SG11201506127WA - Efficient production of steviol glycosides in recombinant hosts - Google Patents

Efficient production of steviol glycosides in recombinant hosts

Info

Publication number
SG11201506127WA
SG11201506127WA SG11201506127WA SG11201506127WA SG11201506127WA SG 11201506127W A SG11201506127W A SG 11201506127WA SG 11201506127W A SG11201506127W A SG 11201506127WA SG 11201506127W A SG11201506127W A SG 11201506127WA SG 11201506127W A SG11201506127W A SG 11201506127WA
Authority
SG
Singapore
Prior art keywords
efficient production
steviol glycosides
recombinant hosts
hosts
recombinant
Prior art date
Application number
SG11201506127WA
Other languages
English (en)
Inventor
Ernesto Simon
Iben Nordmark Andersen
Michael Dalgaard Mikkelsen
Jorgen Hansen
Original Assignee
Evolva Sa
Ernesto Simon
Anderson Iben Nordmark
Michael Dalgaard Mikkelsen
Jorgen Hansen
Douchin Veronique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evolva Sa, Ernesto Simon, Anderson Iben Nordmark, Michael Dalgaard Mikkelsen, Jorgen Hansen, Douchin Veronique filed Critical Evolva Sa
Publication of SG11201506127WA publication Critical patent/SG11201506127WA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/395—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • C12N9/0038—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
    • C12N9/0042—NADPH-cytochrome P450 reductase (1.6.2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C12N9/1062—Sucrose synthase (2.4.1.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P15/00—Preparation of compounds containing at least three condensed carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y106/00—Oxidoreductases acting on NADH or NADPH (1.6)
    • C12Y106/02—Oxidoreductases acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
    • C12Y106/02004—NADPH-hemoprotein reductase (1.6.2.4), i.e. NADP-cytochrome P450-reductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/13—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen (1.14.13)
    • C12Y114/13078—Ent-kaurene oxidase (1.14.13.78)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01013—Sucrose synthase (2.4.1.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01035—Phenol beta-glucosyltransferase (2.4.1.35)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01029—Geranylgeranyl diphosphate synthase (2.5.1.29)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
    • C12Y402/03019—Ent-kaurene synthase (4.2.3.19)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y505/00—Intramolecular lyases (5.5)
    • C12Y505/01—Intramolecular lyases (5.5.1)
    • C12Y505/01013—Ent-copalyl diphosphate synthase (5.5.1.13)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
SG11201506127WA 2013-02-11 2014-02-11 Efficient production of steviol glycosides in recombinant hosts SG11201506127WA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361763308P 2013-02-11 2013-02-11
US201361763290P 2013-02-11 2013-02-11
PCT/EP2014/052675 WO2014122328A1 (fr) 2013-02-11 2014-02-11 Production efficace de glycosides de stéviol dans des hôtes recombinés

Publications (1)

Publication Number Publication Date
SG11201506127WA true SG11201506127WA (en) 2015-09-29

Family

ID=50112893

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201705993YA SG10201705993YA (en) 2013-02-11 2014-02-11 Efficient production of steviol glycosides in recombinant hosts
SG11201506127WA SG11201506127WA (en) 2013-02-11 2014-02-11 Efficient production of steviol glycosides in recombinant hosts

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201705993YA SG10201705993YA (en) 2013-02-11 2014-02-11 Efficient production of steviol glycosides in recombinant hosts

Country Status (12)

Country Link
US (3) US10017804B2 (fr)
EP (1) EP2954061B1 (fr)
JP (2) JP6576247B2 (fr)
KR (1) KR20150128705A (fr)
CN (1) CN105189771B (fr)
AU (2) AU2014213918B2 (fr)
BR (1) BR112015019160A2 (fr)
CA (1) CA2900882A1 (fr)
MX (1) MX2015010098A (fr)
MY (1) MY184253A (fr)
SG (2) SG10201705993YA (fr)
WO (1) WO2014122328A1 (fr)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9107436B2 (en) 2011-02-17 2015-08-18 Purecircle Sdn Bhd Glucosylated steviol glycoside as a flavor modifier
US10696706B2 (en) 2010-03-12 2020-06-30 Purecircle Usa Inc. Methods of preparing steviol glycosides and uses of the same
MX349121B (es) 2010-06-02 2017-07-12 Evolva Inc Produccion recombinante de esteviol glucosidos.
US11690391B2 (en) 2011-02-17 2023-07-04 Purecircle Sdn Bhd Glucosylated steviol glycoside as a flavor modifier
US9771434B2 (en) 2011-06-23 2017-09-26 Purecircle Sdn Bhd Products from stevia rebaudiana
WO2013022989A2 (fr) 2011-08-08 2013-02-14 Evolva Sa Production par recombinaison de glycosides de stéviol
US9752174B2 (en) 2013-05-28 2017-09-05 Purecircle Sdn Bhd High-purity steviol glycosides
JP6346174B2 (ja) 2012-05-22 2018-06-20 ピュアサークル スンディリアン ブルハド 高純度ステビオールグリコシド
MX369525B (es) 2013-02-06 2019-11-11 Evolva Sa Métodos para mejorar la produccion de rebaudiosido d y rebaudiosido m.
EP3004366B1 (fr) * 2013-05-31 2019-02-27 DSM IP Assets B.V. Microorganismes utilisables en vue de la production de diterpène
CN105682467A (zh) 2013-06-07 2016-06-15 谱赛科美国股份有限公司 含有选择的甜叶菊醇糖苷作为香、咸和甜度特征修饰物的甜叶菊提取物
US10952458B2 (en) 2013-06-07 2021-03-23 Purecircle Usa Inc Stevia extract containing selected steviol glycosides as flavor, salty and sweetness profile modifier
EP3885443A1 (fr) * 2013-07-15 2021-09-29 DSM IP Assets B.V. Herstellung von diterpen
US10370418B2 (en) * 2014-05-20 2019-08-06 Lawrence Livermore National Security, Llc Engineered microorganisms having resistance to ionic liquids
SG11201700651RA (en) 2014-08-11 2017-02-27 Evolva Sa Production of steviol glycosides in recombinant hosts
BR112017004240B1 (pt) 2014-09-02 2022-04-05 The Coca-Cola Company Processo para preparar uma composição de glicosídeo de esteviol aquoso não tratado, extrato de stevia aquoso não tratado preparado pelo referido processo e alimento ou bebida
EP3190905A2 (fr) * 2014-09-09 2017-07-19 Evolva SA Production de glycosides de stéviol dans des hôtes de recombinaison
HUE045992T2 (hu) * 2014-10-03 2020-01-28 Conagen Inc Kalóriamentes édesítõszerek és szintézismódszereik
EP3204506B1 (fr) 2014-10-08 2022-01-12 DSM IP Assets B.V. Production de glycosides de stéviol
MY185981A (en) * 2014-11-24 2021-06-14 Cargill Inc Glycoside compositions
JP6855376B2 (ja) 2014-12-17 2021-04-07 カーギル インコーポレイテッド 経口摂取又は経口使用のためのステビオールグリコシド化合物、組成物、及びステビオールグリコシド溶解度を増強するための方法
SG11201705606PA (en) 2015-01-30 2017-08-30 Evolva Sa Production of steviol glycosides in recombinant hosts
MX2017010311A (es) * 2015-02-10 2017-12-14 Purecircle Usa Inc Metodos de produccion y recuperacion de rebaudiosido m biosintetico.
EP3862426A3 (fr) * 2015-03-16 2021-11-17 DSM IP Assets B.V. Glycosyltransférases udp
EP3718417A1 (fr) 2015-04-03 2020-10-07 DSM IP Assets B.V. Glycosides de stéviol
EP4134442A1 (fr) 2015-05-29 2023-02-15 Cargill, Incorporated Procédés de fermentation permettant de produire des glycosides de stéviol à l'aide d'un ph élevé
WO2016196345A1 (fr) 2015-05-29 2016-12-08 Cargill, Incorporated Traitement thermique pour produire des glycosides
CN107614677A (zh) * 2015-05-29 2018-01-19 嘉吉公司 用于使用多阶段进料生产甜菊醇糖苷的发酵方法
CN105154348B (zh) * 2015-08-05 2018-05-04 大连理工大学 一种提高酿酒酵母对纤维素水解液抑制物耐受性的方法
JP2018521680A (ja) 2015-08-06 2018-08-09 カーギル・インコーポレイテッド ステビオール配糖体を生成するための発酵法
CN108271391A (zh) * 2015-08-07 2018-07-10 埃沃尔瓦公司 重组宿主中的甜菊醇糖苷的产生
WO2017025649A1 (fr) * 2015-08-13 2017-02-16 Dsm Ip Assets B.V. Transport de glycoside de stéviol
CN114196559A (zh) * 2015-08-13 2022-03-18 帝斯曼知识产权资产管理有限公司 甜菊醇糖苷转运
US10774314B2 (en) 2015-08-21 2020-09-15 Manus Bio Inc. Increasing productivity of E. coli host cells that functionally express P450 enzymes
US9765117B2 (en) 2015-08-24 2017-09-19 Romek Figa Peptides for treating cancer
EP3141610A1 (fr) * 2015-09-12 2017-03-15 Jennewein Biotechnologie GmbH Production d'oligosaccharides du lait humain dans des hôtes microbiens comprenant une systeme d'importation/exportation modifieé
CN108495559A (zh) 2015-10-26 2018-09-04 谱赛科美国股份有限公司 甜菊醇糖苷组合物
CN108712864A (zh) 2015-12-15 2018-10-26 谱赛科美国股份有限公司 甜菊醇糖苷组合物
CN109154010A (zh) 2016-03-11 2019-01-04 埃沃尔瓦公司 在重组宿主中生产甜菊醇糖苷
JP2019513392A (ja) 2016-04-13 2019-05-30 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． 組み換え宿主におけるステビオールグリコシドの産生
CN109312378A (zh) 2016-05-16 2019-02-05 埃沃尔瓦公司 在重组宿主中产生甜菊醇糖苷
KR20190018512A (ko) 2016-06-15 2019-02-22 코덱시스, 인코포레이티드 조작된 베타-글루코시다아제 및 글루코실화 방법
EP3472308A4 (fr) * 2016-06-15 2020-07-29 Codexis, Inc. Glycosylation enzymatique des glycosides de stéviol et autres composés à l'aide de glucose-1-phosphate
CA3027697C (fr) * 2016-06-17 2024-02-20 Cargill, Incorporated Compositions de glycosides de steviol pour ingestion ou utilisation orale
WO2018031955A2 (fr) 2016-08-12 2018-02-15 Amyris, Inc. Glycosyltransférase dépendant de l'udp pour la production à haut rendement de rébaudiosides
WO2018083338A1 (fr) 2016-11-07 2018-05-11 Evolva Sa Production de glycosides de stéviol dans des hôtes recombinants
CN116064264A (zh) * 2016-11-23 2023-05-05 中国科学院天津工业生物技术研究所 一种产生对萜类或含萜精油的耐受性提高的重组宿主细胞的方法及其用途
CN110121556A (zh) 2016-12-27 2019-08-13 三得利控股株式会社 甜菊醇糖苷己糖转移酶及编码该物质的基因
ES2959508T3 (es) 2017-01-26 2024-02-26 Manus Bio Inc Ingeniería metabólica para la producción microbiana de productos terpenoides
WO2018144679A2 (fr) 2017-02-03 2018-08-09 Codexis, Inc. Glycosyl transférases modifiées et procédés de glucosylation de glycosides de stéviol
CN110494564B (zh) 2017-04-12 2024-03-15 三得利控股株式会社 来自甜菊的鼠李糖合成酶及基因
WO2018211032A1 (fr) 2017-05-17 2018-11-22 Evolva Sa Production de glycosides de stéviol dans des hôtes recombinants
WO2019006312A1 (fr) * 2017-06-30 2019-01-03 Myriant Corporation Micro-organisme ayant un nombre de copies stabilisé d'une séquence d'adn fonctionnelle et méthodes associées
US11365417B2 (en) 2017-09-12 2022-06-21 Bio Capital Holdings, LLC Biological devices and methods of use thereof to produce steviol glycosides
WO2019099649A1 (fr) * 2017-11-20 2019-05-23 Manus Bio, Inc. Cellules hôtes microbiennes pour la production de glycosides de stéviol
EP3720968A1 (fr) 2017-12-05 2020-10-14 Evolva SA Production de glycosides de stéviol dans des hôtes recombinants
CN108070602B (zh) * 2017-12-12 2020-11-06 山东隆科特酶制剂有限公司 一种减少及推迟芽孢杆菌芽孢生成的分子改造方法
WO2019211230A1 (fr) 2018-04-30 2019-11-07 Dsm Ip Assets B.V. Transport de glycoside de stéviol
KR101929158B1 (ko) * 2018-06-07 2018-12-13 씨제이제일제당 (주) 5'-크산틸산을 생산하는 미생물 및 이를 이용한 5'-크산틸산의 제조방법
MX2021008747A (es) * 2019-01-24 2021-09-08 Amyris Inc Transportadores abc para la produccion de alta eficiencia de rebaudiosidos.
CN112322648A (zh) * 2019-07-30 2021-02-05 上海市农业科学院 一种abc转运蛋白基因mrp1s及其制备方法和应用
EP4044823A4 (fr) * 2019-10-16 2024-04-24 Sweegen Inc Formulations de glycoside de stéviol pour aliments et boissons
CN110846363B (zh) * 2019-11-11 2023-02-17 天津大学 一锅法生产莱鲍迪苷d的方法
CN115836083A (zh) * 2020-04-27 2023-03-21 布鲁塞尔自由大学 用于减少乳酸菌污染的酵母菌菌株
CN114214378A (zh) * 2021-11-23 2022-03-22 安徽金禾实业股份有限公司 一种利用枯草芽孢杆菌发酵催化制备莱鲍迪苷m的方法
WO2023122801A2 (fr) * 2021-12-24 2023-06-29 The Regents Of The University Of California Production de saponine dans levure
CN114561310B (zh) * 2022-03-17 2022-12-02 江南大学 一种生产甜茶苷的酿酒酵母及其应用

Family Cites Families (142)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58149697A (ja) 1982-02-27 1983-09-06 Dainippon Ink & Chem Inc β−１，３グリコシルステビオシドの製造方法
JPS591408A (ja) 1982-06-28 1984-01-06 Fukue Ito ヘヤ−トニツクの製造方法
JPS59101408A (ja) 1982-12-02 1984-06-12 Junichi Iwamura 植物生長調整剤
US6946587B1 (en) 1990-01-22 2005-09-20 Dekalb Genetics Corporation Method for preparing fertile transgenic corn plants
US5484956A (en) 1990-01-22 1996-01-16 Dekalb Genetics Corporation Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin
JPH03277275A (ja) 1990-03-28 1991-12-09 Dainippon Ink & Chem Inc 新規酵素及びその酵素を用いた配糖体の製造方法
US5204253A (en) 1990-05-29 1993-04-20 E. I. Du Pont De Nemours And Company Method and apparatus for introducing biological substances into living cells
US5306862A (en) 1990-10-12 1994-04-26 Amoco Corporation Method and composition for increasing sterol accumulation in higher plants
US5460949A (en) 1990-11-15 1995-10-24 Amoco Corporation Method and composition for increasing the accumulation of squalene and specific sterols in yeast
US5712112A (en) 1992-11-04 1998-01-27 National Science Council Of R.O.C. Gene expression system comprising the promoter region of the alpha-amylase genes
EP0785988A1 (fr) 1993-07-15 1997-07-30 Neose Pharmaceuticals, Inc Procede de synthese de compositions de saccharide
US7186891B1 (en) 1996-04-12 2007-03-06 University Of Kentucky, Research Foundation Plant cells and plants expressing chimeric isoprenoid synthases
JPH10117776A (ja) 1996-10-22 1998-05-12 Japan Tobacco Inc インディカイネの形質転換方法
WO1999018224A1 (fr) 1997-10-06 1999-04-15 The Centre National De Recherche Scientifique Genes d'hydroxylase d'acide gras provenant de vegetaux
US6255557B1 (en) 1998-03-31 2001-07-03 Her Majesty The Queen In Right Of Canada As Represented By The Ministerof Agriculture And Agri-Food Canada Stevia rebaudiana with altered steviol glycoside composition
CA2736981A1 (fr) 1998-04-14 1999-10-21 Kyowa Hakko Bio Co., Ltd. Processus de production de composes isoprenoides par des micro-organismes
EP0955363A3 (fr) 1998-05-06 2004-01-28 F. Hoffmann-La Roche Ag Séquences d'ADN codant pour des enzymes impliqués dans la production des isoprénoides
TWI250210B (en) 1998-05-06 2006-03-01 Dsm Ip Assets Bv An isolated DNA sequence coding for an enzyme involved in the mevalonate pathway or the pathway from isopentenyl pyrophosphate to farnesyl pyrophosphate
US6531303B1 (en) 1998-07-06 2003-03-11 Arkion Life Sciences Llc Method of producing geranylgeraniol
MX219130B (es) 1998-07-06 2004-02-10 Dcv Inc Haciendo Negocios Como Metodo para producir vitamina.
AR021636A1 (es) 1998-12-17 2002-07-31 Rubicon Forests Holdings Ltd Materiales y metodos para la modificacion del contenido, la composicion y el metabolismo de los isoprenoides
EP1141356A2 (fr) 1998-12-23 2001-10-10 The Samuel Roberts Noble Foundation, Inc. Procede de transformation de vegetaux
ATE316578T1 (de) 1999-04-15 2006-02-15 Calgene Llc Nukleinsäuresequenzen für proteine, die an der tocopherolbiosynthese beteiligt sind
WO2000063400A2 (fr) 1999-04-21 2000-10-26 The Samuel Roberts Noble Foundation Procede de transformation de plante
WO2001011055A1 (fr) 1999-08-04 2001-02-15 Adelbert Bacher Biosynthese d'isoprenoides
WO2001012828A1 (fr) 1999-08-18 2001-02-22 Paradigm Genetics, Inc. Procedes et dispositifs pour la transformation de plantes monocotyledones, reposant sur l'utilisation d'agrobacteries avec infiltration sous vide
WO2001083769A2 (fr) 2000-05-03 2001-11-08 The Salk Institute For Biological Studies Modulation de la voie de biosynthese des isoprenoides independante du mevalonate
DE10027821A1 (de) 2000-06-05 2001-12-06 Adelbert Bacher Der Mevalonat-unabhängige Isoprenoidbiosyntheseweg
US20030033626A1 (en) 2000-07-31 2003-02-13 Hahn Frederick M. Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms
AU2001286811B2 (en) 2000-08-24 2007-03-01 Syngenta Participations Ag Stress-regulated genes of plants, transgenic plants containing same, and methods of use
US6660507B2 (en) 2000-09-01 2003-12-09 E. I. Du Pont De Nemours And Company Genes involved in isoprenoid compound production
US6689601B2 (en) 2000-09-01 2004-02-10 E. I. Du Pont De Nemours And Company High growth methanotropic bacterial strain
US6818424B2 (en) 2000-09-01 2004-11-16 E. I. Du Pont De Nemours And Company Production of cyclic terpenoids
EP1409530A2 (fr) * 2000-09-19 2004-04-21 Microbia, Inc. Modulation de production de metabolites secondaires par des proteines en bouquet binucleaire a zinc
US20030219798A1 (en) 2000-09-29 2003-11-27 Gokarn Ravi R. Isoprenoid production
US6949362B2 (en) 2000-12-12 2005-09-27 E. I. Du Pont De Nemours And Company Rhodococcus cloning and expression vectors
CA2474172C (fr) 2001-01-25 2012-07-10 Evolva Ltd. Genotheque cellulaire
US20040078846A1 (en) 2002-01-25 2004-04-22 Desouza Mervyn L. Carotenoid biosynthesis
US20050003474A1 (en) 2001-01-26 2005-01-06 Desouza Mervyn L. Carotenoid biosynthesis
DE10201458A1 (de) 2001-04-11 2002-10-17 Adelbert Bacher Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg
US7034140B2 (en) 2001-04-24 2006-04-25 E.I. Du Pont De Nemours And Company Genes involved in isoprenoid compound production
ATE405638T1 (de) 2001-06-06 2008-09-15 Dsm Ip Assets Bv Verbesserte isoprenoid herstellung
EP1402042A2 (fr) 2001-06-22 2004-03-31 Syngenta Participations AG Polynucleotides et polypeptides repondant au stress abiotique
NZ513755A (en) * 2001-08-24 2001-09-28 Ann Rachel Holmes Protein expression system in yeast comprising a vector encoding a heterologous membrane protein and its application in screening for drugs
US20040072311A1 (en) 2001-08-28 2004-04-15 Dicosimo Deana J. Production of cyclic terpenoids
US20040010815A1 (en) 2001-09-26 2004-01-15 Lange B. Markus Identification and characterization of plant genes
US7172886B2 (en) 2001-12-06 2007-02-06 The Regents Of The University Of California Biosynthesis of isopentenyl pyrophosphate
ATE444367T1 (de) 2002-08-20 2009-10-15 Suntory Holdings Ltd Neue glycosyltransferase-gene
ATE394477T1 (de) 2002-09-27 2008-05-15 Dsm Ip Assets Bv Squalene synthase (sqs) gen
US7098000B2 (en) 2003-06-04 2006-08-29 E. I. Du Pont De Nemoure And Company Method for production of C30-aldehyde carotenoids
CN1806042B (zh) 2003-06-12 2012-07-04 帝斯曼知识产权资产管理有限公司 具有反馈抗性的甲羟戊酸激酶
US7569389B2 (en) 2004-09-30 2009-08-04 Ceres, Inc. Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics
CA2567547C (fr) 2004-05-21 2012-10-23 The Regents Of The University Of California Procede de production ameliore de composes isoprenoides
EP1765857A2 (fr) 2004-07-02 2007-03-28 Metanomics GmbH Procede de production de produits chimiques fins
US20060014264A1 (en) 2004-07-13 2006-01-19 Stowers Institute For Medical Research Cre/lox system with lox sites having an extended spacer region
WO2006016395A1 (fr) 2004-08-09 2006-02-16 National University Corporation Tohoku University Udp-glucuronyle transferase et gene codant pour celle-ci
US7572609B2 (en) 2004-08-19 2009-08-11 Dsm Ip Assets B.V. Production of isoprenoids
US7923552B2 (en) 2004-10-18 2011-04-12 SGF Holdings, LLC High yield method of producing pure rebaudioside A
EP1824969B1 (fr) 2004-12-14 2011-03-02 DSM IP Assets B.V. Mevalonate kinase amelioree
CA2598792A1 (fr) 2005-03-02 2006-09-08 Metanomics Gmbh Procede de production de produits chimiques fins
WO2006093289A1 (fr) 2005-03-04 2006-09-08 National Institute Of Advanced Industrial Science And Technology Procédé de production de udp-xylose
WO2006096392A2 (fr) 2005-03-04 2006-09-14 Diversa Corporation Enzymes intervenant dans les voies de synthese biologique d'astaxanthines, de carotenoides et d'isoprenoides, genes codant ces enzymes et procedes de production et d'utilisation de celles-ci
WO2007022318A2 (fr) 2005-08-17 2007-02-22 Cornell Research Foundation Acides nucleiques et proteines associees a l'accumulation de sucrose dans le cafe
US8293307B2 (en) 2005-10-11 2012-10-23 Purecircle Sdn Bhd Process for manufacturing a sweetener and use thereof
BRPI0618945A2 (pt) 2005-11-23 2011-09-27 Coca Cola Co composição adoçante, método para conferir um perfil temporal mais parecido com o do açúcar, um perfil de flavor mais parecido com o do açúcar ou ambos a um adoçante de alta potência natural, composição adoçada, e, método para conferir um perfil temporal mais parecido com o do açúcar, um perfil de flavor ou ambos a uma composição adoçada de alta potência natural
KR100784261B1 (ko) 2006-01-02 2007-12-11 한국과학기술원 탄저균의 포자외막 단백질을 이용한 목적단백질의 미생물표면발현방법
US7927851B2 (en) 2006-03-21 2011-04-19 Vineland Research And Innovation Centre Compositions having ent-kaurenoic acid 13-hydroxylase activity and methods for producing same
CA2644273A1 (fr) 2006-04-05 2008-03-27 Metanomics Gmbh Procede de production d'un produit chimique fin
WO2007136847A2 (fr) 2006-05-19 2007-11-29 The Regents Of The University Of California Procédés servant à augmenter la production d'isoprénoïdes et de précurseurs d'isoprénoïdes en modulant les niveaux d'acides gras
KR101440639B1 (ko) 2006-06-19 2014-09-22 지보당 에스아 핵산, 폴리펩타이드 및 이의 용도
WO2008008256A2 (fr) 2006-07-07 2008-01-17 The Regents Of The University Of California Procédés permettant d'améliorer la production de composés isoprénoïdes par des cellules hôtes
US8257957B2 (en) 2006-09-26 2012-09-04 The Regents Of The University Of California Production of isoprenoids and isoprenoid precursors
US7629156B2 (en) 2006-09-28 2009-12-08 E.I. Du Pont De Nemours And Company Ethanol production in fermentation of mixed sugars containing xylose
US7741119B2 (en) 2006-09-28 2010-06-22 E. I. Du Pont De Nemours And Company Xylitol synthesis mutant of xylose-utilizing zymomonas for ethanol production
CN101200480B (zh) 2006-12-15 2011-03-30 成都华高药业有限公司 莱鲍迪甙a的提取方法
JP4915917B2 (ja) 2006-12-22 2012-04-11 独立行政法人農業・食品産業技術総合研究機構 ラクト−ｎ−ビオースｉ及びガラクト−ｎ−ビオースの製造方法
JP2008237110A (ja) 2007-03-27 2008-10-09 Institute Of Physical & Chemical Research ステビオール合成酵素遺伝子及びステビオールの製造方法
CA2691998A1 (fr) 2007-05-17 2008-11-27 Tetravitae Bioscience, Inc. Procedes et compositions permettant de produire des solvants
US20080292775A1 (en) 2007-05-22 2008-11-27 The Coca-Cola Company Delivery Systems for Natural High-Potency Sweetener Compositions, Methods for Their Formulation, and Uses
WO2009005704A1 (fr) 2007-07-03 2009-01-08 The Regents Of The University Of California Procédés d'augmentation de la production d'isoprénoïde ou de précurseur d'isoprénoïde
JP2009034080A (ja) 2007-08-03 2009-02-19 Sanei Gen Ffi Inc 新規糖転移酵素、及びそれを利用した配糖体の製造
US7964232B2 (en) 2007-09-17 2011-06-21 Pepsico, Inc. Steviol glycoside isomers
BRPI0816880A2 (pt) 2007-09-21 2015-09-08 Basf Plant Science Gmbh métodos para produzir uma planta com rendimento aumentado em comparação com uma planta do tipo selvagem correspondente, para produzir uma planta transgênica com rendimento aumentado em comparação com uma planta do tipo selvagem não transformada correspondente, para produzir uma composição agrícola, para identificar uma planta com um rendimento aumentado, e para aumentar o rendimento de uma população de plantas, molécula de ácido nucleico isolada, construção de ácido nucléico, vetor, processos para produzir um polipeptídeo, e para identificar um composto, polipeptídeo, anticorpo, núcleo de célula de planta, célula de planta, tecido de planta, material de propagação, pólen, progênie, material colhido ou planta, semente, parte de planta, planta transgênica, planta transgênica, núcleo de célula de planta transgênica, célula de planta transgênica, planta que compreende um ou mais de tais núcleos de célula de planta transgênica ou células de planta, progênie, semente ou pólen derivado de ou produzido por uma planta transgênica, composição, e, uso dos ácidos nucleicos.
WO2009071277A1 (fr) 2007-12-03 2009-06-11 Dsm Ip Assets B.V. Nouvelles compositions nutraceutiques contenant un extrait de stevia ou des constituants d'un extrait de stevia et leurs utilisations
US20100285201A1 (en) 2007-12-27 2010-11-11 Catani Steven J Synergistic sweetening compositions
US20110061124A1 (en) 2008-02-20 2011-03-10 Ceres, Inc Nucleotide sequences and corresponding polypeptides conferring improved nitrogen use efficiency characteristics in plants
TWI475963B (zh) 2008-02-25 2015-03-11 Coca Cola Co 甜菊糖苷ａ衍生性產物以及製造彼的方法
WO2009111513A1 (fr) 2008-03-03 2009-09-11 Joule Biotechnologies, Inc. Microorganismes de synthèse fixant le co2 et produisant des produits carbonés d’intérêt
US9005444B2 (en) 2008-05-13 2015-04-14 Cargill, Incorporated Separation of rebaudioside A from stevia glycosides using chromatography
WO2010021001A2 (fr) 2008-08-19 2010-02-25 Kaushik Ramakrishnan S Procédé de préparation d’un édulcorant à partir de stevia rebaudiana
PL2350110T3 (pl) * 2008-10-03 2016-12-30 Nowe glikozydy stewiolowe
CN101720910B (zh) 2008-10-23 2012-07-25 大闽食品（漳州）有限公司 一种甜菊糖甙的制备方法
US8614085B2 (en) * 2009-02-27 2013-12-24 Butamax(Tm) Advanced Biofuels Llc Yeast with increased butanol tolerance involving a multidrug efflux pump gene
US20100297722A1 (en) 2009-05-20 2010-11-25 Board Of Trustees Of Southern Illinois University Transgenic moss producing terpenoids
WO2010142305A1 (fr) 2009-06-08 2010-12-16 Jennewein Biotechnologie Gmbh Synthèse de hmo
ES2523997T3 (es) 2009-06-16 2014-12-03 Epc (Beijing) Natural Products Co., Ltd. Reducción o eliminación del sabor residual en un edulcorante utilizando rebaudiósido D
CA2773134A1 (fr) 2009-09-04 2011-03-10 Redpoint Bio Corporation Renforcateurs du gout sucre contenant du rebaudioside a ou du rebaudioside d
MX2012003489A (es) 2009-09-22 2012-07-30 Redpoint Bio Corp Polimorfos novedosos de rebaudiosida c y metodos para elaborarlos y utilizarlos.
MX2012003686A (es) 2009-10-15 2012-07-25 Purecircle Sdn Bhd Rebaudiosido d de alta pureza y aplicaciones.
US8299224B2 (en) 2009-10-15 2012-10-30 Purecircle Sdn Bhd High-purity Rebaudioside D
US8703224B2 (en) 2009-11-04 2014-04-22 Pepsico, Inc. Method to improve water solubility of Rebaudioside D
BR112012011073B8 (pt) 2009-11-10 2023-01-10 Massachusetts Inst Technology Método para aumentar a produção de terpenoide em uma célula que produz um ou mais terpenoides
US8993840B2 (en) 2009-11-23 2015-03-31 E I du Pont de Nemours and Compay Sucrose transporter genes for increasing plant seed lipids
AU2010327998B2 (en) 2009-12-10 2015-11-12 Iowa State University Research Foundation, Inc. TAL effector-mediated DNA modification
RU2572756C2 (ru) 2009-12-28 2016-01-20 Дзе Кока-Кола Компании Усилители сладости, их композиции и способы применения
KR101244315B1 (ko) 2010-10-19 2013-03-14 이화여자대학교 산학협력단 에탄올―저항성 효모 유전자 및 이의 용도
WO2011140329A1 (fr) 2010-05-06 2011-11-10 Ceres, Inc. Plantes transgéniques à biomasse augmentée
US9476082B2 (en) 2010-05-20 2016-10-25 Evolva Sa Method of producing isoprenoid compounds in yeast
US9249420B2 (en) * 2010-05-31 2016-02-02 Vib Vzw Isobutanol production using yeasts with modified transporter expression
MX349121B (es) 2010-06-02 2017-07-12 Evolva Inc Produccion recombinante de esteviol glucosidos.
US20120021111A1 (en) 2010-07-23 2012-01-26 Aexelon Therapeutics, Inc. Natural Low Caloric Sweetener Compositions for Use in Beverages, Foods and Pharmaceuticals, and Their Methods of Manufacture
US20120050021A1 (en) 2010-08-27 2012-03-01 Ford Global Technologies, Llc Method and Apparatus for In-Vehicle Presence Detection and Driver Alerting
US20120083593A1 (en) 2010-10-01 2012-04-05 Shanghai Yongyou Bioscience Inc. Separation and Purification of Stevioside and Rebaudioside A
EP2645847B1 (fr) 2010-11-30 2018-01-17 Massachusetts Institute of Technology Production microbienne d'édulcorants naturels, glycosides de stéviol diterpénoïdes
KR20130014227A (ko) 2011-07-29 2013-02-07 한국생명공학연구원 신규한 α-글루코실 스테비오사이드 및 이의 제조 방법
WO2013022989A2 (fr) 2011-08-08 2013-02-14 Evolva Sa Production par recombinaison de glycosides de stéviol
EP2742131B1 (fr) 2011-08-08 2018-11-28 Evolva SA Procédés et matières pour la production recombinante de composés du safran
US9920349B2 (en) 2011-11-23 2018-03-20 Evolva Sa Methods and materials for enzymatic synthesis of mogroside compounds
CN103159808B (zh) 2011-12-09 2017-03-29 上海泓博智源医药股份有限公司 一种制备天然甜味剂的工艺方法
PL3009010T3 (pl) 2011-12-19 2020-10-19 Purecircle Sdn Bhd Sposoby oczyszczania glikozydów stewiolowych
CN104203005A (zh) 2012-01-23 2014-12-10 帝斯曼知识产权资产管理有限公司 二萜的生产
JP6251669B2 (ja) 2012-03-16 2017-12-20 サントリーホールディングス株式会社 ステビオール配糖体化酵素およびそれをコードする遺伝子
JP6346174B2 (ja) 2012-05-22 2018-06-20 ピュアサークル スンディリアン ブルハド 高純度ステビオールグリコシド
CN103710318B (zh) 2012-09-29 2017-01-18 中国科学院上海生命科学研究院 利用微生物生产甜菊糖苷类化合物的方法
EP2928321A1 (fr) 2012-12-05 2015-10-14 Evolva SA Compositions à base de glycosides de stéviol à profil gustatif amélioré
MX369525B (es) 2013-02-06 2019-11-11 Evolva Sa Métodos para mejorar la produccion de rebaudiosido d y rebaudiosido m.
WO2014191580A1 (fr) 2013-05-31 2014-12-04 Dsm Ip Assets B.V. Production extracellulaire de diterpène
EP3004366B1 (fr) 2013-05-31 2019-02-27 DSM IP Assets B.V. Microorganismes utilisables en vue de la production de diterpène
KR101559478B1 (ko) 2013-06-24 2015-10-13 한국생명공학연구원 효소전환법을 이용한 천연 고감미료의 제조방법
EP3885443A1 (fr) 2013-07-15 2021-09-29 DSM IP Assets B.V. Herstellung von diterpen
WO2015011209A1 (fr) 2013-07-23 2015-01-29 Dsm Ip Assets B.V. Production de diterpène dans la yarrowia
WO2015014969A1 (fr) 2013-07-31 2015-02-05 Dsm Ip Assets B.V. Glycosides de stéviol
CN108064226A (zh) 2013-07-31 2018-05-22 帝斯曼知识产权资产管理有限公司 甜菊糖苷的回收
AU2014297224A1 (en) 2013-08-02 2016-03-03 Suntory Holdings Limited Method for using hexenol glycosyl transferase
CN103397064B (zh) 2013-08-14 2015-04-15 苏州汉酶生物技术有限公司 一种酶法制备瑞鲍迪甙m的方法
EP3039132A2 (fr) 2013-08-30 2016-07-06 Evolva SA Procédé de production de resvératrol modifié
EP3114210A2 (fr) 2014-03-07 2017-01-11 Evolva SA Procédés de production recombinante de composés du safran
SG11201700651RA (en) 2014-08-11 2017-02-27 Evolva Sa Production of steviol glycosides in recombinant hosts
EP3190905A2 (fr) 2014-09-09 2017-07-19 Evolva SA Production de glycosides de stéviol dans des hôtes de recombinaison
SG11201705606PA (en) 2015-01-30 2017-08-30 Evolva Sa Production of steviol glycosides in recombinant hosts
CN104845990A (zh) 2015-06-11 2015-08-19 山东大学 拟南芥糖基转移酶基因ugt73c7在提高植物抗病性中的应用
CN108271391A (zh) 2015-08-07 2018-07-10 埃沃尔瓦公司 重组宿主中的甜菊醇糖苷的产生

Also Published As

Publication number Publication date
EP2954061B1 (fr) 2023-11-22
SG10201705993YA (en) 2017-08-30
JP2019162110A (ja) 2019-09-26
AU2014213918A1 (en) 2015-08-20
US10017804B2 (en) 2018-07-10
CN105189771A (zh) 2015-12-23
US11021727B2 (en) 2021-06-01
KR20150128705A (ko) 2015-11-18
MY184253A (en) 2021-03-29
JP6576247B2 (ja) 2019-09-18
AU2018200950A1 (en) 2018-03-01
BR112015019160A2 (pt) 2017-08-22
US20150361476A1 (en) 2015-12-17
JP2016506743A (ja) 2016-03-07
EP2954061A1 (fr) 2015-12-16
WO2014122328A8 (fr) 2015-09-17
AU2014213918B2 (en) 2017-11-09
CA2900882A1 (fr) 2014-08-14
MX2015010098A (es) 2016-04-19
WO2014122328A1 (fr) 2014-08-14
US20180371517A1 (en) 2018-12-27
US20220017932A1 (en) 2022-01-20
CN105189771B (zh) 2019-11-05

Similar Documents

Publication Publication Date Title
SG11201506127WA (en) Efficient production of steviol glycosides in recombinant hosts
SG11201705606PA (en) Production of steviol glycosides in recombinant hosts
SG11201701677UA (en) Production of steviol glycosides in recombinant hosts
SG11201700651RA (en) Production of steviol glycosides in recombinant hosts
HK1259194A1 (zh) 甜菊醇糖苷、其組合物以及其純化
EP3063286A4 (fr) Production par recombinaison de glycosides de stéviol
EP3004127A4 (fr) Glycosides de stéviol de grande pureté
SG10201606565XA (en) Recombinant production of steviol glycosides
EP3019197A4 (fr) Rébaudioside x pour accentuer la sucrosité
EP2852296A4 (fr) Glycosides de stéviol d'une grande pureté
EP3030302A4 (fr) Améliorations apportées à un traitement ventilatoire
IL283447A (en) Production of recombinant lubricin
AU353315S (en) Lounge setting
EP2983569A4 (fr) Améliorations apportées à un moulin à café
EP2967479A4 (fr) Biopsie guidée par tomosynthèse dans une position couchée
BR112016006155A2 (pt) glicosídeo de esteviol glicosilado como um modificador de sabor
SG11201505879YA (en) Alkyl glycosides as surfactants
EP3082461A4 (fr) Glycoside de stéviol stabilisé dans un sirop concentré
EP2996486A4 (fr) Composition de stévia
EP2983717A4 (fr) Composition nutraceutique topique
GB201314415D0 (en) Flight mill
GB201300324D0 (en) Improvements to letter-plates
GB201322720D0 (en) Insulative panel
GB201319223D0 (en) Improvement in or relating to bras
GB201319102D0 (en) Improvements relating to auction mechanisms