MX2021000605A - Producción de glucósidos de esteviol a través de biotransformación de células enteras. - Google Patents

Producción de glucósidos de esteviol a través de biotransformación de células enteras.

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Publication number
MX2021000605A
MX2021000605A MX2021000605A MX2021000605A MX2021000605A MX 2021000605 A MX2021000605 A MX 2021000605A MX 2021000605 A MX2021000605 A MX 2021000605A MX 2021000605 A MX2021000605 A MX 2021000605A MX 2021000605 A MX2021000605 A MX 2021000605A
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MX
Mexico
Prior art keywords
intermediates
production
whole cell
steviol glycosides
glycosylation
Prior art date
Application number
MX2021000605A
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English (en)
Inventor
Ajikumar Parayil Kumaran
Aaron Love
Christine Nicole S Santos
Jason Eric Donald
Mary Elizabeth Fowler
Ryan N Philippe
Christopher Scott Frei
Original Assignee
Manus Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Manus Bio Inc filed Critical Manus Bio Inc
Publication of MX2021000605A publication Critical patent/MX2021000605A/es

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    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
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    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
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  • Chemical & Material Sciences (AREA)
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Abstract

En varios aspectos y modalidades, la invención proporciona células microbianas y métodos para producir productos de glucosilación avanzados a partir de intermedios glucosilados inferiores. La célula microbiana expresa una o más enzimas de glicosil transferasa dependiente de UDP en el citoplasma, para la glucosilación de los intermedios. Cuando se incuba la cepa microbiana con un extracto vegetal o una parte de este que comprende los intermedios, estos intermedios glucosilados están disponibles para la glucosilación adicional por la célula y los productos de glucosilación avanzados pueden recuperarse del medio y/o de las células microbianas.
MX2021000605A 2018-07-16 2019-07-16 Producción de glucósidos de esteviol a través de biotransformación de células enteras. MX2021000605A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862698617P 2018-07-16 2018-07-16
PCT/US2019/041957 WO2020018506A2 (en) 2018-07-16 2019-07-16 Production of steviol glycosides through whole cell biotransformation

Publications (1)

Publication Number Publication Date
MX2021000605A true MX2021000605A (es) 2021-06-23

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MX2021000605A MX2021000605A (es) 2018-07-16 2019-07-16 Producción de glucósidos de esteviol a través de biotransformación de células enteras.

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US (1) US11230724B2 (es)
EP (1) EP3824093A4 (es)
JP (1) JP7305087B2 (es)
KR (1) KR102532079B1 (es)
CN (1) CN112867799A (es)
AU (1) AU2019304965A1 (es)
BR (1) BR112021000876A2 (es)
CA (1) CA3106633A1 (es)
IL (1) IL280151A (es)
MX (1) MX2021000605A (es)
SG (1) SG11202100450TA (es)
WO (1) WO2020018506A2 (es)

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CN109295087B (zh) * 2018-11-09 2021-08-24 沈阳农业大学 一种表达制备udp-葡萄糖-己糖-1-磷酸尿苷酰转移酶的方法
MX2022000150A (es) * 2019-06-25 2022-05-20 Manus Bio Inc Enzima de glicosiltransferasa dependiente de difosfato de uridina.
CN110699373B (zh) * 2019-10-16 2023-05-26 中国药科大学 尿苷二磷酸葡萄糖高产菌株及其应用
CN111518825B (zh) * 2020-04-30 2022-10-11 浙江工业大学 一种多基因组合表达制备蛹虫草多糖的方法
CA3177183A1 (en) * 2020-05-13 2021-11-18 Ginkgo Bioworks, Inc. Biosynthesis of mogrosides
JP2024500432A (ja) * 2020-12-23 2024-01-09 サムヤン コーポレイション 糖転移酵素およびこれを用いたステビオール配糖体の製造方法
WO2023000243A1 (zh) * 2021-07-22 2023-01-26 深圳先进技术研究院 重组酵母生物转化生产葡萄糖的方法
KR20230098495A (ko) * 2021-12-24 2023-07-04 주식회사 삼양사 당전이 효소 변이체 및 이를 이용한 스테비올 배당체의 제조방법
CN114540396A (zh) * 2022-02-24 2022-05-27 天津大学 希瓦氏菌株中葡萄糖代谢通路的构建方法
CN114561310B (zh) * 2022-03-17 2022-12-02 江南大学 一种生产甜茶苷的酿酒酵母及其应用
WO2024121721A1 (en) * 2022-12-05 2024-06-13 Tate & Lyle Solutions Usa Llc Methods for obtaining steviol glycosides

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CA3106633A1 (en) 2020-01-23
SG11202100450TA (en) 2021-02-25
KR102532079B1 (ko) 2023-05-12
US20220162658A1 (en) 2022-05-26
CN112867799A (zh) 2021-05-28
BR112021000876A2 (pt) 2021-04-13
WO2020018506A3 (en) 2020-03-12
AU2019304965A1 (en) 2021-02-11
US11230724B2 (en) 2022-01-25
WO2020018506A2 (en) 2020-01-23
US20200087692A1 (en) 2020-03-19
IL280151A (en) 2021-03-01
JP7305087B2 (ja) 2023-07-10
JP2021530228A (ja) 2021-11-11
EP3824093A4 (en) 2022-06-01
KR20210066790A (ko) 2021-06-07
EP3824093A2 (en) 2021-05-26

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