CO2019013821A2 - Materiales y métodos para modificar células por ingeniería genética y usos de los mismos en inmunooncología - Google Patents

Materiales y métodos para modificar células por ingeniería genética y usos de los mismos en inmunooncología

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Publication number
CO2019013821A2
CO2019013821A2 CONC2019/0013821A CO2019013821A CO2019013821A2 CO 2019013821 A2 CO2019013821 A2 CO 2019013821A2 CO 2019013821 A CO2019013821 A CO 2019013821A CO 2019013821 A2 CO2019013821 A2 CO 2019013821A2
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Colombia
Prior art keywords
methods
materials
oncology
immuno
genetic engineering
Prior art date
Application number
CONC2019/0013821A
Other languages
English (en)
Inventor
Jonathan Alexander Terrett
Demetrios Kalaitzidis
Lawrence Klein
Original Assignee
Crispr Therapeutics Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crispr Therapeutics Ag filed Critical Crispr Therapeutics Ag
Publication of CO2019013821A2 publication Critical patent/CO2019013821A2/es

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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
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    • C12N2510/00—Genetically modified cells
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    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/30—Phosphoric diester hydrolysing, i.e. nuclease
    • C12Q2521/301—Endonuclease

Abstract

RESUMEN Materiales y métodos para producir células editadas genómicamente modificados por ingeniería genética para expresar una construcción de receptor de antígeno quimérico (CAR) sobre la superficie celular y materiales y métodos de edición genómica para modular la expresión, la función o la actividad de uno o más genes relacionados con la inmunooncología en una célula y materiales y métodos para tratar a un paciente usando las células modificadas por ingeniería genética con el genoma editado.
CONC2019/0013821A 2017-05-12 2019-12-09 Materiales y métodos para modificar células por ingeniería genética y usos de los mismos en inmunooncología CO2019013821A2 (es)

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