AR089718A1 - AGONISTAS DE mGlu2/3 - Google Patents

AGONISTAS DE mGlu2/3

Info

Publication number
AR089718A1
AR089718A1 ARP130100108A ARP130100108A AR089718A1 AR 089718 A1 AR089718 A1 AR 089718A1 AR P130100108 A ARP130100108 A AR P130100108A AR P130100108 A ARP130100108 A AR P130100108A AR 089718 A1 AR089718 A1 AR 089718A1
Authority
AR
Argentina
Prior art keywords
hydrogen
mglu2
agonists
fluorophenyl
benzyl
Prior art date
Application number
ARP130100108A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR089718A1 publication Critical patent/AR089718A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/26Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms containing rings other than aromatic rings
    • C07C55/30Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms containing rings other than aromatic rings containing condensed ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/50Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/52Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/12Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/753Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of polycyclic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14All rings being cycloaliphatic
    • C07C2602/18All rings being cycloaliphatic the ring system containing six carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/04Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18Fluorenes; Hydrogenated fluorenes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/93Spiro compounds
    • C07C2603/94Spiro compounds containing "free" spiro atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente se refiere a agonistas de mGlu2/3 útiles en el tratamiento de trastornos neurológicos o psiquiátricos. Reivindicación 1: Un compuesto de fórmula (1) caracterizado porque R¹ es hidrógeno, R² es hidrógeno, y R³ es hidrógeno; R¹ es hidrógeno, R² es (2S)-2-aminopropanoilo, y R³ es hidrógeno; R¹ es hidrógeno, R² es (2S)-2-amino-4-metilsulfanil-butanoil, y R³ es hidrógeno; R¹ es hidrógeno, R² es 2-aminoacetilo, y R³ es hidrógeno; R¹ es bencilo, R² es hidrógeno, y R³ es bencilo; o R¹ es (2-fluorofenil)metilo, R² es hidrógeno, y R³ es (2-fluorofenil)metilo; o una sal del mismo farmacéuticamente aceptable.
ARP130100108A 2012-02-01 2013-01-14 AGONISTAS DE mGlu2/3 AR089718A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12382038 2012-02-01
US201261619139P 2012-04-02 2012-04-02

Publications (1)

Publication Number Publication Date
AR089718A1 true AR089718A1 (es) 2014-09-10

Family

ID=48870759

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP130100108A AR089718A1 (es) 2012-02-01 2013-01-14 AGONISTAS DE mGlu2/3

Country Status (35)

Country Link
US (1) US8575214B2 (es)
EP (1) EP2809647B1 (es)
JP (1) JP5755821B2 (es)
KR (1) KR101518365B1 (es)
CN (1) CN104093703B (es)
AP (1) AP2014007821A0 (es)
AR (1) AR089718A1 (es)
AU (1) AU2013215396B2 (es)
BR (1) BR112014018760A8 (es)
CA (1) CA2863085C (es)
CL (1) CL2014001928A1 (es)
CO (1) CO7020921A2 (es)
CR (1) CR20140344A (es)
DK (1) DK2809647T3 (es)
DO (1) DOP2014000179A (es)
EA (1) EA023678B1 (es)
ES (1) ES2592166T3 (es)
GT (1) GT201400168A (es)
HK (1) HK1199014A1 (es)
HR (1) HRP20160867T1 (es)
HU (1) HUE028863T2 (es)
IL (1) IL233732A0 (es)
LT (1) LT2809647T (es)
MA (1) MA35884B1 (es)
MX (1) MX355779B (es)
NZ (1) NZ626456A (es)
PE (1) PE20141680A1 (es)
PH (1) PH12014501725A1 (es)
PL (1) PL2809647T3 (es)
PT (1) PT2809647T (es)
RS (1) RS54976B1 (es)
SG (1) SG11201404138VA (es)
SI (1) SI2809647T1 (es)
TW (1) TW201343610A (es)
WO (1) WO2013116174A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101481164B1 (ko) * 2008-01-30 2015-01-09 주식회사 미래셀바이오 체세포 유래 다능성 줄기세포의 제조 방법

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR199800877T2 (xx) 1995-11-16 1998-09-21 Eli Lilly And Company Uyar�c� amino asit t�revleri.
GB9605429D0 (en) * 1995-11-16 1996-05-15 Lilly Co Eli Excitatory amino acid receptor antagonists
ZA983930B (en) * 1997-05-14 1999-11-08 Lilly Co Eli Excitatory amino acid receptor modulators.
EP1110943B1 (en) * 1998-08-31 2004-06-16 Taisho Pharmaceutical Co. Ltd. 6-fluorobicyclo 3. 1.0]hexane derivatives
GB2355982A (en) * 1999-11-03 2001-05-09 Lilly Co Eli Heterocyclic amino acids
AU2001267854B2 (en) * 2000-06-28 2005-12-01 Taisho Pharmaceutical Co., Ltd. Novel dicarboxylic acid derivatives
HUP0400620A3 (en) 2001-01-11 2012-09-28 Lilly Co Eli Prodrugs of excitatory amino acids and pharmaceutical compositions containing them and process for preparation the compounds
US7038077B2 (en) 2001-01-11 2006-05-02 Eli Lilly And Company Prodrugs of excitatory amino acids
NZ556437A (en) 2002-06-11 2008-11-28 Lilly Co Eli Prodrugs of excitatory amino acids
WO2005000791A1 (ja) 2003-06-26 2005-01-06 Taisho Pharmaceutical Co., Ltd. 2-アミノ-ビシクロ[3.1.0]ヘキサン-2,6-ジカルボン酸エステル誘導体
AR079343A1 (es) 2009-12-21 2012-01-18 Lilly Co Eli Compuesto de acido 2-amino-4-(4h-1,2,4-triazol-3-ilsulfanil)biciclo[3.1.0]hexano-2,6-dicarboxilico, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar un trastorno psiquiatrico

Also Published As

Publication number Publication date
AU2013215396A8 (en) 2014-08-07
CR20140344A (es) 2014-08-25
AU2013215396A1 (en) 2014-07-17
KR20140107658A (ko) 2014-09-04
EA023678B1 (ru) 2016-06-30
MX2014008598A (es) 2014-08-22
SI2809647T1 (sl) 2016-08-31
LT2809647T (lt) 2016-10-10
EP2809647A1 (en) 2014-12-10
SG11201404138VA (en) 2014-08-28
DK2809647T3 (en) 2016-10-03
EA201491291A1 (ru) 2014-10-30
KR101518365B1 (ko) 2015-05-08
NZ626456A (en) 2016-02-26
CL2014001928A1 (es) 2014-11-07
MX355779B (es) 2018-04-30
PT2809647T (pt) 2016-08-29
PE20141680A1 (es) 2014-11-08
BR112014018760A2 (es) 2017-06-20
ES2592166T3 (es) 2016-11-28
PL2809647T3 (pl) 2017-07-31
HK1199014A1 (en) 2015-06-19
HUE028863T2 (en) 2017-01-30
CN104093703B (zh) 2016-01-20
WO2013116174A1 (en) 2013-08-08
DOP2014000179A (es) 2014-10-15
US8575214B2 (en) 2013-11-05
JP2015512870A (ja) 2015-04-30
RS54976B1 (sr) 2016-11-30
HRP20160867T1 (hr) 2016-10-07
CA2863085A1 (en) 2013-08-08
JP5755821B2 (ja) 2015-07-29
GT201400168A (es) 2015-08-27
MA35884B1 (fr) 2014-12-01
US20130197079A1 (en) 2013-08-01
EP2809647B1 (en) 2016-07-06
CA2863085C (en) 2015-11-17
PH12014501725A1 (en) 2014-11-24
TW201343610A (zh) 2013-11-01
CO7020921A2 (es) 2014-08-11
IL233732A0 (en) 2014-09-30
AU2013215396B2 (en) 2015-03-12
BR112014018760A8 (pt) 2017-07-11
AP2014007821A0 (en) 2014-07-31
CN104093703A (zh) 2014-10-08

Similar Documents

Publication Publication Date Title
CR20150078A (es) Análogos de piridazina 1,4-disustituida y métodos para el tratamiento de condiciones relacionadas con la deficiencia de smn
CR20150418A (es) Compuestos de tetrahidropirrolotiazina
PH12016502382A1 (en) Substituted indazole compounds as irak4 inhibitors
RS54873B1 (sr) Policiklična-karbamoilpiridonska jedinjenja i njihova farmaceutska upotreba
GEP20207105B (en) 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives and 1,1,1-trifluoro-4-hydroxybutan-2yl carbamate derivatives as magl inhibitors
EA030199B9 (ru) Терапевтически активные соединения и способы их применения
CO6480931A2 (es) Sulfonamidas heterocíclicas, usos y composiciones farmacéuticas de las mismas.
BR112015026325A2 (pt) dosagem oral de compostos glp-1
EA201391615A1 (ru) Дейтерированные потенциаторы cftr
NZ626618A (en) Hydroxamic acid derivatives and uses thereof
AR103680A1 (es) Inhibidores selectivos de bace1
CO2018009561A2 (es) Métodos para tratar la depresión con antagonistas del receptor de orexina-2
WO2016085939A3 (en) Compounds and methods of treating ocular disorders
AR098274A1 (es) Inhibidor de grelina o-acil transferasa
UY33910A (es) 6-cicloalquil-pirazolopirimidinonas para el tratamiento de trastornos del SNC
BR112015009649A2 (pt) composto de triazolo
AR094553A1 (es) Formas de oxadiazolpirazina
MX355142B (es) Acetamidas heterociclicas sustituidas como agonistas del receptor opioide kappa (kor).
AR095097A1 (es) Compuestos de fenoxietoxi
CR20150419A (es) Derivados sustituidos del ácido bisfenil butanóico fosfónico como inhibidores de la nep
IN2012DN00765A (es)
PE20151718A1 (es) Compuestos piridinilpirazoloquinolina
CL2012000263A1 (es) Compuestos derivados de amidas espiro ciclica, agonista b-adrenoreceptor y antagonista muscarinico; utiles en el tratamiento en enfermedades inflamatorias, tales como epoc.
AR095015A1 (es) Compuestos de azetidiniloxifenilpirrolidina
MD20160105A2 (ro) 2-Amino-6-metil-4,4a,5,6-tetrahidropirano[3,4-d][1,3]tiazin-8a(8H)-il-1,3-tiazol-4-il amide

Legal Events

Date Code Title Description
FB Suspension of granting procedure