RU2004101292A - Композиции, содержащие эффектор дипептидилпептидазы iv - Google Patents

Композиции, содержащие эффектор дипептидилпептидазы iv Download PDF

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Publication number
RU2004101292A
RU2004101292A RU2004101292/15A RU2004101292A RU2004101292A RU 2004101292 A RU2004101292 A RU 2004101292A RU 2004101292/15 A RU2004101292/15 A RU 2004101292/15A RU 2004101292 A RU2004101292 A RU 2004101292A RU 2004101292 A RU2004101292 A RU 2004101292A
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Russia
Prior art keywords
composition according
pyrrolidine
thiazolidine
effector
isoleucyl
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RU2004101292/15A
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English (en)
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Ханс-Ульрих ДЕМУТ (DE)
Ханс-Ульрих Демут
Конрад ГЛУНД (DE)
Конрад ГЛУНД
Дагмар ШЛЕНЦИГ (DE)
Дагмар ШЛЕНЦИГ
Зузанне КРУБЕР (DE)
Зузанне КРУБЕР
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Пробиодруг Аг (De)
Пробиодруг Аг
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Publication of RU2004101292A publication Critical patent/RU2004101292A/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Detergent Compositions (AREA)

Claims (19)

1. Композиция, включающая эффектор дипептидилпептидазы IV или дипептидилпептидазы IV-аналогичной ферментативной активности и другое антидиабетическое средство, или их соли.
2. Композиция по п.1, отличающаяся тем, что дополнительно включает один или несколько фармацевтически приемлемых носителей и/или растворителей и является фармацевтической.
3. Композиция по п.1, отличающаяся тем, что эффектор выбран из субстратов, псевдосубстратов, ингибиторов, связывающих белков или антител.
4. Композиция по п.1, отличающаяся тем, что эффектор представляет собой дипептидный миметик.
5. Композиция по п.4, отличающаяся тем, что эффектор представляет собой дипептидный миметик, включающий аминокислоту и пирролидиновую или тиазолидиновую группу.
6. Композиция по п.5, отличающаяся тем, что дипептидный миметик выбран из L-трео-изолейцил-пирролидина, L-трео-изолейцил-тиазолидина, L-алло-изолейцил-тиазолидина, L-алло-изолейцил-пирролидина, глутаминил-пирролидина, глутаминил-тиазолидина, аланил-тиазолидина, аланил-пирролидина, валил-тиазолидина и валил-пирролидина.
7. Композиция по одному из предшествующих пп.1-6, отличающаяся тем, что другое антидиабетическое средство выбрано из бигуанидов, сульфонилмочевин, сахаридов и тиазолидиндионов.
8. Композиция по п.7, отличающаяся тем, что бигуанид является метформином.
9. Композиция по п.7, отличающаяся тем, что сульфонилмочевиной является глибенкламид.
10. Композиция по п.7, отличающаяся тем, что сахаридом является акарбоза.
11. Композиция по п.7, отличающаяся тем, что тиазолидиндионом является пиоглитазон.
12. Применение композиции по одному из предшествующих пунктов для получения лекарственного средства для лечения заболеваний, связанных с обменом веществ, у млекопитающих.
13. Применение по п.12, отличающееся тем, что заболевание, связанное с обменом веществ, представляет собой заболевание, выбранное из нарушенной толерантности к глюкозе, глюкозурии, гиперлипемии, метаболических ацидозов, сахарного диабета, диабетической невропатии и нефропатии, а также вызываемых сахарным диабетом осложнений.
14. Применение по п.12 для повышения стабильности по меньшей мере одного эндогенного или введенного экзогенного GIP1-42, GLP-17-36 или GLP-17-37 или их аналогов.
15. Применение по п.12 для повышения уровня инкретинов и для стимулирования рецепторов инкретинов Лангергансовых клеток.
16. Применение по п.12 для повышения активности Лангергансовых клеток.
17. Применение по п.12 для стимулирования углеводного обмена у млекопитающих.
18. Применение по п.12 для снижения содержания сахара в крови при характерной для гипергликемии концентрации глюкозы в сыворотке млекопитающего.
19. Применение по пп.12-18 для орального введения при лечении млекопитающих.
RU2004101292/15A 1998-05-28 2004-01-15 Композиции, содержащие эффектор дипептидилпептидазы iv RU2004101292A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19823831A DE19823831A1 (de) 1998-05-28 1998-05-28 Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen
DE19823831.2 1998-05-28

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
RU2000133251/04A Division RU2227800C2 (ru) 1998-05-28 1999-05-28 Новые эффекторы дипептидилпептидазы iv

Publications (1)

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RU2004101292A true RU2004101292A (ru) 2005-06-20

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ID=7869159

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Application Number Title Priority Date Filing Date
RU2003121766/04A RU2309161C2 (ru) 1998-05-28 1999-05-28 Эффекторы дипептидилпептидазу iv
RU2000133251/04A RU2227800C2 (ru) 1998-05-28 1999-05-28 Новые эффекторы дипептидилпептидазы iv
RU2004101292/15A RU2004101292A (ru) 1998-05-28 2004-01-15 Композиции, содержащие эффектор дипептидилпептидазы iv

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RU2003121766/04A RU2309161C2 (ru) 1998-05-28 1999-05-28 Эффекторы дипептидилпептидазу iv
RU2000133251/04A RU2227800C2 (ru) 1998-05-28 1999-05-28 Новые эффекторы дипептидилпептидазы iv

Country Status (24)

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US (4) US6548481B1 (ru)
EP (6) EP1214936B1 (ru)
JP (1) JP2002516318A (ru)
KR (2) KR100628668B1 (ru)
CN (4) CN101095675A (ru)
AT (6) ATE272059T1 (ru)
AU (1) AU764262B2 (ru)
BR (1) BR9910758A (ru)
CA (1) CA2333603C (ru)
DE (10) DE19823831A1 (ru)
DK (2) DK1304327T3 (ru)
ES (5) ES2223981T3 (ru)
HK (3) HK1033316A1 (ru)
HU (1) HUP0102001A3 (ru)
IL (3) IL139862A0 (ru)
IS (3) IS5728A (ru)
NO (1) NO317989B1 (ru)
NZ (2) NZ508260A (ru)
PL (1) PL344403A1 (ru)
PT (2) PT1304327E (ru)
RU (3) RU2309161C2 (ru)
SI (2) SI1082314T1 (ru)
UA (1) UA54599C2 (ru)
WO (1) WO1999061431A1 (ru)

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