ATE269293T1 - 6-fluoro(3.1.0)hexan-derivate - Google Patents
6-fluoro(3.1.0)hexan-derivateInfo
- Publication number
- ATE269293T1 ATE269293T1 AT99931532T AT99931532T ATE269293T1 AT E269293 T1 ATE269293 T1 AT E269293T1 AT 99931532 T AT99931532 T AT 99931532T AT 99931532 T AT99931532 T AT 99931532T AT E269293 T1 ATE269293 T1 AT E269293T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- cycloalkyl
- hydrogen atom
- alkoxy group
- atom
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fertilizers (AREA)
- Filling Or Discharging Of Gas Storage Vessels (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24634398 | 1998-08-31 | ||
| JP8260799 | 1999-03-25 | ||
| PCT/JP1999/003984 WO2000012464A1 (en) | 1998-08-31 | 1999-07-26 | 6-fluorobicyclo[3. 1.0]hexane derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE269293T1 true ATE269293T1 (de) | 2004-07-15 |
Family
ID=26423636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99931532T ATE269293T1 (de) | 1998-08-31 | 1999-07-26 | 6-fluoro(3.1.0)hexan-derivate |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6333428B1 (de) |
| EP (1) | EP1110943B1 (de) |
| KR (1) | KR100469182B1 (de) |
| CN (1) | CN1247527C (de) |
| AT (1) | ATE269293T1 (de) |
| AU (1) | AU746806B2 (de) |
| CA (1) | CA2341865C (de) |
| DE (1) | DE69918136T2 (de) |
| DK (1) | DK1110943T3 (de) |
| ES (1) | ES2222715T3 (de) |
| PT (1) | PT1110943E (de) |
| WO (1) | WO2000012464A1 (de) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6313159B1 (en) | 1999-08-20 | 2001-11-06 | Guilford Pharmaceuticals Inc. | Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors |
| AU6785501A (en) | 2000-06-28 | 2002-01-08 | Taisho Pharmaceutical Co Ltd | Intermediate and process for producing fluorinated carboxylic acid derivative from the same |
| AU6785401A (en) | 2000-06-28 | 2002-01-08 | Taisho Pharmaceutical Co Ltd | Novel dicarboxylic acid derivatives |
| EP1423411A2 (de) * | 2001-07-09 | 2004-06-02 | Eli Lilly And Company | Prodrug von exzitatorischen aminosäuren |
| AU2002353845A1 (en) * | 2001-11-23 | 2003-06-10 | Eli Lilly And Company | Prodrugs of excitatory amino acids |
| US20050009912A1 (en) * | 2001-12-21 | 2005-01-13 | Bueno Melendo Ana Belen | Prodrugs of excitatory amino acids |
| ATE405289T1 (de) * | 2001-12-27 | 2008-09-15 | Taisho Pharmaceutical Co Ltd | 6-fluorobicyclo 3.1.0 hexan-derivate |
| DK1517915T3 (da) | 2002-06-11 | 2009-03-16 | Lilly Co Eli | Promedikamenter af excitatoriske aminosyrer |
| WO2004004706A1 (en) * | 2002-07-05 | 2004-01-15 | Eli Lilly And Company | Prodrugs of excitatory amino acids |
| DK2123630T3 (da) | 2003-06-26 | 2012-10-22 | Braincells Inc | 2-Amino-bicyclo[3.1.0]hexan-2,6-dicarboxylsyreesterderivat |
| RU2409557C2 (ru) * | 2003-06-26 | 2011-01-20 | Таишо Фармасьютикал Ко., Лтд. | Сложноэфирное производное 2-амино-бицикло[3.1.0]гексан-2,6-дикарбоновой кислоты |
| CN100475800C (zh) * | 2003-11-07 | 2009-04-08 | 大正制药株式会社 | 二环[3.1.0]己烷衍生物的制备方法及其中间体 |
| US20070043100A1 (en) | 2005-08-16 | 2007-02-22 | Hagen Eric J | Novel polymorphs of azabicyclohexane |
| EP2258359A3 (de) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin |
| JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス，インコーポレイティド | ムスカリン性受容体調節による神経発生 |
| US7985756B2 (en) | 2005-10-21 | 2011-07-26 | Braincells Inc. | Modulation of neurogenesis by PDE inhibition |
| WO2007053596A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| TWI417095B (zh) * | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途 |
| US20080045725A1 (en) | 2006-04-28 | 2008-02-21 | Murry Jerry A | Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane |
| WO2007134077A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| WO2007134136A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| EP2068872A1 (de) * | 2006-09-08 | 2009-06-17 | Braincells, Inc. | Kombinationen mit einem 4-acylaminopyridin-derivat |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| TW200845978A (en) * | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| CA2696948C (en) | 2007-09-14 | 2013-04-30 | Jose Maria Cid-Nunez | 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h,1'h-[1,4']bipyridinyl-2'-ones |
| KR20100080597A (ko) * | 2007-09-14 | 2010-07-09 | 오르토-맥닐-얀센 파마슈티칼스 인코포레이티드 | １,３-이치환된-４-페닐-1ｈ-피리딘-2-온 |
| KR20100065191A (ko) | 2007-09-14 | 2010-06-15 | 오르토-맥닐-얀센 파마슈티칼스 인코포레이티드 | １,３-이치환된 ４-(아릴-ｘ-페닐)-１ｈ-피리딘-２-온 |
| EP2220083B1 (de) * | 2007-11-14 | 2017-07-19 | Janssen Pharmaceuticals, Inc. | Imidazo[1,2-a]-pyridin-derivate und ihre verwendung als positive allosterische modulatoren von mglur2-rezeptoren |
| EP2298755A4 (de) * | 2008-05-21 | 2012-12-05 | Taisho Pharmaceutical Co Ltd | Verfahren zur herstellung von bicyclo[3.1.0]hexanderivaten unter verwendung eines enzyms |
| CA2735764C (en) | 2008-09-02 | 2016-06-14 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
| AU2009304293B2 (en) | 2008-10-16 | 2012-04-26 | Addex Pharma S.A. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
| BRPI0921333A2 (pt) | 2008-11-28 | 2015-12-29 | Addex Pharmaceuticals Sa | derivados de indol e benzoxazina como moduladores de receptores de glutamato metabotrópicos |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| WO2010111080A2 (en) | 2009-03-27 | 2010-09-30 | Eli Lilly And Company | Optimized treatment of schizophrenia |
| EA020671B1 (ru) | 2009-05-12 | 2014-12-30 | Янссен Фармасьютикалз, Инк. | ПРОИЗВОДНЫЕ 1,2,4-ТРИАЗОЛО[4,3-a]ПИРИДИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ПОЛОЖИТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2 |
| NZ596078A (en) | 2009-05-12 | 2013-06-28 | Janssen Pharmaceuticals Inc | 1,2,4-TRIAZOLO [4,3-a] PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| CN103298810B (zh) | 2010-11-08 | 2016-03-16 | 杨森制药公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
| CA2815002C (en) | 2010-11-08 | 2019-10-22 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| EP2643320B1 (de) | 2010-11-08 | 2015-03-04 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridinderivate und ihre verwendung als positiv allosterische modulatoren des mglur2 receptors |
| BR112013031928B1 (pt) | 2011-06-17 | 2022-05-24 | Eli Lilly And Company | Derivados de ácido biciclo (3.1.0) hexano-2,6-dicarboxílico, seu uso, e composição farmacêutica |
| AR089718A1 (es) * | 2012-02-01 | 2014-09-10 | Lilly Co Eli | AGONISTAS DE mGlu2/3 |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| KR102414246B1 (ko) | 2014-01-21 | 2022-06-27 | 얀센 파마슈티카 엔.브이. | 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도 |
| LT3431106T (lt) | 2014-01-21 | 2021-02-10 | Janssen Pharmaceutica Nv | Deriniai, apimantys 2 potipio metabotropinio glutamaterginio receptoriaus teigiamus alosterinius moduliatorius arba ortosterinius agonistus, ir jų panaudojimas |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL182285B1 (pl) | 1994-08-12 | 2001-12-31 | Lilly Co Eli | Syntetyczne aminokwasy oraz ich estry i srodki farmaceutyczne je zawierajace PL PL PL PL PL PL PL |
| US5661184A (en) | 1994-08-12 | 1997-08-26 | Eli Lilly And Company | Psychiatric agents |
| IL118727A (en) * | 1995-06-29 | 2003-01-12 | Lilly Co Eli | (-)-2-spiro-5-hydantoinbicyclo [3.1.0] hexane-6-carboxylic acid, salts thereof and use thereof for the preparation of (+)-(2) aminobicyclo [3.1.0] hexane-2,6-dicarboxylic acid |
| ZA969485B (en) | 1995-11-16 | 1998-05-12 | Lilly Co Eli | Excitatory amino acid receptor antagonists. |
| GB9605429D0 (en) | 1995-11-16 | 1996-05-15 | Lilly Co Eli | Excitatory amino acid receptor antagonists |
| US5912248A (en) * | 1995-11-16 | 1999-06-15 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| KR19990067597A (ko) | 1995-11-16 | 1999-08-25 | 피터 지. 스트링거 | 흥분성 아미노산 수용체 길항제 |
| ZA983930B (en) * | 1997-05-14 | 1999-11-08 | Lilly Co Eli | Excitatory amino acid receptor modulators. |
| JP3727791B2 (ja) | 1998-01-08 | 2005-12-14 | ファイザー・プロダクツ・インク | 二環式［３．１．０］ヘキサン及び関連化合物 |
| JP4171549B2 (ja) | 1998-01-28 | 2008-10-22 | 大正製薬株式会社 | 含フッ素アミノ酸誘導体 |
| ES2191412T3 (es) | 1998-01-28 | 2003-09-01 | Taisho Pharmaceutical Co Ltd | Derivados de aminoacidos que contienen fluor. |
-
1999
- 1999-07-26 DK DK99931532T patent/DK1110943T3/da active
- 1999-07-26 CA CA002341865A patent/CA2341865C/en not_active Expired - Fee Related
- 1999-07-26 AT AT99931532T patent/ATE269293T1/de active
- 1999-07-26 PT PT99931532T patent/PT1110943E/pt unknown
- 1999-07-26 KR KR10-2001-7002530A patent/KR100469182B1/ko not_active Expired - Fee Related
- 1999-07-26 EP EP99931532A patent/EP1110943B1/de not_active Expired - Lifetime
- 1999-07-26 DE DE69918136T patent/DE69918136T2/de not_active Expired - Lifetime
- 1999-07-26 WO PCT/JP1999/003984 patent/WO2000012464A1/ja not_active Ceased
- 1999-07-26 ES ES99931532T patent/ES2222715T3/es not_active Expired - Lifetime
- 1999-07-26 US US09/763,408 patent/US6333428B1/en not_active Expired - Lifetime
- 1999-07-26 CN CNB998101834A patent/CN1247527C/zh not_active Expired - Fee Related
- 1999-07-26 AU AU48007/99A patent/AU746806B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU746806B2 (en) | 2002-05-02 |
| EP1110943A4 (de) | 2002-07-10 |
| DK1110943T3 (da) | 2004-10-11 |
| KR100469182B1 (ko) | 2005-02-02 |
| HK1049996A1 (en) | 2003-06-06 |
| DE69918136D1 (de) | 2004-07-22 |
| ES2222715T3 (es) | 2005-02-01 |
| EP1110943A1 (de) | 2001-06-27 |
| DE69918136T2 (de) | 2005-07-07 |
| US6333428B1 (en) | 2001-12-25 |
| CA2341865C (en) | 2006-01-17 |
| WO2000012464A1 (en) | 2000-03-09 |
| CN1383423A (zh) | 2002-12-04 |
| CA2341865A1 (en) | 2000-03-09 |
| CN1247527C (zh) | 2006-03-29 |
| EP1110943B1 (de) | 2004-06-16 |
| KR20010092268A (ko) | 2001-10-24 |
| PT1110943E (pt) | 2004-08-31 |
| AU4800799A (en) | 2000-03-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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