NZ334032A - Strains of Escherichia coli in fermentation processes for L-threonine production - Google Patents
Strains of Escherichia coli in fermentation processes for L-threonine productionInfo
- Publication number
- NZ334032A NZ334032A NZ334032A NZ33403297A NZ334032A NZ 334032 A NZ334032 A NZ 334032A NZ 334032 A NZ334032 A NZ 334032A NZ 33403297 A NZ33403297 A NZ 33403297A NZ 334032 A NZ334032 A NZ 334032A
- Authority
- NZ
- New Zealand
- Prior art keywords
- threonine
- coli
- strains
- strain
- escherichia coli
- Prior art date
Links
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 title abstract 11
- 239000004473 Threonine Substances 0.000 title abstract 7
- 229960002898 threonine Drugs 0.000 title abstract 7
- 241000588724 Escherichia coli Species 0.000 title abstract 4
- 238000000855 fermentation Methods 0.000 title 1
- 230000004151 fermentation Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 4
- 210000000349 chromosome Anatomy 0.000 abstract 2
- OJCKRNPLOZHAOU-RSXXJMTFSA-N (1r,2r)-2-[(2s,4e,6e,8r,9s,11r,13s,15s,16s)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxo-1-oxacyclooctadeca-4,6-dien-2-yl]cyclopentane-1-carboxylic acid Chemical group O1C(=O)C[C@H](O)[C@@H](C)C[C@@H](C)C[C@@H](C)C[C@H](C)[C@@H](O)\C(C#N)=C\C=C\C[C@H]1[C@H]1[C@H](C(O)=O)CCC1 OJCKRNPLOZHAOU-RSXXJMTFSA-N 0.000 abstract 1
- OJCKRNPLOZHAOU-BNXNOGCYSA-N Borrelidin Natural products CC1CC(C)CC(C)C(O)C(=C/C=C/CC(OC(=O)CC(O)C(C)C1)C2CCCC2C(=O)O)C#N OJCKRNPLOZHAOU-BNXNOGCYSA-N 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 230000001851 biosynthetic effect Effects 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 238000003780 insertion Methods 0.000 abstract 1
- 230000037431 insertion Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000013612 plasmid Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01003—Homoserine dehydrogenase (1.1.1.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
- C12Y207/01039—Homoserine kinase (2.7.1.39)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/02—Phosphotransferases with a carboxy group as acceptor (2.7.2)
- C12Y207/02004—Aspartate kinase (2.7.2.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
- C12Y402/03001—Threonine synthase (4.2.3.1)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2240796P | 1996-07-30 | 1996-07-30 | |
| PCT/US1997/013359 WO1998004715A1 (en) | 1996-07-30 | 1997-07-30 | Novel strains of escherichia coli, methods of preparing the same and use thereof in fermentation processes for l-threonine production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ334032A true NZ334032A (en) | 2000-09-29 |
Family
ID=21809430
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ334032A NZ334032A (en) | 1996-07-30 | 1997-07-30 | Strains of Escherichia coli in fermentation processes for L-threonine production |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5939307A (enExample) |
| EP (1) | EP0917578B1 (enExample) |
| JP (2) | JP4919529B2 (enExample) |
| KR (1) | KR20000029691A (enExample) |
| CN (1) | CN1261576C (enExample) |
| AT (1) | ATE421587T1 (enExample) |
| AU (1) | AU730102B2 (enExample) |
| BR (1) | BR9710503A (enExample) |
| CA (1) | CA2262813C (enExample) |
| DE (1) | DE69739234D1 (enExample) |
| HU (1) | HUP9903856A2 (enExample) |
| ID (1) | ID19402A (enExample) |
| IL (3) | IL128293A (enExample) |
| NO (1) | NO320044B1 (enExample) |
| NZ (1) | NZ334032A (enExample) |
| PL (1) | PL191395B1 (enExample) |
| RU (1) | RU2212448C2 (enExample) |
| TR (1) | TR199900213T2 (enExample) |
| WO (1) | WO1998004715A1 (enExample) |
| ZA (1) | ZA976803B (enExample) |
Families Citing this family (118)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002508921A (ja) * | 1997-10-04 | 2002-03-26 | フォルシュングスツェントルム・ユーリッヒ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | アスパラギン酸−及び（又は）グルタミン酸系アミノ酸の微生物による産生方法及びこの方法で使用可能な剤 |
| RU2368659C2 (ru) * | 1999-04-09 | 2009-09-27 | Адзиномото Ко., Инк. | Бактерия, продуцирующая l-аминокислоту, и способ получения l-аминокислоты |
| US6984512B1 (en) * | 1999-08-02 | 2006-01-10 | Archer-Daniels-Midland Company | Bacterial strains, methods of preparing the same and use thereof in fermentation processes for L-lysine production |
| CN100443592C (zh) * | 2000-05-27 | 2008-12-17 | 德古萨股份公司 | 发酵制备l-苏氨酸的方法 |
| WO2002006459A1 (en) * | 2000-07-18 | 2002-01-24 | Degussa Ag | Process for the fermentative preparation of l-threonine |
| US20030190712A1 (en) * | 2000-08-31 | 2003-10-09 | Degussa Ag | Fermentation process for the preparation of L-threonine |
| US6562601B2 (en) * | 2000-08-31 | 2003-05-13 | Degussa Ag | Fermentation process for the preparation of L-threonine |
| WO2002018543A2 (en) * | 2000-08-31 | 2002-03-07 | Degussa Ag | Fermentation process for the preparation of l-threonine |
| US7220571B2 (en) | 2000-09-28 | 2007-05-22 | Archer-Daniels-Midland Company | Escherichia coli strains which over-produce L-threonine and processes for the production of L-threonine by fermentation |
| KR100427480B1 (ko) * | 2001-01-16 | 2004-04-27 | 씨제이 주식회사 | Ｌ-쓰레오닌의 제조방법 |
| US7368266B2 (en) * | 2001-02-13 | 2008-05-06 | Cj Corporation | Method for L-threonine production |
| KR100397423B1 (ko) * | 2001-02-13 | 2003-09-13 | 씨제이 주식회사 | Ｌ-쓰레오닌의 제조방법 |
| EP1383903B1 (en) * | 2001-04-04 | 2008-09-24 | Genencor International, Inc. | Methods for the production of ascorbic acid intermediates in host cells |
| EP2055773B1 (en) * | 2001-04-04 | 2011-06-15 | Danisco US Inc. | Uncoupled productive and catabolic host cell pathways |
| KR100426807B1 (ko) * | 2001-06-19 | 2004-04-13 | 씨제이 주식회사 | 엘-쓰레오닌 생산 미생물 및 이를 이용한 엘-쓰레오닌 제조방법 |
| KR100426808B1 (ko) * | 2001-06-19 | 2004-04-13 | 씨제이 주식회사 | 엘-쓰레오닌 생산 미생물 및 이를 이용한 엘-쓰레오닌 제조방법 |
| DE10132945A1 (de) * | 2001-07-06 | 2003-01-16 | Degussa | Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung von Stämmen der Familie Enterobacteriaceae |
| DE60224536T2 (de) * | 2001-07-06 | 2009-01-08 | Evonik Degussa Gmbh | Verfahren zur herstellung von l-aminosäuren unter verwendung von stämmen aus der familie der enterobacteriaceae |
| ES2313555T3 (es) * | 2001-07-11 | 2009-03-01 | Evonik Degussa Gmbh | Proceso para la preparacion de l-treonina que utiliza cepas de la familia enterobacteriaceas. |
| EP1686184B1 (en) * | 2001-07-11 | 2008-08-27 | Evonik Degussa GmbH | Process for the preparation of L-threonine using strains of the enterobacteriaceae family |
| DE60232725D1 (de) * | 2001-07-18 | 2009-08-06 | Evonik Degussa Gmbh | Verfahren zur herstellung von l-threonin durch enterobakteriaceae-stämmen mit verstärkter exprimierung der succ und sucd gene |
| KR100547882B1 (ko) | 2002-02-26 | 2006-02-01 | 삼성전자주식회사 | 안테나 선택 다이버시티를 지원하는 이동통신시스템에서순방향 채널 상태 정보를 송수신하는 방법 및 장치 |
| RU2244007C2 (ru) * | 2002-02-27 | 2005-01-10 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | Способ получения l-треонина, штамм escherichia coli - продуцент треонина (варианты) |
| DE10210960A1 (de) | 2002-03-13 | 2003-09-25 | Degussa | Verfahren zur fermentativen Hestellung von L-Aminosäuren unter Verwendung von Stämmen der Familie Enterobacteriaceae |
| KR100451299B1 (ko) * | 2002-03-21 | 2004-10-06 | 씨제이 주식회사 | Ｌ―쓰레오닌의 제조방법 |
| US7378267B1 (en) | 2002-05-16 | 2008-05-27 | Cheil Jedang Corporation | Method for L-threonine production |
| CA2500741C (en) | 2002-10-04 | 2017-02-28 | Genencor International, Inc. | Glucose transport mutants for production of biomaterial |
| KR100505797B1 (ko) * | 2002-10-11 | 2005-08-04 | 씨제이 주식회사 | 염색체 상의 ｆａｄＲ 유전자가 불활성화된 Ｌ-쓰레오닌 생성 변이 미생물과 이를 이용한 Ｌ-쓰레오닌의 제조방법 |
| KR100478468B1 (ko) * | 2003-09-06 | 2005-03-23 | 씨제이 주식회사 | Ｌ―쓰레오닌의 제조방법 |
| JP4380305B2 (ja) * | 2003-11-21 | 2009-12-09 | 味の素株式会社 | 発酵法によるｌ−アミノ酸の製造法 |
| RU2275424C2 (ru) * | 2003-12-05 | 2006-04-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | Способ получения l-треонина с использованием бактерий, принадлежащих к роду escherichia |
| EP1664318B1 (en) * | 2004-01-30 | 2009-09-23 | Ajinomoto Co., Inc. | L-amino acid-producing microorganism and method for producing l-amino acid |
| RU2288264C2 (ru) * | 2004-02-12 | 2006-11-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | Бактерия, принадлежащая к роду escherichia - продуцент l-треонина и способ получения l-треонина |
| US20050181488A1 (en) * | 2004-02-12 | 2005-08-18 | Akhverdian Valery Z. | Method for producing L-threonine using bacteria belonging to the genus Escherichia |
| US7915018B2 (en) | 2004-10-22 | 2011-03-29 | Ajinomoto Co., Inc. | Method for producing L-amino acids using bacteria of the Enterobacteriaceae family |
| RU2304166C2 (ru) * | 2005-01-19 | 2007-08-10 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | СПОСОБ ПОЛУЧЕНИЯ L-ТРЕОНИНА С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ, ПРИНАДЛЕЖАЩЕЙ К РОДУ Escherichia, В КОТОРОЙ ИНАКТИВИРОВАН ГЕН ltaE |
| US20070212764A1 (en) * | 2005-01-19 | 2007-09-13 | Ptitsyn Leonid R | Method for producing l-amino acids using bacterium of the enterobacteriaceae family |
| US7723097B2 (en) * | 2005-03-11 | 2010-05-25 | Archer-Daniels-Midland Company | Escherichia coli strains that over-produce L-threonine and processes for their production |
| DE102005018835A1 (de) | 2005-04-22 | 2006-11-02 | Degussa Ag | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung verbesserter Stämme der Familie Enterobacteriaceae |
| WO2007001982A1 (en) * | 2005-06-20 | 2007-01-04 | Archer-Daniels-Midland Company | Altered glyoxylate shunt for improved production of aspartate-derived amino acids and chemicals |
| JP2009095237A (ja) | 2006-02-02 | 2009-05-07 | Ajinomoto Co Inc | Ｌ−アミノ酸の製造法 |
| JP2009118740A (ja) | 2006-03-03 | 2009-06-04 | Ajinomoto Co Inc | Ｌ−アミノ酸の製造法 |
| EP2351830B1 (en) | 2006-03-23 | 2014-04-23 | Ajinomoto Co., Inc. | A method for producing an L-amino acid using bacterium of the Enterobacteriaceae family with attenuated expression of a gene coding for small RNA |
| JP2009165355A (ja) | 2006-04-28 | 2009-07-30 | Ajinomoto Co Inc | Ｌ−アミノ酸を生産する微生物及びｌ−アミノ酸の製造法 |
| EP2021458A1 (en) | 2006-05-23 | 2009-02-11 | Ajinomoto Co., Inc. | A method for producing an l-amino acid using a bacterium of the enterobacteriaceae family |
| RU2006143864A (ru) | 2006-12-12 | 2008-06-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА ENTEROBACTERIACEAE, В КОТОРОЙ ОСЛАБЛЕНА ЭКСПРЕССИЯ ГЕНОВ cynT, cynS, cynX, ИЛИ cynR, ИЛИ ИХ КОМБИНАЦИИ |
| JP2010041920A (ja) | 2006-12-19 | 2010-02-25 | Ajinomoto Co Inc | Ｌ−アミノ酸の製造法 |
| CN101627110B (zh) | 2007-01-22 | 2014-08-13 | 味之素株式会社 | 生产l-氨基酸的微生物和l-氨基酸的生产方法 |
| JP2010110216A (ja) | 2007-02-20 | 2010-05-20 | Ajinomoto Co Inc | Ｌ−アミノ酸または核酸の製造方法 |
| JP2010110217A (ja) | 2007-02-22 | 2010-05-20 | Ajinomoto Co Inc | Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法 |
| DE102007051024A1 (de) | 2007-03-05 | 2008-09-11 | Evonik Degussa Gmbh | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von Stämmen der Familie Enterobacteriaceae |
| KR100858913B1 (ko) | 2007-03-09 | 2008-09-17 | 한국과학기술원 | 부위특이적 변이에 의해 제조된 고수율의 ｌ－쓰레오닌생산균주 및 이를 이용한 ｌ－쓰레오닌의 제조방법 |
| EP1975241A1 (de) | 2007-03-29 | 2008-10-01 | Evonik Degussa GmbH | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
| EP2149608A4 (en) | 2007-04-16 | 2013-02-20 | Ajinomoto Kk | PROCESS FOR PREPARING AN ORGANIC ACID |
| WO2009031565A1 (ja) | 2007-09-04 | 2009-03-12 | Ajinomoto Co., Inc. | アミノ酸生産微生物及びアミノ酸の製造法 |
| DE102007044134A1 (de) | 2007-09-15 | 2009-03-19 | Evonik Degussa Gmbh | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
| DE102007052270A1 (de) | 2007-11-02 | 2009-05-07 | Evonik Degussa Gmbh | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
| EP2060636A1 (de) | 2007-11-14 | 2009-05-20 | Evonik Degussa GmbH | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
| JP5644108B2 (ja) | 2007-12-06 | 2014-12-24 | 味の素株式会社 | 有機酸の製造方法 |
| KR20090075549A (ko) * | 2008-01-04 | 2009-07-08 | 씨제이제일제당 (주) | 향상된 ｌ-쓰레오닌 생산능을 갖는 대장균 및 이를 이용한ｌ-쓰레오닌의 생산 방법 |
| KR100966324B1 (ko) | 2008-01-08 | 2010-06-28 | 씨제이제일제당 (주) | 향상된 ｌ－쓰레오닌 생산능을 갖는 대장균 및 이를 이용한ｌ－쓰레오닌의 생산 방법 |
| JP2011067095A (ja) | 2008-01-10 | 2011-04-07 | Ajinomoto Co Inc | 発酵法による目的物質の製造法 |
| BRPI0906795A2 (pt) | 2008-01-23 | 2015-08-18 | Ajinomoto Kk | Método para produzir um l-aminoácido |
| RU2008105793A (ru) | 2008-02-19 | 2009-08-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | Способ конструирования оперонов, содержащих трансляционно сопряженные гены, бактерия, содержащая такой оперон, способ продукции полезного метаболита и способ мониторинга экспрессии гена |
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| RU2212448C2 (ru) | 2003-09-20 |
| BR9710503A (pt) | 2000-01-11 |
| IL128293A (en) | 2006-12-31 |
| CA2262813A1 (en) | 1998-02-05 |
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| WO1998004715A1 (en) | 1998-02-05 |
| CN1261576C (zh) | 2006-06-28 |
| AU3899497A (en) | 1998-02-20 |
| IL166145A (en) | 2006-12-31 |
| ATE421587T1 (de) | 2009-02-15 |
| ZA976803B (en) | 1998-02-19 |
| NO320044B1 (no) | 2005-10-17 |
| AU730102B2 (en) | 2001-02-22 |
| TR199900213T2 (xx) | 1999-04-21 |
| CN1226931A (zh) | 1999-08-25 |
| IL166146A0 (en) | 2006-01-15 |
| US5939307A (en) | 1999-08-17 |
| KR20000029691A (ko) | 2000-05-25 |
| NO990362L (no) | 1999-01-26 |
| NO990362D0 (no) | 1999-01-26 |
| IL166146A (en) | 2006-12-31 |
| ID19402A (id) | 1998-07-09 |
| JP2012070752A (ja) | 2012-04-12 |
| CA2262813C (en) | 2011-09-13 |
| HUP9903856A2 (hu) | 2000-03-28 |
| IL166145A0 (en) | 2006-01-15 |
| EP0917578B1 (en) | 2009-01-21 |
| DE69739234D1 (de) | 2009-03-12 |
| IL128293A0 (en) | 1999-11-30 |
| JP2000515763A (ja) | 2000-11-28 |
| JP4919529B2 (ja) | 2012-04-18 |
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