MX369525B - Métodos para mejorar la produccion de rebaudiosido d y rebaudiosido m. - Google Patents

Métodos para mejorar la produccion de rebaudiosido d y rebaudiosido m.

Info

Publication number
MX369525B
MX369525B MX2015010043A MX2015010043A MX369525B MX 369525 B MX369525 B MX 369525B MX 2015010043 A MX2015010043 A MX 2015010043A MX 2015010043 A MX2015010043 A MX 2015010043A MX 369525 B MX369525 B MX 369525B
Authority
MX
Mexico
Prior art keywords
rebaudioside
methods
improved production
compositions containing
recombinant production
Prior art date
Application number
MX2015010043A
Other languages
English (en)
Other versions
MX2015010043A (es
Inventor
Carlsen Simon
Dalgaard Mikkelsen Michael
Hansen Jorgen
Simon Ernesto
Brianza Federico
Semmler Angelika
Olsson Kim
Düring Louis
Ouspenski Alexei
Hicks Paula
Original Assignee
Evolva Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50064631&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX369525(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Evolva Sa filed Critical Evolva Sa
Publication of MX2015010043A publication Critical patent/MX2015010043A/es
Publication of MX369525B publication Critical patent/MX369525B/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/44Preparation of O-glycosides, e.g. glucosides
    • C12P19/56Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52Adding ingredients
    • A23L2/60Sweeteners
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30Artificial sweetening agents
    • A23L27/33Artificial sweetening agents containing sugars or derivatives
    • A23L27/36Terpene glycosides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0071Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1051Hexosyltransferases (2.4.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1081Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1085Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90Isomerases (5.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y204/00Glycosyltransferases (2.4)
    • C12Y204/01Hexosyltransferases (2.4.1)
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y204/00Glycosyltransferases (2.4)
    • C12Y204/99Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Seasonings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Non-Alcoholic Beverages (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención se refiere a métodos para la producción recombinante de glicósido de esteviol y composiciones que contienen glicósidos de esteviol.
MX2015010043A 2013-02-06 2014-02-06 Métodos para mejorar la produccion de rebaudiosido d y rebaudiosido m. MX369525B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361761490P 2013-02-06 2013-02-06
US201361886442P 2013-10-03 2013-10-03
PCT/EP2014/052363 WO2014122227A2 (en) 2013-02-06 2014-02-06 Methods for improved production of rebaudioside d and rebaudioside m

Publications (2)

Publication Number Publication Date
MX2015010043A MX2015010043A (es) 2016-03-04
MX369525B true MX369525B (es) 2019-11-11

Family

ID=50064631

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015010043A MX369525B (es) 2013-02-06 2014-02-06 Métodos para mejorar la produccion de rebaudiosido d y rebaudiosido m.

Country Status (11)

Country Link
US (4) US9957540B2 (es)
EP (2) EP3892728A1 (es)
JP (4) JP6379112B2 (es)
KR (1) KR20150115002A (es)
CN (2) CN105051195B (es)
AU (4) AU2014214004B2 (es)
CA (2) CA2899276C (es)
MX (1) MX369525B (es)
MY (1) MY190346A (es)
SG (2) SG11201505597SA (es)
WO (1) WO2014122227A2 (es)

Families Citing this family (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9107436B2 (en) 2011-02-17 2015-08-18 Purecircle Sdn Bhd Glucosylated steviol glycoside as a flavor modifier
US10696706B2 (en) 2010-03-12 2020-06-30 Purecircle Usa Inc. Methods of preparing steviol glycosides and uses of the same
US11155888B2 (en) 2010-03-12 2021-10-26 Purecircle Usa Inc. Stevia composition, production method and uses
MY167872A (en) 2010-06-02 2018-09-26 Evolva Inc Recombinant production of steviol glycosides
US11690391B2 (en) 2011-02-17 2023-07-04 Purecircle Sdn Bhd Glucosylated steviol glycoside as a flavor modifier
US9771434B2 (en) 2011-06-23 2017-09-26 Purecircle Sdn Bhd Products from stevia rebaudiana
WO2013022989A2 (en) 2011-08-08 2013-02-14 Evolva Sa Recombinant production of steviol glycosides
CA2867112C (en) 2012-03-16 2021-04-20 Suntory Holdings Limited Steviol glucosyltransferases and genes encoding the same
ES2820518T3 (es) 2012-03-27 2021-04-21 Suntory Holdings Ltd Método para producir glucósido de esteviol
US9752174B2 (en) 2013-05-28 2017-09-05 Purecircle Sdn Bhd High-purity steviol glycosides
WO2013176738A1 (en) 2012-05-22 2013-11-28 Purecircle Sdn Bhd High-purity steviol glycosides
TW201402599A (zh) 2012-05-30 2014-01-16 Suntory Holdings Ltd 甜菊糖苷糖苷轉化酵素及編碼該酵素之基因
CN105051195B (zh) * 2013-02-06 2019-09-06 埃沃尔瓦公司 用于提高莱鲍迪苷d和莱鲍迪苷m之产生的方法
AU2014213918B2 (en) 2013-02-11 2017-11-09 Danstar Ferment Ag Efficient production of steviol glycosides in recombinant hosts
EP3004366B1 (en) * 2013-05-31 2019-02-27 DSM IP Assets B.V. Microorganisms for diterpene production
US10952458B2 (en) 2013-06-07 2021-03-23 Purecircle Usa Inc Stevia extract containing selected steviol glycosides as flavor, salty and sweetness profile modifier
MX2015016791A (es) 2013-06-07 2016-09-09 Purecircle Usa Inc Extracto de estevia que contiene glicosidos de esteviol seleccionados como modificador del perfil de sabor, salado y de dulzura.
WO2015007748A1 (en) * 2013-07-15 2015-01-22 Dsm Ip Assets B.V. Diterpene production
DK3027632T3 (da) 2013-07-31 2019-06-17 Dsm Ip Assets Bv Indvinding af steviolglycosider fra et fermenteringsmedium
CN103397064B (zh) 2013-08-14 2015-04-15 苏州汉酶生物技术有限公司 一种酶法制备瑞鲍迪甙m的方法
US9522929B2 (en) 2014-05-05 2016-12-20 Conagen Inc. Non-caloric sweetener
SG10201901007PA (en) 2014-08-11 2019-03-28 Evolva Sa Production of steviol glycosides in recombinant hosts
CN106795523B (zh) * 2014-08-19 2021-11-26 谱赛科有限责任公司 制备莱鲍迪苷i的方法以及用途
BR112017004238A2 (pt) 2014-09-02 2017-12-12 Purecircle Usa Inc extratos de estévia enriquecidos em rebaudiosídeo d, e, n e/ou o e processo para a preparação dos mesmos
EP3190905A2 (en) * 2014-09-09 2017-07-19 Evolva SA Production of steviol glycosides in recombinant hosts
EP4166010A1 (en) * 2014-09-19 2023-04-19 PureCircle SDN BHD High-purity steviol glycosides
HUE045992T2 (hu) * 2014-10-03 2020-01-28 Conagen Inc Kalóriamentes édesítõszerek és szintézismódszereik
JP6946183B2 (ja) * 2014-11-05 2021-10-06 マナス バイオシンセシス インコーポレイテッド ステビオール配糖体の微生物による生成
BR112017013051B1 (pt) 2014-12-17 2022-10-04 Cargill, Incorporated Composto, composição, método para fornecer ou melhorar a doçura a uma composição e método para melhorar a solubilidade de um glicosídeo de esteviol
EP3250686A1 (en) * 2015-01-30 2017-12-06 Evolva SA Production of steviol glycosides in recombinant hosts
MX2017010311A (es) 2015-02-10 2017-12-14 Purecircle Usa Inc Metodos de produccion y recuperacion de rebaudiosido m biosintetico.
EP3268487A1 (en) 2015-03-10 2018-01-17 Rijksuniversiteit Groningen Methods for the enzymatic modification of steviol glycosides, modified steviol glycosides obtainable thereby, and the use thereof as sweeteners
WO2016146711A1 (en) * 2015-03-16 2016-09-22 Dsm Ip Assets B.V. Udp-glycosyltransferases
BR112017021066B1 (pt) 2015-04-03 2022-02-08 Dsm Ip Assets B.V. Glicosídeos de esteviol, método para a produção de um glicosídeo de esteviol, composição, usos relacionados, gênero alimentício, alimento para animais e bebida
CN107548417B (zh) 2015-04-14 2021-11-09 康纳根有限公司 使用工程化全细胞催化剂生产无热量甜味剂
EP3286303A1 (en) * 2015-04-21 2018-02-28 DSM IP Assets B.V. Microbial production of terpenoids
CN107613785A (zh) * 2015-05-20 2018-01-19 嘉吉公司 糖苷组合物
US11225678B2 (en) 2015-05-29 2022-01-18 Cargill, Incorporated Fermentation methods for producing steviol glycosides with multi-phase feeding
BR112017025614A2 (pt) 2015-05-29 2018-09-11 Cargill, Incorporated método para produzir glicosídeo de esteviol e composição
CA2987587C (en) 2015-05-29 2022-05-03 Cargill, Incorporated Heat treatment to produce glycosides
US10844414B2 (en) 2015-08-06 2020-11-24 Cargill, Incorporated Methods for producing steviol glycosides in engineered yeast
MX2018001620A (es) * 2015-08-07 2018-06-11 Evolva Sa Produccion de glucosidos de esteviol en hospedadores recombinantes.
WO2017031424A1 (en) * 2015-08-20 2017-02-23 Pepsico, Inc. Preparation of rebaudioside m in a single reaction vessel
JP2018528977A (ja) * 2015-09-22 2018-10-04 バイタリティ バイオファーマ インコーポレイテッドVitality Biopharma, Inc. カンナビノイドグリコシドプロドラッグおよび合成の方法
EP4043558A3 (en) 2015-10-05 2022-11-16 DSM IP Assets B.V. Kaurenoic acid hydroxylases
PL3367816T3 (pl) * 2015-10-26 2024-05-06 Purecircle Usa Inc. Kompozycje glikozydów stewiolowych
CN108884484A (zh) * 2015-11-30 2018-11-23 谱赛科有限责任公司 用于制备高纯度甜菊醇糖苷的方法
MY190650A (en) * 2015-11-30 2022-04-30 Cargill Inc Steviol glycoside compositions for oral ingestion or use
EP3387136B1 (en) * 2015-12-10 2022-01-05 Evolva SA Production of steviol glycosides in recombinant hosts
WO2017106577A1 (en) 2015-12-15 2017-06-22 Purecircle Usa Inc. Steviol glycoside compositions
US20190048356A1 (en) * 2016-03-11 2019-02-14 Evolva Sa Production of steviol glycosides in recombinant hosts
MY198001A (en) * 2016-04-13 2023-07-25 Evolva Sa Production of steviol glycoside in recombinant hosts
US10815514B2 (en) 2016-05-16 2020-10-27 Evolva Sa Production of steviol glycosides in recombinant hosts
SG11201809483UA (en) * 2016-05-16 2018-11-29 Evolva Sa Production of steviol glycosides in recombinant hosts
WO2017218325A1 (en) 2016-06-15 2017-12-21 Codexis, Inc. Engineered beta-glucosidases and glucosylation methods
CA3027730A1 (en) * 2016-06-17 2017-12-21 Cargill, Incorporated Steviol glycoside compositions for oral ingestion or use
US20190343159A1 (en) * 2016-06-17 2019-11-14 Cargill, Incorporated Steviol glycoside compositions for oral ingestion or use
JP7404068B2 (ja) * 2016-08-12 2023-12-25 アミリス, インコーポレイテッド レバウジオシドの高効率の産生のためのudp依存性グリコシルトランスフェラーゼ
HUE064754T2 (hu) * 2016-10-14 2024-04-28 Conagen Inc Szteviol-glikozidok bioszintetikus elõállítása és az ehhez szükséges eljárások
CA3041147A1 (en) 2016-10-21 2018-04-26 Pepsico, Inc. Method for preparing rebaudioside j using enzymatic method
WO2018072203A1 (zh) 2016-10-21 2018-04-26 苏州汉酶生物技术有限公司 一种酶法制备瑞鲍迪甙c的方法
WO2018072213A1 (zh) 2016-10-21 2018-04-26 苏州汉酶生物技术有限公司 一种酶法制备瑞鲍迪甙n的方法
WO2018078014A1 (en) * 2016-10-27 2018-05-03 Dsm Ip Assets B.V. Geranylgeranyl pyrophosphate synthases
WO2018083338A1 (en) 2016-11-07 2018-05-11 Evolva Sa Production of steviol glycosides in recombinant hosts
CN106834389B (zh) * 2016-12-13 2020-03-17 南京工业大学 一种重组菌催化莱鲍迪甙a制备莱鲍迪甙m2的方法
WO2018124141A1 (ja) * 2016-12-27 2018-07-05 サントリーホールディングス株式会社 ステビオール配糖体ヘキソース転移酵素およびそれをコードする遺伝子
TW202237834A (zh) 2017-02-03 2022-10-01 美商克迪科思股份有限公司 經工程處理之醣基轉移酶及甜菊糖之葡萄糖苷化方法
AU2018225152A1 (en) 2017-02-24 2019-09-19 Corn Products Development, Inc. Use of steviol glycoside in malting
WO2018165330A1 (en) * 2017-03-08 2018-09-13 Purecircle Usa Inc. High rebaudioside m stevia plant cultivars and methods of producing the same
EP3634390B1 (en) 2017-05-09 2023-09-27 Graphium Biosciences, Inc. Antimicrobial compositions comprising cbd or thc against c. difficile infection or e. faecalis
WO2018211032A1 (en) 2017-05-17 2018-11-22 Evolva Sa Production of steviol glycosides in recombinant hosts
JP7116751B2 (ja) 2017-06-30 2022-08-10 コナゲン インコーポレイテッド β-グルコシダーゼによるステビオール配糖体の加水分解
CN107287264B (zh) * 2017-07-11 2020-09-04 山东大学 糖基转移酶ugt71c3在催化合成水杨酸甲酯糖苷中的应用
WO2019055325A2 (en) 2017-09-12 2019-03-21 Biocapital Holdings, Llc BIOOGICAL DEVICES AND METHODS OF USING THE SAME TO PRODUCE STEVIOL GLYCOSIDES
US20200291442A1 (en) 2017-12-05 2020-09-17 Evolva Sa Production of steviol glycosides in recombinant hosts
JP6981267B2 (ja) 2018-01-17 2021-12-15 東京エレクトロン株式会社 エッチング方法及びエッチング装置
EP3765627A4 (en) 2018-03-12 2021-10-13 Conagen Inc. BIOSYNTHETIC PRODUCTION OF STEVIOL GLYCOSIDES REBAUDIOSIDE J AND REBAUDIOSIDE N
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
US11274328B2 (en) * 2018-09-29 2022-03-15 Sichuan Ingia Biosynthetic Co., Ltd. Methods for producing rebaudioside D and rebaudioside M and compositions thereof
CN109234341A (zh) * 2018-09-29 2019-01-18 四川盈嘉合生科技有限公司 全细胞催化合成甜味剂组合物的方法
WO2020062437A1 (zh) * 2018-09-29 2020-04-02 四川盈嘉合生科技有限公司 复合甜味剂及其生产方法
CN109393426A (zh) * 2018-09-29 2019-03-01 四川盈嘉合生科技有限公司 一种复合甜味剂
CA3122403A1 (en) * 2018-12-12 2020-06-18 Conagen Inc. Biosynthetic production of variant steviol glycosides
CN109750071A (zh) * 2019-01-31 2019-05-14 南京工业大学 一种生物催化合成莱鲍迪苷m的方法
CN112080480B (zh) * 2019-06-14 2023-01-03 中国科学院分子植物科学卓越创新中心 糖基转移酶突变体及其应用
BR112021026306A2 (pt) * 2019-06-25 2022-09-06 Manus Bio Inc Enzima de glicosiltransferase dependente de uridina difosfato
CN110684813A (zh) * 2019-09-18 2020-01-14 江苏施宇甜生物科技有限公司 在重组宿主中生产甜菊醇糖苷的方法
CN112553175B (zh) * 2019-09-26 2023-04-07 中国科学院分子植物科学卓越创新中心 糖基转移酶ugt76g1突变体的制备及其应用
CN110734944B (zh) * 2019-11-11 2023-02-21 中化健康产业发展有限公司 一步法合成莱鲍迪苷m的方法
CN110872586B (zh) * 2019-11-11 2024-01-30 天津大学 固定化葡萄糖基转移酶及制备方法及催化生产莱鲍迪苷d的方法
CN111187316B (zh) * 2020-02-14 2021-06-15 南京全凯生物基材料研究院有限公司 一种从甜菊糖母液中提取莱包迪苷d和莱包迪苷m的方法
WO2023006179A1 (en) 2020-07-27 2023-02-02 Dsm Ip Assets B.V. Method to produce retinyl acetate
US10894812B1 (en) 2020-09-30 2021-01-19 Alpine Roads, Inc. Recombinant milk proteins
US10947552B1 (en) 2020-09-30 2021-03-16 Alpine Roads, Inc. Recombinant fusion proteins for producing milk proteins in plants
WO2022072718A1 (en) 2020-09-30 2022-04-07 Nobell Foods, Inc. Recombinant milk proteins and food compositions comprising the same
AU2021367159A1 (en) 2020-10-22 2023-05-04 Cargill, Incorporated Microorganisms for diterpene production
CN112852653A (zh) * 2021-01-26 2021-05-28 江南大学 从头合成莱鲍迪苷m的酿酒酵母工程菌及其应用
US11299700B1 (en) 2021-02-19 2022-04-12 Acequia Biotechnology, Llc Bioreactor containers and methods of growing hairy roots using the same
MX2023010079A (es) 2021-03-01 2023-11-03 Cargill Inc Glicósidos de esteviol xilosilados y métodos enzimáticos para su producción.
WO2023006851A1 (en) 2021-07-27 2023-02-02 Dsm Ip Assets B.V. Fermentative production of retinyl acetate in the presence of ethanol
CN113462670B (zh) * 2021-08-23 2023-03-24 兴化格林生物制品有限公司 一种糖基转移酶突变体及其催化合成莱鲍迪苷m的方法
WO2023044368A1 (en) * 2021-09-17 2023-03-23 Doublerainbow Biosciences Inc. Method for producing glycosylated therapeutics by using an immobilized enzyme preparation
WO2023044365A1 (en) * 2021-09-17 2023-03-23 Doublerainbow Biosciences Inc. Use of cyclodextrin to enhance solubility of substrates and increase enzymatic glycosylation reaction efficiency
CN114045273B (zh) * 2021-11-15 2022-07-22 四川大学 糖基转移酶OsUGT91C1突变体及其应用
WO2024010442A1 (en) 2022-07-07 2024-01-11 Purecircle Sdn Bhd High-purity steviol glycosides
WO2024121721A1 (en) * 2022-12-05 2024-06-13 Tate & Lyle Solutions Usa Llc Methods for obtaining steviol glycosides

Family Cites Families (133)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58149697A (ja) 1982-02-27 1983-09-06 Dainippon Ink & Chem Inc β−1,3グリコシルステビオシドの製造方法
US5484956A (en) 1990-01-22 1996-01-16 Dekalb Genetics Corporation Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin
US6946587B1 (en) 1990-01-22 2005-09-20 Dekalb Genetics Corporation Method for preparing fertile transgenic corn plants
JPH03277275A (ja) 1990-03-28 1991-12-09 Dainippon Ink & Chem Inc 新規酵素及びその酵素を用いた配糖体の製造方法
US5204253A (en) 1990-05-29 1993-04-20 E. I. Du Pont De Nemours And Company Method and apparatus for introducing biological substances into living cells
US5306862A (en) 1990-10-12 1994-04-26 Amoco Corporation Method and composition for increasing sterol accumulation in higher plants
US5460949A (en) 1990-11-15 1995-10-24 Amoco Corporation Method and composition for increasing the accumulation of squalene and specific sterols in yeast
US5712112A (en) 1992-11-04 1998-01-27 National Science Council Of R.O.C. Gene expression system comprising the promoter region of the alpha-amylase genes
CN1129953A (zh) 1993-07-15 1996-08-28 尼奥斯药品公司 糖组分的合成方法
US7186891B1 (en) 1996-04-12 2007-03-06 University Of Kentucky, Research Foundation Plant cells and plants expressing chimeric isoprenoid synthases
JPH10117776A (ja) 1996-10-22 1998-05-12 Japan Tobacco Inc インディカイネの形質転換方法
AU9455398A (en) 1997-10-06 1999-04-27 Centre National De La Recherche Scientifique Plant fatty acid hydroxylase genes
US6255557B1 (en) 1998-03-31 2001-07-03 Her Majesty The Queen In Right Of Canada As Represented By The Ministerof Agriculture And Agri-Food Canada Stevia rebaudiana with altered steviol glycoside composition
EP2175025A1 (en) 1998-04-14 2010-04-14 Kyowa Hakko Bio Co., Ltd. Process for producing isoprenoid compounds by using microorganisms
EP0955363A3 (en) 1998-05-06 2004-01-28 F. Hoffmann-La Roche Ag Dna sequences encoding enzymes involved in production of isoprenoids
TWI250210B (en) 1998-05-06 2006-03-01 Dsm Ip Assets Bv An isolated DNA sequence coding for an enzyme involved in the mevalonate pathway or the pathway from isopentenyl pyrophosphate to farnesyl pyrophosphate
ES2379212T3 (es) 1998-07-06 2012-04-23 Dcv Inc. Doing Business As Bio-Technical Resourses Procedimiento de producción de vitaminas
EP2305825B1 (en) 1998-07-06 2015-01-14 DCV Inc. doing business as Bio-Technical Resourses Method of vitamin production
AR021636A1 (es) 1998-12-17 2002-07-31 Rubicon Forests Holdings Ltd Materiales y metodos para la modificacion del contenido, la composicion y el metabolismo de los isoprenoides
EP1141356A2 (en) 1998-12-23 2001-10-10 The Samuel Roberts Noble Foundation, Inc. Plant transformation process
ATE316578T1 (de) 1999-04-15 2006-02-15 Calgene Llc Nukleinsäuresequenzen für proteine, die an der tocopherolbiosynthese beteiligt sind
AU4365200A (en) 1999-04-21 2000-11-02 Samuel Roberts Noble Foundation, Inc., The Plant transformation process
EP1198575B1 (en) 1999-08-04 2007-09-19 Adelbert Bacher Isoprenoid biosynthesis
AU6780700A (en) 1999-08-18 2001-03-13 Paradigm Genetics, Inc. Methods and apparatus for transformation of monocotyledenous plants using agrobacterium in combination with vacuum filtration
AU2001269685A1 (en) 2000-05-03 2001-11-12 The Salk Institute For Biological Studies Crystallization of 4-diphosphocytidyl-2-c-methylerythritol synthesis
DE10027821A1 (de) 2000-06-05 2001-12-06 Adelbert Bacher Der Mevalonat-unabhängige Isoprenoidbiosyntheseweg
US20030033626A1 (en) 2000-07-31 2003-02-13 Hahn Frederick M. Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms
CA2420555C (en) 2000-08-24 2012-10-23 Jeffrey F. Harper Stress-regulated genes of plants, transgenic plants containing same, and methods of use
US6818424B2 (en) 2000-09-01 2004-11-16 E. I. Du Pont De Nemours And Company Production of cyclic terpenoids
US6689601B2 (en) 2000-09-01 2004-02-10 E. I. Du Pont De Nemours And Company High growth methanotropic bacterial strain
US6660507B2 (en) 2000-09-01 2003-12-09 E. I. Du Pont De Nemours And Company Genes involved in isoprenoid compound production
EP1409530A2 (en) 2000-09-19 2004-04-21 Microbia, Inc. Modulation of secondary metabolite production by zinc binuclear cluster proteins
WO2002026933A2 (en) 2000-09-29 2002-04-04 Cargill Incorporated Isoprenoid production
US6949362B2 (en) 2000-12-12 2005-09-27 E. I. Du Pont De Nemours And Company Rhodococcus cloning and expression vectors
JP2004525624A (ja) 2001-01-25 2004-08-26 エボルバ バイオテック アクティーゼルスカブ 細胞コレクションのライブラリー
US20050003474A1 (en) 2001-01-26 2005-01-06 Desouza Mervyn L. Carotenoid biosynthesis
US20040078846A1 (en) 2002-01-25 2004-04-22 Desouza Mervyn L. Carotenoid biosynthesis
DE10201458A1 (de) 2001-04-11 2002-10-17 Adelbert Bacher Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg
US7034140B2 (en) 2001-04-24 2006-04-25 E.I. Du Pont De Nemours And Company Genes involved in isoprenoid compound production
US6989257B2 (en) 2001-06-06 2006-01-24 Dsm Ip Assets B.V. Isoprenoid production
WO2003008540A2 (en) 2001-06-22 2003-01-30 Syngenta Participations Ag Abiotic stress responsive polynucleotides and polypeptides
NZ513755A (en) 2001-08-24 2001-09-28 Ann Rachel Holmes Protein expression system in yeast comprising a vector encoding a heterologous membrane protein and its application in screening for drugs
US20040072311A1 (en) 2001-08-28 2004-04-15 Dicosimo Deana J. Production of cyclic terpenoids
US20040010815A1 (en) 2001-09-26 2004-01-15 Lange B. Markus Identification and characterization of plant genes
US7172886B2 (en) 2001-12-06 2007-02-06 The Regents Of The University Of California Biosynthesis of isopentenyl pyrophosphate
US7514597B2 (en) 2002-08-20 2009-04-07 Suntory Limited Glycosyltransferase gene
EP1543115B1 (en) 2002-09-27 2008-05-07 DSM IP Assets B.V. Squalene synthase (sqs) gene
US7098000B2 (en) 2003-06-04 2006-08-29 E. I. Du Pont De Nemoure And Company Method for production of C30-aldehyde carotenoids
DE602004020218D1 (de) 2003-06-12 2009-05-07 Dsm Ip Assets Bv Feedback resistante mevalonate kinase
US7569389B2 (en) 2004-09-30 2009-08-04 Ceres, Inc. Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics
WO2006085899A2 (en) 2004-05-21 2006-08-17 The Regents Of The University Of California Method for enhancing production of isoprenoid compounds
US20060014264A1 (en) 2004-07-13 2006-01-19 Stowers Institute For Medical Research Cre/lox system with lox sites having an extended spacer region
WO2006016395A1 (ja) 2004-08-09 2006-02-16 National University Corporation Tohoku University Udp−グルクロニル基転移酵素およびその遺伝子
JP5074185B2 (ja) 2004-08-19 2012-11-14 ディーエスエム アイピー アセッツ ビー.ブイ. イソプレノイドの生成
US7923552B2 (en) 2004-10-18 2011-04-12 SGF Holdings, LLC High yield method of producing pure rebaudioside A
WO2006063752A1 (en) 2004-12-14 2006-06-22 Dsm Ip Assets B.V. Improved mevalonate kinase
AU2006219823A1 (en) 2005-03-02 2006-09-08 Metanomics Gmbh Process for the production of fine chemicals
JP4284562B2 (ja) 2005-03-04 2009-06-24 独立行政法人産業技術総合研究所 Udp−キシロースの製造方法
WO2006096392A2 (en) 2005-03-04 2006-09-14 Diversa Corporation Enzymes involved in astaxanthin, carotenoid and isoprenoid biosynthetic pathways, genes encoding them and methods of making and using them
WO2007022318A2 (en) 2005-08-17 2007-02-22 Cornell Research Foundation Nucleic acids and proteins associated with sucrose accumulation in coffee
US8293307B2 (en) 2005-10-11 2012-10-23 Purecircle Sdn Bhd Process for manufacturing a sweetener and use thereof
JP2009517022A (ja) 2005-11-23 2009-04-30 ザ・コカ−コーラ・カンパニー 改善された経時的プロファイル及び/又は香味プロファイルを有する天然高甘味度甘味料組成物、その配合方法、および使用
KR100784261B1 (ko) 2006-01-02 2007-12-11 한국과학기술원 탄저균의 포자외막 단백질을 이용한 목적단백질의 미생물표면발현방법
US7927851B2 (en) 2006-03-21 2011-04-19 Vineland Research And Innovation Centre Compositions having ent-kaurenoic acid 13-hydroxylase activity and methods for producing same
AU2007299219A1 (en) 2006-04-05 2008-03-27 Metanomics Gmbh Process for the production of a fine chemical
US8114645B2 (en) 2006-05-19 2012-02-14 The Regents Of The University Of California Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels
KR101440639B1 (ko) 2006-06-19 2014-09-22 지보당 에스아 핵산, 폴리펩타이드 및 이의 용도
WO2008008256A2 (en) 2006-07-07 2008-01-17 The Regents Of The University Of California Methods for enhancing production of isoprenoid compounds by host cells
DK2066778T3 (en) 2006-09-26 2016-04-18 Amyris Biotechnologies Inc PREPARATION OF ISOPRENOIDS AND ISOPRENOID PRECURSORS
US7629156B2 (en) 2006-09-28 2009-12-08 E.I. Du Pont De Nemours And Company Ethanol production in fermentation of mixed sugars containing xylose
US7741119B2 (en) 2006-09-28 2010-06-22 E. I. Du Pont De Nemours And Company Xylitol synthesis mutant of xylose-utilizing zymomonas for ethanol production
CN101200480B (zh) 2006-12-15 2011-03-30 成都华高药业有限公司 莱鲍迪甙a的提取方法
JP4915917B2 (ja) 2006-12-22 2012-04-11 独立行政法人農業・食品産業技術総合研究機構 ラクト−n−ビオースi及びガラクト−n−ビオースの製造方法
JP5307730B2 (ja) 2007-01-22 2013-10-02 カーギル・インコーポレイテッド 溶媒/貧溶媒晶析を用いる精製レバウディオサイドa組成物の製法
JP2008237110A (ja) 2007-03-27 2008-10-09 Institute Of Physical & Chemical Research ステビオール合成酵素遺伝子及びステビオールの製造方法
BRPI0811747A8 (pt) 2007-05-17 2014-10-14 Univ Illinois Métodos e composições para a produção de solventes
US20080292775A1 (en) 2007-05-22 2008-11-27 The Coca-Cola Company Delivery Systems for Natural High-Potency Sweetener Compositions, Methods for Their Formulation, and Uses
WO2009005704A1 (en) 2007-07-03 2009-01-08 The Regents Of The University Of California Methods of increasing isoprenoid or isoprenoid precursor production
US7964232B2 (en) 2007-09-17 2011-06-21 Pepsico, Inc. Steviol glycoside isomers
MY155722A (en) 2007-12-03 2015-11-30 Dsm Ip Assets Bv Novel nutraceutical compositions containing stevia extract or stevia extract constituents and uses thereof
CA2710629C (en) 2007-12-27 2016-06-21 Mcneil Nutritionals, Llc Synergistic sweetening compositions
BRPI0907786B1 (pt) 2008-02-20 2021-06-01 Ceres, Inc. Método de produção de uma planta e método de aumentar o nível de tolerância a baixo teor de nitrogênio em uma planta
TWI475963B (zh) 2008-02-25 2015-03-11 Coca Cola Co 甜菊糖苷a衍生性產物以及製造彼的方法
US9005444B2 (en) 2008-05-13 2015-04-14 Cargill, Incorporated Separation of rebaudioside A from stevia glycosides using chromatography
WO2010021001A2 (en) 2008-08-19 2010-02-25 Kaushik Ramakrishnan S Process for preparing sweetener from stevia rebaudiana
ES2959686T3 (es) 2008-10-03 2024-02-27 Morita Kagaku Kogyo Nuevos glucósidos de esteviol
CN101720910B (zh) 2008-10-23 2012-07-25 大闽食品(漳州)有限公司 一种甜菊糖甙的制备方法
US8614085B2 (en) 2009-02-27 2013-12-24 Butamax(Tm) Advanced Biofuels Llc Yeast with increased butanol tolerance involving a multidrug efflux pump gene
US20100297722A1 (en) * 2009-05-20 2010-11-25 Board Of Trustees Of Southern Illinois University Transgenic moss producing terpenoids
NZ597129A (en) 2009-06-08 2012-12-21 Jennewein Biotechnologie Gmbh Hmo synthesis
RU2012101269A (ru) 2009-06-16 2013-07-27 ИПиСи (БЕЙДЖИН) НЭЧЕРАЛ ПРОДАКТС КО., ЛТД. Композиция, включающая ребаудиозид d, для снижения или удаления послевкусия и способ ее получения
WO2011028671A1 (en) 2009-09-04 2011-03-10 Redpoint Bio Corporation Sweetness enhancers including rebaudioside a or d
CA2773917A1 (en) 2009-09-22 2011-03-31 Redpoint Bio Corporation Novel polymorphs of rebaudioside c and methods for making and using the same
US8299224B2 (en) 2009-10-15 2012-10-30 Purecircle Sdn Bhd High-purity Rebaudioside D
ES2661539T3 (es) * 2009-10-15 2018-04-02 Purecircle Sdn Bhd Rebaudiósido D de pureza elevada y aplicaciones
US8703224B2 (en) 2009-11-04 2014-04-22 Pepsico, Inc. Method to improve water solubility of Rebaudioside D
SG181422A1 (en) 2009-11-10 2012-07-30 Massachusetts Inst Technology Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway
CA2780527C (en) 2009-11-23 2020-12-01 E. I. Du Pont De Nemours And Company Sucrose transporter genes for increasing plant seed lipids
JP2013513389A (ja) 2009-12-10 2013-04-22 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ Talエフェクターに媒介されるdna修飾
JP2013515492A (ja) 2009-12-28 2013-05-09 ザ コカ・コーラ カンパニー 甘味増強剤、甘味増強剤を含む組成物、及びそれらの使用方法
KR101244315B1 (ko) 2010-10-19 2013-03-14 이화여자대학교 산학협력단 에탄올―저항성 효모 유전자 및 이의 용도
US9441233B2 (en) 2010-05-06 2016-09-13 Ceres, Inc. Transgenic plants having increased biomass
US9476082B2 (en) 2010-05-20 2016-10-25 Evolva Sa Method of producing isoprenoid compounds in yeast
US9249420B2 (en) 2010-05-31 2016-02-02 Vib Vzw Isobutanol production using yeasts with modified transporter expression
MY167872A (en) * 2010-06-02 2018-09-26 Evolva Inc Recombinant production of steviol glycosides
US20120021111A1 (en) 2010-07-23 2012-01-26 Aexelon Therapeutics, Inc. Natural Low Caloric Sweetener Compositions for Use in Beverages, Foods and Pharmaceuticals, and Their Methods of Manufacture
US20120083593A1 (en) 2010-10-01 2012-04-05 Shanghai Yongyou Bioscience Inc. Separation and Purification of Stevioside and Rebaudioside A
WO2012075030A1 (en) * 2010-11-30 2012-06-07 Massachusetts Institute Of Technology Microbial production of natural sweeteners, diterpenoid steviol glycosides
KR20130014227A (ko) 2011-07-29 2013-02-07 한국생명공학연구원 신규한 α-글루코실 스테비오사이드 및 이의 제조 방법
WO2013022989A2 (en) 2011-08-08 2013-02-14 Evolva Sa Recombinant production of steviol glycosides
KR101815063B1 (ko) 2011-08-08 2018-01-05 에볼바 에스아 사프란 화합물의 재조합 생성을 위한 방법 및 물질
CN103159808B (zh) 2011-12-09 2017-03-29 上海泓博智源医药股份有限公司 一种制备天然甜味剂的工艺方法
BR122020009091B1 (pt) * 2011-12-19 2021-08-17 The Coca-Cola Company Método para purificar reb x
EA201400836A8 (ru) 2012-01-23 2016-03-31 ДСМ АйПи АССЕТС Б.В. Получение дитерпена
CA2867112C (en) 2012-03-16 2021-04-20 Suntory Holdings Limited Steviol glucosyltransferases and genes encoding the same
WO2013176738A1 (en) 2012-05-22 2013-11-28 Purecircle Sdn Bhd High-purity steviol glycosides
WO2014048392A1 (zh) 2012-09-29 2014-04-03 中国科学院上海生命科学研究院 利用微生物生产甜菊糖苷类化合物的方法
WO2014086890A1 (en) 2012-12-05 2014-06-12 Evolva Sa Steviol glycoside compositions sensory properties
CN105051195B (zh) 2013-02-06 2019-09-06 埃沃尔瓦公司 用于提高莱鲍迪苷d和莱鲍迪苷m之产生的方法
AU2014213918B2 (en) 2013-02-11 2017-11-09 Danstar Ferment Ag Efficient production of steviol glycosides in recombinant hosts
EP3004366B1 (en) 2013-05-31 2019-02-27 DSM IP Assets B.V. Microorganisms for diterpene production
US20160102331A1 (en) 2013-05-31 2016-04-14 Dsm Ip Assets B.V. Extracellular diterpene production
KR101559478B1 (ko) 2013-06-24 2015-10-13 한국생명공학연구원 효소전환법을 이용한 천연 고감미료의 제조방법
WO2015011209A1 (en) 2013-07-23 2015-01-29 Dsm Ip Assets B.V. Diterpene production in yarrowia
DK3027632T3 (da) 2013-07-31 2019-06-17 Dsm Ip Assets Bv Indvinding af steviolglycosider fra et fermenteringsmedium
AU2014298430A1 (en) 2013-07-31 2016-02-11 Dsm Ip Assets B.V. Steviol glycosides
US9957539B2 (en) 2013-08-02 2018-05-01 Suntory Holdings Limited Method for using hexenol glycosyl transferase
CN103397064B (zh) 2013-08-14 2015-04-15 苏州汉酶生物技术有限公司 一种酶法制备瑞鲍迪甙m的方法
SG10201901007PA (en) 2014-08-11 2019-03-28 Evolva Sa Production of steviol glycosides in recombinant hosts
EP3190905A2 (en) 2014-09-09 2017-07-19 Evolva SA Production of steviol glycosides in recombinant hosts
HUE045992T2 (hu) 2014-10-03 2020-01-28 Conagen Inc Kalóriamentes édesítõszerek és szintézismódszereik
WO2016146711A1 (en) 2015-03-16 2016-09-22 Dsm Ip Assets B.V. Udp-glycosyltransferases
US10844414B2 (en) * 2015-08-06 2020-11-24 Cargill, Incorporated Methods for producing steviol glycosides in engineered yeast

Also Published As

Publication number Publication date
WO2014122227A3 (en) 2014-11-20
EP2954058A2 (en) 2015-12-16
WO2014122227A4 (en) 2014-12-18
JP2018198607A (ja) 2018-12-20
CN110551646B (zh) 2024-04-26
US20200308617A1 (en) 2020-10-01
JP2020103292A (ja) 2020-07-09
CA2899276A1 (en) 2014-08-14
US20160186225A1 (en) 2016-06-30
MX2015010043A (es) 2016-03-04
US9957540B2 (en) 2018-05-01
BR112015018872A2 (es) 2017-08-15
JP7061145B2 (ja) 2022-04-27
US20230279459A1 (en) 2023-09-07
SG11201505597SA (en) 2015-08-28
AU2022283672B2 (en) 2024-07-25
AU2014214004B2 (en) 2018-05-24
JP2022047541A (ja) 2022-03-24
US20190203243A1 (en) 2019-07-04
AU2020273296B2 (en) 2022-09-08
WO2014122227A9 (en) 2015-02-05
CA3171770A1 (en) 2014-08-14
AU2018220068B2 (en) 2020-08-20
AU2022283672A1 (en) 2023-02-02
MY190346A (en) 2022-04-15
JP7465252B2 (ja) 2024-04-10
JP6660980B2 (ja) 2020-03-11
WO2014122227A8 (en) 2015-09-11
CN110551646A (zh) 2019-12-10
AU2020273296A1 (en) 2020-12-17
JP6379112B2 (ja) 2018-08-22
JP2016506739A (ja) 2016-03-07
SG10201705926YA (en) 2017-08-30
CN105051195B (zh) 2019-09-06
CA2899276C (en) 2022-11-01
KR20150115002A (ko) 2015-10-13
CN105051195A (zh) 2015-11-11
EP2954058B1 (en) 2021-03-31
US10612066B2 (en) 2020-04-07
US11530431B2 (en) 2022-12-20
AU2018220068A1 (en) 2018-09-13
AU2014214004A1 (en) 2015-07-30
EP3892728A1 (en) 2021-10-13
WO2014122227A2 (en) 2014-08-14

Similar Documents

Publication Publication Date Title
MY190346A (en) Methods for improved production of rebaudioside d and rebaudioside m
MX2017003130A (es) Produccion de glucosidos de esteviol en hospederos recombinantes.
MX2017001859A (es) Produccion de glicosidos de esteviol en hospederos recombinantes.
MX2018001620A (es) Produccion de glucosidos de esteviol en hospedadores recombinantes.
EP3691468A4 (en) EASILY SOLUBLE STEVIOL GLYCOSIDE COMPOSITIONS
HK1259194A1 (zh) 甜菊醇糖苷、其組合物以及其純化
PL3464607T3 (pl) Kompozycje glikozylowanych glikozydów stewiolowych
SG11201705606PA (en) Production of steviol glycosides in recombinant hosts
MY179680A (en) Non-caloric sweeteners and methods for synthesizing
EP3063286A4 (en) Recombinant production of steviol glycosides
EP3215629A4 (en) Microbial production of steviol glycosides
HK1258324A1 (zh) 甜菊醇糖苷共混物、組合物和方法
EP3297455A4 (en) GLYCOSIDZUSAMMENSETZUNGEN
EP2986149A4 (en) Novel Glucosylsteviolglycosides, their compositions and their purification
BR112018011611A2 (pt) produção de glicosídeos de esteviol em hospedeiros recombinantes
MY198001A (en) Production of steviol glycoside in recombinant hosts
PL3217813T3 (pl) Kompozycja zawierająca glukozylowane glikozydy stewiolowe
BR112018000550A2 (pt) composição de glicosídeo de esteviol
MX2023004432A (es) Composiciones de glicosido de esteviol.
EP3592157A4 (en) BIOSYNTHETIC PRODUCTION OF STEVIOL GLYCOSIDE REBAUDIOSIDE D4 FROM REBAUDIOSIDE E
SG10202111903TA (en) Novel steviol glycoside and production method therefor, and sweetener composition containing same
MX2016007813A (es) Glucosido de esteviol estabilizado en jarabe concentrado.
BR112018000298A2 (pt) composição de glicosídeo de esteviol
EP3389403A4 (en) STEVIOL GLYCOSIDE COMPOSITIONS
GB201612978D0 (en) Glycosylated steviol glycoside compositions and methods of preparing glycosylated steviol glycoside compositions

Legal Events

Date Code Title Description
FG Grant or registration