MX2021008747A - Transportadores abc para la produccion de alta eficiencia de rebaudiosidos. - Google Patents

Transportadores abc para la produccion de alta eficiencia de rebaudiosidos.

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Publication number
MX2021008747A
MX2021008747A MX2021008747A MX2021008747A MX2021008747A MX 2021008747 A MX2021008747 A MX 2021008747A MX 2021008747 A MX2021008747 A MX 2021008747A MX 2021008747 A MX2021008747 A MX 2021008747A MX 2021008747 A MX2021008747 A MX 2021008747A
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MX
Mexico
Prior art keywords
steviol glycosides
host cell
rebaudiosides
high efficiency
heterologous
Prior art date
Application number
MX2021008747A
Other languages
English (en)
Inventor
Gale A Wichmann
Sean Lund
Yi Xiong
Joshua Lerman
Hanxiao Jiang
Original Assignee
Amyris Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amyris Inc filed Critical Amyris Inc
Publication of MX2021008747A publication Critical patent/MX2021008747A/es

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    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
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    • C12N9/0038—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
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Abstract

En el presente documento se proporcionan células hospederas modificadas genéticamente, composiciones y métodos para mejorar la producción de glicósidos de esteviol. En algunas modalidades, la célula hospedera se modifica genéticamente para comprender un casete de expresión de ácido nucleico heterólogo que expresa un transportador ABC capaz de transportar glicósidos de esteviol al espacio extracelular o al espacio luminal de un orgánulo intracelular. En algunas modalidades, la célula hospedera comprende además una o más secuencias de nucleótidos heterólogas que codifican para enzimas adicionales de una vía capaz de producir uno o más glucósidos de esteviol en la célula hospedera. Las células hospederas, las composiciones y los métodos descritos en el presente documento proporcionan una ruta eficaz para la producción heteróloga de glicósidos de esteviol, que incluyen, entre otros, rebaudiósido D y rebaudiósido M.
MX2021008747A 2019-01-24 2020-01-23 Transportadores abc para la produccion de alta eficiencia de rebaudiosidos. MX2021008747A (es)

Applications Claiming Priority (2)

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US201962796228P 2019-01-24 2019-01-24
PCT/US2020/014859 WO2020154549A2 (en) 2019-01-24 2020-01-23 Abc transporters for the high efficiency production of rebaudiosides

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US (1) US20220106619A1 (es)
EP (1) EP3914700A2 (es)
JP (1) JP7518838B2 (es)
KR (1) KR20210120027A (es)
CN (1) CN113631698A (es)
AU (1) AU2020211408A1 (es)
BR (1) BR112021014143A2 (es)
CA (1) CA3127249A1 (es)
MX (1) MX2021008747A (es)
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WO (1) WO2020154549A2 (es)

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CN118374427A (zh) * 2024-05-07 2024-07-23 山东三元生物科技股份有限公司 一株催化甜菊糖粗糖生成莱鲍迪甙d的重组菌及其应用

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JP5056897B2 (ja) 2010-05-14 2012-10-24 トヨタ自動車株式会社 ２−ブタノールの製造方法及び２−ブタノール生産能を有する組換え微生物
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