ES2114502A1 - Aplicacion de nanoparticulas a base de polimeros hidrofilicos como formas farmaceuticas. - Google Patents

Aplicacion de nanoparticulas a base de polimeros hidrofilicos como formas farmaceuticas.

Info

Publication number
ES2114502A1
ES2114502A1 ES09601685A ES9601685A ES2114502A1 ES 2114502 A1 ES2114502 A1 ES 2114502A1 ES 09601685 A ES09601685 A ES 09601685A ES 9601685 A ES9601685 A ES 9601685A ES 2114502 A1 ES2114502 A1 ES 2114502A1
Authority
ES
Spain
Prior art keywords
nanoparticles
hydrophilic polymers
active
pharmaceutical forms
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09601685A
Other languages
English (en)
Other versions
ES2114502B1 (es
Inventor
Fernandez Maria Jose Alonso
Salve Pilar Calvo
Lopez Carmen Remunan
Jato Jose Luis Vila
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidade de Santiago de Compostela
Original Assignee
Universidade de Santiago de Compostela
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES09601685A priority Critical patent/ES2114502B1/es
Application filed by Universidade de Santiago de Compostela filed Critical Universidade de Santiago de Compostela
Priority to PCT/ES1996/000186 priority patent/WO1998004244A1/es
Priority to EP96932607A priority patent/EP0860166B1/en
Priority to DE69634135T priority patent/DE69634135T2/de
Priority to DK96932607T priority patent/DK0860166T3/da
Priority to CA002233501A priority patent/CA2233501C/en
Priority to AT96932607T priority patent/ATE285758T1/de
Priority to PT96932607T priority patent/PT860166E/pt
Publication of ES2114502A1 publication Critical patent/ES2114502A1/es
Application granted granted Critical
Publication of ES2114502B1 publication Critical patent/ES2114502B1/es
Priority to US09/908,372 priority patent/US6649192B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

APLICACION DE NANOPARTICULAS A BASE DE POLIMERAS HIDROFILICOS COMO FORMAS FARMACEUTICAS PARA LA ADMINISTRACION DE MACROMOLECULAS ACTIVAS. LAS NANOPARTICULAS (DE TAMAÑO NANOMETRICO Y CARACTER HIDROFILICO), TAMBIEN DENOMINADAS NANOSFERAS O LATEXES, SON SISTEMAS COLOIDALES FORMADOS POR LA COMBINACION DE POLIMERAS HIDROFILICOS Y UN INGREDIENTE ACTIVO DE ELEVADO PESO MOLECULAR (MACROMOLECULA ACTIVA, PESO MOLECULAR SUPERIOR A 1000 DALTONS). LOS POLIMERAS HIDROFILICOS SON EL QUITOSANO (UN AMINOPOLISACARIDO) O SUS DERIVADOS Y EL POLIOXIETILENO O SUS DERIVADOS. LA ASOCIACION DE LA MACROMOLECULA ACTIVA A DICHAS NANOPARTICULAS TRANSCURRE EN FASE ACUOSA SIN NECESIDAD DE UTILIZAR DISOLVENTES ORGANICOS NI SUSTANCIAS AUXILIARES DE NATURALEZA TOXICA. LA CAPACIDAD DE CARGA DE INGREDIENTE ACTIVO DE LAS NANOPARTICULAS ES EXTREMADAMENTE ELEVADA Y ADEMAS DICHA CARGA ES LIBERADA DE UN MODO CONTROLADO Y PROLONGADO EN EL TIEMPO. ADEMAS DICHAS NANOPARTICULAS PRESENTAN UNA CARGA ELECTRICA SUPERFICIAL POSITIVA CUYA INTENSIDAD PUEDE VARIARSE EN BASE A SU COMPOSICION.
ES09601685A 1996-07-29 1996-07-29 Aplicacion de nanoparticulas a base de polimeros hidrofilicos como formas farmaceuticas. Expired - Fee Related ES2114502B1 (es)

Priority Applications (9)

Application Number Priority Date Filing Date Title
ES09601685A ES2114502B1 (es) 1996-07-29 1996-07-29 Aplicacion de nanoparticulas a base de polimeros hidrofilicos como formas farmaceuticas.
EP96932607A EP0860166B1 (en) 1996-07-29 1996-10-22 Nanoparticles based on hydrophilic polymers as pharmaceutical forms
DE69634135T DE69634135T2 (de) 1996-07-29 1996-10-22 Nanopartikel auf der Basis hydrophiler Polymere als Arzneiformen
DK96932607T DK0860166T3 (da) 1996-07-29 1996-10-22 Anvendelse af nanopartikler baseret på hydrofile polymerer som farmaceutiske former
PCT/ES1996/000186 WO1998004244A1 (es) 1996-07-29 1996-10-22 Aplicacion de nanoparticulas a base de polimeros hidrofilicos como formas farmaceuticas
CA002233501A CA2233501C (en) 1996-07-29 1996-10-22 Application of nanoparticles based on hydrophilic polymers as pharmaceutical forms
AT96932607T ATE285758T1 (de) 1996-07-29 1996-10-22 Nanopartikel auf der basis hydrophiler polymere als arzneiformen
PT96932607T PT860166E (pt) 1996-07-29 1996-10-22 Aplicacao de nanoparticulas a base de polimeros hidrofilos como formas farmaceuticas
US09/908,372 US6649192B2 (en) 1996-07-29 2001-07-18 Application of nanoparticles based on hydrophilic polymers as pharmaceutical forms

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09601685A ES2114502B1 (es) 1996-07-29 1996-07-29 Aplicacion de nanoparticulas a base de polimeros hidrofilicos como formas farmaceuticas.

Publications (2)

Publication Number Publication Date
ES2114502A1 true ES2114502A1 (es) 1998-05-16
ES2114502B1 ES2114502B1 (es) 1999-07-01

Family

ID=8295659

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09601685A Expired - Fee Related ES2114502B1 (es) 1996-07-29 1996-07-29 Aplicacion de nanoparticulas a base de polimeros hidrofilicos como formas farmaceuticas.

Country Status (7)

Country Link
EP (1) EP0860166B1 (es)
AT (1) ATE285758T1 (es)
CA (1) CA2233501C (es)
DE (1) DE69634135T2 (es)
ES (1) ES2114502B1 (es)
PT (1) PT860166E (es)
WO (1) WO1998004244A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004112758A1 (es) * 2003-06-20 2004-12-29 Advanced In Vitro Cell Technologies, S.L. Nanopartículas de ácido hialurónico

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9713980D0 (en) * 1997-07-03 1997-09-10 Danbiosyst Uk New conjugates
DE19940794A1 (de) * 1999-08-27 2001-03-01 Lohmann Therapie Syst Lts Pharmazeutische Zubereitung
DE19952073A1 (de) * 1999-10-29 2001-07-12 Cognis Deutschland Gmbh Verfahren zur Herstellung von nanopartikulären Chitosanen oder Chitosan-Derivaten
FR2800634B1 (fr) * 1999-11-08 2001-12-14 Oligocaps Lab Microgranules de polymeres heterosidiques contenant des substances hydrophiles ou hydrophobes, procedures d'utilisation et applications dans les domaines alimentaires dietetiques ou pharmaceutiques
US7767197B2 (en) * 2000-06-22 2010-08-03 Endo Pharmaceuticals Colorado LLC Delivery vehicle composition and methods for delivering antigens and other drugs
ES2221530B1 (es) * 2002-07-19 2006-02-16 Universidad De Santiago De Compostela Nanoparticulas para la administracion de ingredientes activos,procedimiento para la elaboracion de dichas particulas y composicion que las contienen.
ES2246694B1 (es) 2004-04-29 2007-05-01 Instituto Cientifico Y Tecnologico De Navarra, S.A. Nanoparticulas pegiladas.
ES2246695B1 (es) 2004-04-29 2007-05-01 Instituto Cientifico Y Tecnologico De Navarra, S.A. Composicion estimuladora de la respuesta inmunitaria que comprende nanoparticulas a base de un copolimero de metil vinil eter y anhidrido maleico.
ES2259914B1 (es) * 2005-03-14 2007-06-16 Advanced In Vitro Cell Technologies, S.L. Nanoparticulas de quitosano y polietilenglicol como sistema de administracion de moleculas biologicamente activas.
ES2272156B1 (es) * 2005-04-18 2008-04-01 Italfarmaco, S.A. Sistemas microparticulares.
ES2277743B2 (es) * 2005-06-02 2008-12-16 Universidade De Santiago De Compostela Nanoparticulas que comprenden quitosano y ciclodextrina.
EP1774971A1 (en) * 2005-10-14 2007-04-18 Advanced in Vitro Cell Technologies, S.L. Chitosan and heparin nanoparticles
BRPI0716658A2 (pt) * 2006-08-11 2015-02-10 Panacea Biotec Ltd Partículas para distribuição de ingredientes ativos, processo de fabricação e suas composições
EP1977739A1 (en) * 2007-04-03 2008-10-08 Bioiberica, S.A. Nanoparticulate composition of chitosan and chondroitin sulfate
CN101129373B (zh) * 2007-08-16 2010-12-01 华中师范大学 一种制备咪喹莫特壳聚糖纳米粒的方法
WO2009048958A2 (en) * 2007-10-08 2009-04-16 The Board Of Regents Of The University Of Texas System Methods and compositions involving chitosan nanoparticles
EP2306829B1 (en) * 2008-07-01 2017-01-04 University of Chicago Particles containing a peripheral opioid receptor antagonist
WO2010040020A1 (en) 2008-10-02 2010-04-08 Salix Pharmaceuticals, Ltd. Methods of treating hepatic encephalopathy
CN102100672A (zh) * 2011-01-26 2011-06-22 浙江大学 一种血管内皮生长因子壳聚糖微球及应用
CN102830356A (zh) * 2012-09-07 2012-12-19 天津大学 人体嵌入式元器件的生物老化方法
WO2016003536A1 (en) * 2014-06-30 2016-01-07 Salix Pharmaceuticals, Inc. Methods for retreating irritable bowel syndrome (ibs)
EP3581174A4 (en) 2017-02-09 2020-12-30 Universidade de Santiago de Compostela PURIFIED POLLEN PARTICLES AND THEIR USE TO DELIVER NANOSYSTEMS

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5346703A (en) * 1990-08-07 1994-09-13 Mediventures, Inc. Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels
WO1996005810A1 (en) * 1994-08-20 1996-02-29 Danbiosyst Uk Limited Drug delivery composition containing chitosan or derivative thereof having a defined z. potential
WO1996020698A2 (en) * 1995-01-05 1996-07-11 The Board Of Regents Acting For And On Behalf Of The University Of Michigan Surface-modified nanoparticles and method of making and using same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5346703A (en) * 1990-08-07 1994-09-13 Mediventures, Inc. Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels
WO1996005810A1 (en) * 1994-08-20 1996-02-29 Danbiosyst Uk Limited Drug delivery composition containing chitosan or derivative thereof having a defined z. potential
WO1996020698A2 (en) * 1995-01-05 1996-07-11 The Board Of Regents Acting For And On Behalf Of The University Of Michigan Surface-modified nanoparticles and method of making and using same

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004112758A1 (es) * 2003-06-20 2004-12-29 Advanced In Vitro Cell Technologies, S.L. Nanopartículas de ácido hialurónico
ES2226567A1 (es) * 2003-06-20 2005-03-16 Universidad De Santiago De Compostela Nanoparticulas de acido hialuronico.
AU2004248936B2 (en) * 2003-06-20 2009-05-07 Advancell Advanced In Vitro Cell Technologies, S.A. Hyaluronic acid nanoparticles

Also Published As

Publication number Publication date
WO1998004244A1 (es) 1998-02-05
ATE285758T1 (de) 2005-01-15
PT860166E (pt) 2005-04-29
CA2233501C (en) 2007-02-13
CA2233501A1 (en) 1998-02-05
EP0860166A1 (en) 1998-08-26
DE69634135D1 (de) 2005-02-03
ES2114502B1 (es) 1999-07-01
DE69634135T2 (de) 2005-12-08
EP0860166B1 (en) 2004-12-29

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