NL7511890A - Nieuwe biguanidezouten. - Google Patents

Nieuwe biguanidezouten.

Info

Publication number
NL7511890A
NL7511890A NL7511890A NL7511890A NL7511890A NL 7511890 A NL7511890 A NL 7511890A NL 7511890 A NL7511890 A NL 7511890A NL 7511890 A NL7511890 A NL 7511890A NL 7511890 A NL7511890 A NL 7511890A
Authority
NL
Netherlands
Prior art keywords
biguanide salts
new
new biguanide
salts
biguanide
Prior art date
Application number
NL7511890A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NL7511890A publication Critical patent/NL7511890A/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
NL7511890A 1974-10-11 1975-10-09 Nieuwe biguanidezouten. NL7511890A (nl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1369774A CH602612A5 (nl) 1974-10-11 1974-10-11

Publications (1)

Publication Number Publication Date
NL7511890A true NL7511890A (nl) 1976-04-13

Family

ID=4394567

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7511890A NL7511890A (nl) 1974-10-11 1975-10-09 Nieuwe biguanidezouten.

Country Status (26)

Country Link
US (1) US4028402A (nl)
JP (1) JPS51125718A (nl)
AR (1) AR209457A1 (nl)
AT (1) AT343676B (nl)
BE (1) BE834369A (nl)
BR (1) BR7506595A (nl)
CA (1) CA1053258A (nl)
CH (1) CH602612A5 (nl)
CU (1) CU34371A (nl)
DD (1) DD123322A5 (nl)
DE (1) DE2542598A1 (nl)
DK (1) DK140834B (nl)
ES (1) ES441673A1 (nl)
FI (1) FI752626A (nl)
FR (1) FR2287221A1 (nl)
GB (1) GB1473256A (nl)
IE (1) IE41807B1 (nl)
IL (1) IL48116A (nl)
LU (1) LU73557A1 (nl)
NL (1) NL7511890A (nl)
NO (1) NO753447L (nl)
PH (1) PH12279A (nl)
PL (1) PL95259B1 (nl)
SE (1) SE7511357L (nl)
SU (1) SU572200A3 (nl)
ZA (1) ZA755861B (nl)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2401898A1 (fr) * 1977-09-05 1979-03-30 Aec Chim Organ Biolog Nouveau sel de l'acide patoique
DE122010000020I1 (de) 1996-04-25 2010-07-08 Prosidion Ltd Verfahren zur Senkung des Blutglukosespiegels in Säugern
US20020006899A1 (en) * 1998-10-06 2002-01-17 Pospisilik Andrew J. Use of dipeptidyl peptidase IV effectors for lowering blood pressure in mammals
WO1998027982A1 (fr) 1996-12-24 1998-07-02 Sumitomo Pharmaceuticals Co., Ltd. Composition contenant de l'acide ascorbique
DE19823831A1 (de) 1998-05-28 1999-12-02 Probiodrug Ges Fuer Arzneim Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen
DE19828114A1 (de) 1998-06-24 2000-01-27 Probiodrug Ges Fuer Arzneim Produgs instabiler Inhibitoren der Dipeptidyl Peptidase IV
DE19828113A1 (de) 1998-06-24 2000-01-05 Probiodrug Ges Fuer Arzneim Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV
DE19834591A1 (de) 1998-07-31 2000-02-03 Probiodrug Ges Fuer Arzneim Verfahren zur Steigerung des Blutglukosespiegels in Säugern
US20030176357A1 (en) * 1998-10-06 2003-09-18 Pospisilik Andrew J. Dipeptidyl peptidase IV inhibitors and their uses for lowering blood pressure levels
DE19926233C1 (de) 1999-06-10 2000-10-19 Probiodrug Ges Fuer Arzneim Verfahren zur Herstellung von Thiazolidin
DE19940130A1 (de) * 1999-08-24 2001-03-01 Probiodrug Ges Fuer Arzneim Neue Effektoren der Dipeptidyl Peptidase IV zur topischen Anwendung
WO2001024790A1 (fr) * 1999-10-06 2001-04-12 Kurokawa, Kiyoshi Agents permettant de soulager le stress induit par le carbonyle
US20080076811A1 (en) * 2000-01-21 2008-03-27 Bork Balkan Combinations comprising depeptidypeptidase-iv inhibitors and antidiabetic agents
US6500804B2 (en) * 2000-03-31 2002-12-31 Probiodrug Ag Method for the improvement of islet signaling in diabetes mellitus and for its prevention
FR2809310B1 (fr) 2000-05-26 2004-02-13 Centre Nat Rech Scient Utilisation de derives de biguanide pour fabriquer un medicament ayant un effet cicatrisant
JP2005097117A (ja) * 2000-06-30 2005-04-14 Chugai Pharmaceut Co Ltd 糖尿病治療剤
US7132104B1 (en) 2000-10-27 2006-11-07 Probiodrug Ag Modulation of central nervous system (CNS) dipeptidyl peptidase IV (DPIV) -like activity for the treatment of neurological and neuropsychological disorders
IL155116A0 (en) * 2000-10-27 2003-10-31 Probiodrug Ag Pharmaceutical compositions containing as inhibitor of dipeptidyl peptidase iv and of similar enzymes
US6890905B2 (en) 2001-04-02 2005-05-10 Prosidion Limited Methods for improving islet signaling in diabetes mellitus and for its prevention
US7368421B2 (en) 2001-06-27 2008-05-06 Probiodrug Ag Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis
DE10150203A1 (de) 2001-10-12 2003-04-17 Probiodrug Ag Peptidylketone als Inhibitoren der DPIV
US20030130199A1 (en) * 2001-06-27 2003-07-10 Von Hoersten Stephan Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents
EP1492525A2 (en) * 2001-08-16 2005-01-05 Probiodrug AG Use of inhibitors of proline endopeptidase to modulate inositol (1,4,5) triphosphate concentration dependent on intracellular signal cascades
US6844316B2 (en) 2001-09-06 2005-01-18 Probiodrug Ag Inhibitors of dipeptidyl peptidase I
PL372316A1 (en) 2002-02-28 2005-07-11 Prosidion Limited Glutaminyl based dpiv inhibitors
US20030232761A1 (en) * 2002-03-28 2003-12-18 Hinke Simon A. Novel analogues of glucose-dependent insulinotropic polypeptide
US20040033051A1 (en) * 2002-08-16 2004-02-19 Ip Kiril Kun Wan Method and system for producing and displaying visual presentations which inhibit off-screen duplication
DE60331747D1 (de) * 2002-09-18 2010-04-29 Prosidion Ltd Sekundäre bindungsstelle von dipeptidylpeptidase iv (dp iv)
US20040058876A1 (en) * 2002-09-18 2004-03-25 Torsten Hoffmann Secondary binding site of dipeptidyl peptidase IV (DP IV)
KR20110059664A (ko) 2003-05-05 2011-06-02 프로비오드룩 아게 글루타미닐 및 글루타메이트 사이클라제의 이펙터의 용도
JP4806628B2 (ja) 2003-05-05 2011-11-02 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤
KR101121882B1 (ko) * 2003-10-15 2012-04-12 프로비오드룩 아게 글루타미닐 및 글루타메이트 사이클라제 이펙터의 용도
US20050171112A1 (en) * 2003-11-03 2005-08-04 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
US20100099721A1 (en) * 2003-11-03 2010-04-22 Probiodrug Ag Novel compounds for the treatment of neurological disorders
EP1713780B1 (en) 2004-02-05 2012-01-18 Probiodrug AG Novel inhibitors of glutaminyl cyclase
KR100926417B1 (ko) 2007-01-29 2009-11-12 한올제약주식회사 Ｎ,ｎ―디메틸 이미도디카르본이미딕 디아미드의 초산염,그의 제조방법 및 그를 포함하는 약제학적 조성물
US20080188457A1 (en) * 2007-02-02 2008-08-07 Braincells, Inc. Modulation of Neurogenesis with Biguanides and GSK3-beta Agents
JP5292404B2 (ja) * 2007-09-21 2013-09-18 ハンオル バイオファーマ カンパニー，リミテッド Ｎ，ｎ−ジメチルイミドジカルボンイミド酸ジアミドのジカルボン酸塩、その製造方法、及びその薬剤学的組成物
WO2009088220A2 (ko) * 2008-01-08 2009-07-16 Hanall Pharmaceutical Company. Ltd Ｎ,ｎ-디메틸 이미도디카르본이미딕 디아미드의 니코틴산염, 그의 제조방법 및 그를 포함하는 약제학적 조성물
SI2303838T1 (sl) 2008-06-26 2014-07-31 Laboratorios Silanes, S.A. De C.V. Nova sol metformin glicinata za nadzor glukoze v krvi
US20110021634A1 (en) 2009-06-18 2011-01-27 Patel Pranav Dushyant Processes for preparing metformin hydrochloride
WO2011049400A2 (ko) * 2009-10-23 2011-04-28 한올바이오파마주식회사 N,n-디메틸 이미도디카르본이미딕 디아미드의 산 부가염을 포함하는 항암용 약제학적 조성물
KR101324283B1 (ko) 2010-04-27 2013-11-01 한올바이오파마주식회사 바이구아나이드 화합물의 신규 염, 그의 제조방법, 그를 포함하는 약제학적 조성물
BR112019006401A2 (pt) 2016-09-30 2019-06-25 Laboratorios Silanes S A De C V glicinato de metformina, composições farmacêuticas que compreendem o mesmo e métodos de uso do mesmo
US11510886B2 (en) 2016-09-30 2022-11-29 Laboratorios Silanes, S.A. De C.V. Metformin amino acid compounds and methods of using the same
CN107118130A (zh) * 2017-05-11 2017-09-01 杜剑平 一类治疗肿瘤的药物化合物及其应用
CN106986791A (zh) * 2017-05-11 2017-07-28 杜剑平 一种治疗肿瘤的药物化合物及其制备方法和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3179562A (en) * 1961-08-23 1965-04-20 Du Pont Treatment of diabetes with alpha, alpha substituted acetic acid derivatives

Also Published As

Publication number Publication date
DD123322A5 (nl) 1976-12-12
SE7511357L (sv) 1976-04-12
CU34371A (es) 1979-06-01
FI752626A (nl) 1976-04-12
ZA755861B (en) 1976-08-25
BR7506595A (pt) 1976-08-17
GB1473256A (en) 1977-05-11
PH12279A (en) 1978-12-12
DK457475A (nl) 1976-04-12
CA1053258A (en) 1979-04-24
LU73557A1 (nl) 1977-05-24
US4028402A (en) 1977-06-07
CH602612A5 (nl) 1978-07-31
BE834369A (fr) 1976-04-12
JPS51125718A (en) 1976-11-02
DK140834C (nl) 1980-04-28
NO753447L (nl) 1976-04-13
AR209457A1 (es) 1977-04-29
IL48116A0 (en) 1975-11-25
PL95259B1 (pl) 1977-10-31
IE41807B1 (en) 1980-03-26
DK140834B (da) 1979-11-26
ATA776375A (de) 1977-10-15
DE2542598A1 (de) 1976-04-22
AU8497775A (en) 1977-03-24
IL48116A (en) 1979-07-25
AT343676B (de) 1978-06-12
FR2287221A1 (fr) 1976-05-07
IE41807L (en) 1976-04-11
ES441673A1 (es) 1977-04-01
SU572200A3 (ru) 1977-09-05

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Legal Events

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BV The patent application has lapsed