JP5366269B2 - １，３−二置換４−（アリル−ｘ−フェニル）−１ｈ−ピリジン−２−オン - Google Patents
１，３−二置換４−（アリル−ｘ−フェニル）−１ｈ−ピリジン−２−オン Download PDFInfo
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- JP5366269B2 JP5366269B2 JP2010524403A JP2010524403A JP5366269B2 JP 5366269 B2 JP5366269 B2 JP 5366269B2 JP 2010524403 A JP2010524403 A JP 2010524403A JP 2010524403 A JP2010524403 A JP 2010524403A JP 5366269 B2 JP5366269 B2 JP 5366269B2
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Classifications
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Landscapes
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| PCT/EP2008/007549 WO2009033702A1 (en) | 2007-09-14 | 2008-09-12 | 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones |
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| GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| TW200922566A (en) | 2007-09-14 | 2009-06-01 | Ortho Mcneil Janssen Pharm | 1,3 disubstituted 4-(aryl-X-phenyl)-1H-pyridin-2-ones |
| BRPI0816970A2 (pt) | 2007-09-14 | 2015-03-24 | Ortho Mcneil Janssen Pharm | 1,3-dissubstituídas-4-fenil-1h-piridin-2-onas |
| EA017648B1 (ru) * | 2007-09-14 | 2013-02-28 | Орто-Макнейл-Янссен Фармасьютикалз, Инк. | 1',3'-двузамещенные-4-фенил-3,4,5,6-тетрагидро-2н,1'н-[1,4']бипириди-нил-2'-оны |
| CA2704436C (en) * | 2007-11-14 | 2016-01-05 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| JP5547194B2 (ja) | 2008-09-02 | 2014-07-09 | ジャンセン ファーマシューティカルズ， インコーポレイテッド． | 代謝型グルタミン酸受容体の調節因子としての３−アザビシクロ［３．１．０］ヘキシル誘導体 |
| WO2010043396A1 (en) | 2008-10-16 | 2010-04-22 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
| JP5690277B2 (ja) | 2008-11-28 | 2015-03-25 | ジャンセン ファーマシューティカルズ， インコーポレイテッド． | 代謝型グルタミン酸受容体の調節因子としてのインドールおよびベンゾオキサジン誘導体 |
| HRP20131122T1 (hr) | 2009-05-12 | 2013-12-20 | Janssen Pharmaceuticals, Inc. | Derivati 1,2,4-triazolo[4,3-a] piridina i njihova uporaba u lijeäśenju ili prevenciji neuroloških i psihijatrijskih poremeä†aja |
| MY153913A (en) * | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| CN102439015B (zh) | 2009-05-12 | 2015-05-13 | 杨森制药有限公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物和其作为mGluR2受体的正向变构调节剂的用途 |
| ES2536433T3 (es) | 2010-11-08 | 2015-05-25 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
| EP2661435B1 (en) | 2010-11-08 | 2015-08-19 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
| JP5852664B2 (ja) | 2010-11-08 | 2016-02-03 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体のポジティブアロステリックモジュレーターとしてのそれらの使用 |
| JP5924984B2 (ja) * | 2012-03-06 | 2016-05-25 | 国立大学法人東京農工大学 | トリフルオロメチルピリジノン化合物およびその製造方法 |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| PE20160664A1 (es) | 2013-06-27 | 2016-07-09 | Pfizer | Compuestos heteroaromaticos y su uso como ligandos d1 de dopamina |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| ME03518B (me) | 2014-01-21 | 2020-04-20 | Janssen Pharmaceutica Nv | Kombinacije koje obuhvataju pozitivne alosterične modulatore ili ortosterične agoniste metabotropnog glutamatergičnog receptora podtipa 2 i njihova primjena |
| PL3096790T3 (pl) | 2014-01-21 | 2020-01-31 | Janssen Pharmaceutica, N.V. | Kombinacje zawierające pozytywne modulatory allosteryczne lub agonistów ortosterycznych metabotropowego receptora glutaminergicznego podtypu 2 i ich zastosowanie |
| RU2569741C1 (ru) * | 2014-11-28 | 2015-11-27 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт психического здоровья" | Лабораторный способ диагностики шизотипического расстройства |
| IL315313A (en) * | 2018-08-24 | 2024-10-01 | Xeniopro GmbH | Aromatic molecules for use in the treatment of pathological conditions |
| US20210393621A1 (en) | 2018-10-26 | 2021-12-23 | The Research Foundation For The State University Of New York | Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia |
| EP4367600A4 (en) * | 2021-08-12 | 2025-03-19 | Kapoor, Puneet | WIRE-EMBED LABEL ON A SPECIAL SUBSTRATE WITH OR WITHOUT INDUCTIVE COUPLING |
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| BE790440A (enExample) | 1971-10-23 | 1973-04-24 | Bayer Ag | |
| US3906953A (en) | 1974-05-23 | 1975-09-23 | American Optical Corp | Endoscopic surgical laser system |
| SU509578A1 (ru) | 1974-09-19 | 1976-04-05 | Стерлитамакский Химический Завод | Способ получени пропилендиаминов |
| GB1502312A (en) | 1975-03-20 | 1978-03-01 | Ici Ltd | Quinolone derivatives |
| IE43079B1 (en) | 1975-03-20 | 1980-12-17 | Ici Ltd | Quinolone derivatives |
| FR2311776A1 (fr) | 1975-05-23 | 1976-12-17 | Sogeras | Diamino-2,4 bromo-5 chloro-6 pyrimidines et procede pour leur preparation |
| GB1570494A (en) | 1975-11-28 | 1980-07-02 | Ici Ltd | Thienopyrimidine derivatives and their use as pesticides |
| ZA782648B (en) | 1977-05-23 | 1979-06-27 | Ici Australia Ltd | The prevention,control or eradication of infestations of ixodid ticks |
| DE2750288A1 (de) | 1977-11-10 | 1979-05-17 | Thomae Gmbh Dr K | Neue 9-(omega-heteroarylamino- alkylamino)-erythromycine, ihre salze, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
| US4358453A (en) | 1982-01-08 | 1982-11-09 | Schering Corporation | 1,2,4-Triazolo[4,3-a]pyridines |
| DE3406329A1 (de) | 1984-02-22 | 1985-08-22 | Merck Patent Gmbh, 6100 Darmstadt | Pyridone |
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| EP2638040A1 (en) | 2010-11-08 | 2013-09-18 | Janssen Pharmaceuticals, Inc. | RADIOLABELLED mGLuR2 PET LIGANDS |
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2008
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- 2008-09-12 KR KR1020107008032A patent/KR20100065191A/ko not_active Withdrawn
- 2008-09-12 AU AU2008297876A patent/AU2008297876B2/en not_active Ceased
- 2008-09-12 DK DK08802103.5T patent/DK2200985T3/da active
- 2008-09-12 CA CA2697399A patent/CA2697399C/en not_active Expired - Fee Related
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Also Published As
| Publication number | Publication date |
|---|---|
| KR20100065191A (ko) | 2010-06-15 |
| DK2200985T3 (da) | 2011-10-24 |
| HK1144159A1 (en) | 2011-01-28 |
| EA019085B1 (ru) | 2014-01-30 |
| US8748621B2 (en) | 2014-06-10 |
| EP2200985A1 (en) | 2010-06-30 |
| US20120309793A1 (en) | 2012-12-06 |
| ES2365966T3 (es) | 2011-10-14 |
| ZA201001221B (en) | 2011-04-28 |
| CN101848893A (zh) | 2010-09-29 |
| CA2697399C (en) | 2016-01-19 |
| CN101848893B (zh) | 2012-06-06 |
| AR068512A1 (es) | 2009-11-18 |
| WO2009033702A1 (en) | 2009-03-19 |
| CL2008002746A1 (es) | 2009-05-22 |
| TW200922566A (en) | 2009-06-01 |
| JP2010539119A (ja) | 2010-12-16 |
| EA201000331A1 (ru) | 2011-02-28 |
| EP2200985B1 (en) | 2011-07-13 |
| NZ584152A (en) | 2011-11-25 |
| PT2200985E (pt) | 2011-07-21 |
| MX2010002538A (es) | 2010-08-10 |
| PL2200985T3 (pl) | 2011-12-30 |
| US20100286206A1 (en) | 2010-11-11 |
| CA2697399A1 (en) | 2009-03-19 |
| BRPI0817101A2 (pt) | 2017-05-09 |
| AU2008297876A1 (en) | 2009-03-19 |
| ATE516272T1 (de) | 2011-07-15 |
| US8252937B2 (en) | 2012-08-28 |
| AU2008297876B2 (en) | 2011-07-07 |
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