ATE513036T1 - Entkoppelte anabole und katabole stoffwechselwege in wirtszellen - Google Patents

Entkoppelte anabole und katabole stoffwechselwege in wirtszellen

Info

Publication number
ATE513036T1
ATE513036T1 AT08020730T AT08020730T ATE513036T1 AT E513036 T1 ATE513036 T1 AT E513036T1 AT 08020730 T AT08020730 T AT 08020730T AT 08020730 T AT08020730 T AT 08020730T AT E513036 T1 ATE513036 T1 AT E513036T1
Authority
AT
Austria
Prior art keywords
host cells
uncoupled
anabolic
nucleic acid
metabolic pathways
Prior art date
Application number
AT08020730T
Other languages
English (en)
Inventor
Timothy Dodge
Fernando Valle
Original Assignee
Danisco Us Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Danisco Us Inc filed Critical Danisco Us Inc
Application granted granted Critical
Publication of ATE513036T1 publication Critical patent/ATE513036T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/02—Monosaccharides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P25/00—Preparation of compounds containing alloxazine or isoalloxazine nucleus, e.g. riboflavin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/58—Aldonic, ketoaldonic or saccharic acids
    • C12P7/60—2-Ketogulonic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT08020730T 2001-04-04 2002-04-04 Entkoppelte anabole und katabole stoffwechselwege in wirtszellen ATE513036T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28161801P 2001-04-04 2001-04-04
US28225901P 2001-04-05 2001-04-05

Publications (1)

Publication Number Publication Date
ATE513036T1 true ATE513036T1 (de) 2011-07-15

Family

ID=26960977

Family Applications (2)

Application Number Title Priority Date Filing Date
AT08020730T ATE513036T1 (de) 2001-04-04 2002-04-04 Entkoppelte anabole und katabole stoffwechselwege in wirtszellen
AT02763934T ATE421577T1 (de) 2001-04-04 2002-04-04 Entkoppelte anabole und katabole stoffwechselwege in wirtszellen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT02763934T ATE421577T1 (de) 2001-04-04 2002-04-04 Entkoppelte anabole und katabole stoffwechselwege in wirtszellen

Country Status (9)

Country Link
US (2) US7241587B2 (de)
EP (2) EP2055773B1 (de)
JP (2) JP4430869B2 (de)
AT (2) ATE513036T1 (de)
AU (1) AU2002338340A1 (de)
CA (1) CA2443145C (de)
DE (1) DE60230971D1 (de)
DK (1) DK1373480T3 (de)
WO (1) WO2002081631A2 (de)

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JP2005510999A (ja) * 2001-04-04 2005-04-28 ジェネンコー・インターナショナル・インク 宿主細胞における生成物の生産方法
WO2005121349A2 (en) * 2003-12-18 2005-12-22 Basf Aktiengesellschaft Methods for the preparation of a fine chemical by fermentation
WO2007028610A2 (en) * 2005-09-09 2007-03-15 Dsm Ip Assets B.V. Novel gene gms 08
US7790427B1 (en) * 2005-09-20 2010-09-07 Battelle Memorial Institute Method of treating biocells
US8222223B2 (en) * 2005-09-20 2012-07-17 Battelle Memorial Institute Method of treating biocells
AT505263B1 (de) * 2007-06-01 2009-08-15 Vogelbusch Gmbh Verfahren zum herstellen von ascorbinsäure
CN102027124B (zh) 2007-12-13 2015-11-25 丹尼斯科美国公司 用于生产异戊二烯的组合物和方法
EP2279251A2 (de) * 2008-04-23 2011-02-02 Danisco US Inc. Isoprensynthasevarianten zur verbesserten mikrobiellen herstellung von isopren
JP5624980B2 (ja) 2008-06-30 2014-11-12 ザ・グッドイヤー・タイヤ・アンド・ラバー・カンパニーＴｈｅ Ｇｏｏｄｙｅａｒｔｉｒｅ ＆ Ｒｕｂｂｅｒ Ｃｏｍｐａｎｙ 再生資源に由来するイソプレンの重合体
ES2716231T3 (es) 2008-07-02 2019-06-11 Danisco Us Inc Procedimientos para producir isopreno
US20100184178A1 (en) * 2008-09-15 2010-07-22 Zachary Quinn Beck Increased isoprene production using mevalonate kinase and isoprene synthase
ZA201102109B (en) * 2008-09-15 2013-10-30 Goodyear Tire & Rubber Conversion of prenyl derivatives to isoprene
EP2337844A1 (de) * 2008-09-15 2011-06-29 Danisco US Inc. Verringerung der kohlendioxidemission während der isoprenproduktion mittels fermentation
MY156562A (en) 2008-09-15 2016-02-26 Danisco Us Inc Increased isoprene production using the archaeal lower mevalonate pathway
MY156588A (en) 2008-09-15 2016-03-15 Danisco Us Inc Systems using cell culture for production of isoprene
EP2382312A2 (de) 2008-12-30 2011-11-02 Danisco US Inc. Verfahren zur herstellung von isopren und einem beiprodukt
WO2010092924A1 (ja) * 2009-02-10 2010-08-19 国立大学法人宮崎大学 ペントース資化性エタノール生産組換え大腸菌及びこれを用いるエタノールの製造方法
US8518686B2 (en) * 2009-04-23 2013-08-27 Danisco Us Inc. Three-dimensional structure of isoprene synthase and its use thereof for generating variants
TWI427149B (zh) * 2009-06-17 2014-02-21 Danisco Us Inc 使用ｄｘｐ及ｍｖａ途徑之改良之異戊二烯製造
TWI434921B (zh) * 2009-06-17 2014-04-21 Danisco Us Inc 從生物異戊二烯組合物製造燃料成分之方法及系統
US8933282B2 (en) 2010-06-17 2015-01-13 Danisco Us Inc. Fuel compositions comprising isoprene derivatives
CN107603935A (zh) * 2010-07-12 2018-01-19 因比奥斯公司 用于生产附加值生物产品的代谢改造的生物
CN103443271A (zh) 2010-10-27 2013-12-11 丹尼斯科美国公司 用于增加异戊二烯产量的异戊二烯合酶变体
US8288137B2 (en) * 2010-11-15 2012-10-16 E I Du Pont De Nemours And Company Recombinant Escherichia coli having enhanced acetyl-coenzyme a synthetase activity for producing glyerol and glycerol-derived products
BR112013016264A2 (pt) 2010-12-22 2018-06-19 Danisco Us Inc produção biológica de açúcares de pentose com o uso de células recombinantes
SG191235A1 (en) 2010-12-22 2013-07-31 Danisco Us Inc Compositions and methods for improved isoprene production using two types of ispg enzymes
US9163263B2 (en) 2012-05-02 2015-10-20 The Goodyear Tire & Rubber Company Identification of isoprene synthase variants with improved properties for the production of isoprene

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Also Published As

Publication number Publication date
CA2443145A1 (en) 2002-10-17
US20030073200A1 (en) 2003-04-17
JP2005503769A (ja) 2005-02-10
US20070059811A1 (en) 2007-03-15
JP5328038B2 (ja) 2013-10-30
DE60230971D1 (de) 2009-03-12
EP2055773A1 (de) 2009-05-06
EP2055773B1 (de) 2011-06-15
CA2443145C (en) 2013-01-22
EP1373480A4 (de) 2005-02-02
DK1373480T3 (da) 2009-05-11
AU2002338340A1 (en) 2002-10-21
EP1373480A2 (de) 2004-01-02
US7407780B2 (en) 2008-08-05
JP4430869B2 (ja) 2010-03-10
WO2002081631A2 (en) 2002-10-17
JP2010057499A (ja) 2010-03-18
WO2002081631A3 (en) 2002-11-28
ATE421577T1 (de) 2009-02-15
EP1373480B1 (de) 2009-01-21
US7241587B2 (en) 2007-07-10

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