CL2008002746A1 - Compuestos derivados de 4-(4-aril-o-fenil)-1h-piridin-2-ona; 4-(4-aril-s-fenil)-1h-piridin-2-ona; 4-(4-aril-so-fenil)-1h-piridin-2-ona; 4-(4-aril-so2-fenil)-1h-piridin-2-ona y 4-(4-aril-cf2-fenil)-1h-piridin-2-ona 1,3-disustituida; composicion que los comprende; y uso para el tratamiento y/o prevencion de trastornos del snc que involucran al receptor mglur2. - Google Patents

Compuestos derivados de 4-(4-aril-o-fenil)-1h-piridin-2-ona; 4-(4-aril-s-fenil)-1h-piridin-2-ona; 4-(4-aril-so-fenil)-1h-piridin-2-ona; 4-(4-aril-so2-fenil)-1h-piridin-2-ona y 4-(4-aril-cf2-fenil)-1h-piridin-2-ona 1,3-disustituida; composicion que los comprende; y uso para el tratamiento y/o prevencion de trastornos del snc que involucran al receptor mglur2.

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Publication number
CL2008002746A1
CL2008002746A1 CL2008002746A CL2008002746A CL2008002746A1 CL 2008002746 A1 CL2008002746 A1 CL 2008002746A1 CL 2008002746 A CL2008002746 A CL 2008002746A CL 2008002746 A CL2008002746 A CL 2008002746A CL 2008002746 A1 CL2008002746 A1 CL 2008002746A1
Authority
CL
Chile
Prior art keywords
phenyl
pyridin
aryl
prevention
treatment
Prior art date
Application number
CL2008002746A
Other languages
English (en)
Inventor
Gregor James Macdonald
Guillaume Albert Jacques Duvey
Jose Maria Cid-Nunez
Andres Avenlino Trabanco-Suarez
Original Assignee
Ortho Mcneil Janssen Pharmaceuticals Inc
Addex Pharmaceuticals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Janssen Pharmaceuticals Inc, Addex Pharmaceuticals Sa filed Critical Ortho Mcneil Janssen Pharmaceuticals Inc
Publication of CL2008002746A1 publication Critical patent/CL2008002746A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Pain & Pain Management (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
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  • Diabetes (AREA)
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  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Compuestos derivados de 4-fenil-2-piridinona; composición farmacéutica; y uso en el tratamiento o prevención de un trastorno del SNC tal como ansiedad, epilepsia, entre otros.
CL2008002746A 2007-09-14 2008-09-15 Compuestos derivados de 4-(4-aril-o-fenil)-1h-piridin-2-ona; 4-(4-aril-s-fenil)-1h-piridin-2-ona; 4-(4-aril-so-fenil)-1h-piridin-2-ona; 4-(4-aril-so2-fenil)-1h-piridin-2-ona y 4-(4-aril-cf2-fenil)-1h-piridin-2-ona 1,3-disustituida; composicion que los comprende; y uso para el tratamiento y/o prevencion de trastornos del snc que involucran al receptor mglur2. CL2008002746A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07116388 2007-09-14

Publications (1)

Publication Number Publication Date
CL2008002746A1 true CL2008002746A1 (es) 2009-05-22

Family

ID=39052686

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2008002746A CL2008002746A1 (es) 2007-09-14 2008-09-15 Compuestos derivados de 4-(4-aril-o-fenil)-1h-piridin-2-ona; 4-(4-aril-s-fenil)-1h-piridin-2-ona; 4-(4-aril-so-fenil)-1h-piridin-2-ona; 4-(4-aril-so2-fenil)-1h-piridin-2-ona y 4-(4-aril-cf2-fenil)-1h-piridin-2-ona 1,3-disustituida; composicion que los comprende; y uso para el tratamiento y/o prevencion de trastornos del snc que involucran al receptor mglur2.

Country Status (22)

Country Link
US (2) US8252937B2 (es)
EP (1) EP2200985B1 (es)
JP (1) JP5366269B2 (es)
KR (1) KR20100065191A (es)
CN (1) CN101848893B (es)
AR (1) AR068512A1 (es)
AT (1) ATE516272T1 (es)
AU (1) AU2008297876B2 (es)
BR (1) BRPI0817101A2 (es)
CA (1) CA2697399C (es)
CL (1) CL2008002746A1 (es)
DK (1) DK2200985T3 (es)
EA (1) EA019085B1 (es)
ES (1) ES2365966T3 (es)
HK (1) HK1144159A1 (es)
MX (1) MX2010002538A (es)
NZ (1) NZ584152A (es)
PL (1) PL2200985T3 (es)
PT (1) PT2200985E (es)
TW (1) TW200922566A (es)
WO (1) WO2009033702A1 (es)
ZA (1) ZA201001221B (es)

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JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JP6026024B2 (ja) 2013-06-27 2016-11-16 ファイザー・インク 複素芳香族化合物およびそのドーパミンｄ１リガンドとしての使用
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