DE69918136D1 - 6-fluoro[3.1.0]hexan-derivate - Google Patents

6-fluoro[3.1.0]hexan-derivate

Info

Publication number
DE69918136D1
DE69918136D1 DE69918136T DE69918136T DE69918136D1 DE 69918136 D1 DE69918136 D1 DE 69918136D1 DE 69918136 T DE69918136 T DE 69918136T DE 69918136 T DE69918136 T DE 69918136T DE 69918136 D1 DE69918136 D1 DE 69918136D1
Authority
DE
Germany
Prior art keywords
group
cycloalkyl
hydrogen atom
alkoxy group
atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69918136T
Other languages
English (en)
Other versions
DE69918136T2 (de
Inventor
Atsuro Nakazato
Toshihito Kumagai
Kazunari Sakagami
Kazuyuki Tomisawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taisho Pharmaceutical Co Ltd
Original Assignee
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE69918136D1 publication Critical patent/DE69918136D1/de
Publication of DE69918136T2 publication Critical patent/DE69918136T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms
DE69918136T 1998-08-31 1999-07-26 6-Fluorobicyclo[3.1.0]Hexan-Derivate Expired - Lifetime DE69918136T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP24634398 1998-08-31
JP24634398 1998-08-31
JP8260799 1999-03-25
JP8260799 1999-03-25
PCT/JP1999/003984 WO2000012464A1 (fr) 1998-08-31 1999-07-26 Derives de 6-fluorobicyclo[3. 1.0]hexane

Publications (2)

Publication Number Publication Date
DE69918136D1 true DE69918136D1 (de) 2004-07-22
DE69918136T2 DE69918136T2 (de) 2005-07-07

Family

ID=26423636

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69918136T Expired - Lifetime DE69918136T2 (de) 1998-08-31 1999-07-26 6-Fluorobicyclo[3.1.0]Hexan-Derivate

Country Status (13)

Country Link
US (1) US6333428B1 (de)
EP (1) EP1110943B1 (de)
KR (1) KR100469182B1 (de)
CN (1) CN1247527C (de)
AT (1) ATE269293T1 (de)
AU (1) AU746806B2 (de)
CA (1) CA2341865C (de)
DE (1) DE69918136T2 (de)
DK (1) DK1110943T3 (de)
ES (1) ES2222715T3 (de)
HK (1) HK1049996A1 (de)
PT (1) PT1110943E (de)
WO (1) WO2000012464A1 (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6313159B1 (en) 1999-08-20 2001-11-06 Guilford Pharmaceuticals Inc. Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors
AU2001267854B2 (en) * 2000-06-28 2005-12-01 Taisho Pharmaceutical Co., Ltd. Novel dicarboxylic acid derivatives
WO2002000595A1 (fr) * 2000-06-28 2002-01-03 Taisho Pharmaceutical Co., Ltd. Produit intermediaire et procede permettant la production d'un derive d'acide carboxylique fluore a partir de ce produit intermediaire
WO2003006489A2 (en) * 2001-07-09 2003-01-23 Eli Lilly And Company Prodrugs of excitatory amino acids
AU2002353845A1 (en) * 2001-11-23 2003-06-10 Eli Lilly And Company Prodrugs of excitatory amino acids
EP1458671A1 (de) * 2001-12-21 2004-09-22 Eli Lilly And Company Prodrugs exzitatorischer aminosäuren
US7157594B2 (en) * 2001-12-27 2007-01-02 Taisho Pharmaceutical Co., Ltd. 6-Fluorobicyclo[3.1.0]hexane derivatives
NZ564692A (en) * 2002-06-11 2009-05-31 Lilly Co Eli Prodrugs of excitatory amino acids
WO2004004706A1 (en) * 2002-07-05 2004-01-15 Eli Lilly And Company Prodrugs of excitatory amino acids
SI1637517T1 (sl) * 2003-06-26 2011-01-31 Taisho Pharmaceutical Co Ltd Derivat estra 2-aminobiciklo 3.1.0 heksan-2,6-dikarboksilne kisline
US7786314B2 (en) * 2003-11-07 2010-08-31 Taisho Pharmaceutical Co., Ltd Processes for preparing bicyclo [3.1.0] hexane derivatives, and intermediates thereto
US20070043100A1 (en) 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
EP2258358A3 (de) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenese mit Acetylcholinesterasehemmer
EP1928437A2 (de) 2005-08-26 2008-06-11 Braincells, Inc. Neurogenese mittels muscarinrezeptormodulation
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
EP1942879A1 (de) 2005-10-31 2008-07-16 Braincells, Inc. Gaba-rezeptor-vermittelte modulation von neurogenese
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
TWI417095B (zh) * 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
US20080045725A1 (en) 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
CA2651813A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
EP2026813A2 (de) 2006-05-09 2009-02-25 Braincells, Inc. 5-ht-rezeptor-vermittelte neurogenese
BRPI0716604A2 (pt) * 2006-09-08 2013-04-09 Braincells Inc combinaÇÕes contendo um derivado de 4-acilaminopiridina
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) * 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TWI475995B (zh) 2007-09-14 2015-03-11 Janssen Pharmaceuticals Inc １’，３’－二取代－４－苯基－３，４，５，６－四氫－２ｈ，１’ｈ－〔１，４’〕聯吡啶基－２’－酮化物
NZ584152A (en) 2007-09-14 2011-11-25 Ortho Mcneil Janssen Pharm 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones
NZ584148A (en) * 2007-09-14 2011-05-27 Ortho Mcneil Janssen Pharm 1,3-disubstituted-4-phenyl-1 h-pyridin-2-ones
MX2010005110A (es) * 2007-11-14 2010-09-09 Ortho Mcneil Janssen Pharm Derivados de imidazo[1,2-a]piridina y su uso como moduladores alostericos positivos de los receptores de glutamato metabotropico 2.
WO2009142184A1 (ja) 2008-05-21 2009-11-26 大正製薬株式会社 酵素を用いたビシクロ［３．１．０］ヘキサン誘導体の製造方法
MX2011002042A (es) 2008-09-02 2011-06-20 Ortho Mcneil Janssen Pharm Derivados de 3-azabiciclo[3.1.o]hexilo como moduladores de los receptores del glutamato metabotropico.
JP5656848B2 (ja) 2008-10-16 2015-01-21 ジャンセン ファーマシューティカルズ， インコーポレイテッド． 代謝型グルタミン酸受容体モジュレーターとしてのインドールおよびベンゾモルホリンの誘導体
AU2009319387B2 (en) 2008-11-28 2012-05-10 Addex Pharma S.A. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
WO2010111080A2 (en) 2009-03-27 2010-09-30 Eli Lilly And Company Optimized treatment of schizophrenia
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
CN102439008B (zh) 2009-05-12 2015-04-29 杨森制药有限公司 1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途
BRPI1010831A2 (pt) 2009-05-12 2016-04-05 Addex Pharmaceuticals Sa derivados de 1,2,4-triazolo[4,3-a]piridina e seu como moduladores alostéricos positivos de receptores de mglur2
WO2012062751A1 (en) 2010-11-08 2012-05-18 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
EP2661435B1 (de) 2010-11-08 2015-08-19 Janssen Pharmaceuticals, Inc. 1,2,4-triazol[4,3-a]pyridinderivate und ihre verwendung als positive allosterische mglur2-rezeptormodulatoren
CA2814996C (en) 2010-11-08 2019-10-01 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
KR101598679B1 (ko) 2011-06-17 2016-02-29 일라이 릴리 앤드 캄파니 mGlu2 수용체 효능제로서의 비시클로(3.1.0)헥산-2,6-디카르복실산 유도체
AR089718A1 (es) * 2012-02-01 2014-09-10 Lilly Co Eli AGONISTAS DE mGlu2/3
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
BR112016016390B1 (pt) 2014-01-21 2023-04-11 Janssen Pharmaceutica Nv Produto compreendendo modulador alostérico positivo do receptor glutamatérgico metabotrópico do subtipo 2 e ligante da proteína de vesícula sináptica 2a
ME03518B (de) 2014-01-21 2020-04-20 Janssen Pharmaceutica Nv Kombinationen mit positiven allosterischen modulatoren von metabotropem glutamatergen rezeptor vom subtyp 2 und deren verwendung

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5661184A (en) 1994-08-12 1997-08-26 Eli Lilly And Company Psychiatric agents
PL182285B1 (pl) 1994-08-12 2001-12-31 Lilly Co Eli Syntetyczne aminokwasy oraz ich estry i srodki farmaceutyczne je zawierajace PL PL PL PL PL PL PL
IL118727A (en) * 1995-06-29 2003-01-12 Lilly Co Eli (-)-2-spiro-5-hydantoinbicyclo [3.1.0] hexane-6-carboxylic acid, salts thereof and use thereof for the preparation of (+)-(2) aminobicyclo [3.1.0] hexane-2,6-dicarboxylic acid
WO1997017950A1 (en) 1995-11-16 1997-05-22 Eli Lilly And Company Shoulder prosthesis
GB9605429D0 (en) 1995-11-16 1996-05-15 Lilly Co Eli Excitatory amino acid receptor antagonists
ZA969485B (en) 1995-11-16 1998-05-12 Lilly Co Eli Excitatory amino acid receptor antagonists.
US5912248A (en) * 1995-11-16 1999-06-15 Eli Lilly And Company Excitatory amino acid receptor antagonists
ZA983930B (en) * 1997-05-14 1999-11-08 Lilly Co Eli Excitatory amino acid receptor modulators.
JP3727791B2 (ja) 1998-01-08 2005-12-14 ファイザー・プロダクツ・インク 二環式［３．１．０］ヘキサン及び関連化合物
KR100446892B1 (ko) 1998-01-28 2004-09-04 다이쇼 세이야꾸 가부시끼가이샤 함불소 아미노산 유도체
JP4171549B2 (ja) 1998-01-28 2008-10-22 大正製薬株式会社 含フッ素アミノ酸誘導体

Also Published As

Publication number Publication date
CN1383423A (zh) 2002-12-04
ES2222715T3 (es) 2005-02-01
DK1110943T3 (da) 2004-10-11
CA2341865C (en) 2006-01-17
WO2000012464A1 (fr) 2000-03-09
KR100469182B1 (ko) 2005-02-02
AU746806B2 (en) 2002-05-02
AU4800799A (en) 2000-03-21
PT1110943E (pt) 2004-08-31
CA2341865A1 (en) 2000-03-09
EP1110943A1 (de) 2001-06-27
KR20010092268A (ko) 2001-10-24
US6333428B1 (en) 2001-12-25
HK1049996A1 (en) 2003-06-06
ATE269293T1 (de) 2004-07-15
DE69918136T2 (de) 2005-07-07
EP1110943B1 (de) 2004-06-16
EP1110943A4 (de) 2002-07-10
CN1247527C (zh) 2006-03-29

Similar Documents

Publication Publication Date Title
DE69918136D1 (de) 6-fluoro[3.1.0]hexan-derivate
ATE236118T1 (de) Fluorhaltige aminosäurederivate
WO2003051315A3 (en) Heteroaryl substituted triazole modulators of metabotropic glutamate receptor-5
TW200634016A (en) Novel thieno-pyridine and thieno-pyrimidine derivatives and their use as positive allosteric modulators of mglur2-receptors
SG155938A1 (en) Novel pyridinone derivatives and their use as positive allosteric modulators of mglur2-receptors
WO2004089303A3 (en) Di-aryl substituted pyrazole modulators of metabotropic glutamate receptor-5
CA2469813A1 (en) Heteroaryl substituted pyrazole modulators of metabotropic glutamate receptor-5
WO2003053922A3 (en) Heteroaryl substituted imidazole modulators of metabotropic glutamate receptor-5
ATE486600T1 (de) Di-aryl-substituierte tetrazol-modulatoren des metabotropen glutamat-rezeptors-5
WO2004089306A3 (en) Di-aryl substituted triazole modulators of metabotropic glutamate receptor-5
BG106228A (en) Substituted imidazothiazoles as antidepressant agents
AU6517598A (en) 4-tetrahydropyridylpyrimidine derivative
EP1099692A4 (de) N,n-substituierte cyclische aminderivate
AU696458B2 (en) Optically active, substituted phenylalkylamine derivatives
HUT58339A (en) Process for producing new organosilane derivatives and pharmaceutical compositions containing them
DOP2004000983A (es) Antagonistas 4-cicloalquilaminopirazol pirimidina de nmda/nr2b

Legal Events

Date Code Title Description
8364 No opposition during term of opposition