WO2004112758A1 - Nanopartículas de ácido hialurónico - Google Patents
Nanopartículas de ácido hialurónico Download PDFInfo
- Publication number
- WO2004112758A1 WO2004112758A1 PCT/ES2004/000284 ES2004000284W WO2004112758A1 WO 2004112758 A1 WO2004112758 A1 WO 2004112758A1 ES 2004000284 W ES2004000284 W ES 2004000284W WO 2004112758 A1 WO2004112758 A1 WO 2004112758A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nanoparticles
- hyaluronic acid
- salt
- cationic polymer
- active ingredient
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
- C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
- C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/12—Powdering or granulating
- C08J3/14—Powdering or granulating by precipitation from solutions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
- C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Nanotechnology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT04736983T ATE546135T1 (de) | 2003-06-20 | 2004-06-17 | Hyaluronsäure-nanopartikel |
BRPI0411678-0A BRPI0411678A (pt) | 2003-06-20 | 2004-06-17 | nanopartìculas de ácido hialurÈnico |
JP2006516221A JP4959326B2 (ja) | 2003-06-20 | 2004-06-17 | ヒアルロン酸ナノ粒子 |
AU2004248936A AU2004248936B2 (en) | 2003-06-20 | 2004-06-17 | Hyaluronic acid nanoparticles |
US10/561,548 US20060188578A1 (en) | 2003-06-20 | 2004-06-17 | Hyaluronic acid nanoparticles |
CA2535364A CA2535364C (en) | 2003-06-20 | 2004-06-17 | Hyaluronic acid nanoparticles |
EP04736983A EP1652517B8 (en) | 2003-06-20 | 2004-06-17 | Hyaluronic acid nanoparticles |
NO20056239A NO20056239L (no) | 2003-06-20 | 2005-12-29 | Hyaluronsyre nanopartikler |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200301456A ES2226567B1 (es) | 2003-06-20 | 2003-06-20 | Nanoparticulas de acido hialuronico. |
ESP200301456 | 2003-06-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2004112758A1 true WO2004112758A1 (es) | 2004-12-29 |
Family
ID=33522604
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/ES2004/000284 WO2004112758A1 (es) | 2003-06-20 | 2004-06-17 | Nanopartículas de ácido hialurónico |
Country Status (11)
Country | Link |
---|---|
US (1) | US20060188578A1 (es) |
EP (1) | EP1652517B8 (es) |
JP (1) | JP4959326B2 (es) |
KR (1) | KR20060065585A (es) |
AT (1) | ATE546135T1 (es) |
AU (1) | AU2004248936B2 (es) |
BR (1) | BRPI0411678A (es) |
CA (1) | CA2535364C (es) |
ES (1) | ES2226567B1 (es) |
NO (1) | NO20056239L (es) |
WO (1) | WO2004112758A1 (es) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7371738B2 (en) | 2005-04-15 | 2008-05-13 | University Of South Florida | Method of transdermal drug delivery using hyaluronic acid nanoparticles |
WO2008100044A1 (en) * | 2007-02-15 | 2008-08-21 | Amorepacific Corporation | Chemically cross-linked hyaluronic acid hydrogel nanoparticles and the method for preparing thereof |
EP2266546A1 (en) | 2009-06-08 | 2010-12-29 | Advancell Advanced in Vitro Cell Technologies,S.A. | Process for the preparation of colloidal systems for the delivery of active compounds |
WO2012095543A1 (es) | 2011-01-10 | 2012-07-19 | Universidade De Santiago De Compostela | Nanocápsulas con cubierta polimérica |
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EP1507543A4 (en) | 2002-05-09 | 2006-07-26 | Cambridgemed Inc | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF WOOD WITH BLOOD PLASMA OR SERUM |
US7495052B2 (en) * | 2004-09-15 | 2009-02-24 | Bausch & Lomb Incorporated | Method for the production of polymerized nanoparticles and microparticles by ternary agent concentration and temperature alteration induced immiscibility |
US7282194B2 (en) * | 2004-10-05 | 2007-10-16 | Gp Medical, Inc. | Nanoparticles for protein drug delivery |
US8467868B1 (en) * | 2005-04-26 | 2013-06-18 | University Of South Florida | Method of transdermal drug delivery |
US7323184B2 (en) * | 2005-08-22 | 2008-01-29 | Healagenics, Inc. | Compositions and methods for the treatment of wounds and the reduction of scar formation |
EP1859792A1 (en) * | 2006-05-24 | 2007-11-28 | Advanced in Vitro Cell Technologies, S.L. | Nanoparticles of chitosan and hyaluronan for the administration of active molecules |
KR20090031861A (ko) * | 2006-05-24 | 2009-03-30 | 어드밴스드 인 비트로 셀 테크놀로지스, 에스.에이 | 활성분자의 투여를 위한 키토산 및 하이알루로난 나노입자 |
KR100774925B1 (ko) * | 2006-12-01 | 2007-11-08 | 주식회사유한양행 | 표적지향을 위한 나노입자 및 그의 제조방법 |
US20090087569A1 (en) * | 2007-09-27 | 2009-04-02 | Fenchem Enterprises Ltd. | Methods for Preparing Highly Stable Hyaluronic Acid |
WO2009091992A1 (en) * | 2008-01-16 | 2009-07-23 | Purdue Research Foundation | Repairing damaged nervous system tissue with nanoparticles |
ITMI20080284A1 (it) * | 2008-02-22 | 2009-08-23 | Indena Spa | Agenti antitumorali a struttura benzofenantridinica e formulazioni che li contengono |
KR101421049B1 (ko) * | 2008-02-29 | 2014-07-21 | (주)아모레퍼시픽 | 립-플럼핑 및 주름 개선 효과를 주는 입술용 화장료 조성물 |
KR101006755B1 (ko) * | 2008-07-07 | 2011-01-10 | 한국과학기술원 | 활성산소를 감지하는 히알루론산 금 나노입자 및 이의제조방법 |
US20120107229A1 (en) * | 2009-04-15 | 2012-05-03 | Xuefei Huang | Novel nano-probes for molecular imaging and targeted therapy of diseases |
JP5804453B2 (ja) * | 2009-05-14 | 2015-11-04 | 国立大学法人 東京大学 | 結晶性ポリオール微粒子及びその調製方法 |
KR101138258B1 (ko) * | 2009-12-09 | 2012-04-24 | (주)바이오제닉스 | 올리고머 복합체의 형성을 통한 난/불용성 활성물질의 가용화 방법 |
GB201017889D0 (en) * | 2010-10-22 | 2010-12-01 | Univ Dublin | A polymeric nanoparticle |
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EP1187602A4 (en) * | 2000-04-18 | 2004-09-15 | Peptron Inc | SUSTAINABLE RELEASE INJECTABLE PHARMACEUTICAL COMPOSITION AND METHODS OF PREPARING THE SAME |
JP2006525333A (ja) * | 2003-05-02 | 2006-11-09 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ イリノイ | 高親水性で正電荷に帯電した薬剤を取り込んだ生分解性ナノ粒子 |
-
2003
- 2003-06-20 ES ES200301456A patent/ES2226567B1/es not_active Expired - Fee Related
-
2004
- 2004-06-17 AT AT04736983T patent/ATE546135T1/de active
- 2004-06-17 KR KR1020057024506A patent/KR20060065585A/ko active IP Right Grant
- 2004-06-17 JP JP2006516221A patent/JP4959326B2/ja not_active Expired - Fee Related
- 2004-06-17 EP EP04736983A patent/EP1652517B8/en active Active
- 2004-06-17 BR BRPI0411678-0A patent/BRPI0411678A/pt not_active IP Right Cessation
- 2004-06-17 WO PCT/ES2004/000284 patent/WO2004112758A1/es active Search and Examination
- 2004-06-17 AU AU2004248936A patent/AU2004248936B2/en not_active Ceased
- 2004-06-17 CA CA2535364A patent/CA2535364C/en not_active Expired - Fee Related
- 2004-06-17 US US10/561,548 patent/US20060188578A1/en not_active Abandoned
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FR2642329A1 (fr) * | 1989-01-31 | 1990-08-03 | Bioetica Sa | Utilisation de solutions d'atelocollagene et de glycosaminoglycannes pour la fabrication de microcapsules, microcapsules ainsi realisees, procedes de fabrication de telles microcapsules et compositions cosmetiques ou pharmaceutiques ou alimentaires en contenant |
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WO2004009060A1 (es) * | 2002-07-19 | 2004-01-29 | Universidade De Santiago De Compostela | Nanopartículas para la administración de ingredientes activos, procedimiento para la elaboración de dichas partículas y composición que las contienen. |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7371738B2 (en) | 2005-04-15 | 2008-05-13 | University Of South Florida | Method of transdermal drug delivery using hyaluronic acid nanoparticles |
WO2008100044A1 (en) * | 2007-02-15 | 2008-08-21 | Amorepacific Corporation | Chemically cross-linked hyaluronic acid hydrogel nanoparticles and the method for preparing thereof |
EP2266546A1 (en) | 2009-06-08 | 2010-12-29 | Advancell Advanced in Vitro Cell Technologies,S.A. | Process for the preparation of colloidal systems for the delivery of active compounds |
WO2012095543A1 (es) | 2011-01-10 | 2012-07-19 | Universidade De Santiago De Compostela | Nanocápsulas con cubierta polimérica |
Also Published As
Publication number | Publication date |
---|---|
EP1652517B8 (en) | 2012-04-11 |
ATE546135T1 (de) | 2012-03-15 |
CA2535364C (en) | 2011-11-29 |
ES2226567B1 (es) | 2006-07-01 |
JP2007520424A (ja) | 2007-07-26 |
CA2535364A1 (en) | 2004-12-29 |
AU2004248936A1 (en) | 2004-12-29 |
AU2004248936B2 (en) | 2009-05-07 |
US20060188578A1 (en) | 2006-08-24 |
EP1652517B1 (en) | 2012-02-22 |
JP4959326B2 (ja) | 2012-06-20 |
EP1652517A1 (en) | 2006-05-03 |
BRPI0411678A (pt) | 2006-08-29 |
ES2226567A1 (es) | 2005-03-16 |
NO20056239L (no) | 2005-12-29 |
KR20060065585A (ko) | 2006-06-14 |
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