SG11201705606PA - Production of steviol glycosides in recombinant hosts - Google Patents

Production of steviol glycosides in recombinant hosts

Info

Publication number
SG11201705606PA
SG11201705606PA SG11201705606PA SG11201705606PA SG11201705606PA SG 11201705606P A SG11201705606P A SG 11201705606PA SG 11201705606P A SG11201705606P A SG 11201705606PA SG 11201705606P A SG11201705606P A SG 11201705606PA SG 11201705606P A SG11201705606P A SG 11201705606PA
Authority
SG
Singapore
Prior art keywords
production
steviol glycosides
recombinant hosts
hosts
recombinant
Prior art date
Application number
SG11201705606PA
Inventor
Kim Olsson
Ernesto Simon
Mikkelsen Michael Dalgaard
Simon Carlsen
Veronique Douchin
Swee Chuang Lim
Louis During
Original Assignee
Evolva Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evolva Sa filed Critical Evolva Sa
Publication of SG11201705606PA publication Critical patent/SG11201705606PA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/256—Polyterpene radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P15/00—Preparation of compounds containing at least three condensed carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
SG11201705606PA 2015-01-30 2016-01-29 Production of steviol glycosides in recombinant hosts SG11201705606PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562110207P 2015-01-30 2015-01-30
PCT/EP2016/052007 WO2016120486A1 (en) 2015-01-30 2016-01-29 Production of steviol glycosides in recombinant hosts

Publications (1)

Publication Number Publication Date
SG11201705606PA true SG11201705606PA (en) 2017-08-30

Family

ID=55398256

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201705606PA SG11201705606PA (en) 2015-01-30 2016-01-29 Production of steviol glycosides in recombinant hosts

Country Status (9)

Country Link
US (4) US10364450B2 (en)
EP (2) EP4148137A1 (en)
JP (1) JP2018503388A (en)
CN (1) CN108337892B (en)
AU (2) AU2016211124B2 (en)
BR (1) BR112017016338A2 (en)
CA (1) CA2973674A1 (en)
SG (1) SG11201705606PA (en)
WO (1) WO2016120486A1 (en)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011261394C1 (en) 2010-06-02 2016-10-27 Evolva, Inc. Recombinant production of steviol glycosides
MY173212A (en) 2011-08-08 2020-01-06 Evolva Sa Recombinant production of steviol glycosides
KR20150128705A (en) 2013-02-11 2015-11-18 에볼바 에스아 Efficient production of stevio glycosides in recombinant hosts
CA2960693A1 (en) 2014-09-09 2016-03-17 Evolva Sa Production of steviol glycosides in recombinant hosts
CA2970787C (en) 2014-12-17 2022-05-03 Cargill, Incorporated Steviol glycoside compounds, compositions for oral ingestion or use, and method for enhancing steviol glycoside solubility
EP4148137A1 (en) 2015-01-30 2023-03-15 Evolva SA Production of steviol glycosides in recombinant hosts
EP3862426A3 (en) 2015-03-16 2021-11-17 DSM IP Assets B.V. Udp-glycosyltransferases
WO2016156616A1 (en) 2015-04-03 2016-10-06 Dsm Ip Assets B.V. Steviol glycosides
MX2018001620A (en) 2015-08-07 2018-06-11 Evolva Sa Production of steviol glycosides in recombinant hosts.
JP6998884B2 (en) * 2015-11-30 2022-01-18 カーギル インコーポレイテッド Steviol glycoside composition for ingestion or oral use
EP3426791A1 (en) * 2016-03-11 2019-01-16 Evolva SA Production of steviol glycosides in recombinant hosts
AU2017251462B2 (en) 2016-04-13 2022-02-03 Evolva Sa Production of steviol glycosides in recombinant hosts
CN109312378A (en) * 2016-05-16 2019-02-05 埃沃尔瓦公司 Steviol glycoside is generated in the recombination host
WO2017218036A1 (en) * 2016-06-17 2017-12-21 Cargill, Incorporated Steviol glycoside compositions for oral ingestion or use
US20190320699A1 (en) * 2016-06-17 2019-10-24 Cargill, Incorporated Steviol glycoside compositions for oral ingestion or use
PT3497222T (en) 2016-08-12 2022-02-09 Amyris Inc Udp-dependent glycosyltransferase for high efficiency production of rebaudiosides
CN109890221B (en) * 2016-10-04 2023-04-14 可口可乐公司 Diterpene glycosides containing an ent-acteosene core, compositions, and methods
BR112019007504B1 (en) * 2016-10-14 2023-05-09 Conagen Inc METHOD OF PREPARATION OF A STEVIOL GLYCOSIDE COMPOSITION
CA3041123A1 (en) * 2016-10-20 2018-04-26 The Coca-Cola Company Diterpene glycosides isolated from stevia, compositions and methods
WO2018072213A1 (en) 2016-10-21 2018-04-26 苏州汉酶生物技术有限公司 Method for preparing rebaudioside n using enzymatic method
WO2018083338A1 (en) 2016-11-07 2018-05-11 Evolva Sa Production of steviol glycosides in recombinant hosts
CA3050310A1 (en) 2017-02-03 2018-08-09 Codexis, Inc. Engineered glycosyltransferases and steviol glycoside glucosylation methods
AU2018294258A1 (en) 2017-06-30 2020-02-06 Conagen Inc. Hydrolysis of steviol glycosides by beta-glucosidase
WO2019055325A2 (en) 2017-09-12 2019-03-21 Biocapital Holdings, Llc Biological devices and methods for using the same to produce steviol glycosides
JP2021518369A (en) * 2018-03-16 2021-08-02 ピュアサークル ユーエスエー インコーポレイテッド High-purity steviol glycoside
CN112367854A (en) * 2018-06-08 2021-02-12 谱赛科美国股份有限公司 High purity steviol glycosides
KR20210076915A (en) * 2018-10-15 2021-06-24 아미리스 인코퍼레이티드 Stevia rebaudiana kaurenoic acid hydroxylase variant for high-efficiency production of rebaudioside
EP3887383A4 (en) * 2018-11-27 2022-11-09 PureCircle USA Inc. High-purity steviol glycosides
JP7449586B2 (en) 2018-12-12 2024-03-14 コナゲン インコーポレイテッド Biosynthetic production of mutant steviol glycosides
US20220380824A1 (en) * 2019-02-15 2022-12-01 Purecircle Usa Inc. High-purity steviol glycosides
CA3131818A1 (en) * 2019-03-29 2020-10-08 Guohong MAO Biosynthetic production of udp-rhamnose
MX2021013124A (en) * 2019-05-03 2022-01-24 Amyris Inc Kaurenoic acid 13-hydroxylase (kah) variants and uses thereof.
CN112080480B (en) * 2019-06-14 2023-01-03 中国科学院分子植物科学卓越创新中心 Glycosyltransferase mutants and uses thereof
CN110305855B (en) * 2019-06-26 2022-03-22 昆明理工大学 Gastrodia elata GeCPR gene and application thereof
PE20230409A1 (en) * 2019-12-31 2023-03-07 Air Protein Inc FOOD COMPOSITIONS WITH HIGH PROTEIN CONTENT
CN113444131B (en) * 2021-06-24 2022-10-21 鲁东大学 N-acetylglucosamine compounds, and preparation method and application thereof

Family Cites Families (149)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58149697A (en) 1982-02-27 1983-09-06 Dainippon Ink & Chem Inc Preparation of beta-1,3-glycosyl stevioside
JPS59101408A (en) 1982-12-02 1984-06-12 Junichi Iwamura Plant growth regulator
US5198360A (en) 1990-01-19 1993-03-30 Eli Lilly And Company Dna sequence conferring a plaque inhibition phenotype
US5484956A (en) 1990-01-22 1996-01-16 Dekalb Genetics Corporation Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin
US6946587B1 (en) 1990-01-22 2005-09-20 Dekalb Genetics Corporation Method for preparing fertile transgenic corn plants
JPH03277275A (en) 1990-03-28 1991-12-09 Dainippon Ink & Chem Inc Novel enzyme and method for preparing glycoside with same enzyme
US5204253A (en) 1990-05-29 1993-04-20 E. I. Du Pont De Nemours And Company Method and apparatus for introducing biological substances into living cells
US5306862A (en) 1990-10-12 1994-04-26 Amoco Corporation Method and composition for increasing sterol accumulation in higher plants
US5460949A (en) 1990-11-15 1995-10-24 Amoco Corporation Method and composition for increasing the accumulation of squalene and specific sterols in yeast
US5712112A (en) 1992-11-04 1998-01-27 National Science Council Of R.O.C. Gene expression system comprising the promoter region of the alpha-amylase genes
JPH09503905A (en) 1993-07-15 1997-04-22 ネオゼ ファーマシューティカルス Method for synthesizing sugar composition
US7186891B1 (en) 1996-04-12 2007-03-06 University Of Kentucky, Research Foundation Plant cells and plants expressing chimeric isoprenoid synthases
JPH10117776A (en) 1996-10-22 1998-05-12 Japan Tobacco Inc Transformation of indica rice
AU9455398A (en) 1997-10-06 1999-04-27 Centre National De La Recherche Scientifique Plant fatty acid hydroxylase genes
US6255557B1 (en) 1998-03-31 2001-07-03 Her Majesty The Queen In Right Of Canada As Represented By The Ministerof Agriculture And Agri-Food Canada Stevia rebaudiana with altered steviol glycoside composition
EP2175025A1 (en) 1998-04-14 2010-04-14 Kyowa Hakko Bio Co., Ltd. Process for producing isoprenoid compounds by using microorganisms
TWI250210B (en) 1998-05-06 2006-03-01 Dsm Ip Assets Bv An isolated DNA sequence coding for an enzyme involved in the mevalonate pathway or the pathway from isopentenyl pyrophosphate to farnesyl pyrophosphate
EP0955363A3 (en) 1998-05-06 2004-01-28 F. Hoffmann-La Roche Ag Dna sequences encoding enzymes involved in production of isoprenoids
CA2331343C (en) 1998-07-06 2014-01-14 Dcv, Inc., Doing Business As Bio-Technical Resources Production of isoprenoid in recombinant yeast
EP2305825B1 (en) 1998-07-06 2015-01-14 DCV Inc. doing business as Bio-Technical Resourses Method of vitamin production
AR021636A1 (en) 1998-12-17 2002-07-31 Rubicon Forests Holdings Ltd MATERIALS AND METHODS FOR THE MODIFICATION OF CONTENT, COMPOSITION AND METABOLISM OF ISOPRENOIDS
CA2352488A1 (en) 1998-12-23 2000-06-29 The Samuel Roberts Noble Foundation, Inc. Plant transformation process
DE60034224T2 (en) 1999-04-15 2007-12-20 Calgene Llc, Davis NUCLEIC ACID SEQUENCES FOR PROTEINS INVOLVED IN ISOPRENOID SYNTHESIS
WO2000063400A2 (en) 1999-04-21 2000-10-26 The Samuel Roberts Noble Foundation Plant transformation process
ATE373715T1 (en) 1999-08-04 2007-10-15 Adelbert Bacher ISOPRENOID BIOSYNTHESIS
WO2001012828A1 (en) 1999-08-18 2001-02-22 Paradigm Genetics, Inc. Methods and apparatus for transformation of monocotyledenous plants using agrobacterium in combination with vacuum filtration
WO2001083769A2 (en) 2000-05-03 2001-11-08 The Salk Institute For Biological Studies Crystallization of 4-diphosphocytidyl-2-c-methylerythritol synthesis
DE10027821A1 (en) 2000-06-05 2001-12-06 Adelbert Bacher New intermediate in isoprenoid biosynthesis, useful in screening for potential herbicides, comprises mutant encoding-enzymes sequences for imparting herbicide resistance
WO2002010398A2 (en) 2000-07-31 2002-02-07 Hahn Frederick M Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms
AU8681101A (en) 2000-08-24 2002-03-04 Scripps Research Inst Stress-regulated genes of plants, transgenic plants containing same, and methodsof use
US6818424B2 (en) 2000-09-01 2004-11-16 E. I. Du Pont De Nemours And Company Production of cyclic terpenoids
US6660507B2 (en) 2000-09-01 2003-12-09 E. I. Du Pont De Nemours And Company Genes involved in isoprenoid compound production
US6689601B2 (en) 2000-09-01 2004-02-10 E. I. Du Pont De Nemours And Company High growth methanotropic bacterial strain
US7229784B2 (en) 2000-09-19 2007-06-12 Microbia, Inc. Modulation of secondary metabolite production by zinc binuclear cluster proteins
ATE384119T1 (en) 2000-09-29 2008-02-15 Cargill Inc ISOPRENOID PRODUCTION
US6949362B2 (en) 2000-12-12 2005-09-27 E. I. Du Pont De Nemours And Company Rhodococcus cloning and expression vectors
ATE501251T1 (en) 2001-01-25 2011-03-15 Evolva Ltd CELL LIBRARY
US20050003474A1 (en) 2001-01-26 2005-01-06 Desouza Mervyn L. Carotenoid biosynthesis
US20040078846A1 (en) 2002-01-25 2004-04-22 Desouza Mervyn L. Carotenoid biosynthesis
DE10201458A1 (en) 2001-04-11 2002-10-17 Adelbert Bacher New proteins involved in isoprenoid biosynthesis, useful in screening for inhibitors, also new intermediates, potential therapeutic agents, nucleic acids and antibodies
US7034140B2 (en) 2001-04-24 2006-04-25 E.I. Du Pont De Nemours And Company Genes involved in isoprenoid compound production
KR100704072B1 (en) 2001-06-06 2007-04-05 디에스엠 아이피 어셋츠 비.브이. Improved isoprenoid production
EP1402042A2 (en) 2001-06-22 2004-03-31 Syngenta Participations AG Abiotic stress responsive polynucleotides and polypeptides
NZ513755A (en) 2001-08-24 2001-09-28 Ann Rachel Holmes Protein expression system in yeast comprising a vector encoding a heterologous membrane protein and its application in screening for drugs
US20040072311A1 (en) 2001-08-28 2004-04-15 Dicosimo Deana J. Production of cyclic terpenoids
US20040010815A1 (en) 2001-09-26 2004-01-15 Lange B. Markus Identification and characterization of plant genes
US7172886B2 (en) 2001-12-06 2007-02-06 The Regents Of The University Of California Biosynthesis of isopentenyl pyrophosphate
WO2004018682A1 (en) 2002-08-20 2004-03-04 Suntory Limited Novel glycosyltransferase genes
WO2004029255A2 (en) 2002-09-27 2004-04-08 Dsm Ip Assets B.V. Squalene synthase 8sqs9 gen
US7098000B2 (en) 2003-06-04 2006-08-29 E. I. Du Pont De Nemoure And Company Method for production of C30-aldehyde carotenoids
CN1806042B (en) 2003-06-12 2012-07-04 帝斯曼知识产权资产管理有限公司 Feedback-resistant mevalonate kinases
US7569389B2 (en) 2004-09-30 2009-08-04 Ceres, Inc. Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics
EP2365090A1 (en) 2004-05-21 2011-09-14 The Regents of The University of California Method for enhancing production of isoprenoid compounds
AU2005321630A1 (en) 2004-07-02 2006-07-06 Metanomics Gmbh Process for the production of fine chemicals
US20060014264A1 (en) 2004-07-13 2006-01-19 Stowers Institute For Medical Research Cre/lox system with lox sites having an extended spacer region
WO2006016395A1 (en) 2004-08-09 2006-02-16 National University Corporation Tohoku University Udp-glucuronyl transferase and gene encoding the same
KR101169824B1 (en) 2004-08-19 2012-07-30 디에스엠 아이피 어셋츠 비.브이. Production of isoprenoids
US7923552B2 (en) 2004-10-18 2011-04-12 SGF Holdings, LLC High yield method of producing pure rebaudioside A
JP4841562B2 (en) 2004-12-14 2011-12-21 ディーエスエム アイピー アセッツ ビー．ブイ． Improved mevalonate kinase
EP1871883A1 (en) 2005-03-02 2008-01-02 Metanomics GmbH Process for the production of fine chemicals
JP4284562B2 (en) 2005-03-04 2009-06-24 独立行政法人産業技術総合研究所 Method for producing UDP-xylose
WO2006096392A2 (en) 2005-03-04 2006-09-14 Diversa Corporation Enzymes involved in astaxanthin, carotenoid and isoprenoid biosynthetic pathways, genes encoding them and methods of making and using them
WO2007022318A2 (en) 2005-08-17 2007-02-22 Cornell Research Foundation Nucleic acids and proteins associated with sucrose accumulation in coffee
US20080216397A1 (en) 2005-08-22 2008-09-11 Co2 Boost Llc Device and Process to Generate Co2 Used for Indoor Crop Production and Underwater Gardening
US8293307B2 (en) 2005-10-11 2012-10-23 Purecircle Sdn Bhd Process for manufacturing a sweetener and use thereof
US9011956B2 (en) 2005-11-23 2015-04-21 The Coca-Cola Company Natural high-potency sweetener compositions with improved temporal profile and/or flavor profile, methods for their formulation, and uses
KR100784261B1 (en) 2006-01-02 2007-12-11 한국과학기술원 Method for Cell Surface Displaying of Target Proteins Using Bacillus anthracis Exosporium
US7927851B2 (en) 2006-03-21 2011-04-19 Vineland Research And Innovation Centre Compositions having ent-kaurenoic acid 13-hydroxylase activity and methods for producing same
WO2008034648A1 (en) 2006-04-05 2008-03-27 Metanomics Gmbh Process for the production of a fine chemical
WO2007136847A2 (en) 2006-05-19 2007-11-29 The Regents Of The University Of California Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels
WO2007147275A1 (en) 2006-06-19 2007-12-27 Givaudan Sa Nucleic acid, polypeptide and its use
WO2008008256A2 (en) 2006-07-07 2008-01-17 The Regents Of The University Of California Methods for enhancing production of isoprenoid compounds by host cells
BRPI0716954A2 (en) 2006-09-26 2013-10-29 Univ California ISOPRENOID PRODUCTION AND ISOPRENOID PRECURSORS
US7741119B2 (en) 2006-09-28 2010-06-22 E. I. Du Pont De Nemours And Company Xylitol synthesis mutant of xylose-utilizing zymomonas for ethanol production
US7629156B2 (en) 2006-09-28 2009-12-08 E.I. Du Pont De Nemours And Company Ethanol production in fermentation of mixed sugars containing xylose
CN101200480B (en) 2006-12-15 2011-03-30 成都华高药业有限公司 Rebaudioside A extraction method
JP4915917B2 (en) 2006-12-22 2012-04-11 独立行政法人農業・食品産業技術総合研究機構 Method for producing lacto-N-biose I and galacto-N-biose
JP5307730B2 (en) 2007-01-22 2013-10-02 カーギル・インコーポレイテッド Process for the preparation of a purified rebaudioside A composition using solvent / antisolvent crystallization
JP2008237110A (en) 2007-03-27 2008-10-09 Institute Of Physical & Chemical Research Steviol synthetic enzyme gene and method for producing steviol
CA2691998A1 (en) 2007-05-17 2008-11-27 Tetravitae Bioscience, Inc. Methods and compositions for producing solvents
US20080292775A1 (en) 2007-05-22 2008-11-27 The Coca-Cola Company Delivery Systems for Natural High-Potency Sweetener Compositions, Methods for Their Formulation, and Uses
WO2009005704A1 (en) 2007-07-03 2009-01-08 The Regents Of The University Of California Methods of increasing isoprenoid or isoprenoid precursor production
JP2009034080A (en) 2007-08-03 2009-02-19 Sanei Gen Ffi Inc New glycosyltransferase and method for producing glycoside by utilizing the same
US7964232B2 (en) 2007-09-17 2011-06-21 Pepsico, Inc. Steviol glycoside isomers
EP2594646A3 (en) 2007-09-21 2013-11-06 BASF Plant Science GmbH Plant with increased yield
KR101574817B1 (en) 2007-12-03 2015-12-04 디에스엠 아이피 어셋츠 비.브이. Novel nutraceutical compositions containing stevia extract or stevia extract constituents and uses thereof
EP2230939B1 (en) 2007-12-27 2020-04-08 Heartland Consumer Products LLC Synergistic sweetening compositions
CN102007214A (en) 2008-02-20 2011-04-06 塞瑞斯公司 Nucleotide sequences and corresponding polypeptides conferring improved nitrogen use efficiency characteristics in plants
TWI475963B (en) 2008-02-25 2015-03-11 Coca Cola Co Rebaudioside a derivative products and methods for making
EP2706111A1 (en) 2008-03-03 2014-03-12 Joule Unlimited Technologies, Inc. Engineered CO2 fixing microorganisms producing carbon-based products of interest
US9005444B2 (en) 2008-05-13 2015-04-14 Cargill, Incorporated Separation of rebaudioside A from stevia glycosides using chromatography
WO2010021001A2 (en) 2008-08-19 2010-02-25 Kaushik Ramakrishnan S Process for preparing sweetener from stevia rebaudiana
PT2350110T (en) 2008-10-03 2016-07-28 Morita Kagaku Kogyo New steviol glycosides
CN101720910B (en) 2008-10-23 2012-07-25 大闽食品（漳州）有限公司 Method for preparing stevioside
US8614085B2 (en) 2009-02-27 2013-12-24 Butamax(Tm) Advanced Biofuels Llc Yeast with increased butanol tolerance involving a multidrug efflux pump gene
US20100297722A1 (en) 2009-05-20 2010-11-25 Board Of Trustees Of Southern Illinois University Transgenic moss producing terpenoids
JP5580408B2 (en) 2009-06-08 2014-08-27 イェンネワイン バイオテクノロジー ゲーエムベーハー Synthesis of human milk oligosaccharides
DK2482676T3 (en) 2009-06-16 2015-01-19 Epc Beijing Natural Products Co Ltd Reduction or elimination of the aftertaste of a sweetener, using rebaudioside D
EP2473064A1 (en) 2009-09-04 2012-07-11 Redpoint Bio Corporation Sweetness enhancers including rebaudioside a or d
BR112012006282A2 (en) 2009-09-22 2015-09-01 Redpoint Bio Corp Crystalline form I of rebaudioside c alone, methods of manufacturing it, for purifying rebaudioside c, for enhancing a sweet taste of a carbohydrate sweetener, for decreasing the amount of a carbohydrate sweetener in a consumable product, and for increasing the sweetness of carbohydrate. a consumable product, and consumable product.
US8299224B2 (en) 2009-10-15 2012-10-30 Purecircle Sdn Bhd High-purity Rebaudioside D
ES2457641T3 (en) 2009-10-15 2014-04-28 Purecircle Sdn Bhd Procedure for preparing rebaudioside D of high purity
US8703224B2 (en) 2009-11-04 2014-04-22 Pepsico, Inc. Method to improve water solubility of Rebaudioside D
BR112012012374A2 (en) 2009-11-23 2015-09-15 Du Pont higher oil plant seed, plant, method for further increasing oil content in a high oil plant seed, method for evaluating the increased oil content in a plant seed, isolated polynucleotide isolated polypeptide
SG181601A1 (en) 2009-12-10 2012-07-30 Univ Minnesota Tal effector-mediated dna modification
CN104855925B (en) 2009-12-28 2017-04-26 可口可乐公司 Sweetness Enhancers, Compositions Thereof, And Methods For Use
KR101244315B1 (en) 2010-10-19 2013-03-14 이화여자대학교 산학협력단 Ethanol―Resistant Yeast Genes and Uses Thereof
WO2011140329A1 (en) 2010-05-06 2011-11-10 Ceres, Inc. Transgenic plants having increased biomass
US9476082B2 (en) 2010-05-20 2016-10-25 Evolva Sa Method of producing isoprenoid compounds in yeast
US9249420B2 (en) 2010-05-31 2016-02-02 Vib Vzw Isobutanol production using yeasts with modified transporter expression
AU2011261394C1 (en) * 2010-06-02 2016-10-27 Evolva, Inc. Recombinant production of steviol glycosides
US20120021111A1 (en) 2010-07-23 2012-01-26 Aexelon Therapeutics, Inc. Natural Low Caloric Sweetener Compositions for Use in Beverages, Foods and Pharmaceuticals, and Their Methods of Manufacture
US20120083593A1 (en) 2010-10-01 2012-04-05 Shanghai Yongyou Bioscience Inc. Separation and Purification of Stevioside and Rebaudioside A
US9284570B2 (en) 2010-11-30 2016-03-15 Massachusetts Institute Of Technology Microbial production of natural sweeteners, diterpenoid steviol glycosides
KR20130014227A (en) 2011-07-29 2013-02-07 한국생명공학연구원 NOVEL α-GLUCOSYL STEVIOSIDES AND PROCESS FOR PRODUCING THE SAME
MY173212A (en) * 2011-08-08 2020-01-06 Evolva Sa Recombinant production of steviol glycosides
EP2742131B1 (en) 2011-08-08 2018-11-28 Evolva SA Methods and materials for recombinant production of saffron compounds
KR101791597B1 (en) 2011-11-23 2017-10-30 에볼바 에스아 Method and materials for enzymatic synthesis of mogroside compounds
CN103159808B (en) 2011-12-09 2017-03-29 上海泓博智源医药股份有限公司 A kind of process for preparing natural sweetener
EP4124245A1 (en) 2011-12-19 2023-02-01 The Coca-Cola Company Beverage comprising rebaudioside x
MX355028B (en) 2012-01-23 2018-03-28 Dsm Ip Assets Bv Diterpene production.
CA2867112C (en) 2012-03-16 2021-04-20 Suntory Holdings Limited Steviol glucosyltransferases and genes encoding the same
EP4012041A1 (en) 2012-05-22 2022-06-15 PureCircle SDN BHD High-purity steviol glycosides
WO2014048392A1 (en) 2012-09-29 2014-04-03 中国科学院上海生命科学研究院 Method for producing stevioside compounds by microorganism
WO2014086890A1 (en) * 2012-12-05 2014-06-12 Evolva Sa Steviol glycoside compositions sensory properties
MX369525B (en) 2013-02-06 2019-11-11 Evolva Sa Methods for improved production of rebaudioside d and rebaudioside m.
KR20150128705A (en) * 2013-02-11 2015-11-18 에볼바 에스아 Efficient production of stevio glycosides in recombinant hosts
MX2015016379A (en) 2013-05-31 2016-04-13 Dsm Ip Assets Bv Extracellular diterpene production.
AU2014273055A1 (en) 2013-05-31 2015-12-17 Dsm Ip Assets B.V. Microorganisms for diterpene production
KR101559478B1 (en) 2013-06-24 2015-10-13 한국생명공학연구원 Method for Preparing Natural High Intensity Sweetener Rebaudiside A by Using Enzymatic Conversion
CA2914900A1 (en) 2013-07-15 2015-01-22 Dsm Ip Assets B.V. Recombinant microorganism and process for the production of steviol glycosides
EP3024941B1 (en) 2013-07-23 2019-07-03 DSM IP Assets B.V. Diterpene production in yarrowia
DK3027632T3 (en) 2013-07-31 2019-06-17 Dsm Ip Assets Bv RECYCLING STEVIOL GLYCOSIDES FROM A FERMENTATION MEDIUM
CN105658081A (en) 2013-07-31 2016-06-08 帝斯曼知识产权资产管理有限公司 Steviol glycosides
JPWO2015016393A1 (en) 2013-08-02 2017-03-02 サントリーホールディングス株式会社 How to use hexenol glucosylase
CN103397064B (en) 2013-08-14 2015-04-15 苏州汉酶生物技术有限公司 Method for preparing rebaudioside M through enzyme method
EP3039132A2 (en) 2013-08-30 2016-07-06 Evolva SA A method for producing modified resveratrol
WO2015051454A1 (en) 2013-10-07 2015-04-16 Vineland Research And Innovation Centre Compositions and methods for producing steviol and steviol glycosides
WO2015132411A2 (en) 2014-03-07 2015-09-11 Evolva Sa Methods for recombinant production of saffron compounds
US10421983B2 (en) 2014-08-11 2019-09-24 Evolva Sa Production of steviol glycosides in recombinant hosts
CA2960693A1 (en) 2014-09-09 2016-03-17 Evolva Sa Production of steviol glycosides in recombinant hosts
JP6854238B2 (en) * 2014-10-03 2021-04-14 コナゲン インコーポレイテッド Non-caloric sweeteners and methods for synthesis
CA2970787C (en) * 2014-12-17 2022-05-03 Cargill, Incorporated Steviol glycoside compounds, compositions for oral ingestion or use, and method for enhancing steviol glycoside solubility
EP4148137A1 (en) * 2015-01-30 2023-03-15 Evolva SA Production of steviol glycosides in recombinant hosts
EP3862426A3 (en) 2015-03-16 2021-11-17 DSM IP Assets B.V. Udp-glycosyltransferases
WO2016156616A1 (en) * 2015-04-03 2016-10-06 Dsm Ip Assets B.V. Steviol glycosides
CN104845990A (en) 2015-06-11 2015-08-19 山东大学 Application of Arabidopsis glycosyltransferase gene UGT73C7 in improving plant disease resistance
MX2018001620A (en) 2015-08-07 2018-06-11 Evolva Sa Production of steviol glycosides in recombinant hosts.
JP6998884B2 (en) * 2015-11-30 2022-01-18 カーギル インコーポレイテッド Steviol glycoside composition for ingestion or oral use

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