PE20131116A1 - Compuestos heterociclicos potenciadores de ampa - Google Patents
Compuestos heterociclicos potenciadores de ampaInfo
- Publication number
- PE20131116A1 PE20131116A1 PE2013000244A PE2013000244A PE20131116A1 PE 20131116 A1 PE20131116 A1 PE 20131116A1 PE 2013000244 A PE2013000244 A PE 2013000244A PE 2013000244 A PE2013000244 A PE 2013000244A PE 20131116 A1 PE20131116 A1 PE 20131116A1
- Authority
- PE
- Peru
- Prior art keywords
- thadiazine
- dihydropyride
- ring
- ampa
- enhancing
- Prior art date
Links
- MGRVRXRGTBOSHW-UHFFFAOYSA-N (aminomethyl)phosphonic acid Chemical compound NCP(O)(O)=O MGRVRXRGTBOSHW-UHFFFAOYSA-N 0.000 title 1
- 230000002708 enhancing effect Effects 0.000 title 1
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- -1 4-PHENOXYPHENYL Chemical class 0.000 abstract 3
- 206010020772 Hypertension Diseases 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- UUDAMDVQRQNNHZ-UHFFFAOYSA-N (S)-AMPA Chemical compound CC=1ONC(=O)C=1CC(N)C(O)=O UUDAMDVQRQNNHZ-UHFFFAOYSA-N 0.000 abstract 1
- KEIFWROAQVVDBN-UHFFFAOYSA-N 1,2-dihydronaphthalene Chemical compound C1=CC=C2C=CCCC2=C1 KEIFWROAQVVDBN-UHFFFAOYSA-N 0.000 abstract 1
- 102000003678 AMPA Receptors Human genes 0.000 abstract 1
- 108090000078 AMPA Receptors Proteins 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 150000001924 cycloalkanes Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003334 potential effect Effects 0.000 abstract 1
- 239000004576 sand Substances 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010179577 | 2010-08-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20131116A1 true PE20131116A1 (es) | 2013-10-24 |
Family
ID=44534564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2013000244A PE20131116A1 (es) | 2010-08-10 | 2011-08-09 | Compuestos heterociclicos potenciadores de ampa |
Country Status (39)
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5788496B2 (ja) * | 2010-08-10 | 2015-09-30 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| WO2012137982A2 (en) * | 2011-04-05 | 2012-10-11 | Takeda Pharmaceutical Company Limited | Sulfonamide derivative and use thereof |
| WO2013118845A1 (ja) * | 2012-02-08 | 2013-08-15 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| EP3311842A1 (en) * | 2013-06-13 | 2018-04-25 | VeroScience LLC | Compositions and methods for treating metabolic disorders |
| DK3013813T3 (da) | 2013-06-27 | 2019-06-03 | Pfizer | Heteroaromatiske forbindelser og anvendelse deraf som dopamin-d1-ligander |
| JP6524086B2 (ja) | 2013-12-03 | 2019-06-05 | エフ エム シー コーポレーションＦｍｃ Ｃｏｒｐｏｒａｔｉｏｎ | ピロリジノン除草剤 |
| US11589583B2 (en) | 2013-12-03 | 2023-02-28 | Fmc Corporation | Pyrrolidinones herbicides |
| EP3164386B1 (en) | 2014-07-02 | 2020-10-07 | FMC Corporation | Piperidinone herbicides |
| EP3230264B1 (en) | 2014-12-08 | 2019-09-11 | FMC Corporation | 3-oxo-3-(arylamino)propanoates, a process for their preparation, and their use in preparing pyrrolidinones |
| EP3280709B1 (en) | 2015-04-10 | 2021-05-26 | FMC Corporation | Substituted cyclic amides as herbicides |
| CN107531658B (zh) | 2015-04-27 | 2021-07-27 | Fmc公司 | 作为除草剂的丁内酯 |
| MX373652B (es) * | 2015-04-29 | 2020-04-02 | Janssen Pharmaceutica Nv | Imidazopirazinas y pirazolopirimidinas y su uso como moduladores del receptor de ampa. |
| WO2016176460A1 (en) * | 2015-04-29 | 2016-11-03 | Janssen Pharmaceutica Nv | Azabenzimidazoles and their use as ampa receptor modulators |
| PL3294743T3 (pl) | 2015-05-12 | 2020-03-31 | Fmc Corporation | Podstawione arylem związki bicykliczne jako środki chwastobójcze |
| EP3303287B1 (en) | 2015-05-29 | 2020-12-16 | FMC Corporation | Substituted cyclic amides as herbicides |
| US10654804B2 (en) | 2015-06-02 | 2020-05-19 | Fmc Corporation | Substituted cyclic amides and their use as herbicides |
| AU2016303209B2 (en) | 2015-07-31 | 2021-04-01 | Fmc Corporation | Cyclic N-carboxamide compounds useful as herbicides |
| CA2982825C (en) * | 2015-08-06 | 2023-10-17 | F. Hoffmann-La Roche Ag | Processes for the preparation of galnac acid derivatives |
| US20170181292A1 (en) * | 2015-12-16 | 2017-06-22 | Rohm And Haas Electronic Materials Llc | Method for forming organic coating on nickel surface |
| CN105669731B (zh) * | 2016-01-10 | 2017-06-30 | 沧州普瑞东方科技有限公司 | 一种4‑(4‑烷基环己氧基)苯硼酸的合成方法 |
| EP3558962B1 (en) | 2016-12-21 | 2023-07-12 | FMC Corporation | Nitrone herbicides |
| CN107892697B (zh) | 2016-12-26 | 2020-11-03 | 郑州泰基鸿诺医药股份有限公司 | 一种[1,3]噻嗪-2-胺类化合物及应用，药物组合物 |
| BR112019019551A2 (pt) | 2017-03-21 | 2020-04-22 | Fmc Corp | mistura, e, método para controlar o crescimento de vegetação indesejada |
| SG11201908640TA (en) | 2017-03-21 | 2019-10-30 | Fmc Corp | Pyrrolidinones and a process to prepare them |
| AR111967A1 (es) | 2017-05-30 | 2019-09-04 | Fmc Corp | Amidas herbicidas |
| AR111839A1 (es) | 2017-05-30 | 2019-08-21 | Fmc Corp | Lactamas 3-sustituidas herbicidas |
| US11447488B2 (en) | 2017-10-06 | 2022-09-20 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds |
| JP7250686B2 (ja) * | 2017-10-06 | 2023-04-03 | 武田薬品工業株式会社 | 複素環化合物 |
| US12370192B2 (en) | 2019-09-16 | 2025-07-29 | Takeda Pharmaceutical Company Limited | Azole-fused pyridazin-3(2H)-one derivatives |
| WO2021229294A1 (en) | 2020-05-15 | 2021-11-18 | Takeda Pharmaceutical Company Limited | Treatment for depression |
| CN113943294A (zh) * | 2020-07-15 | 2022-01-18 | 成都海博为药业有限公司 | 一种作为btk抑制剂的化合物及其制备方法与用途 |
| WO2025226591A1 (en) | 2024-04-22 | 2025-10-30 | Neurocrine Biosciences, Inc. | Methods of administering 9-[4-(cyclohexyloxy)phenyl]-7-methyl-3,4-dihydropyrazino[2,1-c][1,2,4]thiadiazine 2,2-dioxide without side effects |
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| JPH0437742Y2 (enExample) | 1986-10-22 | 1992-09-04 | ||
| JPH0285851A (ja) * | 1988-09-22 | 1990-03-27 | Konica Corp | 新規な写真用カプラー |
| JPH037742A (ja) | 1989-06-05 | 1991-01-14 | Toyo Tire & Rubber Co Ltd | ラバーチエーン用ゴム組成物 |
| JP2874960B2 (ja) | 1990-06-03 | 1999-03-24 | コニカ株式会社 | 新規な染料を含有するハロゲン化銀写真感光材料 |
| JPH04119890A (ja) | 1990-09-11 | 1992-04-21 | Konica Corp | ピラゾロチアジアジン系色素 |
| JP3430375B2 (ja) | 1993-11-12 | 2003-07-28 | コニカ株式会社 | 感熱転写材料及び該材料に好適な色素 |
| DE19704923A1 (de) | 1997-02-10 | 1998-08-13 | Hoechst Schering Agrevo Gmbh | Klebstoffhaltige Schädlingsbekämpfungsmittel |
| WO2001032013A1 (en) | 1999-11-04 | 2001-05-10 | Colorado State University Research Foundation | Method and device for attracting insects |
| FR2801587B1 (fr) | 1999-11-30 | 2002-01-11 | Adir | Nouveaux derives de benzothiadiazines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| EP1436270A1 (en) * | 2001-10-10 | 2004-07-14 | Neurosearch A/S | Novel benzothiazine derivatives, their preparation and use |
| FR2833955B1 (fr) * | 2001-12-21 | 2004-01-30 | Servier Lab | Nouveaux derives de benzothiazine et de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2854634B1 (fr) | 2003-05-05 | 2005-07-08 | Servier Lab | Nouveaux derives de thiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2865474B1 (fr) | 2004-01-26 | 2008-06-13 | Servier Lab | Nouveaux derives de benzothiazines fluorees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2879201B1 (fr) | 2004-12-10 | 2007-02-16 | Servier Lab | Nouveaux derives de benzothiazine et benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| AU2007100527A4 (en) | 2006-06-23 | 2007-08-23 | Nufarm Australia Limited | Phenoxy alkanoate herbicidal composition and method of preparation and use |
| KR20090082278A (ko) | 2006-12-11 | 2009-07-29 | 일라이 릴리 앤드 캄파니 | Ａｍｐａ 수용체 강화제 |
| US20080167374A1 (en) | 2007-01-09 | 2008-07-10 | Loveland Products, Inc. | Pesticide composition and method of use |
| US8487099B2 (en) * | 2007-11-05 | 2013-07-16 | Merck Sharp & Dohme Corp. | Gamma secretase modulators |
| AU2008345225A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| EP2269990A4 (en) | 2008-03-25 | 2012-04-18 | Takeda Pharmaceutical | Heterocyclic compound |
| JP2009248543A (ja) * | 2008-04-11 | 2009-10-29 | Fujifilm Corp | 光情報記録媒体および情報記録方法 |
| TW201012803A (en) | 2008-06-06 | 2010-04-01 | Organon Nv | Heterocyclic derivatives |
| JP2012508181A (ja) * | 2008-11-06 | 2012-04-05 | シェーリング コーポレイション | γ−セクレターゼ調節剤 |
| TW201030002A (en) | 2009-01-16 | 2010-08-16 | Bristol Myers Squibb Co | Bicyclic compounds for the reduction of beta-amyloid production |
| JP2012051806A (ja) | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | イミダゾリルピラジン誘導体 |
| FR2943342B1 (fr) | 2009-03-20 | 2011-03-04 | Servier Lab | Nouveaux derives de benzothiadiazepines,leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| WO2010140339A1 (ja) | 2009-06-01 | 2010-12-09 | 武田薬品工業株式会社 | 複素環化合物 |
| WO2011007756A1 (ja) | 2009-07-13 | 2011-01-20 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
| WO2011036885A1 (ja) | 2009-09-25 | 2011-03-31 | 武田薬品工業株式会社 | 複素環化合物 |
| WO2011036889A1 (ja) | 2009-09-25 | 2011-03-31 | 武田薬品工業株式会社 | 複素環化合物 |
| JP5788496B2 (ja) * | 2010-08-10 | 2015-09-30 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
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2011
- 2011-08-09 JP JP2013506362A patent/JP5788496B2/ja active Active
- 2011-08-09 LT LTEP11749944.2T patent/LT2603513T/lt unknown
- 2011-08-09 SG SG2013007463A patent/SG187656A1/en unknown
- 2011-08-09 RS RS20200574A patent/RS60311B1/sr unknown
- 2011-08-09 EA EA201390222A patent/EA022078B1/ru not_active IP Right Cessation
- 2011-08-09 MY MYPI2013000428A patent/MY165908A/en unknown
- 2011-08-09 DK DK11749944.2T patent/DK2603513T3/da active
- 2011-08-09 HU HUE11749944A patent/HUE049460T2/hu unknown
- 2011-08-09 GE GEAP201113021A patent/GEP20156216B/en unknown
- 2011-08-09 WO PCT/JP2011/068497 patent/WO2012020848A1/en not_active Ceased
- 2011-08-09 MX MX2013001614A patent/MX349470B/es active IP Right Grant
- 2011-08-09 UY UY0001033551A patent/UY33551A/es not_active Application Discontinuation
- 2011-08-09 PE PE2013000244A patent/PE20131116A1/es active IP Right Grant
- 2011-08-09 AU AU2011290126A patent/AU2011290126B2/en active Active
- 2011-08-09 CA CA2807460A patent/CA2807460C/en active Active
- 2011-08-09 KR KR1020137006113A patent/KR101852215B1/ko active Active
- 2011-08-09 NZ NZ607593A patent/NZ607593A/en unknown
- 2011-08-09 ES ES11749944T patent/ES2793723T3/es active Active
- 2011-08-09 PT PT117499442T patent/PT2603513T/pt unknown
- 2011-08-09 US US13/816,137 patent/US9150591B2/en active Active
- 2011-08-09 TW TW100128311A patent/TWI504604B/zh active
- 2011-08-09 SI SI201131887T patent/SI2603513T1/sl unknown
- 2011-08-09 CN CN201180048970.3A patent/CN103180326B/zh active Active
- 2011-08-09 EP EP11749944.2A patent/EP2603513B1/en active Active
- 2011-08-09 PL PL11749944T patent/PL2603513T3/pl unknown
- 2011-08-09 MA MA35708A patent/MA34509B1/fr unknown
- 2011-08-09 HR HRP20200844TT patent/HRP20200844T1/hr unknown
- 2011-08-09 US US13/206,113 patent/US8575154B2/en active Active
- 2011-08-09 AR ARP110102905A patent/AR082618A1/es active IP Right Grant
- 2011-08-09 CN CN201510259936.0A patent/CN104926837A/zh active Pending
- 2011-08-09 BR BR112013002250-7A patent/BR112013002250B1/pt active IP Right Grant
- 2011-08-09 PH PH1/2013/500247A patent/PH12013500247A1/en unknown
- 2011-09-08 UA UAA201302884A patent/UA111594C2/uk unknown
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2013
- 2013-01-28 IL IL224452A patent/IL224452A/en active IP Right Grant
- 2013-02-05 DO DO2013000030A patent/DOP2013000030A/es unknown
- 2013-02-07 CL CL2013000380A patent/CL2013000380A1/es unknown
- 2013-02-12 ZA ZA2013/01120A patent/ZA201301120B/en unknown
- 2013-02-18 CR CR20130066A patent/CR20130066A/es unknown
- 2013-02-22 US US13/774,707 patent/US8916551B2/en active Active
- 2013-02-22 US US13/774,635 patent/US8778934B2/en active Active
- 2013-03-06 EC ECSP13012478 patent/ECSP13012478A/es unknown
- 2013-03-07 CO CO13046020A patent/CO6680700A2/es active IP Right Grant
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2014
- 2014-11-13 US US14/540,699 patent/US20150073137A1/en not_active Abandoned
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2015
- 2015-07-21 US US14/804,935 patent/US9499568B2/en active Active
- 2015-07-29 JP JP2015149216A patent/JP6113789B2/ja active Active
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2016
- 2016-10-10 US US15/289,650 patent/US9884875B2/en active Active
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2017
- 2017-12-18 US US15/845,621 patent/US20180162875A1/en not_active Abandoned
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2019
- 2019-01-24 US US16/256,773 patent/US10654874B2/en active Active
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2020
- 2020-03-23 US US16/827,316 patent/US11279713B2/en active Active
- 2020-05-25 CY CY20201100475T patent/CY1123507T1/el unknown
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2024
- 2024-03-01 US US18/592,897 patent/US20240360156A1/en active Pending
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