BR112022009204A2 - Terapia de carcinoma de células renais (rcc) usando células t geneticamente manipuladas visando cd70 - Google Patents
Terapia de carcinoma de células renais (rcc) usando células t geneticamente manipuladas visando cd70Info
- Publication number
- BR112022009204A2 BR112022009204A2 BR112022009204A BR112022009204A BR112022009204A2 BR 112022009204 A2 BR112022009204 A2 BR 112022009204A2 BR 112022009204 A BR112022009204 A BR 112022009204A BR 112022009204 A BR112022009204 A BR 112022009204A BR 112022009204 A2 BR112022009204 A2 BR 112022009204A2
- Authority
- BR
- Brazil
- Prior art keywords
- rcc
- cell carcinoma
- renal cell
- therapy
- genetically manipulated
- Prior art date
Links
- 208000006265 Renal cell carcinoma Diseases 0.000 title abstract 6
- 102100025221 CD70 antigen Human genes 0.000 title abstract 3
- 101000934356 Homo sapiens CD70 antigen Proteins 0.000 title abstract 3
- 210000001744 T-lymphocyte Anatomy 0.000 title abstract 3
- 230000008685 targeting Effects 0.000 title abstract 2
- 238000002560 therapeutic procedure Methods 0.000 title abstract 2
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464436—Cytokines
- A61K39/464438—Tumor necrosis factors [TNF], CD70
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001136—Cytokines
- A61K39/001138—Tumor necrosis factors [TNF] or CD70
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/868—Vaccine for a specifically defined cancer kidney
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/26—Universal/off- the- shelf cellular immunotherapy; Allogenic cells or means to avoid rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/56—Kidney
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
Abstract
TERAPIA DE CARCINOMA DE CÉLULAS RENAIS (RCC) USANDO CÉLULAS T GENETICAMENTE MANIPULADAS VISANDO CD70. A presente invenção refere-se a invenção composições compreendendo uma população de células T geneticamente manipuladas que expressam um receptor de antígeno quimérico (CAR) que se liga a CD70 e métodos de uso das mesmas para o tratamento de carcinoma de células renais (RCC).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962934961P | 2019-11-13 | 2019-11-13 | |
US202063034552P | 2020-06-04 | 2020-06-04 | |
PCT/IB2020/060719 WO2021095010A1 (en) | 2019-11-13 | 2020-11-13 | Renal cell carcinoma (rcc) therapy using genetically engineered t cells targeting cd70 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022009204A2 true BR112022009204A2 (pt) | 2022-07-26 |
Family
ID=73695085
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022009204A BR112022009204A2 (pt) | 2019-11-13 | 2020-11-13 | Terapia de carcinoma de células renais (rcc) usando células t geneticamente manipuladas visando cd70 |
Country Status (11)
Country | Link |
---|---|
US (1) | US20220387572A1 (pt) |
EP (1) | EP4058053A1 (pt) |
JP (1) | JP2023501602A (pt) |
KR (1) | KR20220100913A (pt) |
CN (1) | CN114929267A (pt) |
AU (1) | AU2020383021A1 (pt) |
BR (1) | BR112022009204A2 (pt) |
CA (1) | CA3158110A1 (pt) |
IL (1) | IL292468A (pt) |
MX (1) | MX2022005821A (pt) |
WO (1) | WO2021095010A1 (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022238963A2 (en) * | 2021-05-12 | 2022-11-17 | Crispr Therapeutics Ag | Genetically engineered immune cells targeting cd70 for use in treating solid tumors |
WO2023072307A1 (zh) * | 2021-10-25 | 2023-05-04 | 重庆精准生物技术有限公司 | 一种靶向cd70的抗原结合片段、单链抗体和嵌合抗原受体及其应用 |
CN117844811A (zh) * | 2024-03-08 | 2024-04-09 | 上海恒润达生生物科技股份有限公司 | 靶向敲除CD70基因的sgRNA组合物及其应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018007263A1 (en) * | 2016-07-06 | 2018-01-11 | Cellectis | Sequential gene editing in primary immune cells |
EP3621981A2 (en) | 2017-05-12 | 2020-03-18 | CRISPR Therapeutics AG | Materials and methods for engineering cells and uses thereof in immuno-oncology |
WO2019152742A1 (en) * | 2018-02-01 | 2019-08-08 | Pfizer Inc. | Chimeric antigen receptors targeting cd70 |
US20200063100A1 (en) | 2018-05-11 | 2020-02-27 | Crispr Therapeutics Ag | Methods and compositions for treating cancer |
-
2020
- 2020-11-13 CA CA3158110A patent/CA3158110A1/en active Pending
- 2020-11-13 WO PCT/IB2020/060719 patent/WO2021095010A1/en active Application Filing
- 2020-11-13 EP EP20817494.6A patent/EP4058053A1/en active Pending
- 2020-11-13 CN CN202080090978.5A patent/CN114929267A/zh active Pending
- 2020-11-13 AU AU2020383021A patent/AU2020383021A1/en active Pending
- 2020-11-13 MX MX2022005821A patent/MX2022005821A/es unknown
- 2020-11-13 KR KR1020227019520A patent/KR20220100913A/ko unknown
- 2020-11-13 JP JP2022527773A patent/JP2023501602A/ja active Pending
- 2020-11-13 US US17/776,860 patent/US20220387572A1/en active Pending
- 2020-11-13 BR BR112022009204A patent/BR112022009204A2/pt not_active Application Discontinuation
- 2020-11-13 IL IL292468A patent/IL292468A/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP4058053A1 (en) | 2022-09-21 |
MX2022005821A (es) | 2022-08-16 |
AU2020383021A1 (en) | 2022-05-19 |
US20220387572A1 (en) | 2022-12-08 |
CA3158110A1 (en) | 2021-05-20 |
JP2023501602A (ja) | 2023-01-18 |
KR20220100913A (ko) | 2022-07-18 |
IL292468A (en) | 2022-06-01 |
WO2021095010A1 (en) | 2021-05-20 |
CN114929267A (zh) | 2022-08-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112022009204A2 (pt) | Terapia de carcinoma de células renais (rcc) usando células t geneticamente manipuladas visando cd70 | |
CL2021001686A1 (es) | Receptores de antígenos quiméricos basados en anticuerpos de dominio simple y métodos de uso de estos (divisional de solicitud n° 201800378) | |
BR112022009290A2 (pt) | Terapia para malignidades de células hematopoiéticas com o uso de células t geneticamente modificadas visando cd70 | |
BR112018067679A2 (pt) | células que expressam múltiplas moléculas do receptor de antígeno quimérico (car) e seu uso | |
BR112021016984A2 (pt) | Receptores de antígeno quimérico direcionados a dll3 e agentes de ligação | |
PH12020552138A1 (en) | Bcma chimeric antigen receptors and uses thereof | |
BR112017003104A2 (pt) | tratamento de câncer usando um receptor antigênico quimérico anti-cd123 | |
BR112021021843A2 (pt) | Composições de proteína de fusão quimicamente projetada e métodos de uso das mesmas | |
CL2019000760A1 (es) | Tratamiento de migraña refractaria | |
MX2020012927A (es) | Diversos dominios de enlace de antigenos, nuevas plataformas y otras mejoras para terapia celular. | |
BR112017001183A2 (pt) | tratamento de câncer usando receptor de antígeno quimérico anti-bcma humanizado | |
BR112017000939A2 (pt) | tratamento de câncer usando um receptor antigênico quimérico de cll-1 | |
BR112018070676A2 (pt) | construtos de ligação a antígeno multiespecífico que têm como alvo agentes imunoterapêuticos | |
BR112018070636A2 (pt) | método de tratamento de um sujeito humano que tem câncer, anticorpo, uso de um anticorpo, anticorpo para uso, combinação de um anticorpo, kit para uso no tratamento de câncer, composição farmacêutica, anticorpo biespecífico, método para tratamento de câncer, anticorpo biespecífico para uso e método de depleção de células t reguladoras em um tumor sólido em um sujeito | |
BR112018003308A2 (pt) | receptor quimérico de citocina | |
BR112017001242A2 (pt) | tratamento de câncer usando um receptor antigênico quimérico a cd33 | |
BR112016013187A2 (pt) | receptores de antígenos quiméricos de mesotelina humanos e usos dos mesmos | |
BR112022009141A2 (pt) | Terapia contra tumores sólidos cd70+ usando células t geneticamente manipuladas visando cd70 | |
CO2020013089A2 (es) | Anticuerpos contra mica y/o micb y sus usos | |
BR112018073136A2 (pt) | métodos para tratar doença autoimune usando células t alogênicas | |
BR112021026382A2 (pt) | Uso de células t de receptor de antígenos quimérico e inibidores de células nk para tratamento de câncer | |
MX2020012613A (es) | Composiciones y usos de las mismas para el tratamiento de enfermedades o afecciones. | |
BR112021012667A2 (pt) | Proteínas de ligação anti-pd-1 e métodos de uso destas | |
BR112019010128A2 (pt) | proteínas de ligação a antígeno anti-gitr e métodos de uso das mesmas | |
PL422231A1 (pl) | Komórki immunologiczne CAR do leczenia nowotworów |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |