SA519410518B1 - مواد وطرق لمعالجة الخلايا بالهندسة الوراثية واستخداماتها في علم العلاج المناعي للوقاية من الأمراض السرطانية - Google Patents
مواد وطرق لمعالجة الخلايا بالهندسة الوراثية واستخداماتها في علم العلاج المناعي للوقاية من الأمراض السرطانيةInfo
- Publication number
- SA519410518B1 SA519410518B1 SA519410518A SA519410518A SA519410518B1 SA 519410518 B1 SA519410518 B1 SA 519410518B1 SA 519410518 A SA519410518 A SA 519410518A SA 519410518 A SA519410518 A SA 519410518A SA 519410518 B1 SA519410518 B1 SA 519410518B1
- Authority
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- Saudi Arabia
- Prior art keywords
- materials
- methods
- immuno
- oncology
- engineering cells
- Prior art date
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- 239000000463 material Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 238000002619 cancer immunotherapy Methods 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 abstract 4
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 abstract 2
- 238000010362 genome editing Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2521/00—Reaction characterised by the enzymatic activity
- C12Q2521/30—Phosphoric diester hydrolysing, i.e. nuclease
- C12Q2521/301—Endonuclease
Abstract
يتعلق الاختراع الحالي بمواد وطرق لإنتاج خلايا محرَّرة الجينوم genome-edited cells معالجة بالهندسة الوراثية للتعبير عن تركيبة مستقبل مولِّد ضد خيمري chimeric antigen receptor (CAR) على سطح الخلية، ومواد وطرق لتحرير الجينوم لتعديل تعبير، وظيفة، أو نشاط واحد أو أكثر من الجينات المرتبطة بالأورام المناعية في خلية، ومواد وطرق لعلاج مريض باستخدام خلايا محررة الجينوم معالجة بالهندسة الوراثية genome-edited engineered cells. شكل 13أ.
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