RU2227800C2 - Новые эффекторы дипептидилпептидазы iv - Google Patents

Новые эффекторы дипептидилпептидазы iv Download PDF

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Publication number
RU2227800C2
RU2227800C2 RU2000133251/04A RU2000133251A RU2227800C2 RU 2227800 C2 RU2227800 C2 RU 2227800C2 RU 2000133251/04 A RU2000133251/04 A RU 2000133251/04A RU 2000133251 A RU2000133251 A RU 2000133251A RU 2227800 C2 RU2227800 C2 RU 2227800C2
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RU
Russia
Prior art keywords
salts
pharmaceutical composition
composition according
thiazolidine
isoleucyl
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RU2000133251/04A
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English (en)
Russian (ru)
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RU2000133251A (ru
Inventor
Ханс-Ульрих ДЕМУТ (DE)
Ханс-Ульрих Демут
Конрад ГЛУНД (DE)
Конрад ГЛУНД
Дагмар ШЛЕНЦИГ (DE)
Дагмар ШЛЕНЦИГ
Зузанне КРУБЕР (DE)
Зузанне КРУБЕР
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Пробиодруг Аг
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Publication of RU2000133251A publication Critical patent/RU2000133251A/ru
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Detergent Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
RU2000133251/04A 1998-05-28 1999-05-28 Новые эффекторы дипептидилпептидазы iv RU2227800C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19823831.2 1998-05-28
DE19823831A DE19823831A1 (de) 1998-05-28 1998-05-28 Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen

Related Child Applications (2)

Application Number Title Priority Date Filing Date
RU2003121766/04A Division RU2309161C2 (ru) 1998-05-28 1999-05-28 Эффекторы дипептидилпептидазу iv
RU2004101292/15A Division RU2004101292A (ru) 1998-05-28 2004-01-15 Композиции, содержащие эффектор дипептидилпептидазы iv

Publications (2)

Publication Number Publication Date
RU2000133251A RU2000133251A (ru) 2003-01-27
RU2227800C2 true RU2227800C2 (ru) 2004-04-27

Family

ID=7869159

Family Applications (3)

Application Number Title Priority Date Filing Date
RU2000133251/04A RU2227800C2 (ru) 1998-05-28 1999-05-28 Новые эффекторы дипептидилпептидазы iv
RU2003121766/04A RU2309161C2 (ru) 1998-05-28 1999-05-28 Эффекторы дипептидилпептидазу iv
RU2004101292/15A RU2004101292A (ru) 1998-05-28 2004-01-15 Композиции, содержащие эффектор дипептидилпептидазы iv

Family Applications After (2)

Application Number Title Priority Date Filing Date
RU2003121766/04A RU2309161C2 (ru) 1998-05-28 1999-05-28 Эффекторы дипептидилпептидазу iv
RU2004101292/15A RU2004101292A (ru) 1998-05-28 2004-01-15 Композиции, содержащие эффектор дипептидилпептидазы iv

Country Status (24)

Country Link
US (4) US6548481B1 (enExample)
EP (6) EP1215207B1 (enExample)
JP (1) JP2002516318A (enExample)
KR (2) KR100630258B1 (enExample)
CN (4) CN1332954C (enExample)
AT (6) ATE338546T1 (enExample)
AU (1) AU764262B2 (enExample)
BR (1) BR9910758A (enExample)
CA (1) CA2333603C (enExample)
DE (10) DE19823831A1 (enExample)
DK (2) DK1214936T3 (enExample)
ES (5) ES2271723T3 (enExample)
HK (2) HK1047887B (enExample)
HU (1) HUP0102001A3 (enExample)
IL (3) IL139862A0 (enExample)
IS (3) IS5728A (enExample)
NO (1) NO317989B1 (enExample)
NZ (2) NZ508260A (enExample)
PL (1) PL344403A1 (enExample)
PT (2) PT1304327E (enExample)
RU (3) RU2227800C2 (enExample)
SI (2) SI1082314T1 (enExample)
UA (1) UA54599C2 (enExample)
WO (1) WO1999061431A1 (enExample)

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* Cited by examiner, † Cited by third party
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