HUE044652T2 - Arilmetoxi-izoindolin-származékok, az ezeket tartalmazó kompozíciók, és eljárások alkalmazásukra - Google Patents

Arilmetoxi-izoindolin-származékok, az ezeket tartalmazó kompozíciók, és eljárások alkalmazásukra

Info

Publication number
HUE044652T2
HUE044652T2 HUE17157170A HUE044652T2 HU E044652 T2 HUE044652 T2 HU E044652T2 HU E17157170 A HUE17157170 A HU E17157170A HU E044652 T2 HUE044652 T2 HU E044652T2
Authority
HU
Hungary
Prior art keywords
compositions
methods
same
isoindoline derivatives
arylmethoxy isoindoline
Prior art date
Application number
Other languages
English (en)
Hungarian (hu)
Inventor
Hon-Wah Man
George W Muller
Alexander L Ruchelman
Ehab M Khalil
Roger Chen
Weihong Zhang
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of HUE044652T2 publication Critical patent/HUE044652T2/hu

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Tropical Medicine & Parasitology (AREA)
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  • Molecular Biology (AREA)
  • Anesthesiology (AREA)
  • AIDS & HIV (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
HUE17157170 2010-02-11 2011-02-10 Arilmetoxi-izoindolin-származékok, az ezeket tartalmazó kompozíciók, és eljárások alkalmazásukra HUE044652T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30361810P 2010-02-11 2010-02-11

Publications (1)

Publication Number Publication Date
HUE044652T2 true HUE044652T2 (hu) 2019-11-28

Family

ID=43708752

Family Applications (3)

Application Number Title Priority Date Filing Date
HUE17157170 HUE044652T2 (hu) 2010-02-11 2011-02-10 Arilmetoxi-izoindolin-származékok, az ezeket tartalmazó kompozíciók, és eljárások alkalmazásukra
HUE17157178A HUE042011T2 (hu) 2010-02-11 2011-02-10 Arilmetoxi-izoindolin-származékok, azok készítményei és alkalmazási módszereik
HUE11704156A HUE033009T2 (en) 2010-02-11 2011-02-10 Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same

Family Applications After (2)

Application Number Title Priority Date Filing Date
HUE17157178A HUE042011T2 (hu) 2010-02-11 2011-02-10 Arilmetoxi-izoindolin-származékok, azok készítményei és alkalmazási módszereik
HUE11704156A HUE033009T2 (en) 2010-02-11 2011-02-10 Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same

Country Status (33)

Country Link
US (8) US8518972B2 (enExample)
EP (6) EP3202460B1 (enExample)
JP (5) JP2013519675A (enExample)
KR (2) KR101812356B1 (enExample)
CN (2) CN102822165B (enExample)
AR (1) AR081058A1 (enExample)
AU (1) AU2011215877C1 (enExample)
CA (1) CA2787823C (enExample)
CO (1) CO6571916A2 (enExample)
CR (1) CR20120414A (enExample)
CY (3) CY1119177T1 (enExample)
DK (3) DK3202461T3 (enExample)
EC (1) ECSP12012098A (enExample)
ES (5) ES2730763T3 (enExample)
HR (3) HRP20171078T1 (enExample)
HU (3) HUE044652T2 (enExample)
IL (2) IL220992A (enExample)
LT (3) LT3202461T (enExample)
ME (2) ME03441B (enExample)
MX (3) MX2012009237A (enExample)
NI (1) NI201200132A (enExample)
NZ (3) NZ717149A (enExample)
PH (2) PH12012501607A1 (enExample)
PL (3) PL3202461T3 (enExample)
PT (3) PT2536706T (enExample)
RS (3) RS56232B1 (enExample)
RU (1) RU2567753C2 (enExample)
SG (3) SG10202012179RA (enExample)
SI (3) SI3202460T1 (enExample)
SM (3) SMT201900155T1 (enExample)
TR (1) TR201903027T4 (enExample)
UA (2) UA114856C2 (enExample)
WO (1) WO2011100380A1 (enExample)

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US20120134969A1 (en) 2009-05-25 2012-05-31 Hiroshi Handa Pharmaceutical composition containing nuclear factor involved in proliferation and differentiation of central neuronal cells
TR201903027T4 (tr) 2010-02-11 2019-03-21 Celgene Corp Arilmetoksi izoindolin türevleri ve bunları içeren kompozisyonlar ve bunları kullanma yöntemleri.
AU2012236655B2 (en) * 2011-03-28 2016-09-22 Deuterx, Llc, 2',6'-dioxo-3'-deutero-piperdin-3-yl-isoindoline compounds
EP2702410A2 (en) 2011-04-29 2014-03-05 Celgene Corporation Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor
EP3904875B1 (en) 2012-06-29 2024-11-20 Celgene Corporation Methods for determining drug efficacy using ikzf3 (aiolos)
IN2015DN00845A (enExample) * 2012-08-09 2015-06-12 Celgene Corp
ES2881220T3 (es) * 2012-08-09 2021-11-29 Celgene Corp Métodos de tratamiento del cáncer usando 3-(4-((4-(morfolinometil)bencil)oxi)-1-oxoisoindolin-2-il)piperidin-2,6-diona
US20150038511A1 (en) 2012-08-09 2015-02-05 Celgene Corporation Treatment of immune-related and inflammatory diseases
NZ628077A (en) * 2012-08-09 2017-04-28 Celgene Corp Treatment of immune-related and inflammatory diseases
US20140343058A1 (en) * 2012-08-09 2014-11-20 Celgene Corporation Treatment of systemic lupus erythematosus
CA2878954C (en) 2012-08-09 2020-12-08 Benjamin M. Cohen Salts and solid forms of (s)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and compositions comprising and methods of using the same
US9587281B2 (en) 2012-08-14 2017-03-07 Celgene Corporation Cereblon isoforms and their use as biomarkers for therapeutic treatment
JP6306592B2 (ja) 2012-09-10 2018-04-04 セルジーン コーポレイション 局所進行乳癌を治療するための方法
AU2013204922B2 (en) 2012-12-20 2015-05-14 Celgene Corporation Chimeric antigen receptors
AU2014205043B2 (en) 2013-01-14 2018-10-04 Deuterx, Llc 3-(5-substituted-4-oxoquinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives
WO2014116573A1 (en) 2013-01-22 2014-07-31 Celgene Corporation Processes for the preparation of isotopologues of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and pharmaceutically acceptable salts thereof
CA2941560A1 (en) 2013-03-14 2014-09-25 Deuterx, Llc 3-(substituted-4-oxo-quinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives
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