TW200922566A - 1,3 disubstituted 4-(aryl-X-phenyl)-1H-pyridin-2-ones - Google Patents
1,3 disubstituted 4-(aryl-X-phenyl)-1H-pyridin-2-ones Download PDFInfo
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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| JP5707390B2 (ja) | 2009-05-12 | 2015-04-30 | ジャンセン ファーマシューティカルズ， インコーポレイテッド | １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体の正のアロステリック調節因子としてのその使用 |
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| CA2814998C (en) | 2010-11-08 | 2019-10-29 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| JP5924984B2 (ja) * | 2012-03-06 | 2016-05-25 | 国立大学法人東京農工大学 | トリフルオロメチルピリジノン化合物およびその製造方法 |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| CA2916653C (en) | 2013-06-27 | 2017-07-18 | Pfizer Inc. | Heteroaromatic compounds and their use as dopamine d1 ligands |
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| ME03518B (me) | 2014-01-21 | 2020-04-20 | Janssen Pharmaceutica Nv | Kombinacije koje obuhvataju pozitivne alosterične modulatore ili ortosterične agoniste metabotropnog glutamatergičnog receptora podtipa 2 i njihova primjena |
| AU2015208233B2 (en) | 2014-01-21 | 2019-08-29 | Janssen Pharmaceutica Nv | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use |
| RU2569741C1 (ru) * | 2014-11-28 | 2015-11-27 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт психического здоровья" | Лабораторный способ диагностики шизотипического расстройства |
| IL315313A (en) * | 2018-08-24 | 2024-10-01 | Xeniopro GmbH | Aromatic molecules for use in the treatment of pathological conditions |
| US20210393621A1 (en) | 2018-10-26 | 2021-12-23 | The Research Foundation For The State University Of New York | Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia |
| EP4367600A4 (en) * | 2021-08-12 | 2025-03-19 | Kapoor, Puneet | WIRE-EMBED LABEL ON A SPECIAL SUBSTRATE WITH OR WITHOUT INDUCTIVE COUPLING |
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- 2008-09-12 WO PCT/EP2008/007549 patent/WO2009033702A1/en not_active Ceased
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- 2008-09-12 AT AT08802103T patent/ATE516272T1/de active
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| AU2008297876A1 (en) | 2009-03-19 |
| ES2365966T3 (es) | 2011-10-14 |
| JP2010539119A (ja) | 2010-12-16 |
| CA2697399A1 (en) | 2009-03-19 |
| ZA201001221B (en) | 2011-04-28 |
| KR20100065191A (ko) | 2010-06-15 |
| PT2200985E (pt) | 2011-07-21 |
| US8252937B2 (en) | 2012-08-28 |
| US20120309793A1 (en) | 2012-12-06 |
| NZ584152A (en) | 2011-11-25 |
| EP2200985B1 (en) | 2011-07-13 |
| CN101848893A (zh) | 2010-09-29 |
| CL2008002746A1 (es) | 2009-05-22 |
| ATE516272T1 (de) | 2011-07-15 |
| CN101848893B (zh) | 2012-06-06 |
| EP2200985A1 (en) | 2010-06-30 |
| DK2200985T3 (da) | 2011-10-24 |
| US8748621B2 (en) | 2014-06-10 |
| US20100286206A1 (en) | 2010-11-11 |
| EA201000331A1 (ru) | 2011-02-28 |
| MX2010002538A (es) | 2010-08-10 |
| PL2200985T3 (pl) | 2011-12-30 |
| CA2697399C (en) | 2016-01-19 |
| BRPI0817101A2 (pt) | 2017-05-09 |
| HK1144159A1 (en) | 2011-01-28 |
| EA019085B1 (ru) | 2014-01-30 |
| WO2009033702A1 (en) | 2009-03-19 |
| AR068512A1 (es) | 2009-11-18 |
| JP5366269B2 (ja) | 2013-12-11 |
| AU2008297876B2 (en) | 2011-07-07 |
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