RU2014127702A - Модифицированные Cascade-рибонуклеопротеины и их применения - Google Patents

Модифицированные Cascade-рибонуклеопротеины и их применения Download PDF

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RU2014127702A
RU2014127702A RU2014127702A RU2014127702A RU2014127702A RU 2014127702 A RU2014127702 A RU 2014127702A RU 2014127702 A RU2014127702 A RU 2014127702A RU 2014127702 A RU2014127702 A RU 2014127702A RU 2014127702 A RU2014127702 A RU 2014127702A
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nucleic acid
target nucleic
cell
protospacer
motif adjacent
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RU2014127702A
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Стан Йохан Йозеф БРАУНС
ДЕР ОСТ Джон ВАН
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Вагенинген Юниверситейт
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
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    • C07K—PEPTIDES
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    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
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    • C12Y301/21004—Type II site-specific deoxyribonuclease (3.1.21.4)

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RU2014127702A 2011-12-30 2012-12-21 Модифицированные Cascade-рибонуклеопротеины и их применения RU2014127702A (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1122458.1 2011-12-30
GB201122458A GB201122458D0 (en) 2011-12-30 2011-12-30 Modified cascade ribonucleoproteins and uses thereof
PCT/EP2012/076674 WO2013098244A1 (en) 2011-12-30 2012-12-21 Modified cascade ribonucleoproteins and uses thereof

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RU2014127702A true RU2014127702A (ru) 2016-02-20

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US (11) US20140294773A1 (enExample)
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JP (1) JP6408914B2 (enExample)
KR (1) KR101889589B1 (enExample)
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SG (1) SG11201403713QA (enExample)
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