ATE533758T1 - Verfahren zur herstellung von enantiomerenreinem esomeprazol - Google Patents
Verfahren zur herstellung von enantiomerenreinem esomeprazolInfo
- Publication number
- ATE533758T1 ATE533758T1 AT07827582T AT07827582T ATE533758T1 AT E533758 T1 ATE533758 T1 AT E533758T1 AT 07827582 T AT07827582 T AT 07827582T AT 07827582 T AT07827582 T AT 07827582T AT E533758 T1 ATE533758 T1 AT E533758T1
- Authority
- AT
- Austria
- Prior art keywords
- methoxy
- esomeprazole
- pure esomeprazole
- camphorsulfonyl
- sulfinyl
- Prior art date
Links
- 229960004770 esomeprazole Drugs 0.000 title abstract 4
- SUBDBMMJDZJVOS-DEOSSOPVSA-N esomeprazole Chemical compound C([S@](=O)C1=NC2=CC=C(C=C2N1)OC)C1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-DEOSSOPVSA-N 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- -1 3,5-dimethyl-4-methoxy-2-pyridyl Chemical group 0.000 abstract 3
- 230000007935 neutral effect Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- RQPZNWPYLFFXCP-UHFFFAOYSA-L barium dihydroxide Chemical compound [OH-].[OH-].[Ba+2] RQPZNWPYLFFXCP-UHFFFAOYSA-L 0.000 abstract 1
- 229910001863 barium hydroxide Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000006386 neutralization reaction Methods 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IN2007/000433 WO2009040825A1 (en) | 2007-09-25 | 2007-09-25 | A process for preparation of enantiomerically pure esomeprazole |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE533758T1 true ATE533758T1 (de) | 2011-12-15 |
Family
ID=40510780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07827582T ATE533758T1 (de) | 2007-09-25 | 2007-09-25 | Verfahren zur herstellung von enantiomerenreinem esomeprazol |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7947840B2 (de) |
| EP (1) | EP2106397B1 (de) |
| AT (1) | ATE533758T1 (de) |
| DK (1) | DK2106397T3 (de) |
| ES (1) | ES2375515T3 (de) |
| PT (1) | PT2106397E (de) |
| WO (1) | WO2009040825A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2534144B1 (de) | 2010-02-12 | 2014-09-03 | Esteve Química, S.A. | Herstellungsverfahren des Natriumsalz von Esomeprazol |
| CN102285970B (zh) * | 2011-09-21 | 2014-07-23 | 石药集团欧意药业有限公司 | 一种埃索美拉唑化合物、制备方法及其药物组合物 |
| WO2024075017A1 (en) | 2022-10-04 | 2024-04-11 | Zabirnyk Arsenii | Inhibition of aortic valve calcification |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4035455A1 (de) * | 1990-11-08 | 1992-05-14 | Byk Gulden Lomberg Chem Fab | Enantiomerentrennung |
| SE9301830D0 (sv) | 1993-05-28 | 1993-05-28 | Ab Astra | New compounds |
| GB2376231A (en) | 2001-06-06 | 2002-12-11 | Cipla Ltd | Benzimidazole-cyclodextrin inclusion complex |
| EP1515963B1 (de) | 2002-06-27 | 2007-02-14 | Dr. Reddy's Laboratories Ltd. | Verfahren zur herstellung optisch reiner oder optisch angereicherter sulfoxidverbindungen einschliesslich amorphen esomeprazols und dessen salze |
| US20070060556A1 (en) | 2003-05-05 | 2007-03-15 | Yatendra Kumar | Barium salt of benzimidazole derivative |
| ATE437869T1 (de) * | 2004-04-28 | 2009-08-15 | Hetero Drugs Ltd | Verfahren zur herstellung von pyridinylmethyl-1h- benzimidazolverbindungen in enantiomerenangereicherter form oder als einzelne enantiomere |
| ATE443051T1 (de) * | 2004-10-11 | 2009-10-15 | Ranbaxy Lab Ltd | Verfahren zur herstellung substituierter sulfoxide |
| RU2007145207A (ru) | 2005-05-06 | 2009-06-20 | Гленмарк Фармасьютикалз Лимитед (In) | Стронциваемая соль эзомепразола, способ ее получения и содержащее ее фармацевтические композиции |
| KR100641534B1 (ko) * | 2005-07-28 | 2006-11-01 | 한미약품 주식회사 | 에스오메프라졸 및 그의 염의 제조방법 |
-
2007
- 2007-09-25 US US12/279,354 patent/US7947840B2/en not_active Expired - Fee Related
- 2007-09-25 EP EP07827582A patent/EP2106397B1/de not_active Not-in-force
- 2007-09-25 ES ES07827582T patent/ES2375515T3/es active Active
- 2007-09-25 DK DK07827582.3T patent/DK2106397T3/da active
- 2007-09-25 WO PCT/IN2007/000433 patent/WO2009040825A1/en not_active Ceased
- 2007-09-25 PT PT07827582T patent/PT2106397E/pt unknown
- 2007-09-25 AT AT07827582T patent/ATE533758T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| DK2106397T3 (da) | 2012-01-30 |
| EP2106397A4 (de) | 2010-04-07 |
| US20100174087A1 (en) | 2010-07-08 |
| WO2009040825A1 (en) | 2009-04-02 |
| EP2106397B1 (de) | 2011-11-16 |
| ES2375515T3 (es) | 2012-03-01 |
| US7947840B2 (en) | 2011-05-24 |
| PT2106397E (pt) | 2012-01-23 |
| EP2106397A1 (de) | 2009-10-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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