AR089962A1 - Composiciones farmaceuticas oftalmicas y metodos para su elaboracion y uso - Google Patents

Composiciones farmaceuticas oftalmicas y metodos para su elaboracion y uso

Info

Publication number
AR089962A1
AR089962A1 ARP130100420A ARP130100420A AR089962A1 AR 089962 A1 AR089962 A1 AR 089962A1 AR P130100420 A ARP130100420 A AR P130100420A AR P130100420 A ARP130100420 A AR P130100420A AR 089962 A1 AR089962 A1 AR 089962A1
Authority
AR
Argentina
Prior art keywords
polymer
composition
oil
emulsion
ophthalmic pharmaceutical
Prior art date
Application number
ARP130100420A
Other languages
English (en)
Original Assignee
Bausch & Lomb
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bausch & Lomb filed Critical Bausch & Lomb
Publication of AR089962A1 publication Critical patent/AR089962A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A61K31/78—Polymers containing oxygen of acrylic acid or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Una composición farmacéutica oftálmica estable para el alivio, el tratamiento, el control, la mejoría o la prevención de una afección ocular patológica comprende: (a) un primer polímero, cuya viscosidad cambia con un cambio en una concentración de un electrólito, tal como una sal, cuando se agrega a dicho primer polímero; (b) un segundo polímero que es diferente del primer polímero y que puede modificar la viscosidad del primer polímero; y (c) un aceite. En algunas formas de realización, la composición además comprende un surfactante no iónico. La composición puede formar una emulsión estable de aceite en agua con el almacenamiento, si bien se separa en una fase de aceite y una fase de agua cuando se aplica al ojo. La emulsión puede comprender un ingrediente activo farmacéutico oftálmico disuelto en fase de aceite o de agua. La emulsión puede proporcionar mejorada estabilidad a dicho ingrediente farmacéutico activo. Reivindicación 5: La composición de la reivindicación 4, donde dicho primer polímero comprende un polímero o copolímero de monómeros de carboxivinilo, y dicho segundo polímero comprende un polisacárido polianiónico. Reivindicación 8: La composición de la reivindicación 7, donde dicho polisacárido polianiónico es seleccionado del grupo que consiste en alginato, ácido hialurónico, glucuronoxilomanano, carboximetjlcelulosa, carboxietilcelulosa, glucosaminoglicano, pectina y goma de xantano. Reivindicación 14: La composición de la reivindicación 13, donde dicho ingrediente activo farmacéutico es latanoprost.
ARP130100420A 2012-02-13 2013-02-08 Composiciones farmaceuticas oftalmicas y metodos para su elaboracion y uso AR089962A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261597879P 2012-02-13 2012-02-13
US13/739,018 US9278132B2 (en) 2012-02-13 2013-01-11 Ophthalmic pharmaceutical compositions and methods of making and using same

Publications (1)

Publication Number Publication Date
AR089962A1 true AR089962A1 (es) 2014-10-01

Family

ID=48946121

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP130100420A AR089962A1 (es) 2012-02-13 2013-02-08 Composiciones farmaceuticas oftalmicas y metodos para su elaboracion y uso

Country Status (14)

Country Link
US (1) US9278132B2 (es)
EP (1) EP2814463B1 (es)
JP (1) JP5898789B2 (es)
KR (1) KR101760990B1 (es)
CN (1) CN104203215B (es)
AR (1) AR089962A1 (es)
AU (1) AU2013219822B2 (es)
CA (1) CA2864417C (es)
ES (1) ES2576113T3 (es)
HU (1) HUE029276T2 (es)
MX (1) MX349169B (es)
PL (1) PL2814463T3 (es)
TW (1) TWI535462B (es)
WO (1) WO2013122801A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013166385A1 (en) 2012-05-03 2013-11-07 Kala Pharmaceuticals, Inc. Pharmaceutical nanoparticles showing improved mucosal transport
US9827191B2 (en) 2012-05-03 2017-11-28 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
JP6360040B2 (ja) 2012-05-03 2018-07-18 カラ ファーマシューティカルズ インコーポレイテッド 粘液浸透性被覆粒子、組成物、医薬組成物、医薬製剤、及びそれらの形成方法
US11596599B2 (en) 2012-05-03 2023-03-07 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
JP6537775B2 (ja) * 2014-03-10 2019-07-03 小林製薬株式会社 乳化組成物
US10245324B2 (en) 2014-10-31 2019-04-02 Johnson & Johnson Consumer Inc. Ophthalmic composition
JP7072517B2 (ja) 2016-02-29 2022-05-20 サン ファーマ グローバル エフゼットイー 局所用シクロスポリン含有製剤およびその使用
ES2704918T3 (es) * 2016-04-15 2019-03-20 Dr Gerhard Mann Chem Pharm Fabrik Gmbh Composición oftálmica estable en almacenamiento
BR112019018367A2 (pt) * 2017-03-05 2020-04-07 Resdevco Res And Development Co Ltd uso de uma preparação oftálmica para tratamento de irritação não decorrente de infecção
US10933111B2 (en) * 2019-01-08 2021-03-02 Boston Biotechnology US CORP Treating dry eye disorders
DE102021212692A1 (de) 2021-11-11 2023-05-11 Ursapharm Arzneimittel Gmbh Selbstemulgierende öl-in wasser-mikro- oder nanoemulsion so-wie emulgierende zusammensetzung

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4409205A (en) 1979-03-05 1983-10-11 Cooper Laboratories, Inc. Ophthalmic solution
US5209927A (en) 1985-01-23 1993-05-11 Alcon Laboratories, Inc. Ophthalmic solution
ATE132366T1 (de) 1990-05-29 1996-01-15 Boston Ocular Res Zusammensetzung zur behandlung von dry eye erkrankungen
US5474979A (en) * 1994-05-17 1995-12-12 Allergan, Inc. Nonirritating emulsions for sensitive tissue
ES2094688B1 (es) * 1994-08-08 1997-08-01 Cusi Lab Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion.
US6114319A (en) * 1997-05-14 2000-09-05 Senju Pharmaceutical Co., Ltd. Compositions containing difluprednate
CN1456157A (zh) 2002-05-10 2003-11-19 刘继东 左旋氧氟沙星眼用凝胶
CN1180776C (zh) 2002-12-02 2004-12-22 刘继东 凝胶型氧氟沙星眼膏
JP4762718B2 (ja) * 2003-11-07 2011-08-31 千寿製薬株式会社 プロスタグランジン含有医薬組成物
US9161905B2 (en) * 2005-01-12 2015-10-20 Ocular Research Of Boston, Inc. Dry eye treatment
US7288520B2 (en) * 2005-07-13 2007-10-30 Allergan, Inc. Cyclosporin compositions
EP1985298A1 (en) * 2007-04-24 2008-10-29 Azad Pharma AG Ophtalmic oil-in-water emulsions containing prostaglandins
EP2437762B1 (en) 2009-06-05 2017-08-09 Allergan, Inc. Artificial tears and therapeutic uses
FR2962044B1 (fr) * 2010-04-21 2013-02-22 Horus Pharma Emulsion lacrymimetique
FR2961694B1 (fr) 2010-06-29 2013-01-25 Thea Lab Systeme de delivrance polymerique d'une solution non visqueuse a base de prostaglandine sans conservateur
US8957048B2 (en) 2011-10-06 2015-02-17 Allergan, Inc. Compositions for the treatment of dry eye

Also Published As

Publication number Publication date
TW201345564A (zh) 2013-11-16
MX2014009620A (es) 2014-11-10
AU2013219822A1 (en) 2014-08-28
EP2814463B1 (en) 2016-05-18
KR20140121479A (ko) 2014-10-15
TWI535462B (zh) 2016-06-01
CA2864417C (en) 2018-10-16
WO2013122801A1 (en) 2013-08-22
EP2814463A1 (en) 2014-12-24
CA2864417A1 (en) 2013-08-22
US20130210912A1 (en) 2013-08-15
JP2015507010A (ja) 2015-03-05
HUE029276T2 (en) 2017-02-28
US9278132B2 (en) 2016-03-08
JP5898789B2 (ja) 2016-04-06
MX349169B (es) 2017-07-17
AU2013219822B2 (en) 2016-01-14
KR101760990B1 (ko) 2017-07-24
CN104203215A (zh) 2014-12-10
CN104203215B (zh) 2017-04-12
PL2814463T3 (pl) 2016-11-30
ES2576113T3 (es) 2016-07-05

Similar Documents

Publication Publication Date Title
AR089962A1 (es) Composiciones farmaceuticas oftalmicas y metodos para su elaboracion y uso
WO2013037479A8 (en) Ophthalmic compositions comprising prostaglandin f2 alpha derivatives and hyaluronic acid
JP6527468B2 (ja) ヒアルロン酸ナトリウムとカルボキシメチルセルロースを含む人工涙液
BR112015002055A2 (pt) acetato succinato de hidroxialquil metil celulose, composição, dispersão sólida, processo para produzir uma dispersão sólida, forma de dosagem e cápsula de envoltório
IN2014DN09594A (es)
RU2018102693A (ru) Офтальмологические композиции, содержащие кооперативные комплексы низко- и высокомолекулярной гиалуроновой кислоты
NZ602405A (en) A fluid composition comprising a hyaluronan polymer and mannitol for improving skin conditions
WO2016172712A3 (en) Ophthalmic composition
EA201591176A1 (ru) Композиции и способы с использованием пептидной метки, связывающейся с гиалуронаном
FI2887923T3 (fi) Polyoksylilipidin tai polyoksylirasvahapon oftalminen formulaatio ja silmätilojen hoito
RU2012101782A (ru) Водные фармацевтические композиции, содержащие комплексы боратполиол
JP2010540619A5 (es)
WO2008011836A3 (es) Soluciones oftálmicas
AR071334A1 (es) Gel de quitosano para aplicaciones dermatologicas, proceso de obtencion y uso del mismo
BR112015017246A2 (pt) formulação farmacêutica que compreende um corticosteroide insolúvel e um corticosteroide solúvel
WO2012061045A3 (en) Methods and compositions for preserving retinal ganglion cells
RU2014115278A (ru) Косметическая эмульсия типа "масло в воде"
RU2012103538A (ru) Композиции и способы ингибирования пути jak
JP2015504860A5 (es)
RU2013141546A (ru) Применение вязкоэластичной жидкости для получения медицинского продукта для хирургического лечения глаз
RU2014127074A (ru) Состав для эффективной доставки липидов в слезную пленку человека с использованием чувствительной к соли эмульсионной системы
BR112017014016A2 (pt) método de redução da pressão intraocular, e, composição farmacêutica.
UA114088C2 (xx) Лікарська композиція з пролонгованим вивільненням для ін'єкцій
BR112014031463A2 (pt) composição pesticida na forma de emulsão aquosa
HRP20180178T1 (hr) Pripravci ketorolaka, namijenjeni zacjeljivanju rane na rožnici

Legal Events

Date Code Title Description
FB Suspension of granting procedure