SI2536706T1 - Derivati arilmetoksi izoindolina in sestavki,ki jih vsebujejo ter metode uporabe le-teh - Google Patents

Derivati arilmetoksi izoindolina in sestavki,ki jih vsebujejo ter metode uporabe le-teh

Info

Publication number
SI2536706T1
SI2536706T1 SI201131241T SI201131241T SI2536706T1 SI 2536706 T1 SI2536706 T1 SI 2536706T1 SI 201131241 T SI201131241 T SI 201131241T SI 201131241 T SI201131241 T SI 201131241T SI 2536706 T1 SI2536706 T1 SI 2536706T1
Authority
SI
Slovenia
Prior art keywords
compositions
methods
same
isoindoline derivatives
arylmethoxy isoindoline
Prior art date
Application number
SI201131241T
Other languages
English (en)
Slovenian (sl)
Inventor
Hon-Wah Man
George W. Muller
Alexander Ruchelman
Ehab M. Khalil
Roger Shen-Chu Chen
Weihong Zhang
Original Assignee
Celgene Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corporation filed Critical Celgene Corporation
Publication of SI2536706T1 publication Critical patent/SI2536706T1/sl

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
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    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
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  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Anesthesiology (AREA)
  • AIDS & HIV (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
SI201131241T 2010-02-11 2011-02-10 Derivati arilmetoksi izoindolina in sestavki,ki jih vsebujejo ter metode uporabe le-teh SI2536706T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30361810P 2010-02-11 2010-02-11
PCT/US2011/024269 WO2011100380A1 (en) 2010-02-11 2011-02-10 Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same
EP11704156.6A EP2536706B1 (en) 2010-02-11 2011-02-10 Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same

Publications (1)

Publication Number Publication Date
SI2536706T1 true SI2536706T1 (sl) 2017-10-30

Family

ID=43708752

Family Applications (3)

Application Number Title Priority Date Filing Date
SI201131241T SI2536706T1 (sl) 2010-02-11 2011-02-10 Derivati arilmetoksi izoindolina in sestavki,ki jih vsebujejo ter metode uporabe le-teh
SI201131680T SI3202461T1 (sl) 2010-02-11 2011-02-10 Derivati arilmetoksi izoindolina in sestavki, ki jih vsebujejo in metode uporabe le teh
SI201131754T SI3202460T1 (sl) 2010-02-11 2011-02-10 Arilmetoksi izoindolin derivati in sestavki, ki jih obsegajo in metode za uporabo le-teh

Family Applications After (2)

Application Number Title Priority Date Filing Date
SI201131680T SI3202461T1 (sl) 2010-02-11 2011-02-10 Derivati arilmetoksi izoindolina in sestavki, ki jih vsebujejo in metode uporabe le teh
SI201131754T SI3202460T1 (sl) 2010-02-11 2011-02-10 Arilmetoksi izoindolin derivati in sestavki, ki jih obsegajo in metode za uporabo le-teh

Country Status (33)

Country Link
US (8) US8518972B2 (enExample)
EP (6) EP2536706B1 (enExample)
JP (5) JP2013519675A (enExample)
KR (2) KR101812356B1 (enExample)
CN (2) CN104693193B (enExample)
AR (1) AR081058A1 (enExample)
AU (1) AU2011215877C1 (enExample)
CA (1) CA2787823C (enExample)
CO (1) CO6571916A2 (enExample)
CR (1) CR20120414A (enExample)
CY (3) CY1119177T1 (enExample)
DK (3) DK3202461T3 (enExample)
EC (1) ECSP12012098A (enExample)
ES (5) ES2730763T3 (enExample)
HR (3) HRP20171078T1 (enExample)
HU (3) HUE042011T2 (enExample)
IL (2) IL220992A (enExample)
LT (3) LT3202461T (enExample)
ME (2) ME02766B (enExample)
MX (3) MX2012009237A (enExample)
NI (1) NI201200132A (enExample)
NZ (3) NZ601289A (enExample)
PH (2) PH12012501607A1 (enExample)
PL (3) PL2536706T3 (enExample)
PT (3) PT3202460T (enExample)
RS (3) RS56232B1 (enExample)
RU (1) RU2567753C2 (enExample)
SG (3) SG183257A1 (enExample)
SI (3) SI2536706T1 (enExample)
SM (3) SMT201900420T1 (enExample)
TR (1) TR201903027T4 (enExample)
UA (2) UA114856C2 (enExample)
WO (1) WO2011100380A1 (enExample)

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EP2436387B1 (en) 2009-05-25 2018-07-25 Celgene Corporation Pharmaceutical composition comprising crbn for use in treating a disease of the cerebral cortex
SG183257A1 (en) * 2010-02-11 2012-09-27 Celgene Corp Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same
AU2012236655B2 (en) * 2011-03-28 2016-09-22 Deuterx, Llc, 2',6'-dioxo-3'-deutero-piperdin-3-yl-isoindoline compounds
CN103688176A (zh) 2011-04-29 2014-03-26 细胞基因公司 利用cereblon作为预报因子治疗癌和炎性疾病的方法
WO2014004990A2 (en) 2012-06-29 2014-01-03 Celgene Corporation Methods for determining drug efficacy using cereblon-associated proteins
PL2882442T3 (pl) * 2012-08-09 2021-12-13 Celgene Corporation Sposoby leczenia nowotworów z wykorzystaniem 3-(4-((4-(morfolinometylo)benzylo)oksy)-1-oksoizoindolin-2-ylo)piperydyno-2,6-dionu
US20150038511A1 (en) * 2012-08-09 2015-02-05 Celgene Corporation Treatment of immune-related and inflammatory diseases
KR20210073616A (ko) * 2012-08-09 2021-06-18 셀진 코포레이션 면역-관련 및 염증성 질환의 치료
PE20150617A1 (es) * 2012-08-09 2015-05-21 Celgene Corp Formas solidas de 3-(4-((4-(morfolinometil)bencil)oxi)-1-oxoisoindolin-2-il)piperidin-2,6-diona o un estereoisomero del mismo, de sus sales, y composiciones que comprenden las mismas
CA2879151C (en) * 2012-08-09 2021-03-30 Celgene Corporation Processes for the preparation of (s)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and pharmaceutically acceptable forms thereof
US20140343058A1 (en) * 2012-08-09 2014-11-20 Celgene Corporation Treatment of systemic lupus erythematosus
US9587281B2 (en) 2012-08-14 2017-03-07 Celgene Corporation Cereblon isoforms and their use as biomarkers for therapeutic treatment
US9694015B2 (en) * 2012-09-10 2017-07-04 Celgene Corporation Methods for the treatment of locally advanced breast cancer
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