SK282524B6 - Opticky čisté soli (-)-enantioméru pyridylmetylsulfinyl-1H- benzimidazolových zlúčenín, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom, ich použitie a medziprodukty na ich prípravu - Google Patents
Opticky čisté soli (-)-enantioméru pyridylmetylsulfinyl-1H- benzimidazolových zlúčenín, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom, ich použitie a medziprodukty na ich prípravu Download PDFInfo
- Publication number
- SK282524B6 SK282524B6 SK101-95A SK10195A SK282524B6 SK 282524 B6 SK282524 B6 SK 282524B6 SK 10195 A SK10195 A SK 10195A SK 282524 B6 SK282524 B6 SK 282524B6
- Authority
- SK
- Slovakia
- Prior art keywords
- methoxy
- preparation
- optically pure
- methyl
- pyridyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE19939301830A SE9301830D0 (sv) | 1993-05-28 | 1993-05-28 | New compounds |
PCT/SE1994/000509 WO1994027988A1 (en) | 1993-05-28 | 1994-05-27 | Optically pure salts of pyridinylmethyl sulfinyl-ih-benzimidazole compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
SK10195A3 SK10195A3 (en) | 1995-09-13 |
SK282524B6 true SK282524B6 (sk) | 2002-10-08 |
Family
ID=20390088
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK101-95A SK282524B6 (sk) | 1993-05-28 | 1994-05-27 | Opticky čisté soli (-)-enantioméru pyridylmetylsulfinyl-1H- benzimidazolových zlúčenín, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom, ich použitie a medziprodukty na ich prípravu |
Country Status (43)
Families Citing this family (209)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9301830D0 (sv) * | 1993-05-28 | 1993-05-28 | Ab Astra | New compounds |
US6875872B1 (en) | 1993-05-28 | 2005-04-05 | Astrazeneca | Compounds |
US5877192A (en) * | 1993-05-28 | 1999-03-02 | Astra Aktiebolag | Method for the treatment of gastric acid-related diseases and production of medication using (-) enantiomer of omeprazole |
HUT75775A (en) * | 1994-07-08 | 1997-05-28 | Astra Ab | Medicament with multiple unit tablated dosage form containing omeprazole |
SE504459C2 (sv) * | 1994-07-15 | 1997-02-17 | Astra Ab | Förfarande för framställning av substituerade sulfoxider |
SE9500422D0 (sv) * | 1995-02-06 | 1995-02-06 | Astra Ab | New oral pharmaceutical dosage forms |
SE9500478D0 (sv) * | 1995-02-09 | 1995-02-09 | Astra Ab | New pharmaceutical formulation and process |
HRP960232A2 (en) * | 1995-07-03 | 1998-02-28 | Astra Ab | A process for the optical purification of compounds |
US6489346B1 (en) | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
US6699885B2 (en) * | 1996-01-04 | 2004-03-02 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and methods of using same |
US6645988B2 (en) * | 1996-01-04 | 2003-11-11 | Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
SE9600070D0 (sv) | 1996-01-08 | 1996-01-08 | Astra Ab | New oral pharmaceutical dosage forms |
SE508669C2 (sv) * | 1996-04-26 | 1998-10-26 | Astra Ab | Nytt förfarande |
SE510666C2 (sv) * | 1996-12-20 | 1999-06-14 | Astra Ab | Nya Kristallmodifikationer |
SE9702000D0 (sv) * | 1997-05-28 | 1997-05-28 | Astra Ab | New pharmaceutical formulation |
SE510650C2 (sv) * | 1997-05-30 | 1999-06-14 | Astra Ab | Ny förening |
US6747155B2 (en) | 1997-05-30 | 2004-06-08 | Astrazeneca Ab | Process |
SE510643C2 (sv) * | 1997-06-27 | 1999-06-14 | Astra Ab | Termodynamiskt stabil omeprazol natrium form B |
US6096340A (en) * | 1997-11-14 | 2000-08-01 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
US6174548B1 (en) | 1998-08-28 | 2001-01-16 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
EP1037607B1 (en) * | 1997-12-08 | 2004-02-25 | ALTANA Pharma AG | Novel suppository form comprising an acid-labile active compound |
SE9704869D0 (sv) * | 1997-12-22 | 1997-12-22 | Astra Ab | New pharmaceutical formulaton II |
SE9704870D0 (sv) * | 1997-12-22 | 1997-12-22 | Astra Ab | New pharmaceutical formulation I |
CA2298823C (en) * | 1998-04-20 | 2011-06-07 | Eisai Co., Ltd. | Stabilized composition comprising a benzimidazole type compound |
ATE231857T1 (de) | 1998-08-10 | 2003-02-15 | Winston Pharmateuticals Llc | Prodrugs für proton-pump-inhibitoren |
US6733778B1 (en) | 1999-08-27 | 2004-05-11 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
SE9803772D0 (sv) | 1998-11-05 | 1998-11-05 | Astra Ab | Pharmaceutical formulation |
BR9915421A (pt) | 1998-11-18 | 2001-08-07 | Astrazeneca Ab | Processo para a fabricação de sais alcalinos levemente solúveis ou menos solúveis de heterociclos de sulfinila substituìda, forma de dosagem farmacêutica, uso da mesma, método de tratamento de doenças gastrointestinais, e, processo para a fabricação de uma forma de dosagem farmacêutica. |
SE9900274D0 (sv) * | 1999-01-28 | 1999-01-28 | Astra Ab | New compound |
US6852739B1 (en) * | 1999-02-26 | 2005-02-08 | Nitromed Inc. | Methods using proton pump inhibitors and nitric oxide donors |
TWI243672B (en) | 1999-06-01 | 2005-11-21 | Astrazeneca Ab | New use of compounds as antibacterial agents |
WO2000076556A2 (en) * | 1999-06-11 | 2000-12-21 | Neorx Corporation | High dose radionuclide complexes for bone marrow suppression |
US7094885B2 (en) * | 1999-07-11 | 2006-08-22 | Neorx Corporation | Skeletal-targeted radiation to treat bone-associated pathologies |
US6326384B1 (en) | 1999-08-26 | 2001-12-04 | Robert R. Whittle | Dry blend pharmaceutical unit dosage form |
EP1595879A3 (en) * | 1999-08-26 | 2010-01-27 | aaiPharma Inc. | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
US6312712B1 (en) | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Method of improving bioavailability |
US6369087B1 (en) | 1999-08-26 | 2002-04-09 | Robert R. Whittle | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
US6312723B1 (en) | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Pharmaceutical unit dosage form |
US6262086B1 (en) | 1999-08-26 | 2001-07-17 | Robert R. Whittle | Pharmaceutical unit dosage form |
US6262085B1 (en) | 1999-08-26 | 2001-07-17 | Robert R. Whittle | Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
US6268385B1 (en) | 1999-08-26 | 2001-07-31 | Robert R. Whittle | Dry blend pharmaceutical formulations |
US6780880B1 (en) | 1999-08-26 | 2004-08-24 | Robert R. Whittle | FT-Raman spectroscopic measurement |
US6316020B1 (en) * | 1999-08-26 | 2001-11-13 | Robert R. Whittle | Pharmaceutical formulations |
JP2003510348A (ja) * | 1999-10-01 | 2003-03-18 | ナトコ ファーマ リミテッド | 改良された薬学的組成物およびその製造方法 |
JP4081273B2 (ja) * | 1999-10-20 | 2008-04-23 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ベンズイミダゾール系化合物安定化方法 |
SE9903831D0 (sv) | 1999-10-22 | 1999-10-22 | Astra Ab | Formulation of substituted benzimidazoles |
PT1257269E (pt) | 2000-02-24 | 2005-03-31 | Kopran Res Lab Ltd | Derivados do benzimidazole anti-ulcera estavel em relacao ao acido de administracao oral |
SE0000774D0 (sv) | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | New formulation |
WO2001087831A2 (en) * | 2000-05-15 | 2001-11-22 | Ranbaxy Laboratories Limited | Novel amorphous form of omeprazole salts |
US6306435B1 (en) * | 2000-06-26 | 2001-10-23 | Yung Shin Pharmaceutical Industrial Co. Ltd. | Oral pharmaceutical preparation embedded in an oily matrix and methods of making the same |
AU2003204233B8 (en) * | 2000-08-04 | 2008-06-26 | Bernard Charles Sherman | Magnesium salt of S-omeprazole |
CA2386716C (en) * | 2002-05-17 | 2012-07-24 | Bernard Charles Sherman | Magnesium salt of s-omeprazole |
CA2417311C (en) | 2000-08-04 | 2012-07-10 | Takeda Chemical Industries, Ltd. | Crystalline alkali metal salts of lansoprazole and their production and use |
US6544556B1 (en) | 2000-09-11 | 2003-04-08 | Andrx Corporation | Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor |
US20020064555A1 (en) * | 2000-09-29 | 2002-05-30 | Dan Cullen | Proton pump inhibitor formulation |
WO2002062398A2 (en) | 2001-01-08 | 2002-08-15 | Neorx Corporation | Radioactively labelled conjugates of phosphonates |
US7064214B2 (en) * | 2001-04-13 | 2006-06-20 | Apsinterm Llc | Methods of preparing sulfinamides and sulfoxides |
SE0101379D0 (sv) | 2001-04-18 | 2001-04-18 | Diabact Ab | Komposition som hämmar utsöndring av magsyra |
US8206741B2 (en) | 2001-06-01 | 2012-06-26 | Pozen Inc. | Pharmaceutical compositions for the coordinated delivery of NSAIDs |
GB2376231A (en) * | 2001-06-06 | 2002-12-11 | Cipla Ltd | Benzimidazole-cyclodextrin inclusion complex |
SE0102993D0 (sv) | 2001-09-07 | 2001-09-07 | Astrazeneca Ab | New self emulsifying drug delivery system |
KR20040025677A (ko) | 2001-09-18 | 2004-03-24 | 제리아 신야쿠 고교 가부시키 가이샤 | 벤즈이미다졸 유도체 |
US20040006111A1 (en) * | 2002-01-25 | 2004-01-08 | Kenneth Widder | Transmucosal delivery of proton pump inhibitors |
DE60314105T2 (de) * | 2002-03-05 | 2008-01-24 | Astrazeneca Ab | Alkylammoniumsalze von omeprazol und esomeprazol |
MXPA04009968A (es) | 2002-04-09 | 2004-12-13 | Flamel Tech Sa | Formulacion farmaceutica oral bajo forma de suspension acuosa de microcapsulas que permiten la liberacion modificada de principio (s) activo (s). |
US6894066B2 (en) * | 2002-05-09 | 2005-05-17 | Bernard Charles Sherman | Magnesium salt of S-omeprazole |
CA2492718C (en) * | 2002-07-19 | 2010-12-21 | Michael E. Garst | Prodrugs of proton pump inhibitors |
TW200410955A (en) * | 2002-07-29 | 2004-07-01 | Altana Pharma Ag | Novel salt of (S)-PANTOPRAZOLE |
EP1534278A4 (en) * | 2002-08-01 | 2006-09-06 | Nitromed Inc | NITROSED PROTONATE PUMP INHIBITORS, COMPOSITIONS AND USE METHOD |
US7612098B2 (en) | 2002-08-30 | 2009-11-03 | Dr. Reddy's Laboratories Limited | Amorphous hydrous esomeprazole magnesium |
EP2596792A1 (en) | 2002-10-16 | 2013-05-29 | Takeda Pharmaceutical Company Limited | Stable solid preparations |
SE0203065D0 (sv) | 2002-10-16 | 2002-10-16 | Diabact Ab | Gastric acid secretion inhibiting composition |
US20040235903A1 (en) | 2002-10-22 | 2004-11-25 | Khanna Mahavir Singh | Amorphous form of esomeprazole salts |
WO2004046134A2 (en) * | 2002-11-18 | 2004-06-03 | Dr. Reddy's Laboratories Limited | Crystalline form ii of esomeprazole magnesium trihydrate and process for its preparation |
DE10254167A1 (de) | 2002-11-20 | 2004-06-09 | Icon Genetics Ag | Verfahren zur Kontrolle von zellulären Prozessen in Pflanzen |
PT1578742E (pt) | 2002-12-06 | 2013-01-24 | Nycomed Gmbh | Processo para preparar compostos activos opticamente puros |
JP2006514985A (ja) | 2002-12-06 | 2006-05-18 | アルタナ ファルマ アクチエンゲゼルシャフト | (s)−パントプラゾールの製造方法 |
FR2848555B1 (fr) | 2002-12-16 | 2006-07-28 | Negma Gild | Enantiomere(-)du tenatoprazole et son application en therapeutique |
US20040166162A1 (en) * | 2003-01-24 | 2004-08-26 | Robert Niecestro | Novel pharmaceutical formulation containing a proton pump inhibitor and an antacid |
US20040248942A1 (en) * | 2003-02-20 | 2004-12-09 | Bonnie Hepburn | Novel formulation, omeprazole antacid complex-immediate release for rapid and sustained suppression of gastric acid |
CA2517714A1 (en) * | 2003-02-28 | 2004-09-10 | Ranbaxy Laboratories Limited | Polymorphs of s-omeprazole |
WO2004089935A1 (en) * | 2003-04-10 | 2004-10-21 | Hetero Drugs Limitd | Novel crystalline forms of s-omeprazole magnesium |
WO2004099182A1 (en) * | 2003-05-05 | 2004-11-18 | Ranbaxy Laboratories Limited | Zinc salt of (s)-omeprazole |
US20070060556A1 (en) * | 2003-05-05 | 2007-03-15 | Yatendra Kumar | Barium salt of benzimidazole derivative |
PL379542A1 (pl) * | 2003-07-15 | 2006-10-02 | Allergan, Inc. | Sposób wytwarzania izomerycznie czystych proleków inhibitorów pompy protonowej |
US8993599B2 (en) | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
MXPA06000529A (es) * | 2003-07-18 | 2006-08-11 | Santarus Inc | Formulaciones farmaceuticas utiles para inhibir la secrecion de acido y metodos para elaborarlas y utilizarlas. |
CA2531566C (en) * | 2003-07-18 | 2013-05-07 | Santarus, Inc. | Pharmaceutical formulation and method for treating acid-caused gastrointestinal disorders |
CN100457104C (zh) * | 2003-07-23 | 2009-02-04 | 尼科梅德有限责任公司 | 质子泵抑制剂的碱性盐 |
PL1651217T3 (pl) * | 2003-07-23 | 2008-07-31 | Nycomed Gmbh | Sole alkaiczne inhibitorów pompy protonowej |
JPWO2005011637A1 (ja) * | 2003-08-04 | 2006-09-14 | エーザイ株式会社 | 用時分散型製剤 |
SE0302382D0 (sv) | 2003-09-04 | 2003-09-04 | Astrazeneca Ab | New salts II |
SE0302381D0 (sv) * | 2003-09-04 | 2003-09-04 | Astrazeneca Ab | New salts I |
CA2540105A1 (en) * | 2003-09-25 | 2005-03-31 | Natco Pharma Limited | Enteric soft gelatin capsule containing esomeprazole and method of preparation |
EP1708684A2 (en) | 2003-09-26 | 2006-10-11 | Alza Corporation | Drug coating providing high drug loading and methods for providing the same |
US20050075371A1 (en) * | 2003-10-03 | 2005-04-07 | Allergan, Inc. | Methods and compositions for the oral administration of prodrugs of proton pump inhibitors |
AU2003272086A1 (en) * | 2003-10-14 | 2005-04-27 | Natco Pharma Limited | Enteric coated pellets comprising esomeprazole, hard gelatin capsule containing them, and method of preparation |
GB0403165D0 (en) * | 2004-02-12 | 2004-03-17 | Ct | Novel uses for proton pump inhibitors |
US20070161679A1 (en) * | 2004-02-18 | 2007-07-12 | Allergan, Inc. | Method and compositions for the intravenous administration of compounds related to proton pump inhibitors |
BRPI0507784A (pt) * | 2004-02-18 | 2007-07-17 | Allergan Inc | métodos e composições para a administração de pró-fármacos de inibidores da bomba de prótons |
SE0400410D0 (sv) | 2004-02-20 | 2004-02-20 | Astrazeneca Ab | New compounds |
WO2005082888A1 (en) * | 2004-03-01 | 2005-09-09 | Milen Merkez Ilac Endustrisi A.S. | Process for the preparation of magnesium salt of omeprazole |
US7176319B2 (en) | 2004-04-28 | 2007-02-13 | Hetero Drugs Limited | Process for substituted sulfoxides |
US8906940B2 (en) | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
US8815916B2 (en) | 2004-05-25 | 2014-08-26 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
US20050267159A1 (en) * | 2004-05-28 | 2005-12-01 | Aaipharma, Inc. | Magnesium complexes of S-omeprazole |
US20050267157A1 (en) * | 2004-05-28 | 2005-12-01 | David White | Magnesium-S-omeprazole |
DE602004025386D1 (de) * | 2004-05-28 | 2010-03-18 | Hetero Drugs Ltd | Neue stereoselektive synthese von benzimidazolsulfoxiden |
NZ551970A (en) * | 2004-06-24 | 2010-01-29 | Astrazeneca Ab | New process for the preparation of crystal modifications for use in the preparation of esomeprazole sodium salt |
US20080249134A1 (en) * | 2004-06-24 | 2008-10-09 | Ursula Hohlneicher | New Esomeprazole Sodium Salt Crystal Modification |
US20060024362A1 (en) | 2004-07-29 | 2006-02-02 | Pawan Seth | Composition comprising a benzimidazole and process for its manufacture |
US7829718B2 (en) | 2004-08-06 | 2010-11-09 | Eisai R&D Management Co., Ltd. | Salts of benzimidazole derivative with amines and process for manufacturing the same |
KR100847635B1 (ko) * | 2004-08-06 | 2008-07-21 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 벤즈이미다졸 유도체와 아민과의 염 |
US8541026B2 (en) | 2004-09-24 | 2013-09-24 | Abbvie Inc. | Sustained release formulations of opioid and nonopioid analgesics |
EP1830822A1 (en) * | 2004-12-24 | 2007-09-12 | LEK Pharmaceuticals D.D. | Stable pharmaceutical composition comprising an active substance in the form of solid solution |
WO2006073779A1 (en) * | 2004-12-30 | 2006-07-13 | Transform Phamaceuticals, Inc. | Novel omeprazole forms and related methods |
ES2259269B1 (es) | 2005-03-03 | 2007-11-01 | Esteve Quimica, S.A. | Procedimiento para la preparacion de derivados de 2-(2-piridilmetilsulfinil)-bencimidazol opticamente activos. |
CA2597632C (en) | 2005-03-25 | 2012-05-15 | Livzon Pharmaceutical Group Inc. | Substituted sulfoxide compounds, methods for preparing the same and use thereof |
WO2006120520A1 (en) * | 2005-05-06 | 2006-11-16 | Glenmark Pharmaceuticals Limited | Esomeprazole strontium salt, process for its preparation and pharmaceutical compositions containing same |
WO2006121995A2 (en) * | 2005-05-09 | 2006-11-16 | Tap Pharmaceutical Products, Inc. | Methods for treating nephrolithiasis |
US7803817B2 (en) | 2005-05-11 | 2010-09-28 | Vecta, Ltd. | Composition and methods for inhibiting gastric acid secretion |
US7981908B2 (en) | 2005-05-11 | 2011-07-19 | Vecta, Ltd. | Compositions and methods for inhibiting gastric acid secretion |
US7563812B2 (en) * | 2005-06-15 | 2009-07-21 | Hetero Drugs Limited | Amorphous esomeprazole hydrate |
KR100641534B1 (ko) * | 2005-07-28 | 2006-11-01 | 한미약품 주식회사 | 에스오메프라졸 및 그의 염의 제조방법 |
JP5242393B2 (ja) * | 2005-08-03 | 2013-07-24 | タケダ ファーマシューティカルズ ユー.エス.エー. インコーポレイティド | 高血圧症の治療方法 |
US20070043085A1 (en) * | 2005-08-19 | 2007-02-22 | Glenmark Pharmaceuticals Limited | Process for the preparation of amorphous form of neutral esomeprazole |
WO2007031845A2 (en) * | 2005-09-14 | 2007-03-22 | Glenmark Pharmaceuticals Limited | Polymorphic forms of (s)-omeprazole magnesium salts and processes for their preparation |
CN101309917B (zh) * | 2005-10-06 | 2013-09-11 | 奥斯拜客斯制药有限公司 | 具有增强治疗性质的胃h+,k+-atp酶氘代抑制剂 |
US7576219B2 (en) | 2005-10-26 | 2009-08-18 | Hanmi Pharm. Co., Ltd | Crystalline S-omeprazole strontium hydrate, method for preparing same, and pharmaceutical composition containing same |
JP2009518394A (ja) | 2005-12-05 | 2009-05-07 | アストラゼネカ・アクチエボラーグ | エソメプラゾールの非塩形態の新規の製造方法 |
EP1801110A1 (en) | 2005-12-22 | 2007-06-27 | KRKA, tovarna zdravil, d.d., Novo mesto | Esomeprazole arginine salt |
US7553857B2 (en) | 2005-12-23 | 2009-06-30 | Lek Pharmaceuticals D.D. | S-omeprazole magnesium |
US7799925B2 (en) * | 2005-12-28 | 2010-09-21 | Unión Químico Farmacéutica, S.A. | Process for the preparation of the (S)-enantiomer of omeprazole |
US8063074B2 (en) | 2006-05-04 | 2011-11-22 | Dr. Reddy's Laboratories Limited | Polymorphic forms of esomeprazole sodium |
ES2355164T3 (es) * | 2006-06-07 | 2011-03-23 | Astrazeneca Ab | Nuevo método para la preparación de sales de amonio de esomeprazol. |
US7863330B2 (en) | 2006-06-14 | 2011-01-04 | Rottapharm S.P.A. | Deloxiglumide and proton pump inhibitor combination in the treatment of gastrointestinal disorders |
JP2009542624A (ja) | 2006-07-05 | 2009-12-03 | ルピン・リミテッド | スルホキシド化合物の光学的に純粋な又は光学的に富化されたエナンチオマーの調製方法 |
RU2467747C2 (ru) | 2006-07-25 | 2012-11-27 | Векта Лтд. | Композиции и способы для ингибирования секреции желудочной кислоты с использованием производных малых дикарбоновых кислот в сочетании с ppi |
WO2008036201A1 (en) * | 2006-09-19 | 2008-03-27 | Alevium Pharmaceuticals, Inc. | Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety |
CA2665226C (en) | 2006-10-05 | 2014-05-13 | Santarus, Inc. | Novel formulations of proton pump inhibitors and methods of using these formulations |
US20090092658A1 (en) * | 2007-10-05 | 2009-04-09 | Santarus, Inc. | Novel formulations of proton pump inhibitors and methods of using these formulations |
MX2009004475A (es) | 2006-10-27 | 2009-08-12 | Univ Missouri | Composiciones que comprenden agentes acido labiles que inhiben la bomba de protones, por lo menos otro agente farmaceuticamente activo y metodos de uso de las misma. |
WO2008064015A1 (en) * | 2006-11-13 | 2008-05-29 | Takeda Pharmaceuticals North America | Methods for preserving renal function using xanthine oxidoreductase inhibitors |
US20090124623A1 (en) * | 2006-11-13 | 2009-05-14 | Christopher Lademacher | Methods for preserving and/or increasing renal function using xanthine oxidoreductase inhibitors |
EP1947099A1 (en) | 2007-01-18 | 2008-07-23 | LEK Pharmaceuticals D.D. | Process for solvent removal from omeprazole salts |
RU2009131454A (ru) * | 2007-01-19 | 2011-02-27 | Такеда Фармасьютикалз Норт Америка, Инк. (Us) | Способы предупреждения или уменьшения числа обострений подагры с применением ингибиторов ксантиноксидоредуктазы и противовоспалительных средств |
EA200900985A1 (ru) * | 2007-01-31 | 2009-12-30 | Крка, Товарна Здравил, Д. Д., Ново Место | Способ получения оптически чистого омепразола |
US20080194307A1 (en) * | 2007-02-13 | 2008-08-14 | Jeff Sanger | Sports-based game of chance |
CA2678702A1 (en) | 2007-02-21 | 2008-08-28 | Cipla Limited | Process for the preparation of esomeprazole magnesium dihydrate |
KR101303813B1 (ko) * | 2007-04-16 | 2013-09-04 | 에스케이케미칼주식회사 | 라세믹 오메프라졸로부터 에스오메프라졸의 개선된제조방법 |
EP2000468A1 (en) * | 2007-05-09 | 2008-12-10 | Dr. Reddy's Laboratories Ltd. | Esomeprazole salts and processes for preparation thereof |
US8492551B2 (en) * | 2007-06-07 | 2013-07-23 | Aurobindo Pharma. Ltd. | Process for preparing an optically active proton pump inhibitor |
CN101323609B (zh) * | 2007-06-15 | 2013-05-01 | 成都福瑞生物工程有限公司 | 不对称氧化硫醚成亚砜合成对映体含量高的苯并咪唑衍生物的方法 |
ATE533758T1 (de) | 2007-09-25 | 2011-12-15 | Hetero Drugs Ltd | Verfahren zur herstellung von enantiomerenreinem esomeprazol |
WO2009047775A2 (en) * | 2007-10-08 | 2009-04-16 | Hetero Drugs Limited | Polymorphs of esomeprazole salts |
FR2925899B1 (fr) * | 2007-12-27 | 2012-12-21 | Sidem Pharma Sa | Procede de preparation enantioselective de sulfoxydes. |
CA2716367C (en) | 2008-02-20 | 2015-05-26 | The Curators Of The University Of Missouri | Composition comprising a combination of omeprazole and lansoprazole, and a buffering agent, and methods of using same |
WO2009137648A1 (en) * | 2008-05-09 | 2009-11-12 | Aptapharma, Inc. | Multilayer proton pump inhibitor tablets |
US20090280173A1 (en) * | 2008-05-09 | 2009-11-12 | Ishwar Chauhan | Multilayer Omeprazole Tablets |
WO2009145368A1 (en) * | 2008-05-27 | 2009-12-03 | Sk Chemicals Co., Ltd. | Improved preparing method of (s)-omeprazole from omeprazole racemate using optical resolution agent |
EP2143722A1 (en) * | 2008-07-09 | 2010-01-13 | Lek Pharmaceuticals D.D. | Process for preparation of esomeprazole sodium of high chemical purity and new forms of esomeprazole sodium |
EP2147918A1 (en) | 2008-07-21 | 2010-01-27 | LEK Pharmaceuticals D.D. | Process for the preparation of S-omeprazole magnesium in a stable form |
AU2009290712A1 (en) | 2008-09-09 | 2010-03-18 | Astrazeneca Ab | Method for delivering a pharmaceutical composition to patient in need thereof |
EP2264024A1 (en) | 2008-10-14 | 2010-12-22 | LEK Pharmaceuticals d.d. | Process for the preparation of enantiomerically enriched proton pump inhibitors |
WO2010058409A2 (en) | 2008-11-18 | 2010-05-27 | Hetero Research Foundation | Optical purification of esomeprazole |
US20100311756A1 (en) * | 2009-01-22 | 2010-12-09 | Takeda Pharmaceuticals North America, Inc. | Methods for delaying the progression of at least one of cardiac hypertrophy, cardiac remodeling or left ventricular function or the onset of heart failure in subjects in need of treatment thereof |
WO2010097583A1 (en) | 2009-02-24 | 2010-09-02 | Cipla Limited | Esomeprazole potassium polymorph and its preparation |
SG176724A1 (en) | 2009-06-25 | 2012-01-30 | Astrazeneca Ab | Method for treating a patient at risk for developing an nsaid-associated ulcer |
KR20120093140A (ko) * | 2009-06-25 | 2012-08-22 | 포젠 인크. | 아스피린 치료를 필요로 하는 환자의 치료 방법 |
EP2319504A1 (en) | 2009-11-07 | 2011-05-11 | Laboratorios Del. Dr. Esteve, S.A. | Pharmaceutical solid dosage form |
US8748619B2 (en) | 2009-11-12 | 2014-06-10 | Hetero Research Foundation | Process for the resolution of omeprazole |
US20120294937A1 (en) | 2009-12-29 | 2012-11-22 | Novartis Ag | New pharmaceutical dosage form for the treatment of gastric acid-related disorders |
WO2011080502A2 (en) | 2009-12-29 | 2011-07-07 | Orexo Ab | New pharmaceutical dosage form for the treatment of gastric acid-related disorders |
WO2011080500A2 (en) | 2009-12-29 | 2011-07-07 | Orexo Ab | New pharmaceutical dosage form for the treatment of gastric acid-related disorders |
EP2345408A3 (en) | 2010-01-08 | 2012-02-29 | Dr. Reddy's Laboratories Ltd. | Acid labile drug formulations |
CA2789298A1 (en) | 2010-02-12 | 2011-08-18 | Esteve Quimica, S.A. | Preparation process of the sodium salt of esomeprazole |
US20110207779A1 (en) * | 2010-02-25 | 2011-08-25 | Glenmark Generics Ltd | Process for the preparation of esomeprazole magnesium |
ES2532210T3 (es) | 2010-09-10 | 2015-03-25 | Takeda Pharmaceuticals U.S.A., Inc. | Métodos para el tratamiento concomitante de teofilina y febuxostat |
CN102816149B (zh) * | 2011-06-10 | 2015-05-13 | 上海汇伦生命科技有限公司 | 一种高对映选择性合成(s)-奥美拉唑及其盐的制备方法 |
CN102807561A (zh) * | 2011-06-21 | 2012-12-05 | 寿光富康制药有限公司 | S-奥美拉唑铝盐及其制备方法和应用 |
CN102850323A (zh) * | 2011-06-30 | 2013-01-02 | 秦引林 | 一种埃索美拉唑钠的精制方法 |
CN102321071B (zh) * | 2011-07-20 | 2013-01-23 | 江苏奥赛康药业股份有限公司 | 一种高纯度埃索美拉唑钠的工业化生产方法 |
CN102911158B (zh) * | 2011-07-31 | 2015-07-22 | 连云港润众制药有限公司 | 埃索美拉唑镁的晶型 |
WO2013081566A1 (en) | 2011-11-25 | 2013-06-06 | Mahmut Bilgic | A formulation comprising benzimidazole |
EP2601947A1 (en) | 2011-12-05 | 2013-06-12 | Abo Bakr Mohammed Ali Al-Mehdar | Fixed-dose combination for treatment of helicobacter pylori associated diseases |
MX2014007239A (es) | 2011-12-16 | 2014-08-08 | Atopix Therapeutics Ltd | Combinacion de un antagonista crth2 y un inhibidor de bomba de proton para el tratamiento de esofagitis eosinofilica. |
EA028049B1 (ru) | 2011-12-28 | 2017-10-31 | Поузен Инк. | Улучшенные композиции и способы доставки омепразола и ацетилсалициловой кислоты |
WO2013108068A1 (en) | 2012-01-21 | 2013-07-25 | Jubilant Life Sciences Limited | Process for the preparation of 2-pyridinylmethylsulfinyl benzimidazoles, their analogs and optically active enantiomers |
CN103420978A (zh) * | 2012-05-15 | 2013-12-04 | 上海医药工业研究院 | 一种苯并咪唑类化合物的镁盐的制备方法 |
CN102657622A (zh) * | 2012-05-17 | 2012-09-12 | 康普药业股份有限公司 | 一种含有埃索美拉唑钠的冻干粉针剂的制备工艺 |
CN102964335B (zh) * | 2012-11-13 | 2014-06-25 | 凌元敏 | 一种埃索美拉唑钠化合物及其制备方法和用途 |
CN103159737B (zh) * | 2013-04-12 | 2014-03-19 | 四川省惠达药业有限公司 | 一种埃索美拉唑钠化合物及药物组合物 |
US20160256399A1 (en) | 2013-11-04 | 2016-09-08 | Capsugel Belgium Nv | Methods and systems for improved bioavailability of active pharmaceutical ingredients including esomeprazole |
EP2929885A1 (en) | 2014-04-11 | 2015-10-14 | Sanovel Ilac Sanayi ve Ticaret A.S. | Pharmaceutical combinations of rivaroxaban and proton pump inhibitors |
WO2015155281A1 (en) | 2014-04-11 | 2015-10-15 | Sanovel Ilac Sanayi Ve Ticaret A.S. | Pharmaceutical combinations of dabigatran and proton pump inhibitors |
CN104045627A (zh) * | 2014-05-21 | 2014-09-17 | 丽珠医药集团股份有限公司 | 一种奥美拉唑纯化方法 |
CN104530003A (zh) * | 2014-06-10 | 2015-04-22 | 广东东阳光药业有限公司 | 吡啶甲基亚磺酰基-1h-苯并咪唑类化合物的盐的制备方法 |
EP2980086B1 (en) | 2014-07-29 | 2016-06-15 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Efficient process for the preparation of esomeprazole (S)-binol complex |
JP6548336B2 (ja) | 2014-12-26 | 2019-07-24 | 国立大学法人 東京大学 | 光学活性のプロトンポンプ阻害化合物の製造方法 |
ES2615637T3 (es) | 2015-03-06 | 2017-06-07 | F.I.S.- Fabbrica Italiana Sintetici S.P.A. | Procedimiento mejorado para la purificación óptica del esomeprazol |
US10736855B2 (en) | 2016-02-25 | 2020-08-11 | Dexcel Pharma Technologies Ltd. | Compositions comprising proton pump inhibitors |
CN105924430A (zh) * | 2016-06-27 | 2016-09-07 | 杭州富阳伟文环保科技有限公司 | 一种埃索美拉唑钠的精制方法 |
WO2018191210A1 (en) * | 2017-04-11 | 2018-10-18 | Mclaughlin Gormley King Company | Sabadilla oil and uses thereof |
CN108409714A (zh) * | 2018-03-29 | 2018-08-17 | 成都通德药业有限公司 | 埃索美拉唑、埃索美拉唑盐及埃索美拉唑镁的制备方法 |
EP3999033A4 (en) * | 2019-07-16 | 2023-08-09 | Elanco US Inc. | ESOMEPRAZOLE FORMULATIONS FOR HORSES AND METHODS OF USE |
US20220306593A1 (en) | 2019-08-29 | 2022-09-29 | Tokyo University Of Science Foundation | Method for preparing enantiomer of sulfoxide compound, and system for preparing enantiomer |
RU2726320C1 (ru) * | 2020-02-09 | 2020-07-13 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Кемеровский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО КемГМУ) | Способ определения примесных компонентов омепразола |
WO2024075017A1 (en) | 2022-10-04 | 2024-04-11 | Zabirnyk Arsenii | Inhibition of aortic valve calcification |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE7804231L (sv) * | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
US4636085A (en) * | 1982-03-16 | 1987-01-13 | Mapro Inc. | Apparatus for removing volatiles from plastic materials delivered to an extrusion or injection molding machine |
SE8204879D0 (sv) * | 1982-08-26 | 1982-08-26 | Haessle Ab | Novel chemical intermediates |
SE8301182D0 (sv) * | 1983-03-04 | 1983-03-04 | Haessle Ab | Novel compounds |
US4445708A (en) * | 1983-05-09 | 1984-05-01 | General Motors Corporation | Energy absorbing steering column for vehicles |
SE8403179D0 (sv) * | 1984-06-13 | 1984-06-13 | Haessle Ab | New compounds |
IL75400A (en) * | 1984-06-16 | 1988-10-31 | Byk Gulden Lomberg Chem Fab | Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same |
CA1327010C (en) * | 1986-02-13 | 1994-02-15 | Tadashi Makino | Stabilized solid pharmaceutical composition containing antiulcer benzimidazole compound and its production |
GB2189698A (en) * | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated omeprazole tablets |
GB2189699A (en) * | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated acid-labile medicaments |
US5075323A (en) * | 1988-08-24 | 1991-12-24 | Aktiebolaget Hassle | Compounds including omeprazole in the treatment of glaucoma |
DE4035455A1 (de) * | 1990-11-08 | 1992-05-14 | Byk Gulden Lomberg Chem Fab | Enantiomerentrennung |
US5232706A (en) * | 1990-12-31 | 1993-08-03 | Esteve Quimica, S.A. | Oral pharmaceutical preparation containing omeprazol |
AU6713194A (en) * | 1993-04-27 | 1994-11-21 | Sepracor, Inc. | Methods and compositions for treating gastric disorders using optically pure (-) pantoprazole |
SE9301830D0 (sv) * | 1993-05-28 | 1993-05-28 | Ab Astra | New compounds |
US6875872B1 (en) * | 1993-05-28 | 2005-04-05 | Astrazeneca | Compounds |
US5877192A (en) * | 1993-05-28 | 1999-03-02 | Astra Aktiebolag | Method for the treatment of gastric acid-related diseases and production of medication using (-) enantiomer of omeprazole |
SE9302396D0 (sv) * | 1993-07-09 | 1993-07-09 | Ab Astra | A novel compound form |
SE9302395D0 (sv) * | 1993-07-09 | 1993-07-09 | Ab Astra | New pharmaceutical formulation |
HUT75775A (en) * | 1994-07-08 | 1997-05-28 | Astra Ab | Medicament with multiple unit tablated dosage form containing omeprazole |
SE504459C2 (sv) * | 1994-07-15 | 1997-02-17 | Astra Ab | Förfarande för framställning av substituerade sulfoxider |
SE508669C2 (sv) * | 1996-04-26 | 1998-10-26 | Astra Ab | Nytt förfarande |
SE510650C2 (sv) * | 1997-05-30 | 1999-06-14 | Astra Ab | Ny förening |
SE9704183D0 (sv) * | 1997-11-14 | 1997-11-14 | Astra Ab | New process |
SE9900274D0 (sv) * | 1999-01-28 | 1999-01-28 | Astra Ab | New compound |
-
1993
- 1993-05-28 SE SE19939301830A patent/SE9301830D0/xx unknown
-
1994
- 1994-05-06 IS IS4161A patent/IS1854B/is unknown
- 1994-05-11 TW TW083104255A patent/TW389761B/zh not_active IP Right Cessation
- 1994-05-17 HR HR940307A patent/HRP940307B1/xx active IP Right Review Request
- 1994-05-18 LT LTIP1941A patent/LT3287B/lt not_active IP Right Cessation
- 1994-05-19 IL IL10968494A patent/IL109684A/en unknown
- 1994-05-23 ZA ZA943557A patent/ZA943557B/xx unknown
- 1994-05-25 DZ DZ940055A patent/DZ1785A1/fr active
- 1994-05-26 MA MA23521A patent/MA23210A1/fr unknown
- 1994-05-27 PT PT94917244T patent/PT652872E/pt unknown
- 1994-05-27 UA UA95018075A patent/UA60289C2/uk unknown
- 1994-05-27 CA CA002139653A patent/CA2139653C/en not_active Expired - Lifetime
- 1994-05-27 MY MYPI94001349A patent/MY121192A/en unknown
- 1994-05-27 SK SK101-95A patent/SK282524B6/sk not_active IP Right Cessation
- 1994-05-27 SG SG1996008770A patent/SG49283A1/en unknown
- 1994-05-27 CA CA002337581A patent/CA2337581A1/en not_active Abandoned
- 1994-05-27 ES ES94917244T patent/ES2099047T3/es not_active Expired - Lifetime
- 1994-05-27 PL PL94307261A patent/PL178994B1/pl unknown
- 1994-05-27 DK DK00108479T patent/DK1020460T3/da active
- 1994-05-27 NZ NZ266915A patent/NZ266915A/en not_active IP Right Cessation
- 1994-05-27 KR KR1019950700365A patent/KR100337274B1/ko not_active IP Right Cessation
- 1994-05-27 US US08/256,174 patent/US5693818A/en not_active Expired - Lifetime
- 1994-05-27 JP JP50055395A patent/JP3549111B2/ja not_active Expired - Lifetime
- 1994-05-27 PT PT00108480T patent/PT1020461E/pt unknown
- 1994-05-27 PT PT00108479T patent/PT1020460E/pt unknown
- 1994-05-27 EP EP00108479A patent/EP1020460B1/en not_active Expired - Lifetime
- 1994-05-27 ES ES00108480.5T patent/ES2326405T5/es not_active Expired - Lifetime
- 1994-05-27 SI SI9420085A patent/SI22752B/sl active Search and Examination
- 1994-05-27 HU HU9500247A patent/HU226824B1/hu active Protection Beyond IP Right Term
- 1994-05-27 EP EP94917244A patent/EP0652872B1/en not_active Revoked
- 1994-05-27 YU YU31494A patent/YU49065B/sh unknown
- 1994-05-27 CN CN94190335A patent/CN1055469C/zh not_active Expired - Lifetime
- 1994-05-27 CZ CZ1995202A patent/CZ287876B6/cs not_active IP Right Cessation
- 1994-05-27 WO PCT/SE1994/000509 patent/WO1994027988A1/en active IP Right Grant
- 1994-05-27 SI SI9420002A patent/SI9420002B/sl active Search and Examination
- 1994-05-27 ES ES00108479T patent/ES2326404T3/es not_active Expired - Lifetime
- 1994-05-27 TN TNTNSN94058A patent/TNSN94058A1/fr unknown
- 1994-05-27 DK DK94917244T patent/DK0652872T3/da active
- 1994-05-27 DE DE69435221T patent/DE69435221D1/de not_active Expired - Lifetime
- 1994-05-27 AT AT94917244T patent/ATE197452T1/de not_active IP Right Cessation
- 1994-05-27 DK DK00108480.5T patent/DK1020461T4/en active
- 1994-05-27 DE DE69435220T patent/DE69435220D1/de not_active Expired - Lifetime
- 1994-05-27 DE DE69426254T patent/DE69426254T2/de not_active Revoked
- 1994-05-27 EP EP00108480.5A patent/EP1020461B2/en not_active Expired - Lifetime
- 1994-05-27 RU RU95105587A patent/RU2137766C1/ru active
- 1994-05-27 DE DE0652872T patent/DE652872T1/de active Pending
- 1994-06-04 SA SA05260103A patent/SA05260103B1/ar unknown
- 1994-06-04 SA SA94140756A patent/SA94140756B1/ar unknown
- 1994-11-17 EE EE9400363A patent/EE03157B1/xx not_active IP Right Cessation
- 1994-12-30 LV LVP-94-266A patent/LV11034B/en unknown
-
1995
- 1995-01-23 US US08/376,512 patent/US5714504A/en not_active Expired - Lifetime
- 1995-01-24 NO NO950263A patent/NO307378B1/no not_active IP Right Cessation
- 1995-01-27 FI FI950377A patent/FI117755B/fi active Protection Beyond IP Right Term
-
1997
- 1997-05-30 GR GR970300012T patent/GR970300012T1/el unknown
-
1998
- 1998-07-17 HK HK98109228A patent/HK1008330A1/xx not_active IP Right Cessation
-
1999
- 1999-09-03 CN CN99118539A patent/CN1107503C/zh not_active Expired - Lifetime
- 1999-10-15 US US09/419,456 patent/US6143771A/en not_active Expired - Lifetime
-
2000
- 2000-11-23 HK HK00107518.8A patent/HK1028044A1/xx not_active IP Right Cessation
- 2000-11-23 HK HK00107520.4A patent/HK1028045A1/xx not_active IP Right Cessation
-
2001
- 2001-02-05 GR GR20010400191T patent/GR3035365T3/el not_active IP Right Cessation
- 2001-05-22 CY CY0100010A patent/CY2224B1/xx unknown
-
2003
- 2003-09-10 JP JP2003317637A patent/JP3959056B2/ja not_active Expired - Lifetime
- 2003-09-10 JP JP2003317639A patent/JP4039999B2/ja not_active Expired - Lifetime
-
2007
- 2007-01-02 FI FI20070002A patent/FI20070002A/fi not_active Application Discontinuation
- 2007-02-27 US US11/679,264 patent/US20080312449A1/en not_active Abandoned
-
2009
- 2009-04-02 CL CL2009000805A patent/CL2009000805A1/es unknown
- 2009-09-01 US US12/551,828 patent/US20100222591A1/en not_active Abandoned
-
2011
- 2011-06-07 NO NO2011009C patent/NO2011009I1/no unknown
- 2011-09-19 LU LU91870C patent/LU91870I2/fr unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SK282524B6 (sk) | Opticky čisté soli (-)-enantioméru pyridylmetylsulfinyl-1H- benzimidazolových zlúčenín, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom, ich použitie a medziprodukty na ich prípravu | |
US6875872B1 (en) | Compounds | |
WO1995032959A1 (en) | Novel dialkoxy-pyridinyl-benzimidazole derivatives | |
AU676337C (en) | Optically pure salts of pyridinylmethyl sulfinyl-IH- benzimidazole compounds | |
EP0712400A1 (en) | Novel substituted benzimidazoles | |
HUT61995A (en) | Process for producing fluorine-substituted benzimidazole derivatives and pharmaceutical compositions comprising same | |
SK5896A3 (en) | Substituted benzimideazoles |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
SPCF | Filing of an spc |
Free format text: PRODUCT NAME: NAPROXEN A EZOMEPRAZOL; NAT. REGISTRATION NO/DATE: 29/0782/10-S 20101112; FIRST REGISTRATION: GB PL 17901/0263 - 0001 20101105 Spc suppl protection certif: 4-2011 Filing date: 20110510 |
|
SPCR | Rejection of an spc |
Free format text: PRODUCT NAME: NAPROXEN A EZOMEPRAZOL; NAT. REGISTRATION NO/DATE: 29/0782/10-S 20101112; FIRST REGISTRATION; GB PL 17901/0263 20101105 Spc suppl protection certif: 4-2011 Filing date: 20110510 |
|
MG4A | Partial revocation of patent |
Effective date: 20121212 |
|
MK4A | Patent expired |
Expiry date: 20140527 |