BR112015020584A2 - métodos para o tratamento de artrite psoriática usando apremilast - Google Patents
métodos para o tratamento de artrite psoriática usando apremilastInfo
- Publication number
- BR112015020584A2 BR112015020584A2 BR112015020584A BR112015020584A BR112015020584A2 BR 112015020584 A2 BR112015020584 A2 BR 112015020584A2 BR 112015020584 A BR112015020584 A BR 112015020584A BR 112015020584 A BR112015020584 A BR 112015020584A BR 112015020584 A2 BR112015020584 A2 BR 112015020584A2
- Authority
- BR
- Brazil
- Prior art keywords
- apremilast
- methods
- psoriatic arthritis
- treating psoriatic
- treating
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
Abstract
resumo métodos para o tratamento de artrite psoriática usando apremilast métodos de tratamento, gerenciamento ou prevenção de artrite psoriática são divulgados. métodos específicos englobam a administração de apremilast, isoladamente ou em combinação com um segundo agente ativo. 1/1
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361782880P | 2013-03-14 | 2013-03-14 | |
PCT/US2014/025171 WO2014151180A1 (en) | 2013-03-14 | 2014-03-13 | Treatment of psoriatic arthritis using apremilast |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015020584A2 true BR112015020584A2 (pt) | 2017-07-18 |
Family
ID=50549444
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015020584A BR112015020584A2 (pt) | 2013-03-14 | 2014-03-13 | métodos para o tratamento de artrite psoriática usando apremilast |
Country Status (10)
Country | Link |
---|---|
US (1) | US9872854B2 (pt) |
KR (1) | KR20150126618A (pt) |
CN (1) | CN105050624A (pt) |
AU (1) | AU2014235273A1 (pt) |
BR (1) | BR112015020584A2 (pt) |
HK (1) | HK1215671A1 (pt) |
IL (1) | IL239499A0 (pt) |
MX (1) | MX2015008685A (pt) |
NZ (1) | NZ628320A (pt) |
WO (1) | WO2014151180A1 (pt) |
Families Citing this family (21)
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DK2428513T3 (en) | 2006-09-26 | 2017-08-21 | Celgene Corp | 5-substituted quinazolinone derivatives as anti-cancer agents |
MX337169B (es) | 2010-02-11 | 2016-02-16 | Celgene Corp | Derivados de arilmetoxi isoindolina y composiciones que los comprenden y metodos para utilizar los mismos. |
SG192946A1 (en) | 2011-03-11 | 2013-09-30 | Celgene Corp | Solid forms of 3-(5-amino-2methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione, and their pharmaceutical compositions and uses |
CN104755472A (zh) | 2012-09-04 | 2015-07-01 | 细胞基因公司 | 3-(5-氨基-2-甲基-4-氧代喹唑啉-3(4h)-基)哌啶-2,6-二酮的同位素体及其制备方法 |
WO2014116573A1 (en) | 2013-01-22 | 2014-07-31 | Celgene Corporation | Processes for the preparation of isotopologues of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and pharmaceutically acceptable salts thereof |
WO2016025686A1 (en) * | 2014-08-15 | 2016-02-18 | Celgene Corporation | Dosage titration of apremilast for the treatment of diseases ameliorated by pde4 inhibition |
CN105588886B (zh) * | 2014-11-18 | 2020-01-31 | 重庆医药工业研究院有限责任公司 | 一种采用液相色谱法测定阿普斯特及其制剂中杂质的方法 |
CN104458961A (zh) * | 2014-12-11 | 2015-03-25 | 南京艾德凯腾生物医药有限责任公司 | 阿普斯特有关物质检测方法 |
US10287248B2 (en) | 2015-03-19 | 2019-05-14 | Cipla Limited | Process for the preparation of apremilast |
CN106727344A (zh) * | 2015-11-19 | 2017-05-31 | 常州爱诺新睿医药技术有限公司 | 一种无定型阿普斯特的固体分散体及其制备方法 |
US10765665B2 (en) | 2015-11-24 | 2020-09-08 | Melin Jeffrey | Composition comprising combination of rapamycin and an activator of AMP kinase and use thereof for treating diseases |
CN105935350B (zh) * | 2015-12-18 | 2018-11-16 | 重庆两江药物研发中心有限公司 | 一种阿普斯特缓释植入剂及其制备方法 |
US20200170999A1 (en) * | 2015-12-24 | 2020-06-04 | Jiangsu Hengrui Medicine Co., Ltd. | Apremilast sustained release preparation |
CN108181401B (zh) * | 2018-01-26 | 2020-07-31 | 华侨大学 | 一种阿普斯特片有效成分的含量测定方法 |
CN109568302B (zh) * | 2018-11-01 | 2021-07-16 | 郑州大学第一附属医院 | 一种治疗晚期肝癌的药物复合物及其应用 |
US11357775B2 (en) | 2019-04-30 | 2022-06-14 | Celgene Corporation | Combination therapies comprising apremilast and Tyk2 inhibitors |
IL287665A (en) * | 2019-04-30 | 2022-07-01 | Celgene Corp | Combined treatments including apremilaste and tyk2 inhibitors |
US20210315883A1 (en) * | 2020-04-08 | 2021-10-14 | Nostrum Pharmaceuticals, Llc | Compositions and methods for the prophylaxis and/or treatment of viral infections or conditions associated therewith |
WO2023105286A1 (en) | 2021-12-06 | 2023-06-15 | My Personal Therapeutics Ltd | A combination treatment for cancer |
WO2023121670A1 (en) * | 2021-12-23 | 2023-06-29 | Amgen Inc. | Oral suspension of apremilast |
CN116019762A (zh) * | 2022-09-19 | 2023-04-28 | 厦门大学 | 一种用于治疗银屑病的药物组合物、制备方法和用途 |
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US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
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US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
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US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
IT1229203B (it) | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
US5120548A (en) | 1989-11-07 | 1992-06-09 | Merck & Co., Inc. | Swelling modulated polymeric drug delivery device |
US5733566A (en) | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
US5591767A (en) | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
IT1270594B (it) | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida |
US6020358A (en) | 1998-10-30 | 2000-02-01 | Celgene Corporation | Substituted phenethylsulfones and method of reducing TNFα levels |
US7893101B2 (en) | 2002-03-20 | 2011-02-22 | Celgene Corporation | Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof |
US6962940B2 (en) | 2002-03-20 | 2005-11-08 | Celgene Corporation | (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof |
US7276529B2 (en) | 2002-03-20 | 2007-10-02 | Celgene Corporation | Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
US7208516B2 (en) | 2002-03-20 | 2007-04-24 | Celgene Corporation | Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
WO2006065814A1 (en) | 2004-12-13 | 2006-06-22 | Celgene Corporation | Compositions comprising pde4 modulators and their use for the treatment or prevention of airway inflammation |
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MX2010010334A (es) | 2008-03-24 | 2010-10-08 | Celgene Corp | Tratamiento de psoriasis o artritis psoriatica utilizando ciclopropil-n-{2-{(1s)-1-(3-etoxi-4-metoxifenil)-2-(metilsulfonil )etil]-3-oxoisoindolina-4-il}carboxamida. |
CA2736171A1 (en) | 2008-09-10 | 2010-03-18 | Celgene Corporation | Processes for the preparation of aminosulfone compounds |
CN102781443A (zh) * | 2009-11-19 | 2012-11-14 | 细胞基因公司 | 用于治疗结节病的阿普斯特 |
-
2014
- 2014-03-13 US US14/209,874 patent/US9872854B2/en active Active
- 2014-03-13 KR KR1020157024912A patent/KR20150126618A/ko not_active Application Discontinuation
- 2014-03-13 CN CN201480014497.0A patent/CN105050624A/zh active Pending
- 2014-03-13 MX MX2015008685A patent/MX2015008685A/es unknown
- 2014-03-13 AU AU2014235273A patent/AU2014235273A1/en not_active Withdrawn
- 2014-03-13 NZ NZ628320A patent/NZ628320A/en unknown
- 2014-03-13 WO PCT/US2014/025171 patent/WO2014151180A1/en active Application Filing
- 2014-03-13 BR BR112015020584A patent/BR112015020584A2/pt not_active IP Right Cessation
-
2015
- 2015-06-18 IL IL239499A patent/IL239499A0/en unknown
-
2016
- 2016-03-30 HK HK16103616.0A patent/HK1215671A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
CN105050624A (zh) | 2015-11-11 |
AU2014235273A2 (en) | 2015-07-23 |
KR20150126618A (ko) | 2015-11-12 |
IL239499A0 (en) | 2015-08-31 |
AU2014235273A1 (en) | 2015-07-09 |
US20140301980A1 (en) | 2014-10-09 |
WO2014151180A1 (en) | 2014-09-25 |
NZ628320A (en) | 2017-04-28 |
HK1215671A1 (zh) | 2016-09-09 |
MX2015008685A (es) | 2015-10-05 |
US9872854B2 (en) | 2018-01-23 |
US20150174100A2 (en) | 2015-06-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |