MX2021005862A - Glucosiltransferasas modificadas con ingenieria genetica y metodos de glucosilacion de glucosido de esteviol. - Google Patents
Glucosiltransferasas modificadas con ingenieria genetica y metodos de glucosilacion de glucosido de esteviol.Info
- Publication number
- MX2021005862A MX2021005862A MX2021005862A MX2021005862A MX2021005862A MX 2021005862 A MX2021005862 A MX 2021005862A MX 2021005862 A MX2021005862 A MX 2021005862A MX 2021005862 A MX2021005862 A MX 2021005862A MX 2021005862 A MX2021005862 A MX 2021005862A
- Authority
- MX
- Mexico
- Prior art keywords
- enzymes
- methods
- present
- rebaudioside
- polypeptides
- Prior art date
Links
- 108700023372 Glycosyltransferases Proteins 0.000 title abstract 7
- 239000004383 Steviol glycoside Substances 0.000 title 1
- 102000045442 glycosyltransferase activity proteins Human genes 0.000 title 1
- 108700014210 glycosyltransferase activity proteins Proteins 0.000 title 1
- 229930182488 steviol glycoside Natural products 0.000 title 1
- 235000019411 steviol glycoside Nutrition 0.000 title 1
- 150000008144 steviol glycosides Chemical class 0.000 title 1
- 235000019202 steviosides Nutrition 0.000 title 1
- 102000051366 Glycosyltransferases Human genes 0.000 abstract 6
- 108010043934 Sucrose synthase Proteins 0.000 abstract 5
- 108090000790 Enzymes Proteins 0.000 abstract 4
- 102000004190 Enzymes Human genes 0.000 abstract 4
- 102000040430 polynucleotide Human genes 0.000 abstract 4
- 108091033319 polynucleotide Proteins 0.000 abstract 4
- 239000002157 polynucleotide Substances 0.000 abstract 4
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 3
- 229930188195 rebaudioside Natural products 0.000 abstract 2
- RPYRMTHVSUWHSV-CUZJHZIBSA-N rebaudioside D Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O RPYRMTHVSUWHSV-CUZJHZIBSA-N 0.000 abstract 2
- 239000013598 vector Substances 0.000 abstract 2
- 239000001512 FEMA 4601 Substances 0.000 abstract 1
- HELXLJCILKEWJH-SEAGSNCFSA-N Rebaudioside A Natural products O=C(O[C@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)[C@@]1(C)[C@@H]2[C@](C)([C@H]3[C@@]4(CC(=C)[C@@](O[C@H]5[C@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@H](O)[C@@H](CO)O5)(C4)CC3)CC2)CCC1 HELXLJCILKEWJH-SEAGSNCFSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- HELXLJCILKEWJH-UHFFFAOYSA-N entered according to Sigma 01432 Natural products C1CC2C3(C)CCCC(C)(C(=O)OC4C(C(O)C(O)C(CO)O4)O)C3CCC2(C2)CC(=C)C21OC(C1OC2C(C(O)C(O)C(CO)O2)O)OC(CO)C(O)C1OC1OC(CO)C(O)C(O)C1O HELXLJCILKEWJH-UHFFFAOYSA-N 0.000 abstract 1
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 abstract 1
- 235000019203 rebaudioside A Nutrition 0.000 abstract 1
- GSGVXNMGMKBGQU-PHESRWQRSA-N rebaudioside M Chemical compound C[C@@]12CCC[C@](C)([C@H]1CC[C@@]13CC(=C)[C@@](C1)(CC[C@@H]23)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H]1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H]1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O GSGVXNMGMKBGQU-PHESRWQRSA-N 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
- C12N9/1062—Sucrose synthase (2.4.1.13)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C12Y204/01013—Sucrose synthase (2.4.1.13)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La presente invención proporciona enzimas de glucosiltransferasa (GT) modificadas con ingeniería genética, polipéptidos que tienen actividad de GT y polinucleótidos que codifican estas enzimas, así como vectores y células hospederas que comprenden estos polinucleótidos y polipéptidos; la presente invención proporciona enzimas de sacarosa sintasa (SuS) modificadas con ingeniería genética, polipéptidos que tienen actividad de SuS y polinucleótidos que codifican estas enzimas, así como vectores y células hospederas que comprenden estos polinucleótidos y polipéptidos; la presente invención también proporciona composiciones que comprenden las enzimas de GT y métodos de uso de las enzimas de GT modificadas con ingeniería genética para elaborar productos con enlaces ß-glucosa; la presente invención proporciona además composiciones y métodos para la producción de rebaudiósidos (por ejemplo, rebaudiósido M, rebaudiósido A, rebaudiósido I y rebaudiósido D); la presente invención también proporciona composiciones que comprenden las enzimas de SuS y métodos para usarlas; también se proporcionan métodos para producir las enzimas de GT y de SuS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762454417P | 2017-02-03 | 2017-02-03 | |
US201762479262P | 2017-03-30 | 2017-03-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021005862A true MX2021005862A (es) | 2021-08-11 |
Family
ID=63038689
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019009233A MX2019009233A (es) | 2017-02-03 | 2018-02-01 | Glucosiltransferasas modificadas con ingenieria genetica y metodos de glucosilacion de glucosido de esteviol. |
MX2022003824A MX2022003824A (es) | 2017-02-03 | 2019-08-02 | Glucosiltransferasas modificadas con ingenieria genetica y metodos de glucosilacion de glucosido de esteviol. |
MX2021005862A MX2021005862A (es) | 2017-02-03 | 2019-08-02 | Glucosiltransferasas modificadas con ingenieria genetica y metodos de glucosilacion de glucosido de esteviol. |
MX2021005861A MX2021005861A (es) | 2017-02-03 | 2019-08-02 | Glucosiltransferasas modificadas con ingenieria genetica y metodos de glucosilacion de glucosido de esteviol. |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019009233A MX2019009233A (es) | 2017-02-03 | 2018-02-01 | Glucosiltransferasas modificadas con ingenieria genetica y metodos de glucosilacion de glucosido de esteviol. |
MX2022003824A MX2022003824A (es) | 2017-02-03 | 2019-08-02 | Glucosiltransferasas modificadas con ingenieria genetica y metodos de glucosilacion de glucosido de esteviol. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021005861A MX2021005861A (es) | 2017-02-03 | 2019-08-02 | Glucosiltransferasas modificadas con ingenieria genetica y metodos de glucosilacion de glucosido de esteviol. |
Country Status (14)
Country | Link |
---|---|
US (4) | US20180223264A1 (es) |
EP (3) | EP3577229A4 (es) |
JP (4) | JP7248302B2 (es) |
KR (2) | KR102606350B1 (es) |
CN (1) | CN110914445A (es) |
AU (4) | AU2018215335B2 (es) |
BR (1) | BR112019015992A2 (es) |
CA (3) | CA3175070A1 (es) |
IL (2) | IL268121B2 (es) |
MX (4) | MX2019009233A (es) |
PH (1) | PH12019501698A1 (es) |
SG (1) | SG11201906480QA (es) |
TW (3) | TW202237834A (es) |
WO (2) | WO2018144679A2 (es) |
Families Citing this family (23)
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WO2018144679A2 (en) | 2017-02-03 | 2018-08-09 | Codexis, Inc. | Engineered glycosyltransferases and steviol glycoside glucosylation methods |
AU2019304965A1 (en) * | 2018-07-16 | 2021-02-11 | Manus Bio, Inc. | Production of steviol glycosides through whole cell biotransformation |
EP3830106A4 (en) * | 2018-07-30 | 2022-07-06 | Codexis, Inc. | MANIPULATED GLYCOSYLTRANSFERASES AND METHODS FOR STEVIOL GLYCOSIDE GLUCOSYLATION |
CN111500566B (zh) * | 2019-01-28 | 2022-02-15 | 江南大学 | 一种海藻糖合成酶突变体及其制备方法和应用 |
WO2020237226A1 (en) * | 2019-05-23 | 2020-11-26 | Arzeda Corp. | Compositions and methods for producing steviol glycosides |
BR112021026306A2 (pt) | 2019-06-25 | 2022-09-06 | Manus Bio Inc | Enzima de glicosiltransferase dependente de uridina difosfato |
JP2023506242A (ja) * | 2019-12-16 | 2023-02-15 | マナス バイオ インコーポレイテッド | 微生物によるモグロール及びモグロシドの生産 |
CN111662942A (zh) * | 2020-05-25 | 2020-09-15 | 安徽金禾实业股份有限公司 | 一种双酶发酵催化生产莱鲍迪苷a的方法 |
US20230304055A1 (en) | 2020-07-03 | 2023-09-28 | C-Lecta Gmbh | One-pot cell-free glycosylation process |
WO2022084482A1 (en) | 2020-10-22 | 2022-04-28 | Dsm Ip Assets B.V. | Microorganisms for diterpene production |
KR102546737B1 (ko) * | 2020-11-25 | 2023-06-22 | 씨제이제일제당 주식회사 | 포도당 전이 스테비아를 포함하는 감미질이 개선된 조성물 |
CN114958791B (zh) * | 2021-01-08 | 2023-07-28 | 中国科学院华南植物园 | 亚精胺衍生物糖基转移酶LbUGT62及其编码基因和应用 |
CN112704731B (zh) * | 2021-01-13 | 2023-08-25 | 中国农业科学院哈尔滨兽医研究所(中国动物卫生与流行病学中心哈尔滨分中心) | 蛋白酶s273r抑制细胞焦亡的用途及方法 |
JP2024505906A (ja) * | 2021-01-27 | 2024-02-08 | コリア アドバンスト インスティテュート オブ サイエンス アンド テクノロジー | C-グリコシルトランスフェラーゼ変異体およびその用途 |
JP2024520118A (ja) | 2021-06-01 | 2024-05-21 | エーバイオケム バイオテクノロジー(グループ)カンパニー,リミティド | 糖転移酵素及びその使用 |
CN115449514B (zh) * | 2021-06-08 | 2023-09-29 | 弈柯莱生物科技(上海)股份有限公司 | 一种β-1,2-糖基转移酶及其应用 |
CN113462670B (zh) * | 2021-08-23 | 2023-03-24 | 兴化格林生物制品有限公司 | 一种糖基转移酶突变体及其催化合成莱鲍迪苷m的方法 |
WO2023044368A1 (en) * | 2021-09-17 | 2023-03-23 | Doublerainbow Biosciences Inc. | Method for producing glycosylated therapeutics by using an immobilized enzyme preparation |
KR20230057275A (ko) * | 2021-10-19 | 2023-04-28 | 씨제이제일제당 (주) | 리바우디오사이드 d 및 리바우디오사이드 m을 제조하는 방법 |
KR20230098493A (ko) * | 2021-12-24 | 2023-07-04 | 주식회사 삼양사 | 레바우디오사이드의 생산 |
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WO2024121721A1 (en) | 2022-12-05 | 2024-06-13 | Tate & Lyle Solutions Usa Llc | Methods for obtaining steviol glycosides |
CN116426506B (zh) * | 2023-03-10 | 2024-01-30 | 云南师范大学 | 低温活性提高的β-木糖苷酶突变体D259G及其应用 |
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- 2019-08-02 MX MX2021005862A patent/MX2021005862A/es unknown
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2020
- 2020-10-27 US US17/081,904 patent/US20210054348A1/en active Pending
- 2020-10-27 US US17/081,923 patent/US20220306998A1/en active Pending
- 2020-10-27 US US17/081,932 patent/US11920167B2/en active Active
- 2020-11-27 JP JP2020196574A patent/JP7248322B2/ja active Active
- 2020-12-18 AU AU2020289865A patent/AU2020289865B2/en active Active
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2021
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2022
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2023
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