HRP20171078T1 - Derivati arilmetoksi izoindolina i pripravci koji ih sadrže, te postupci njihove uporabe - Google Patents

Derivati arilmetoksi izoindolina i pripravci koji ih sadrže, te postupci njihove uporabe Download PDF

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HRP20171078T1
HRP20171078T1 HRP20171078TT HRP20171078T HRP20171078T1 HR P20171078 T1 HRP20171078 T1 HR P20171078T1 HR P20171078T T HRP20171078T T HR P20171078TT HR P20171078 T HRP20171078 T HR P20171078T HR P20171078 T1 HRP20171078 T1 HR P20171078T1
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image
alkyl
optionally substituted
halogens
heteroaryl
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HRP20171078TT
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Hon-Wah Man
George W. Muller
Alexander Ruchelman
Ehab M. Khalil
Roger Shen-Chu Chen
Weihong Zhang
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Celgene Corporation
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Publication of HRP20171078T1 publication Critical patent/HRP20171078T1/hr

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Claims (6)

1. Spoj s formulom (I): [image] ili njegova farmaceutski prihvatljiva sol, solvat ili stereoizomer, naznačen time da: X je C=O ili CH2; R1 je -Y-R3; R2 je H ili (C1-C6)alkil; Y je: 6 do 10 člani aril, heteroaril ili heterocikal, svaki od kojih može biti proizvoljno supstituiran s jednim ili više halogena; R3 je: -(CH2)n-aril, -O-(CH2)n-aril ili -(CH2)n-O-aril, pri čemu je aril proizvoljno supstituiran s jednim ili više: (C1-C6)alkilom, koji je sam proizvoljno supstituiran s jednim ili više halogena; (C1-C6)alkoksi, koji je sam supstituiran s jednim ili više halogena; okso; amino; karboksilom; cijano; hidroksilom; halogenom; deuterijem; 6 do 10 članim arilom ili heteroarilom, proizvoljno supstituiranim s jednim ili više (C1-C6)alkilom, (C1-C6)alkoksi ili halogenom; -CONH2; ili -COO-(C1-C6)alkil, pri čemu alkil može biti proizvoljno supstituiran s jednim ili više halogena; -(CH2)n-heterocikal, -O-(CH2)n-heterocikal ili -(CH2)n-O-heterocikal, pri čemu je heterocikal proizvoljno supstituiran s jednim ili više: (C1-C6)alkilom, koji je sam proizvoljno supstituiran s jednim ili više halogena; (C1-C6)alkoksi, koji je sam supstituiran s jednim ili više halogena; okso; amino; karboksilom; cijano; hidroksilom; halogenom; deuterijem; 6 do 10 članim arilom ili heteroarilom, proizvoljno supstituiranim s jednim ili više (C1-C6)alkilom, (C1-C6)alkoksi ili halogenom; -CONH2; ili -COO-(C1-C6)alkil, pri čemu alkil može biti proizvoljno supstituiran s jednim ili više halogena; ili -(CH2)n-heteroaril, -O-(CH2)n-heteroaril ili -(CH2)n-O-heteroaril, pri čemu je heteroaril proizvoljno supstituiran s jednim ili više: (C1-C6)alkilom, koji je sam proizvoljno supstituiran s jednim ili više halogena; (C1-C6)alkoksi, koji je sam supstituiran s jednim ili više halogena; okso; amino; karboksilom; cijano; hidroksilom; halogenom; deuterijem; 6 do 10 članim arilom ili heteroarilom, proizvoljno supstituiranim s jednim ili više (C1-C6)alkilom, (C1-C6)alkoksi ili halogenom; -CONH2; ili -COO-(C1-C6)alkil, pri čemu alkil može biti proizvoljno supstituiran s jednim ili više halogena; i n je 0, 1, 2 ili 3; pri čemu izraz (C1-C6)alkil obuhvaća (C3-6)cikloalkil.
2. Spoj prema zahtjevu 1, naznačen time da X je CH2.
3. Spoj prema zahtjevu 1, pri čemu Y je fenil, i R3 je -(CH2)n-heterocikal; ili pri čemu Y je heteroaril, i R3 je -(CH2)n-heterocikal.
4. Spoj prema zahtjevu 1, naznačen time da je: [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] ili njegova farmaceutski prihvatljiva sol, solvat ili stereoizomer.
5. Farmaceutski pripravak naznačen time da sadrži spoj prema bilo kojem od zahtjeva 1-4, ili njegovu farmaceutski prihvatljivu sol, solvat ili stereoizomer.
6. Spoj prema bilo kojem od zahtjeva 1-5, ili njegova farmaceutski prihvatljiva sol, solvat ili stereoizomer naznačen time da je za uporabu u postupku za liječenje, upravljanje ili sprječavanje bolesti ili poremećaja, pri čemu bolest ili poremećaj je rak, poremećaj povezan s angiogenezom, bol, makularna degeneracija ili srodni sindrom, kožna bolest, plućni poremećaj, poremećaj povezan s azbestom, parazitska bolest, disfunkcionalni san ili srodni poremećaj, zarazna bolest, hemoglobinopatija ili srodni poremećaj, ili poremećaj povezan s TNFα.
HRP20171078TT 2010-02-11 2017-07-13 Derivati arilmetoksi izoindolina i pripravci koji ih sadrže, te postupci njihove uporabe HRP20171078T1 (hr)

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US30361810P 2010-02-11 2010-02-11
PCT/US2011/024269 WO2011100380A1 (en) 2010-02-11 2011-02-10 Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same
EP11704156.6A EP2536706B1 (en) 2010-02-11 2011-02-10 Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same

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HRP20190368TT HRP20190368T1 (hr) 2010-02-11 2019-02-26 Derivati arilmetoksi izoindolina i pripravci koji ih sadrže te postupci njihove uporabe
HRP20191312TT HRP20191312T1 (hr) 2010-02-11 2019-07-19 Derivati arilmetoksi izoindolina i pripravci koji ih sadrže te postupci njihove uporabe

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