BR112021006318A2 - terapia de combinação para o tratamento de câncer - Google Patents
terapia de combinação para o tratamento de câncerInfo
- Publication number
- BR112021006318A2 BR112021006318A2 BR112021006318A BR112021006318A BR112021006318A2 BR 112021006318 A2 BR112021006318 A2 BR 112021006318A2 BR 112021006318 A BR112021006318 A BR 112021006318A BR 112021006318 A BR112021006318 A BR 112021006318A BR 112021006318 A2 BR112021006318 A2 BR 112021006318A2
- Authority
- BR
- Brazil
- Prior art keywords
- combination therapy
- cancer treatment
- combination
- daratumumab
- cocrystal
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
Abstract
terapia de combinação para o tratamento de câncer. trata-se de métodos para tratar e/ou controlar cânceres que compreendem administrar a um paciente o composto a, ou um enantiômero ou uma mistura de enantiômeros do mesmo, ou um sal, solvato, hidrato, cocristal, clatrato ou polimorfo farmaceuticamente aceitável do mesmo em combinação com daratumumabe. adicionalmente, métodos para tratar e/ou controlar cânceres que compreendem administrar a um paciente o composto a, ou um enantiômero ou uma mistura de enantiômeros do mesmo, ou um sal, solvato, hidrato, cocristal, clatrato ou polimorfo farmaceuticamente aceitável do mesmo em combinação com daratumumabe e dexametasona são fornecidos no presente documento.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862739809P | 2018-10-01 | 2018-10-01 | |
US201862773980P | 2018-11-30 | 2018-11-30 | |
PCT/US2019/053721 WO2020072334A1 (en) | 2018-10-01 | 2019-09-30 | Combination therapy for the treatment of cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112021006318A2 true BR112021006318A2 (pt) | 2021-07-06 |
Family
ID=69945395
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112021006318A BR112021006318A2 (pt) | 2018-10-01 | 2019-09-30 | terapia de combinação para o tratamento de câncer |
Country Status (12)
Country | Link |
---|---|
US (2) | US11529339B2 (pt) |
EP (1) | EP3860610A4 (pt) |
JP (1) | JP7466549B2 (pt) |
KR (1) | KR20210069642A (pt) |
CN (1) | CN112839658A (pt) |
AU (1) | AU2019351811A1 (pt) |
BR (1) | BR112021006318A2 (pt) |
CA (1) | CA3114401A1 (pt) |
IL (1) | IL281845A (pt) |
MX (1) | MX2021003842A (pt) |
SG (1) | SG11202103141YA (pt) |
WO (1) | WO2020072334A1 (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2019351811A1 (en) | 2018-10-01 | 2021-05-06 | Celgene Corporation | Combination therapy for the treatment of cancer |
CN115315260A (zh) * | 2019-12-02 | 2022-11-08 | 新基公司 | 治疗癌症的疗法 |
JP2023531512A (ja) * | 2020-06-25 | 2023-07-24 | セルジーン コーポレーション | 併用療法を用いて癌を治療するための方法 |
WO2024064646A1 (en) | 2022-09-20 | 2024-03-28 | Celgene Corporation | Salts and solid forms of (s)- or racemic 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and methods of using the same |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ599199A (en) | 2007-03-20 | 2013-10-25 | Celgene Corp | 4'-o-substituted isoindoline derivatives and compositions comprising and methods of using the same |
SI3202461T1 (sl) | 2010-02-11 | 2019-05-31 | Celgene Corporation | Derivati arilmetoksi izoindolina in sestavki, ki jih vsebujejo in metode uporabe le teh |
KR20130038838A (ko) | 2010-03-12 | 2013-04-18 | 셀진 코포레이션 | 레날리도미드, 및 예측 인자로서 유전자 및 단백질 바이오마커를 사용한 비호지킨 림프종의 치료 방법 |
EA201391319A1 (ru) | 2011-03-11 | 2014-03-31 | Селджин Корпорейшн | Способ лечения рака с использованием 3-(5-амино-2-метил-4-оксо-4h-хиназолин-3-ил)пиперидин-2,6-диона |
HUE056127T2 (hu) | 2012-08-09 | 2022-01-28 | Celgene Corp | A rák kezelésének módszerei 3-(4-((4-(morfolino-metil)-benzil)-oxi) -1-oxi-izo-dolin-2-il) - piperidin-2,6-dion alkalmazásával |
CN104718202B (zh) | 2012-08-09 | 2018-11-20 | 细胞基因公司 | 用于制备(s)-3-(4-((4-(吗啉基甲基)苄基)氧基)-1-氧代异吲哚啉-2-基)哌啶-2,6-二酮及其可药用形式的方法 |
US20150038511A1 (en) | 2012-08-09 | 2015-02-05 | Celgene Corporation | Treatment of immune-related and inflammatory diseases |
US20140343058A1 (en) | 2012-08-09 | 2014-11-20 | Celgene Corporation | Treatment of systemic lupus erythematosus |
PL2882441T3 (pl) | 2012-08-09 | 2020-09-21 | Celgene Corporation | Leczenie chorób immunologicznych i zapalnych |
EP3524598B1 (en) | 2012-08-09 | 2021-07-07 | Celgene Corporation | A solid form of (s)-3-(4-((4-morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride |
UA117141C2 (uk) | 2013-10-08 | 2018-06-25 | Селджин Корпорейшн | Склади (s)-3-(4-((4-(морфолінометил)бензил)оксі)-1-оксоізоіндолін-2-іл)піперидин-2,6-діону |
TWI794885B (zh) | 2014-05-19 | 2023-03-01 | 美商西建公司 | 全身紅斑性狼瘡之治療 |
BR112017003620A2 (pt) * | 2014-08-22 | 2017-12-05 | Celgene Corp | métodos de tratamento de mieloma múltiplo com compostos imunomoduladores em combinação com anticorpos |
EP3535295A1 (en) * | 2016-11-02 | 2019-09-11 | EngMab Sàrl | Bispecific antibody against bcma and cd3 and an immunological drug for combined use in treating multiple myeloma |
AU2019351811A1 (en) | 2018-10-01 | 2021-05-06 | Celgene Corporation | Combination therapy for the treatment of cancer |
EA202190865A1 (ru) * | 2018-11-30 | 2021-07-01 | Селджин Корпорейшн | Комбинированная терапия для лечения рака |
-
2019
- 2019-09-30 AU AU2019351811A patent/AU2019351811A1/en active Pending
- 2019-09-30 CA CA3114401A patent/CA3114401A1/en active Pending
- 2019-09-30 US US16/588,318 patent/US11529339B2/en active Active
- 2019-09-30 CN CN201980065270.1A patent/CN112839658A/zh active Pending
- 2019-09-30 BR BR112021006318A patent/BR112021006318A2/pt unknown
- 2019-09-30 WO PCT/US2019/053721 patent/WO2020072334A1/en unknown
- 2019-09-30 EP EP19869422.6A patent/EP3860610A4/en active Pending
- 2019-09-30 JP JP2021542070A patent/JP7466549B2/ja active Active
- 2019-09-30 KR KR1020217009735A patent/KR20210069642A/ko unknown
- 2019-09-30 MX MX2021003842A patent/MX2021003842A/es unknown
- 2019-09-30 SG SG11202103141YA patent/SG11202103141YA/en unknown
-
2021
- 2021-03-25 IL IL281845A patent/IL281845A/en unknown
-
2022
- 2022-11-09 US US17/983,762 patent/US20230277517A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20200101058A1 (en) | 2020-04-02 |
US11529339B2 (en) | 2022-12-20 |
AU2019351811A1 (en) | 2021-05-06 |
WO2020072334A1 (en) | 2020-04-09 |
US20230277517A1 (en) | 2023-09-07 |
JP2022508513A (ja) | 2022-01-19 |
CN112839658A (zh) | 2021-05-25 |
JP7466549B2 (ja) | 2024-04-12 |
KR20210069642A (ko) | 2021-06-11 |
IL281845A (en) | 2021-05-31 |
SG11202103141YA (en) | 2021-04-29 |
EP3860610A1 (en) | 2021-08-11 |
EP3860610A4 (en) | 2022-06-15 |
CA3114401A1 (en) | 2020-04-09 |
MX2021003842A (es) | 2021-05-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] |