SG11201906480QA - Engineered glycosyltransferases and steviol glycoside glucosylation methods - Google Patents

Engineered glycosyltransferases and steviol glycoside glucosylation methods

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Publication number
SG11201906480QA
SG11201906480QA SG11201906480QA SG11201906480QA SG11201906480QA SG 11201906480Q A SG11201906480Q A SG 11201906480QA SG 11201906480Q A SG11201906480Q A SG 11201906480QA SG 11201906480Q A SG11201906480Q A SG 11201906480QA SG 11201906480Q A SG11201906480Q A SG 11201906480QA
Authority
SG
Singapore
Prior art keywords
enzymes
california
redwood city
international
penobscot
Prior art date
Application number
SG11201906480QA
Other languages
English (en)
Inventor
Jonathan Vroom
Stephanie Galanie
Nikki Dellas
Jack Liang
Joyce Liu
David Entwistle
Courtney Moffett
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of SG11201906480QA publication Critical patent/SG11201906480QA/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C12N9/1062—Sucrose synthase (2.4.1.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01013—Sucrose synthase (2.4.1.13)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
SG11201906480QA 2017-02-03 2018-02-01 Engineered glycosyltransferases and steviol glycoside glucosylation methods SG11201906480QA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762454417P 2017-02-03 2017-02-03
US201762479262P 2017-03-30 2017-03-30
PCT/US2018/016359 WO2018144679A2 (en) 2017-02-03 2018-02-01 Engineered glycosyltransferases and steviol glycoside glucosylation methods

Publications (1)

Publication Number Publication Date
SG11201906480QA true SG11201906480QA (en) 2019-08-27

Family

ID=63038689

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201906480QA SG11201906480QA (en) 2017-02-03 2018-02-01 Engineered glycosyltransferases and steviol glycoside glucosylation methods

Country Status (14)

Country Link
US (4) US20180223264A1 (es)
EP (3) EP3577229A4 (es)
JP (4) JP7248302B2 (es)
KR (2) KR102606350B1 (es)
CN (1) CN110914445A (es)
AU (4) AU2018215335B2 (es)
BR (1) BR112019015992A2 (es)
CA (3) CA3175070A1 (es)
IL (2) IL268121B2 (es)
MX (4) MX2019009233A (es)
PH (1) PH12019501698A1 (es)
SG (1) SG11201906480QA (es)
TW (3) TW202237834A (es)
WO (2) WO2018144679A2 (es)

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EP3830106A4 (en) * 2018-07-30 2022-07-06 Codexis, Inc. MANIPULATED GLYCOSYLTRANSFERASES AND METHODS FOR STEVIOL GLYCOSIDE GLUCOSYLATION
CN111500566B (zh) * 2019-01-28 2022-02-15 江南大学 一种海藻糖合成酶突变体及其制备方法和应用
WO2020237226A1 (en) * 2019-05-23 2020-11-26 Arzeda Corp. Compositions and methods for producing steviol glycosides
BR112021026306A2 (pt) 2019-06-25 2022-09-06 Manus Bio Inc Enzima de glicosiltransferase dependente de uridina difosfato
JP2023506242A (ja) * 2019-12-16 2023-02-15 マナス バイオ インコーポレイテッド 微生物によるモグロール及びモグロシドの生産
CN111662942A (zh) * 2020-05-25 2020-09-15 安徽金禾实业股份有限公司 一种双酶发酵催化生产莱鲍迪苷a的方法
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KR102546737B1 (ko) * 2020-11-25 2023-06-22 씨제이제일제당 주식회사 포도당 전이 스테비아를 포함하는 감미질이 개선된 조성물
CN114958791B (zh) * 2021-01-08 2023-07-28 中国科学院华南植物园 亚精胺衍生物糖基转移酶LbUGT62及其编码基因和应用
CN112704731B (zh) * 2021-01-13 2023-08-25 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） 蛋白酶s273r抑制细胞焦亡的用途及方法
JP2024505906A (ja) * 2021-01-27 2024-02-08 コリア アドバンスト インスティテュート オブ サイエンス アンド テクノロジー Ｃ－グリコシルトランスフェラーゼ変異体およびその用途
JP2024520118A (ja) 2021-06-01 2024-05-21 エーバイオケム バイオテクノロジー（グループ）カンパニー，リミティド 糖転移酵素及びその使用
CN115449514B (zh) * 2021-06-08 2023-09-29 弈柯莱生物科技(上海)股份有限公司 一种β-1,2-糖基转移酶及其应用
CN113462670B (zh) * 2021-08-23 2023-03-24 兴化格林生物制品有限公司 一种糖基转移酶突变体及其催化合成莱鲍迪苷m的方法
WO2023044368A1 (en) * 2021-09-17 2023-03-23 Doublerainbow Biosciences Inc. Method for producing glycosylated therapeutics by using an immobilized enzyme preparation
KR20230057275A (ko) * 2021-10-19 2023-04-28 씨제이제일제당 (주) 리바우디오사이드 d 및 리바우디오사이드 m을 제조하는 방법
KR20230098493A (ko) * 2021-12-24 2023-07-04 주식회사 삼양사 레바우디오사이드의 생산
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CN116426506B (zh) * 2023-03-10 2024-01-30 云南师范大学 低温活性提高的β-木糖苷酶突变体D259G及其应用

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