CH602612A5 - - Google Patents

Info

Publication number
CH602612A5
CH602612A5 CH1369774A CH1369774A CH602612A5 CH 602612 A5 CH602612 A5 CH 602612A5 CH 1369774 A CH1369774 A CH 1369774A CH 1369774 A CH1369774 A CH 1369774A CH 602612 A5 CH602612 A5 CH 602612A5
Authority
CH
Switzerland
Application number
CH1369774A
Inventor
Ulf Dr Fischer
Eckehard Dr Lorch
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to CH1369774A priority Critical patent/CH602612A5/xx
Priority to ZA00755861A priority patent/ZA755861B/xx
Priority to IL48116A priority patent/IL48116A/xx
Priority to AU84977/75A priority patent/AU492980B2/en
Priority to FI752626A priority patent/FI752626A/fi
Priority to DE19752542598 priority patent/DE2542598A1/de
Priority to IE2184/75A priority patent/IE41807B1/en
Priority to US05/620,525 priority patent/US4028402A/en
Priority to CU7534371A priority patent/CU34371A/es
Priority to PH17640A priority patent/PH12279A/en
Priority to SU7502178502A priority patent/SU572200A3/ru
Priority to FR7530907A priority patent/FR2287221A1/fr
Priority to SE7511357A priority patent/SE7511357L/xx
Priority to BR7506595*A priority patent/BR7506595A/pt
Priority to NL7511890A priority patent/NL7511890A/xx
Priority to LU73557A priority patent/LU73557A1/xx
Priority to JP50121432A priority patent/JPS51125718A/ja
Priority to CA237,343A priority patent/CA1053258A/en
Priority to AT776375A priority patent/AT343676B/de
Priority to NO753447A priority patent/NO753447L/no
Priority to BE160823A priority patent/BE834369A/xx
Priority to DK457475AA priority patent/DK140834B/da
Priority to ES441673A priority patent/ES441673A1/es
Priority to PL1975183923A priority patent/PL95259B1/pl
Priority to DD188797A priority patent/DD123322A5/xx
Priority to GB4161175A priority patent/GB1473256A/en
Priority to AR260639A priority patent/AR209457A1/es
Publication of CH602612A5 publication Critical patent/CH602612A5/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
CH1369774A 1974-10-11 1974-10-11 CH602612A5 (ru)

Priority Applications (27)

Application Number Priority Date Filing Date Title
CH1369774A CH602612A5 (ru) 1974-10-11 1974-10-11
ZA00755861A ZA755861B (en) 1974-10-11 1975-09-15 Novel salts of biguanides
IL48116A IL48116A (en) 1974-10-11 1975-09-17 Salts of biguanides their manufacture and pharmaceutical compositions containing them
AU84977/75A AU492980B2 (en) 1975-09-18 Novel salts of biguanides
FI752626A FI752626A (ru) 1974-10-11 1975-09-19
DE19752542598 DE2542598A1 (de) 1974-10-11 1975-09-24 Neue biguanidsalze
IE2184/75A IE41807B1 (en) 1974-10-11 1975-10-06 Biguanide salts
US05/620,525 US4028402A (en) 1974-10-11 1975-10-08 Biguanide salts
CU7534371A CU34371A (es) 1974-10-11 1975-10-08 Nuevas sales de biguanida y su procedimiento de obsales de biguanida y su procedimiento de obtenciontenci on
PH17640A PH12279A (en) 1974-10-11 1975-10-08 Biguanide dichlorcacetates and pharmaceutical preparations containing them
SU7502178502A SU572200A3 (ru) 1974-10-11 1975-10-09 Способ получени бигуанидовых солей
FR7530907A FR2287221A1 (fr) 1974-10-11 1975-10-09 Nouveaux sels de biguanides, leur procede de preparation et leur application en tant que medicaments
SE7511357A SE7511357L (sv) 1974-10-11 1975-10-09 Nya biguanidsalter
BR7506595*A BR7506595A (pt) 1974-10-11 1975-10-09 Processo para a producao de sais de biguanida,sais assim obtidos,e sua aplicacao
NL7511890A NL7511890A (nl) 1974-10-11 1975-10-09 Nieuwe biguanidezouten.
LU73557A LU73557A1 (ru) 1974-10-11 1975-10-09
JP50121432A JPS51125718A (en) 1974-10-11 1975-10-09 Production of biguanide salt
CA237,343A CA1053258A (en) 1974-10-11 1975-10-09 Salts of biguanides
AT776375A AT343676B (de) 1974-10-11 1975-10-10 Verfahren zur herstellung von neuen biguanid-dichlorazetaten
NO753447A NO753447L (ru) 1974-10-11 1975-10-10
BE160823A BE834369A (fr) 1974-10-11 1975-10-10 Nouveaux sels de biguanides
DK457475AA DK140834B (da) 1974-10-11 1975-10-10 Analogifremgangsmåde til fremstilling af biguanidsalte.
ES441673A ES441673A1 (es) 1974-10-11 1975-10-10 Un procedimiento para la preparacion de sales de biguanida.
PL1975183923A PL95259B1 (pl) 1974-10-11 1975-10-10 Sposob wytwarzania nowych soli dwuguanidu
DD188797A DD123322A5 (ru) 1974-10-11 1975-10-10
GB4161175A GB1473256A (en) 1974-10-11 1975-10-10 Biguanide salts
AR260639A AR209457A1 (es) 1974-10-11 1975-10-11 Procedimiento para la preparacion de nuevas sales de biguanidas

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1369774A CH602612A5 (ru) 1974-10-11 1974-10-11

Publications (1)

Publication Number Publication Date
CH602612A5 true CH602612A5 (ru) 1978-07-31

Family

ID=4394567

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1369774A CH602612A5 (ru) 1974-10-11 1974-10-11

Country Status (26)

Country Link
US (1) US4028402A (ru)
JP (1) JPS51125718A (ru)
AR (1) AR209457A1 (ru)
AT (1) AT343676B (ru)
BE (1) BE834369A (ru)
BR (1) BR7506595A (ru)
CA (1) CA1053258A (ru)
CH (1) CH602612A5 (ru)
CU (1) CU34371A (ru)
DD (1) DD123322A5 (ru)
DE (1) DE2542598A1 (ru)
DK (1) DK140834B (ru)
ES (1) ES441673A1 (ru)
FI (1) FI752626A (ru)
FR (1) FR2287221A1 (ru)
GB (1) GB1473256A (ru)
IE (1) IE41807B1 (ru)
IL (1) IL48116A (ru)
LU (1) LU73557A1 (ru)
NL (1) NL7511890A (ru)
NO (1) NO753447L (ru)
PH (1) PH12279A (ru)
PL (1) PL95259B1 (ru)
SE (1) SE7511357L (ru)
SU (1) SU572200A3 (ru)
ZA (1) ZA755861B (ru)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2401898A1 (fr) * 1977-09-05 1979-03-30 Aec Chim Organ Biolog Nouveau sel de l'acide patoique
US20020006899A1 (en) * 1998-10-06 2002-01-17 Pospisilik Andrew J. Use of dipeptidyl peptidase IV effectors for lowering blood pressure in mammals
DE122010000020I1 (de) 1996-04-25 2010-07-08 Prosidion Ltd Verfahren zur Senkung des Blutglukosespiegels in Säugern
WO1998027982A1 (fr) 1996-12-24 1998-07-02 Sumitomo Pharmaceuticals Co., Ltd. Composition contenant de l'acide ascorbique
DE19823831A1 (de) * 1998-05-28 1999-12-02 Probiodrug Ges Fuer Arzneim Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen
DE19828113A1 (de) 1998-06-24 2000-01-05 Probiodrug Ges Fuer Arzneim Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV
DE19828114A1 (de) 1998-06-24 2000-01-27 Probiodrug Ges Fuer Arzneim Produgs instabiler Inhibitoren der Dipeptidyl Peptidase IV
DE19834591A1 (de) 1998-07-31 2000-02-03 Probiodrug Ges Fuer Arzneim Verfahren zur Steigerung des Blutglukosespiegels in Säugern
US20030176357A1 (en) * 1998-10-06 2003-09-18 Pospisilik Andrew J. Dipeptidyl peptidase IV inhibitors and their uses for lowering blood pressure levels
DE19926233C1 (de) 1999-06-10 2000-10-19 Probiodrug Ges Fuer Arzneim Verfahren zur Herstellung von Thiazolidin
DE19940130A1 (de) * 1999-08-24 2001-03-01 Probiodrug Ges Fuer Arzneim Neue Effektoren der Dipeptidyl Peptidase IV zur topischen Anwendung
WO2001024790A1 (fr) * 1999-10-06 2001-04-12 Kurokawa, Kiyoshi Agents permettant de soulager le stress induit par le carbonyle
US20080076811A1 (en) * 2000-01-21 2008-03-27 Bork Balkan Combinations comprising depeptidypeptidase-iv inhibitors and antidiabetic agents
EP2055302B1 (en) * 2000-03-31 2014-09-10 Royalty Pharma Collection Trust Method for the improvement of islet signaling in diabetes mellitus and for its prevention
FR2809310B1 (fr) 2000-05-26 2004-02-13 Centre Nat Rech Scient Utilisation de derives de biguanide pour fabriquer un medicament ayant un effet cicatrisant
JP2005097117A (ja) * 2000-06-30 2005-04-14 Chugai Pharmaceut Co Ltd 糖尿病治療剤
RU2286149C2 (ru) * 2000-10-27 2006-10-27 Пробиодруг Аг Способ для лечения неврологических и нейропсихологических нарушений
US7132104B1 (en) 2000-10-27 2006-11-07 Probiodrug Ag Modulation of central nervous system (CNS) dipeptidyl peptidase IV (DPIV) -like activity for the treatment of neurological and neuropsychological disorders
US6890905B2 (en) 2001-04-02 2005-05-10 Prosidion Limited Methods for improving islet signaling in diabetes mellitus and for its prevention
US7368421B2 (en) 2001-06-27 2008-05-06 Probiodrug Ag Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis
DE10150203A1 (de) 2001-10-12 2003-04-17 Probiodrug Ag Peptidylketone als Inhibitoren der DPIV
US20030130199A1 (en) * 2001-06-27 2003-07-10 Von Hoersten Stephan Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents
EP1492525A2 (en) * 2001-08-16 2005-01-05 Probiodrug AG Use of inhibitors of proline endopeptidase to modulate inositol (1,4,5) triphosphate concentration dependent on intracellular signal cascades
US6844316B2 (en) 2001-09-06 2005-01-18 Probiodrug Ag Inhibitors of dipeptidyl peptidase I
SK3622004A3 (sk) 2002-02-28 2005-02-04 Prosidion Limited Inhibítory DPIV na báze glutaminylu
US20030232761A1 (en) * 2002-03-28 2003-12-18 Hinke Simon A. Novel analogues of glucose-dependent insulinotropic polypeptide
US20040033051A1 (en) * 2002-08-16 2004-02-19 Ip Kiril Kun Wan Method and system for producing and displaying visual presentations which inhibit off-screen duplication
WO2004031374A2 (en) * 2002-09-18 2004-04-15 Prosidion Ltd. Secondary binding site of dipeptidyl peptidase iv (dp iv)
US20040058876A1 (en) * 2002-09-18 2004-03-25 Torsten Hoffmann Secondary binding site of dipeptidyl peptidase IV (DP IV)
CN101837127A (zh) 2003-05-05 2010-09-22 前体生物药物股份公司 谷氨酰胺酰基和谷氨酸环化酶效应物的应用
DE602004026289D1 (de) 2003-05-05 2010-05-12 Probiodrug Ag Glutaminylcyclase-hemmer
WO2005039548A2 (en) * 2003-10-15 2005-05-06 Probiodrug Ag Use of effectors of glutaminyl and glutamate cyclases
US20050171112A1 (en) * 2003-11-03 2005-08-04 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
US20100099721A1 (en) * 2003-11-03 2010-04-22 Probiodrug Ag Novel compounds for the treatment of neurological disorders
AU2005210004B2 (en) 2004-02-05 2010-10-28 Probiodrug Ag Novel inhibitors of glutaminyl cyclase
EP2109447B1 (en) * 2007-01-29 2015-06-10 HanAll Biopharma Co., Ltd. N, n- dimethyl imidodicarbonimidic diamide acetate, method for producing the same and pharmaceutical compositions comprising the same
WO2008097861A2 (en) * 2007-02-02 2008-08-14 Braincells, Inc. MODULATION OF NEUROGENESIS WITH BIGUANIDES AND GSK3-ß AGENTS
EP2203418B1 (en) * 2007-09-21 2017-10-25 HanAll Biopharma Co., Ltd. N,n-dimethyl imidodicarbonimidic diamide dicarboxylate, method for producing the same and pharmaceutical compositions comprising the same
WO2009088220A2 (ko) * 2008-01-08 2009-07-16 Hanall Pharmaceutical Company. Ltd Ｎ,ｎ-디메틸 이미도디카르본이미딕 디아미드의 니코틴산염, 그의 제조방법 및 그를 포함하는 약제학적 조성물
JP5551691B2 (ja) * 2008-06-26 2014-07-16 ラボラトリオス シラネス、エセ．ア．デ セ．べ． 血糖制御のための新規グリシン酸メトホルミン塩
WO2010146604A2 (en) 2009-06-18 2010-12-23 Exemed Pharmaceuticals Processes for preparing metformin hydrochloride
WO2011049400A2 (ko) * 2009-10-23 2011-04-28 한올바이오파마주식회사 N,n-디메틸 이미도디카르본이미딕 디아미드의 산 부가염을 포함하는 항암용 약제학적 조성물
KR101324283B1 (ko) 2010-04-27 2013-11-01 한올바이오파마주식회사 바이구아나이드 화합물의 신규 염, 그의 제조방법, 그를 포함하는 약제학적 조성물
WO2018060959A1 (en) 2016-09-30 2018-04-05 Laboratorios Silanes S.A. De C.V. Metformin glycinate, pharmaceutical compositions comprising the same, and methods of using the same
US11510886B2 (en) 2016-09-30 2022-11-29 Laboratorios Silanes, S.A. De C.V. Metformin amino acid compounds and methods of using the same
CN107118130A (zh) * 2017-05-11 2017-09-01 杜剑平 一类治疗肿瘤的药物化合物及其应用
CN106986791A (zh) * 2017-05-11 2017-07-28 杜剑平 一种治疗肿瘤的药物化合物及其制备方法和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3179562A (en) * 1961-08-23 1965-04-20 Du Pont Treatment of diabetes with alpha, alpha substituted acetic acid derivatives

Also Published As

Publication number Publication date
GB1473256A (en) 1977-05-11
DE2542598A1 (de) 1976-04-22
IL48116A (en) 1979-07-25
NL7511890A (nl) 1976-04-13
SE7511357L (sv) 1976-04-12
DK457475A (ru) 1976-04-12
LU73557A1 (ru) 1977-05-24
ATA776375A (de) 1977-10-15
IL48116A0 (en) 1975-11-25
ES441673A1 (es) 1977-04-01
BR7506595A (pt) 1976-08-17
PL95259B1 (pl) 1977-10-31
DK140834B (da) 1979-11-26
AU8497775A (en) 1977-03-24
CU34371A (es) 1979-06-01
FI752626A (ru) 1976-04-12
PH12279A (en) 1978-12-12
US4028402A (en) 1977-06-07
ZA755861B (en) 1976-08-25
AR209457A1 (es) 1977-04-29
NO753447L (ru) 1976-04-13
AT343676B (de) 1978-06-12
FR2287221A1 (fr) 1976-05-07
IE41807B1 (en) 1980-03-26
BE834369A (fr) 1976-04-12
JPS51125718A (en) 1976-11-02
CA1053258A (en) 1979-04-24
DK140834C (ru) 1980-04-28
DD123322A5 (ru) 1976-12-12
SU572200A3 (ru) 1977-09-05
IE41807L (en) 1976-04-11

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Legal Events

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PL Patent ceased