SG10202107829YA - Hydrogel cross-linked hyaluronic acid prodrug compositions and methods - Google Patents

Hydrogel cross-linked hyaluronic acid prodrug compositions and methods

Info

Publication number
SG10202107829YA
SG10202107829YA SG10202107829YA SG10202107829YA SG10202107829YA SG 10202107829Y A SG10202107829Y A SG 10202107829YA SG 10202107829Y A SG10202107829Y A SG 10202107829YA SG 10202107829Y A SG10202107829Y A SG 10202107829YA SG 10202107829Y A SG10202107829Y A SG 10202107829YA
Authority
SG
Singapore
Prior art keywords
methods
hyaluronic acid
linked hyaluronic
acid prodrug
hydrogel cross
Prior art date
Application number
SG10202107829YA
Other languages
English (en)
Inventor
Sebastian Stark
Thomas Knappe
Harald Rau
Nicola Bisek
Burkhardt Laufer
Samuel Weisbrod
Tobias Voigt
Germaine Fuh
Patrick Koenig
Chingwei Vivian Lee
Daniela Bumbaca Yadav
Original Assignee
Genentech Inc
Ascendis Pharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc, Ascendis Pharma As filed Critical Genentech Inc
Publication of SG10202107829YA publication Critical patent/SG10202107829YA/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6903Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being semi-solid, e.g. an ointment, a gel, a hydrogel or a solidifying gel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SG10202107829YA 2017-03-22 2018-03-22 Hydrogel cross-linked hyaluronic acid prodrug compositions and methods SG10202107829YA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762475094P 2017-03-22 2017-03-22

Publications (1)

Publication Number Publication Date
SG10202107829YA true SG10202107829YA (en) 2021-08-30

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
SG10202107829YA SG10202107829YA (en) 2017-03-22 2018-03-22 Hydrogel cross-linked hyaluronic acid prodrug compositions and methods
SG11201908547V SG11201908547VA (en) 2017-03-22 2018-03-22 Hydrogel cross-linked hyaluronic acid prodrug compositions and methods

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201908547V SG11201908547VA (en) 2017-03-22 2018-03-22 Hydrogel cross-linked hyaluronic acid prodrug compositions and methods

Country Status (14)

Country Link
US (3) US11642415B2 (cg-RX-API-DMAC7.html)
EP (1) EP3600441A1 (cg-RX-API-DMAC7.html)
JP (2) JP7216006B2 (cg-RX-API-DMAC7.html)
KR (2) KR20240150530A (cg-RX-API-DMAC7.html)
CN (1) CN110891611B (cg-RX-API-DMAC7.html)
AR (1) AR111190A1 (cg-RX-API-DMAC7.html)
AU (1) AU2018240375C1 (cg-RX-API-DMAC7.html)
CA (1) CA3055985A1 (cg-RX-API-DMAC7.html)
IL (1) IL269506B2 (cg-RX-API-DMAC7.html)
MA (1) MA49265A (cg-RX-API-DMAC7.html)
SG (2) SG10202107829YA (cg-RX-API-DMAC7.html)
TW (1) TWI857935B (cg-RX-API-DMAC7.html)
WO (1) WO2018175788A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201905930B (cg-RX-API-DMAC7.html)

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WO2023001288A1 (zh) * 2021-07-23 2023-01-26 百奥泰生物制药股份有限公司 整合素GPIIb/IIIa拮抗剂及其和抗VEGF抗体联合用药的应用
JP2024546134A (ja) 2021-12-13 2024-12-17 アセンディス ファーマ オンコロジー ディヴィジョン エー/エス Tlr7/8アゴニストを用いたがん治療
KR20250004729A (ko) * 2022-04-15 2025-01-08 발리터 인코포레이티드 정제된 다가 단백질-히알루론산 중합체 컨쥬게이트
CN115389681B (zh) * 2022-11-01 2023-01-20 常州百瑞吉生物医药有限公司 一种巯基化透明质酸衍生物中二硫苏糖醇残留的检测方法
TW202434299A (zh) 2023-01-05 2024-09-01 丹麥商阿仙帝斯製藥公司 製造水凝膠微球之方法
TW202430223A (zh) 2023-01-05 2024-08-01 丹麥商阿仙帝斯眼科製藥有限公司 用於治療眼部病症之藥物結合物
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JP2020515545A (ja) 2020-05-28
CA3055985A1 (en) 2018-09-27
US20250255973A1 (en) 2025-08-14
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RU2019133326A (ru) 2021-04-22
US12246070B2 (en) 2025-03-11
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AU2018240375A2 (en) 2020-03-05
MA49265A (fr) 2020-02-05
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EP3600441A1 (en) 2020-02-05
IL269506A (en) 2019-11-28
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IL269506B1 (en) 2023-12-01
KR20200007776A (ko) 2020-01-22
TW201842936A (zh) 2018-12-16
US11642415B2 (en) 2023-05-09
BR112019019658A2 (pt) 2020-04-22
US20230414770A1 (en) 2023-12-28
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