DE69918136D1 - 6-fluoro[3.1.0]hexan-derivate - Google Patents
6-fluoro[3.1.0]hexan-derivateInfo
- Publication number
- DE69918136D1 DE69918136D1 DE69918136T DE69918136T DE69918136D1 DE 69918136 D1 DE69918136 D1 DE 69918136D1 DE 69918136 T DE69918136 T DE 69918136T DE 69918136 T DE69918136 T DE 69918136T DE 69918136 D1 DE69918136 D1 DE 69918136D1
- Authority
- DE
- Germany
- Prior art keywords
- group
- cycloalkyl
- hydrogen atom
- alkoxy group
- atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical class CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000020925 Bipolar disease Diseases 0.000 abstract 1
- 201000006474 Brain Ischemia Diseases 0.000 abstract 1
- 206010008120 Cerebral ischaemia Diseases 0.000 abstract 1
- 208000012661 Dyskinesia Diseases 0.000 abstract 1
- 206010019196 Head injury Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 102000016193 Metabotropic glutamate receptors Human genes 0.000 abstract 1
- 108010010914 Metabotropic glutamate receptors Proteins 0.000 abstract 1
- 206010028570 Myelopathy Diseases 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 206010008118 cerebral infarction Diseases 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000006843 cycloalkyl-C1-5-alkyl Chemical group 0.000 abstract 1
- 125000005366 cycloalkylthio group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 206010013663 drug dependence Diseases 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 239000003823 glutamate receptor agonist Substances 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000003387 muscular Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP24634398 | 1998-08-31 | ||
JP24634398 | 1998-08-31 | ||
JP8260799 | 1999-03-25 | ||
JP8260799 | 1999-03-25 | ||
PCT/JP1999/003984 WO2000012464A1 (fr) | 1998-08-31 | 1999-07-26 | Derives de 6-fluorobicyclo[3. 1.0]hexane |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69918136D1 true DE69918136D1 (de) | 2004-07-22 |
DE69918136T2 DE69918136T2 (de) | 2005-07-07 |
Family
ID=26423636
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69918136T Expired - Lifetime DE69918136T2 (de) | 1998-08-31 | 1999-07-26 | 6-Fluorobicyclo[3.1.0]Hexan-Derivate |
Country Status (13)
Country | Link |
---|---|
US (1) | US6333428B1 (de) |
EP (1) | EP1110943B1 (de) |
KR (1) | KR100469182B1 (de) |
CN (1) | CN1247527C (de) |
AT (1) | ATE269293T1 (de) |
AU (1) | AU746806B2 (de) |
CA (1) | CA2341865C (de) |
DE (1) | DE69918136T2 (de) |
DK (1) | DK1110943T3 (de) |
ES (1) | ES2222715T3 (de) |
HK (1) | HK1049996A1 (de) |
PT (1) | PT1110943E (de) |
WO (1) | WO2000012464A1 (de) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6313159B1 (en) | 1999-08-20 | 2001-11-06 | Guilford Pharmaceuticals Inc. | Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors |
AU2001267854B2 (en) * | 2000-06-28 | 2005-12-01 | Taisho Pharmaceutical Co., Ltd. | Novel dicarboxylic acid derivatives |
WO2002000595A1 (fr) * | 2000-06-28 | 2002-01-03 | Taisho Pharmaceutical Co., Ltd. | Produit intermediaire et procede permettant la production d'un derive d'acide carboxylique fluore a partir de ce produit intermediaire |
WO2003006489A2 (en) * | 2001-07-09 | 2003-01-23 | Eli Lilly And Company | Prodrugs of excitatory amino acids |
AU2002353845A1 (en) * | 2001-11-23 | 2003-06-10 | Eli Lilly And Company | Prodrugs of excitatory amino acids |
EP1458671A1 (de) * | 2001-12-21 | 2004-09-22 | Eli Lilly And Company | Prodrugs exzitatorischer aminosäuren |
US7157594B2 (en) * | 2001-12-27 | 2007-01-02 | Taisho Pharmaceutical Co., Ltd. | 6-Fluorobicyclo[3.1.0]hexane derivatives |
NZ564692A (en) * | 2002-06-11 | 2009-05-31 | Lilly Co Eli | Prodrugs of excitatory amino acids |
WO2004004706A1 (en) * | 2002-07-05 | 2004-01-15 | Eli Lilly And Company | Prodrugs of excitatory amino acids |
SI1637517T1 (sl) * | 2003-06-26 | 2011-01-31 | Taisho Pharmaceutical Co Ltd | Derivat estra 2-aminobiciklo 3.1.0 heksan-2,6-dikarboksilne kisline |
US7786314B2 (en) * | 2003-11-07 | 2010-08-31 | Taisho Pharmaceutical Co., Ltd | Processes for preparing bicyclo [3.1.0] hexane derivatives, and intermediates thereto |
US20070043100A1 (en) | 2005-08-16 | 2007-02-22 | Hagen Eric J | Novel polymorphs of azabicyclohexane |
EP2258358A3 (de) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenese mit Acetylcholinesterasehemmer |
EP1928437A2 (de) | 2005-08-26 | 2008-06-11 | Braincells, Inc. | Neurogenese mittels muscarinrezeptormodulation |
JP2009512711A (ja) | 2005-10-21 | 2009-03-26 | ブレインセルス,インコーポレイティド | Pde阻害による神経新生の調節 |
EP1942879A1 (de) | 2005-10-31 | 2008-07-16 | Braincells, Inc. | Gaba-rezeptor-vermittelte modulation von neurogenese |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
TWI417095B (zh) * | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | 1,4-二取代之3-氰基-吡啶酮衍生物及其作為mGluR2-受體之正向異位性調節劑之用途 |
US20080045725A1 (en) | 2006-04-28 | 2008-02-21 | Murry Jerry A | Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane |
CA2651813A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
EP2026813A2 (de) | 2006-05-09 | 2009-02-25 | Braincells, Inc. | 5-ht-rezeptor-vermittelte neurogenese |
BRPI0716604A2 (pt) * | 2006-09-08 | 2013-04-09 | Braincells Inc | combinaÇÕes contendo um derivado de 4-acilaminopiridina |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
TW200845978A (en) * | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
TWI475995B (zh) | 2007-09-14 | 2015-03-11 | Janssen Pharmaceuticals Inc | 1’,3’-二取代-4-苯基-3,4,5,6-四氫-2h,1’h-〔1,4’〕聯吡啶基-2’-酮化物 |
NZ584152A (en) | 2007-09-14 | 2011-11-25 | Ortho Mcneil Janssen Pharm | 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones |
NZ584148A (en) * | 2007-09-14 | 2011-05-27 | Ortho Mcneil Janssen Pharm | 1,3-disubstituted-4-phenyl-1 h-pyridin-2-ones |
MX2010005110A (es) * | 2007-11-14 | 2010-09-09 | Ortho Mcneil Janssen Pharm | Derivados de imidazo[1,2-a]piridina y su uso como moduladores alostericos positivos de los receptores de glutamato metabotropico 2. |
WO2009142184A1 (ja) | 2008-05-21 | 2009-11-26 | 大正製薬株式会社 | 酵素を用いたビシクロ[3.1.0]ヘキサン誘導体の製造方法 |
MX2011002042A (es) | 2008-09-02 | 2011-06-20 | Ortho Mcneil Janssen Pharm | Derivados de 3-azabiciclo[3.1.o]hexilo como moduladores de los receptores del glutamato metabotropico. |
JP5656848B2 (ja) | 2008-10-16 | 2015-01-21 | ジャンセン ファーマシューティカルズ, インコーポレイテッド. | 代謝型グルタミン酸受容体モジュレーターとしてのインドールおよびベンゾモルホリンの誘導体 |
AU2009319387B2 (en) | 2008-11-28 | 2012-05-10 | Addex Pharma S.A. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
WO2010111080A2 (en) | 2009-03-27 | 2010-09-30 | Eli Lilly And Company | Optimized treatment of schizophrenia |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
CN102439008B (zh) | 2009-05-12 | 2015-04-29 | 杨森制药有限公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途 |
BRPI1010831A2 (pt) | 2009-05-12 | 2016-04-05 | Addex Pharmaceuticals Sa | derivados de 1,2,4-triazolo[4,3-a]piridina e seu como moduladores alostéricos positivos de receptores de mglur2 |
WO2012062751A1 (en) | 2010-11-08 | 2012-05-18 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
EP2661435B1 (de) | 2010-11-08 | 2015-08-19 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazol[4,3-a]pyridinderivate und ihre verwendung als positive allosterische mglur2-rezeptormodulatoren |
CA2814996C (en) | 2010-11-08 | 2019-10-01 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
KR101598679B1 (ko) | 2011-06-17 | 2016-02-29 | 일라이 릴리 앤드 캄파니 | mGlu2 수용체 효능제로서의 비시클로(3.1.0)헥산-2,6-디카르복실산 유도체 |
AR089718A1 (es) * | 2012-02-01 | 2014-09-10 | Lilly Co Eli | AGONISTAS DE mGlu2/3 |
JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
BR112016016390B1 (pt) | 2014-01-21 | 2023-04-11 | Janssen Pharmaceutica Nv | Produto compreendendo modulador alostérico positivo do receptor glutamatérgico metabotrópico do subtipo 2 e ligante da proteína de vesícula sináptica 2a |
ME03518B (de) | 2014-01-21 | 2020-04-20 | Janssen Pharmaceutica Nv | Kombinationen mit positiven allosterischen modulatoren von metabotropem glutamatergen rezeptor vom subtyp 2 und deren verwendung |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5661184A (en) | 1994-08-12 | 1997-08-26 | Eli Lilly And Company | Psychiatric agents |
PL182285B1 (pl) | 1994-08-12 | 2001-12-31 | Lilly Co Eli | Syntetyczne aminokwasy oraz ich estry i srodki farmaceutyczne je zawierajace PL PL PL PL PL PL PL |
IL118727A (en) * | 1995-06-29 | 2003-01-12 | Lilly Co Eli | (-)-2-spiro-5-hydantoinbicyclo [3.1.0] hexane-6-carboxylic acid, salts thereof and use thereof for the preparation of (+)-(2) aminobicyclo [3.1.0] hexane-2,6-dicarboxylic acid |
WO1997017950A1 (en) | 1995-11-16 | 1997-05-22 | Eli Lilly And Company | Shoulder prosthesis |
GB9605429D0 (en) | 1995-11-16 | 1996-05-15 | Lilly Co Eli | Excitatory amino acid receptor antagonists |
ZA969485B (en) | 1995-11-16 | 1998-05-12 | Lilly Co Eli | Excitatory amino acid receptor antagonists. |
US5912248A (en) * | 1995-11-16 | 1999-06-15 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
ZA983930B (en) * | 1997-05-14 | 1999-11-08 | Lilly Co Eli | Excitatory amino acid receptor modulators. |
JP3727791B2 (ja) | 1998-01-08 | 2005-12-14 | ファイザー・プロダクツ・インク | 二環式[3.1.0]ヘキサン及び関連化合物 |
KR100446892B1 (ko) | 1998-01-28 | 2004-09-04 | 다이쇼 세이야꾸 가부시끼가이샤 | 함불소 아미노산 유도체 |
JP4171549B2 (ja) | 1998-01-28 | 2008-10-22 | 大正製薬株式会社 | 含フッ素アミノ酸誘導体 |
-
1999
- 1999-07-26 DK DK99931532T patent/DK1110943T3/da active
- 1999-07-26 WO PCT/JP1999/003984 patent/WO2000012464A1/ja active IP Right Grant
- 1999-07-26 PT PT99931532T patent/PT1110943E/pt unknown
- 1999-07-26 KR KR10-2001-7002530A patent/KR100469182B1/ko not_active IP Right Cessation
- 1999-07-26 AU AU48007/99A patent/AU746806B2/en not_active Ceased
- 1999-07-26 AT AT99931532T patent/ATE269293T1/de active
- 1999-07-26 CA CA002341865A patent/CA2341865C/en not_active Expired - Fee Related
- 1999-07-26 EP EP99931532A patent/EP1110943B1/de not_active Expired - Lifetime
- 1999-07-26 CN CNB998101834A patent/CN1247527C/zh not_active Expired - Fee Related
- 1999-07-26 US US09/763,408 patent/US6333428B1/en not_active Expired - Lifetime
- 1999-07-26 DE DE69918136T patent/DE69918136T2/de not_active Expired - Lifetime
- 1999-07-26 ES ES99931532T patent/ES2222715T3/es not_active Expired - Lifetime
-
2003
- 2003-03-31 HK HK03102289A patent/HK1049996A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CN1383423A (zh) | 2002-12-04 |
ES2222715T3 (es) | 2005-02-01 |
DK1110943T3 (da) | 2004-10-11 |
CA2341865C (en) | 2006-01-17 |
WO2000012464A1 (fr) | 2000-03-09 |
KR100469182B1 (ko) | 2005-02-02 |
AU746806B2 (en) | 2002-05-02 |
AU4800799A (en) | 2000-03-21 |
PT1110943E (pt) | 2004-08-31 |
CA2341865A1 (en) | 2000-03-09 |
EP1110943A1 (de) | 2001-06-27 |
KR20010092268A (ko) | 2001-10-24 |
US6333428B1 (en) | 2001-12-25 |
HK1049996A1 (en) | 2003-06-06 |
ATE269293T1 (de) | 2004-07-15 |
DE69918136T2 (de) | 2005-07-07 |
EP1110943B1 (de) | 2004-06-16 |
EP1110943A4 (de) | 2002-07-10 |
CN1247527C (zh) | 2006-03-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |