DE69918136D1 - 6-fluoro[3.1.0]hexan-derivate - Google Patents

6-fluoro[3.1.0]hexan-derivate

Info

Publication number
DE69918136D1
DE69918136D1 DE69918136T DE69918136T DE69918136D1 DE 69918136 D1 DE69918136 D1 DE 69918136D1 DE 69918136 T DE69918136 T DE 69918136T DE 69918136 T DE69918136 T DE 69918136T DE 69918136 D1 DE69918136 D1 DE 69918136D1
Authority
DE
Germany
Prior art keywords
group
cycloalkyl
hydrogen atom
alkoxy group
atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69918136T
Other languages
English (en)
Other versions
DE69918136T2 (de
Inventor
Atsuro Nakazato
Toshihito Kumagai
Kazunari Sakagami
Kazuyuki Tomisawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taisho Pharmaceutical Co Ltd
Original Assignee
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Publication of DE69918136D1 publication Critical patent/DE69918136D1/de
Application granted granted Critical
Publication of DE69918136T2 publication Critical patent/DE69918136T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Filling Or Discharging Of Gas Storage Vessels (AREA)
  • Fertilizers (AREA)
DE69918136T 1998-08-31 1999-07-26 6-Fluorobicyclo[3.1.0]Hexan-Derivate Expired - Lifetime DE69918136T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP24634398 1998-08-31
JP24634398 1998-08-31
JP8260799 1999-03-25
JP8260799 1999-03-25
PCT/JP1999/003984 WO2000012464A1 (en) 1998-08-31 1999-07-26 6-fluorobicyclo[3. 1.0]hexane derivatives

Publications (2)

Publication Number Publication Date
DE69918136D1 true DE69918136D1 (de) 2004-07-22
DE69918136T2 DE69918136T2 (de) 2005-07-07

Family

ID=26423636

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69918136T Expired - Lifetime DE69918136T2 (de) 1998-08-31 1999-07-26 6-Fluorobicyclo[3.1.0]Hexan-Derivate

Country Status (12)

Country Link
US (1) US6333428B1 (de)
EP (1) EP1110943B1 (de)
KR (1) KR100469182B1 (de)
CN (1) CN1247527C (de)
AT (1) ATE269293T1 (de)
AU (1) AU746806B2 (de)
CA (1) CA2341865C (de)
DE (1) DE69918136T2 (de)
DK (1) DK1110943T3 (de)
ES (1) ES2222715T3 (de)
PT (1) PT1110943E (de)
WO (1) WO2000012464A1 (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6313159B1 (en) 1999-08-20 2001-11-06 Guilford Pharmaceuticals Inc. Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors
KR100699393B1 (ko) * 2000-06-28 2007-03-26 다이쇼 세이야꾸 가부시끼가이샤 중간체 및 이를 사용한 불소 함유 카르복실산 유도체의제조 방법
US6770676B2 (en) 2000-06-28 2004-08-03 Taisho Pharmaceutical Co., Ltd. Dicarboxylic acid derivatives
EP1423411A2 (de) * 2001-07-09 2004-06-02 Eli Lilly And Company Prodrug von exzitatorischen aminosäuren
AU2002353845A1 (en) * 2001-11-23 2003-06-10 Eli Lilly And Company Prodrugs of excitatory amino acids
EP1458671A1 (de) * 2001-12-21 2004-09-22 Eli Lilly And Company Prodrugs exzitatorischer aminosäuren
PT1459765E (pt) * 2001-12-27 2008-10-03 Taisho Pharmaceutical Co Ltd Derivados de 6-fluorobiciclo [3.1.0] hexano
US7371872B2 (en) * 2002-06-11 2008-05-13 Eli Lilly And Company Prodrugs of excitatory amino acids
WO2004004706A1 (en) * 2002-07-05 2004-01-15 Eli Lilly And Company Prodrugs of excitatory amino acids
PL1637517T3 (pl) * 2003-06-26 2011-04-29 Taisho Pharmaceutical Co Ltd Pochodne estrowe kwasu 2-aminobicyklo[3.1.0]heksano-2,6-dikarboksylowego
RU2349580C2 (ru) * 2003-06-26 2009-03-20 Таишо Фармасьютикал Ко., Лтд Сложноэфирное производное 2-амино-бицикло[3.1.0]гексан-2,6-дикарбоновой кислоты, обладающее свойствами антагониста метаботропных глутаматных рецепторов ii группы
US7786314B2 (en) * 2003-11-07 2010-08-31 Taisho Pharmaceutical Co., Ltd Processes for preparing bicyclo [3.1.0] hexane derivatives, and intermediates thereto
US20070043100A1 (en) 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
EP2258359A3 (de) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin
WO2007025177A2 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2377530A3 (de) 2005-10-21 2012-06-20 Braincells, Inc. Modulation von Neurogenese durch PDE-Hemmung
EP1942879A1 (de) 2005-10-31 2008-07-16 Braincells, Inc. Gaba-rezeptor-vermittelte modulation von neurogenese
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
TWI417095B (zh) 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
US20080045725A1 (en) 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
EP2021000A2 (de) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenese mittels angiotensin-modulation
BRPI0716604A2 (pt) * 2006-09-08 2013-04-09 Braincells Inc combinaÇÕes contendo um derivado de 4-acilaminopiridina
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) * 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
CA2698929C (en) * 2007-09-14 2016-01-19 Addex Pharma S.A. 1,3-disubstituted-4-phenyl-1h-pyridin-2-ones
WO2009033702A1 (en) 2007-09-14 2009-03-19 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones
PL2203439T3 (pl) 2007-09-14 2011-06-30 Addex Pharmaceuticals Sa 1',3'-dipodstawione-4-fenylo-3,4,5,6-tetrahydro-2H, 1'H-[1, 4']bipirydynylo-2'-ketony
US8785486B2 (en) * 2007-11-14 2014-07-22 Janssen Pharmaceuticals, Inc. Imidazo[1,2-A]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
WO2009142184A1 (ja) 2008-05-21 2009-11-26 大正製薬株式会社 酵素を用いたビシクロ［３．１．０］ヘキサン誘導体の製造方法
ES2439291T3 (es) 2008-09-02 2014-01-22 Janssen Pharmaceuticals, Inc. Derivados de 3-azabiciclo[3.1.0]hexilo como moduladores de receptores de glutamato metabotrópicos
MX2011003691A (es) 2008-10-16 2011-09-06 Ortho Mcneil Janssen Pharm Derivados de indol y benzomorfolina como moduladores de los receptores de glutamato metabotropico.
ES2401691T3 (es) 2008-11-28 2013-04-23 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Derivados de indol y de benzoxacina como moduladores de los receptores metabotrópicos de glutamato
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
WO2010111080A2 (en) 2009-03-27 2010-09-30 Eli Lilly And Company Optimized treatment of schizophrenia
JP5634506B2 (ja) 2009-05-12 2014-12-03 ジャンセン ファーマシューティカルズ， インコーポレイテッド １，２，３−トリアゾロ［４，３−ａ］ピリジン誘導体ならびに神経障害および精神障害の治療または予防のためのその使用
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
AU2010246607B2 (en) 2009-05-12 2012-09-27 Addex Pharma S.A. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
JP5852665B2 (ja) 2010-11-08 2016-02-03 ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体のポジティブアロステリックモジュレーターとしてのそれらの使用
ES2552455T3 (es) 2010-11-08 2015-11-30 Janssen Pharmaceuticals, Inc. Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
JP5852666B2 (ja) 2010-11-08 2016-02-03 ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体のポジティブアロステリックモジュレーターとしてのそれらの使用
AU2012271024B2 (en) 2011-06-17 2015-07-09 Eli Lilly And Company Bicyclo (3.1.0) hexane- 2, 6 -dicarboxylic acid derivatives as mGlu2 receptor agonist
AR089718A1 (es) * 2012-02-01 2014-09-10 Lilly Co Eli AGONISTAS DE mGlu2/3
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
KR20220038826A (ko) 2014-01-21 2022-03-29 얀센 파마슈티카 엔.브이. 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
KR20200036063A (ko) 2014-01-21 2020-04-06 얀센 파마슈티카 엔.브이. 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL182285B1 (pl) 1994-08-12 2001-12-31 Lilly Co Eli Syntetyczne aminokwasy oraz ich estry i srodki farmaceutyczne je zawierajace PL PL PL PL PL PL PL
US5750566A (en) 1994-08-12 1998-05-12 Eli Lilly And Company Synthetic excitatory amino acids
IL118727A (en) * 1995-06-29 2003-01-12 Lilly Co Eli (-)-2-spiro-5-hydantoinbicyclo [3.1.0] hexane-6-carboxylic acid, salts thereof and use thereof for the preparation of (+)-(2) aminobicyclo [3.1.0] hexane-2,6-dicarboxylic acid
US5912248A (en) * 1995-11-16 1999-06-15 Eli Lilly And Company Excitatory amino acid receptor antagonists
BR9611521A (pt) 1995-11-16 1999-06-29 Lilly Co Eli Antagonistas de receptor de aminoácido excitador
ZA969485B (en) 1995-11-16 1998-05-12 Lilly Co Eli Excitatory amino acid receptor antagonists.
GB9605429D0 (en) 1995-11-16 1996-05-15 Lilly Co Eli Excitatory amino acid receptor antagonists
ZA983930B (en) 1997-05-14 1999-11-08 Lilly Co Eli Excitatory amino acid receptor modulators.
JP3727791B2 (ja) 1998-01-08 2005-12-14 ファイザー・プロダクツ・インク 二環式［３．１．０］ヘキサン及び関連化合物
JP4171549B2 (ja) 1998-01-28 2008-10-22 大正製薬株式会社 含フッ素アミノ酸誘導体
ATE236118T1 (de) 1998-01-28 2003-04-15 Taisho Pharmaceutical Co Ltd Fluorhaltige aminosäurederivate

Also Published As

Publication number Publication date
US6333428B1 (en) 2001-12-25
CA2341865A1 (en) 2000-03-09
ATE269293T1 (de) 2004-07-15
AU4800799A (en) 2000-03-21
DK1110943T3 (da) 2004-10-11
CA2341865C (en) 2006-01-17
KR100469182B1 (ko) 2005-02-02
EP1110943A4 (de) 2002-07-10
CN1247527C (zh) 2006-03-29
EP1110943B1 (de) 2004-06-16
DE69918136T2 (de) 2005-07-07
PT1110943E (pt) 2004-08-31
KR20010092268A (ko) 2001-10-24
WO2000012464A1 (en) 2000-03-09
EP1110943A1 (de) 2001-06-27
CN1383423A (zh) 2002-12-04
HK1049996A1 (en) 2003-06-06
ES2222715T3 (es) 2005-02-01
AU746806B2 (en) 2002-05-02

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Legal Events

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