NO20056239L - Hyaluronsyre nanopartikler - Google Patents
Hyaluronsyre nanopartiklerInfo
- Publication number
- NO20056239L NO20056239L NO20056239A NO20056239A NO20056239L NO 20056239 L NO20056239 L NO 20056239L NO 20056239 A NO20056239 A NO 20056239A NO 20056239 A NO20056239 A NO 20056239A NO 20056239 L NO20056239 L NO 20056239L
- Authority
- NO
- Norway
- Prior art keywords
- nanoparticles
- hyaluronic acid
- preparing
- active ingredient
- salt
- Prior art date
Links
- 239000002105 nanoparticle Substances 0.000 title abstract 8
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 5
- 229920002674 hyaluronan Polymers 0.000 title abstract 3
- 229960003160 hyaluronic acid Drugs 0.000 title abstract 3
- 239000004480 active ingredient Substances 0.000 abstract 3
- 239000000243 solution Substances 0.000 abstract 3
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 1
- 229920006317 cationic polymer Polymers 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
- C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
- C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/12—Powdering or granulating
- C08J3/14—Powdering or granulating by precipitation from solutions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
- C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Oppfinnelsen vedrører hyaluronsyre nanopartikler for adminisfrering av minst en aktiv ingrediens. Nanopartiklene i henhold til oppfinnelsen innbefatter hyaluronsyre i saltform, en positivt ladet polymer, et polyanionisk salt og minst en aktiv ingrediens. Fremgangsmåten ved fremstilling av ovennevnte nanopartikler innbefatter følgende trinn: fremstille en vandig løsning av et hyaluronsyresalt, fremstille en vandig løsning av en kationisk polymer, tilsette et polyanionisk salt til løsningen av hyaluronsyresaltet og røre-blande nevnte løsninger slik at det dannes nanopartikler. Den aktive ingrediensen blir oppløst i en av de innledende løsningene eller i suspensjonen av nanopartiklene for å bli absorbert på nanopartiklene. Oppfinnelsen vedrører også farmasøytiske eller kosmetiske blandinger som inneholder ovennevnte nanopartikler.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200301456A ES2226567B1 (es) | 2003-06-20 | 2003-06-20 | Nanoparticulas de acido hialuronico. |
PCT/ES2004/000284 WO2004112758A1 (es) | 2003-06-20 | 2004-06-17 | Nanopartículas de ácido hialurónico |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20056239L true NO20056239L (no) | 2005-12-29 |
Family
ID=33522604
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20056239A NO20056239L (no) | 2003-06-20 | 2005-12-29 | Hyaluronsyre nanopartikler |
Country Status (11)
Country | Link |
---|---|
US (1) | US20060188578A1 (no) |
EP (1) | EP1652517B8 (no) |
JP (1) | JP4959326B2 (no) |
KR (1) | KR20060065585A (no) |
AT (1) | ATE546135T1 (no) |
AU (1) | AU2004248936B2 (no) |
BR (1) | BRPI0411678A (no) |
CA (1) | CA2535364C (no) |
ES (1) | ES2226567B1 (no) |
NO (1) | NO20056239L (no) |
WO (1) | WO2004112758A1 (no) |
Families Citing this family (45)
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RU2308954C2 (ru) | 2002-05-09 | 2007-10-27 | Медиджинез | Фармацевтическая композиция для лечения ран, содержащая плазму или сыворотку крови |
US7495052B2 (en) * | 2004-09-15 | 2009-02-24 | Bausch & Lomb Incorporated | Method for the production of polymerized nanoparticles and microparticles by ternary agent concentration and temperature alteration induced immiscibility |
US7282194B2 (en) * | 2004-10-05 | 2007-10-16 | Gp Medical, Inc. | Nanoparticles for protein drug delivery |
US7371738B2 (en) | 2005-04-15 | 2008-05-13 | University Of South Florida | Method of transdermal drug delivery using hyaluronic acid nanoparticles |
US8467868B1 (en) * | 2005-04-26 | 2013-06-18 | University Of South Florida | Method of transdermal drug delivery |
US7323184B2 (en) * | 2005-08-22 | 2008-01-29 | Healagenics, Inc. | Compositions and methods for the treatment of wounds and the reduction of scar formation |
WO2007135164A1 (en) * | 2006-05-24 | 2007-11-29 | Advanced In Vitro Cell Technologies, S.A. | Nanoparticles of chitosan and hyaluronan for the administration of active molecules |
EP1859792A1 (en) * | 2006-05-24 | 2007-11-28 | Advanced in Vitro Cell Technologies, S.L. | Nanoparticles of chitosan and hyaluronan for the administration of active molecules |
KR100774925B1 (ko) * | 2006-12-01 | 2007-11-08 | 주식회사유한양행 | 표적지향을 위한 나노입자 및 그의 제조방법 |
KR100852944B1 (ko) * | 2007-02-15 | 2008-08-19 | (주)아모레퍼시픽 | 화학적으로 가교된 히알루론산 하이드로겔 나노입자의제조방법 |
US20090087569A1 (en) * | 2007-09-27 | 2009-04-02 | Fenchem Enterprises Ltd. | Methods for Preparing Highly Stable Hyaluronic Acid |
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KR101006755B1 (ko) * | 2008-07-07 | 2011-01-10 | 한국과학기술원 | 활성산소를 감지하는 히알루론산 금 나노입자 및 이의제조방법 |
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KR101138258B1 (ko) | 2009-12-09 | 2012-04-24 | (주)바이오제닉스 | 올리고머 복합체의 형성을 통한 난/불용성 활성물질의 가용화 방법 |
GB201017889D0 (en) * | 2010-10-22 | 2010-12-01 | Univ Dublin | A polymeric nanoparticle |
KR101294719B1 (ko) * | 2010-12-31 | 2013-08-08 | 연세대학교 산학협력단 | 키토산-트리포스페이트/히알루론산을 이용한 신경손상 치료용 유전자 전달체 |
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ES2658972T3 (es) | 2012-06-20 | 2018-03-13 | University Of Waterloo | Sistema de administración de nanopartículas mucoadhesivas |
US9878000B2 (en) | 2012-06-20 | 2018-01-30 | University Of Waterloo | Mucoadhesive nanoparticle composition comprising immunosuppresant and methods of use thereof |
JP6120397B2 (ja) * | 2012-10-11 | 2017-04-26 | ポーラ化成工業株式会社 | キトサン及びヒアルロナンを含むナノ粒子の製造方法 |
WO2014064121A2 (en) * | 2012-10-25 | 2014-05-01 | Unilever Plc | Improvements relating to surface treatment compositions |
JP6162943B2 (ja) * | 2012-11-02 | 2017-07-12 | ポーラ化成工業株式会社 | ヒアルロナンを含むナノ粒子 |
CZ2012842A3 (cs) * | 2012-11-27 | 2014-08-20 | Contipro Biotech S.R.O. | Nanomicelární kompozice na bázi C6-C18-acylovaného hyaluronanu, způsob přípravy C6-C18-acylovaného hyaluronanu, způsob přípravy nanomicelární kompozice a stabilizované nanomicelární kompozice a použití |
CZ305153B6 (cs) | 2014-03-11 | 2015-05-20 | Contipro Biotech S.R.O. | Konjugáty oligomeru kyseliny hyaluronové nebo její soli, způsob jejich přípravy a použití |
CZ2014451A3 (cs) | 2014-06-30 | 2016-01-13 | Contipro Pharma A.S. | Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití |
WO2016066864A1 (es) | 2014-10-30 | 2016-05-06 | Innovaciones Fisicas Y Quimicas Sostenibles, S.L. | Nanopartículas para la liberación controlada de ingredientes activos |
CZ309295B6 (cs) | 2015-03-09 | 2022-08-10 | Contipro A.S. | Samonosný, biodegradabilní film na bázi hydrofobizované kyseliny hyaluronové, způsob jeho přípravy a použití |
CZ306479B6 (cs) | 2015-06-15 | 2017-02-08 | Contipro A.S. | Způsob síťování polysacharidů s využitím fotolabilních chránicích skupin |
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JP6602626B2 (ja) * | 2015-09-28 | 2019-11-06 | 嘉寛 徳留 | ヒアルロナンを含む複合粒子を含有する乳化組成物 |
CZ308106B6 (cs) | 2016-06-27 | 2020-01-08 | Contipro A.S. | Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití |
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CN107998103A (zh) * | 2018-01-19 | 2018-05-08 | 近镒生技股份有限公司 | 载体结构、药物载体、其制造方法及其用途 |
CN111334468B (zh) * | 2020-03-12 | 2024-08-06 | 青岛农业大学 | 一种低分子量透明质酸片段诱发血红细胞钱串状聚集的应用 |
TW202245732A (zh) * | 2021-02-10 | 2022-12-01 | 日商資生堂股份有限公司 | 化妝料 |
CN115645377A (zh) * | 2022-11-04 | 2023-01-31 | 华东理工大学 | 包载挥发性精油的纳米级天然聚电解质凝聚体的制备方法 |
CN115814169A (zh) * | 2022-12-15 | 2023-03-21 | 宁波旸曜医疗科技有限公司 | 一种鼻窦支架及其制备方法 |
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FR2777193B1 (fr) * | 1998-04-14 | 2001-06-08 | Coletica | Particule a groupement hydroxamique chelatante d'ions metalliques et leur utilisation en cosmetique ou en pharmacie |
FR2777895A1 (fr) * | 1998-04-28 | 1999-10-29 | Debio Rech Pharma Sa | Polymere sequence non-reticule,procede pour sa preparation, et ses utilisations |
US20030059465A1 (en) * | 1998-05-11 | 2003-03-27 | Unger Evan C. | Stabilized nanoparticle formulations of camptotheca derivatives |
IN191203B (no) * | 1999-02-17 | 2003-10-04 | Amarnath Prof Maitra | |
WO2000064954A1 (en) * | 1999-04-22 | 2000-11-02 | Vanderbilt University | Polymeric encapsulation system promoting angiogenesis |
US6743446B2 (en) * | 1999-12-15 | 2004-06-01 | The Ohio State University Research Foundation | Methods for stabilizing biologically active agents encapsulated in biodegradable controlled-release polymers |
US6465425B1 (en) * | 2000-02-10 | 2002-10-15 | Alkermes Controlled Therapeutics, Inc. | Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins |
US6749865B2 (en) * | 2000-02-15 | 2004-06-15 | Genzyme Corporation | Modification of biopolymers for improved drug delivery |
EP1187602A4 (en) * | 2000-04-18 | 2004-09-15 | Peptron Inc | SUSTAINABLE RELEASE INJECTABLE PHARMACEUTICAL COMPOSITION AND METHODS OF PREPARING THE SAME |
ES2221530B1 (es) * | 2002-07-19 | 2006-02-16 | Universidad De Santiago De Compostela | Nanoparticulas para la administracion de ingredientes activos,procedimiento para la elaboracion de dichas particulas y composicion que las contienen. |
CA2524368A1 (en) * | 2003-05-02 | 2004-11-18 | The Board Of Trustees Of The University Of Illinois | Biodegradable nanoparticles comprising an aminoglycoside and a polymer like a polysaccharide |
-
2003
- 2003-06-20 ES ES200301456A patent/ES2226567B1/es not_active Expired - Fee Related
-
2004
- 2004-06-17 KR KR1020057024506A patent/KR20060065585A/ko active IP Right Grant
- 2004-06-17 AU AU2004248936A patent/AU2004248936B2/en not_active Ceased
- 2004-06-17 BR BRPI0411678-0A patent/BRPI0411678A/pt not_active IP Right Cessation
- 2004-06-17 US US10/561,548 patent/US20060188578A1/en not_active Abandoned
- 2004-06-17 JP JP2006516221A patent/JP4959326B2/ja not_active Expired - Fee Related
- 2004-06-17 EP EP04736983A patent/EP1652517B8/en not_active Expired - Lifetime
- 2004-06-17 WO PCT/ES2004/000284 patent/WO2004112758A1/es active Search and Examination
- 2004-06-17 AT AT04736983T patent/ATE546135T1/de active
- 2004-06-17 CA CA2535364A patent/CA2535364C/en not_active Expired - Fee Related
-
2005
- 2005-12-29 NO NO20056239A patent/NO20056239L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU2004248936A1 (en) | 2004-12-29 |
WO2004112758A1 (es) | 2004-12-29 |
JP4959326B2 (ja) | 2012-06-20 |
US20060188578A1 (en) | 2006-08-24 |
JP2007520424A (ja) | 2007-07-26 |
EP1652517A1 (en) | 2006-05-03 |
ATE546135T1 (de) | 2012-03-15 |
EP1652517B1 (en) | 2012-02-22 |
ES2226567B1 (es) | 2006-07-01 |
ES2226567A1 (es) | 2005-03-16 |
CA2535364A1 (en) | 2004-12-29 |
KR20060065585A (ko) | 2006-06-14 |
AU2004248936B2 (en) | 2009-05-07 |
EP1652517B8 (en) | 2012-04-11 |
CA2535364C (en) | 2011-11-29 |
BRPI0411678A (pt) | 2006-08-29 |
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