

Country Link
US (1) US8080396B2 (ja)
EP (2) EP2133417A4 (ja)
JP (1) JP2010130899A (ja)
CN (2) CN103396976B (ja)
BR (1) BRPI0808939B1 (ja)
PE (2) PE20130323A1 (ja)
WO (1) WO2008114721A1 (ja)

Cited By (4)

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WO2013069634A1 (ja) 2011-11-11 2013-05-16 味の素株式会社 発酵法による目的物質の製造法
WO2015005406A1 (ja) 2013-07-09 2015-01-15 味の素株式会社 有用物質の製造方法
WO2015060391A1 (ja) 2013-10-23 2015-04-30 味の素株式会社 目的物質の製造法
CN115725532A (zh) * 2022-11-06 2023-03-03 呼伦贝尔东北阜丰生物科技有限公司 一种生物素合酶突变体及其在构建谷氨酸生产菌株中的应用

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WO2008133161A1 (ja) 2007-04-17 2008-11-06 Ajinomoto Co., Inc. カルボキシル基を有する酸性物質の製造法
JP2010226957A (ja) 2007-10-17 2010-10-14 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
EP2248906A4 (en) 2008-01-23 2012-07-11 Ajinomoto Kk PROCESS FOR THE PREPARATION OF L-AMINO ACID
JP2011167071A (ja) * 2008-05-22 2011-09-01 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
EP2343371B1 (en) 2008-09-05 2015-10-21 Ajinomoto Co., Inc. Method for producing l-amino acid
JP2012223092A (ja) 2009-08-28 2012-11-15 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2013074795A (ja) 2010-02-08 2013-04-25 Ajinomoto Co Inc 変異型ｒｐｓＡ遺伝子及びＬ−アミノ酸の製造法
RU2471870C2 (ru) 2010-06-03 2013-01-10 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) СПОСОБ ПОЛУЧЕНИЯ L-АРГИНИНА И L-ЦИТРУЛЛИНА С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА ENTEROBACTERIACEAE, В КОТОРОЙ ОСЛАБЛЕНА ЭКСПРЕССИЯ ГЕНА pepA
RU2482188C2 (ru) 2010-07-21 2013-05-20 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) СПОСОБ ПОЛУЧЕНИЯ L-АРГИНИНА С ИСПОЛЬЗОВАНИЕМ БАКТЕРИЙ РОДА Escherichia, В КОТОРОЙ ИНАКТИВИРОВАН ОПЕРОН astCADBE
RU2501858C2 (ru) 2010-07-21 2013-12-20 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТЫ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА Enterobacteriaceae
JP2014036576A (ja) 2010-12-10 2014-02-27 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
RU2013118637A (ru) 2013-04-23 2014-10-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА ENTEROBACTERIACEAE, В КОТОРОЙ РАЗРЕГУЛИРОВАН ГЕН yjjK
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RU2013140115A (ru) 2013-08-30 2015-03-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА Enterobacteriaceae, В КОТОРОЙ НАРУШЕНА ЭКСПРЕССИЯ КЛАСТЕРА ГЕНОВ znuACB
RU2013144250A (ru) 2013-10-02 2015-04-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА Enterobacteriaceae, В КОТОРОЙ ОСЛАБЛЕНА ЭКСПРЕССИЯ ГЕНА, КОДИРУЮЩЕГО ФОСФАТНЫЙ ТРАНСПОРТЕР
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CN104480058B (zh) * 2014-12-30 2017-07-21 福建师范大学 一株高产l‑亮氨酸工程菌及其应用
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