NO812542L - Nye trisubstituerte imidazolderivater, fremgangsmaate til deres fremstilling, farmasoeytiske preparater som inneholder disse samt deres anvendelse - Google Patents

Nye trisubstituerte imidazolderivater, fremgangsmaate til deres fremstilling, farmasoeytiske preparater som inneholder disse samt deres anvendelse

Info

Publication number
NO812542L
NO812542L NO812542A NO812542A NO812542L NO 812542 L NO812542 L NO 812542L NO 812542 A NO812542 A NO 812542A NO 812542 A NO812542 A NO 812542A NO 812542 L NO812542 L NO 812542L
Authority
NO
Norway
Prior art keywords
phenyl
formula
substituted
atoms
pyridyl
Prior art date
Application number
NO812542A
Other languages
English (en)
Norwegian (no)
Inventor
Alfred Sallmann
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of NO812542L publication Critical patent/NO812542L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/26—Radicals substituted by carbon atoms having three bonds to hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
NO812542A 1980-07-25 1981-07-24 Nye trisubstituerte imidazolderivater, fremgangsmaate til deres fremstilling, farmasoeytiske preparater som inneholder disse samt deres anvendelse NO812542L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH571580 1980-07-25

Publications (1)

Publication Number Publication Date
NO812542L true NO812542L (no) 1982-01-26

Family

ID=4298165

Family Applications (1)

Application Number Title Priority Date Filing Date
NO812542A NO812542L (no) 1980-07-25 1981-07-24 Nye trisubstituerte imidazolderivater, fremgangsmaate til deres fremstilling, farmasoeytiske preparater som inneholder disse samt deres anvendelse

Country Status (23)

Country Link
US (1) US4447431A (enExample)
EP (1) EP0045081B1 (enExample)
JP (1) JPS5756466A (enExample)
KR (13) KR850000883B1 (enExample)
AR (1) AR230269A1 (enExample)
AT (1) ATE17349T1 (enExample)
AU (2) AU7340481A (enExample)
CA (1) CA1175431A (enExample)
DD (2) DD201677A5 (enExample)
DE (1) DE3173434D1 (enExample)
DK (1) DK331881A (enExample)
ES (8) ES8301472A1 (enExample)
FI (1) FI812326L (enExample)
GB (1) GB2080805B (enExample)
GR (1) GR75287B (enExample)
IE (1) IE52071B1 (enExample)
IL (1) IL63410A (enExample)
NO (1) NO812542L (enExample)
NZ (1) NZ197828A (enExample)
PL (8) PL236997A1 (enExample)
PT (1) PT73424B (enExample)
SU (8) SU1235454A3 (enExample)
ZA (1) ZA815078B (enExample)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
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WO1983002613A1 (fr) * 1981-07-20 1983-08-04 Sallmann, Alfred Composes oxazoiques a triple substitution
EP0084756A1 (de) * 1982-01-22 1983-08-03 Ciba-Geigy Ag Trisubstituierte Oxazaverbindungen
FR2633291B1 (fr) * 1988-06-27 1990-09-07 Oreal Derives d'hydroxy-4 isoxazoles, leur procede de preparation et compositions cosmetiques et pharmaceutiques les contenant
US5252322A (en) * 1989-09-22 1993-10-12 The Gillette Company Skin tanning compositions containing imidazoles
NZ239161A (en) * 1990-07-31 1994-01-26 Smithkline Beecham Corp Substituted [1h-imidazol-5-yl] alkanoic acid derivatives; medicaments,
IL104369A0 (en) * 1992-01-13 1993-05-13 Smithkline Beecham Corp Novel compounds and compositions
US5916891A (en) 1992-01-13 1999-06-29 Smithkline Beecham Corporation Pyrimidinyl imidazoles
US5593991A (en) * 1993-07-16 1997-01-14 Adams; Jerry L. Imidazole compounds, use and process of making
US5670527A (en) * 1993-07-16 1997-09-23 Smithkline Beecham Corporation Pyridyl imidazole compounds and compositions
US5593992A (en) * 1993-07-16 1997-01-14 Smithkline Beecham Corporation Compounds
DE69433501T2 (de) * 1993-11-08 2004-11-04 Smithkline Beecham Corp. Oxazole zur behandlung von zytokinvermittelten erkrankungen
US5723477A (en) * 1994-11-10 1998-03-03 Sibia Neurosciences, Inc. Modulators of acetylcholine receptors
US6369068B1 (en) 1995-06-07 2002-04-09 Smithkline Beecham Corporation Amino substituted pyrimidine containing compounds
IL118544A (en) 1995-06-07 2001-08-08 Smithkline Beecham Corp History of imidazole, the process for their preparation and the pharmaceutical preparations containing them
US5739143A (en) * 1995-06-07 1998-04-14 Smithkline Beecham Corporation Imidazole compounds and compositions
ZA9610687B (en) 1995-12-22 1997-09-29 Smithkline Beecham Corp Novel synthesis.
ZA97175B (en) * 1996-01-11 1997-11-04 Smithkline Beecham Corp Novel substituted imidazole compounds.
US5756499A (en) * 1996-01-11 1998-05-26 Smithkline Beecham Corporation Substituted imidazole compounds
US6046208A (en) * 1996-01-11 2000-04-04 Smithkline Beecham Corporation Substituted imidazole compounds
AP9700912A0 (en) 1996-01-11 1997-01-31 Smithkline Beecham Corp Novel cycloalkyl substituted imidazoles
JP2000507558A (ja) * 1996-03-25 2000-06-20 スミスクライン・ビーチャム・コーポレイション Ｃｎｓ損傷についての新規な治療
EP0956018A4 (en) 1996-08-21 2000-01-12 Smithkline Beecham Corp IMIDAZOLE COMPOUNDS, COMPOSITIONS CONTAINING THEM AND THEIR USE
US5929076A (en) * 1997-01-10 1999-07-27 Smithkline Beecham Corporation Cycloalkyl substituted imidazoles
DK1028954T3 (da) * 1997-04-24 2003-10-27 Ortho Mcneil Pharm Inc Substituerede imidazoler egnede til behandling af inflammatoriske sygdomme
US20020156104A1 (en) 1997-06-13 2002-10-24 Jerry L. Adams Novel pyrazole and pyrazoline substituted compounds
AU8154998A (en) 1997-06-19 1999-01-04 Smithkline Beecham Corporation Novel aryloxy substituted pyrimidine imidazole compounds
US7301021B2 (en) * 1997-07-02 2007-11-27 Smithkline Beecham Corporation Substituted imidazole compounds
TW517055B (en) 1997-07-02 2003-01-11 Smithkline Beecham Corp Novel substituted imidazole compounds
US6489325B1 (en) 1998-07-01 2002-12-03 Smithkline Beecham Corporation Substituted imidazole compounds
US6562832B1 (en) 1997-07-02 2003-05-13 Smithkline Beecham Corporation Substituted imidazole compounds
AR016294A1 (es) * 1997-07-02 2001-07-04 Smithkline Beecham Corp Compuesto de imidazol sustituido, composicion farmaceutica que la contiene, su uso en la fabricacion de un medicamento y procedimiento para supreparacion
EP1019396A1 (en) 1997-07-02 2000-07-19 SmithKline Beecham Corporation Novel cycloalkyl substituted imidazoles
EP1041989A4 (en) 1997-10-08 2002-11-20 Smithkline Beecham Corp NEW SUBSTITUTED CYCLOALCENYL COMPOUNDS
AU1924699A (en) 1997-12-19 1999-07-12 Smithkline Beecham Corporation Compounds of heteroaryl substituted imidazole, their pharmaceutical compositionsand uses
CZ20004339A3 (cs) 1998-05-22 2001-10-17 Smithkline Beecham Corporation Nové 2-alkylem substituované imidazolové sloučeniny
US6858617B2 (en) 1998-05-26 2005-02-22 Smithkline Beecham Corporation Substituted imidazole compounds
ES2221426T3 (es) * 1998-08-20 2004-12-16 Smithkline Beecham Corporation Nuevos compuestos de triazol sustituidos.
EP1126852B1 (en) * 1998-11-04 2004-01-21 SmithKline Beecham Corporation Pyridin-4-yl or pyrimidin-4-yl substituted pyrazines
WO2000029399A1 (en) * 1998-11-12 2000-05-25 Boehringer Ingelheim (Canada) Ltd. Antiherpes compounds
US6239279B1 (en) 1998-12-16 2001-05-29 Smithkline Beecham Corporation Synthesis for 4-aryl-5-pyrimidine imidazole substituted derivatives
ATE382044T1 (de) 1999-11-22 2008-01-15 Smithkline Beecham Plc Imidazol- derivate
DE60020595T2 (de) 1999-11-23 2006-03-16 Smithkline Beecham Corp. 3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p38-kinase-inhibitoren
ES2230171T3 (es) 1999-11-23 2005-05-01 Smithkline Beecham Corporation Compuestos 3,4-dihidro-(1h)quinazolin-2-ona como inhibidores de csbp/p38 quinasa.
US6759410B1 (en) 1999-11-23 2004-07-06 Smithline Beecham Corporation 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
JP2003528043A (ja) 1999-11-23 2003-09-24 スミスクライン・ビーチャム・コーポレイション ＣＳＢＰ／ｐ３８キナーゼ阻害剤としての３，４‐ジヒドロ−（１Ｈ）キナゾリン−２−オン化合物
US7235551B2 (en) * 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
GB0005357D0 (en) 2000-03-06 2000-04-26 Smithkline Beecham Plc Compounds
EP1263753B1 (en) * 2000-03-06 2004-05-06 SmithKline Beecham plc Imidazol derivatives as raf kinase inhibitors
ES2372028T3 (es) * 2000-10-23 2012-01-13 Glaxosmithkline Llc Nuevo compuesto de 8h-pirido[2,3-d]pirimidin-7-ona trisustituida para el tratamiento de enfermedades mediadas por la csbp/p38 quinasa.
GB0112348D0 (en) * 2001-05-19 2001-07-11 Smithkline Beecham Plc Compounds
WO2003022837A1 (en) * 2001-09-05 2003-03-20 Smithkline Beecham P.L.C. Heterocycle-carboxamide derivatives as raf kinase inhibitors
RU2312101C2 (ru) * 2001-12-18 2007-12-10 Ф.Хоффманн-Ля Рош Аг Цис-имидазолины в качестве ингибиторов mdm2
TW200505446A (en) * 2003-01-17 2005-02-16 Fuj Isawa Pharmaceutical Co Ltd Inhibitor of cox
WO2004099130A2 (en) * 2003-05-08 2004-11-18 Astellas Pharma Inc. 1,2-diarylimidazoles useful as inhibitors of cox
MY145281A (en) 2005-03-25 2012-01-13 Glaxo Group Ltd Novel compounds
KR20080002865A (ko) * 2005-03-25 2008-01-04 글락소 그룹 리미티드 피리도[２,３-ｄ]피리미딘-７-온 및３,４-디히드로피리미도[４,５-ｄ]피리미딘-２(１ｈ)-온유도체의 제조 방법
WO2013049272A2 (en) 2011-09-29 2013-04-04 Theraceutix, Llc Composition and method for treatment of symptoms associated with various skin conditions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3558645A (en) * 1968-07-08 1971-01-26 Sandoz Ag 2-(4-(4',5-diphenyl - 2 - imidazolyl)-phenoxy) lower aliphatic monocarboxylic acids
CH561202A5 (enExample) * 1971-05-10 1975-04-30 Ciba Geigy Ag
GB1469532A (en) * 1973-06-28 1977-04-06 Dumex Ltd As Imimdazolyl-alkanoic acid derivatives
US4372964A (en) * 1980-10-30 1983-02-08 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-1H-imidazole-2-methanols

Also Published As

Publication number Publication date
ES514582A0 (es) 1983-05-16
KR850002745A (ko) 1985-05-15
NZ197828A (en) 1985-11-08
KR850002756A (ko) 1985-05-15
US4447431A (en) 1984-05-08
KR850002754A (ko) 1985-05-15
PL237002A1 (en) 1983-02-28
DD202554A5 (de) 1983-09-21
AU7340481A (en) 1982-01-28
IE52071B1 (en) 1987-06-10
GB2080805B (en) 1984-03-07
KR850002749A (ko) 1985-05-15
AR230269A1 (es) 1984-03-01
SU1205763A3 (ru) 1986-01-15
KR850000889B1 (ko) 1985-06-26
EP0045081B1 (de) 1986-01-08
PT73424A (en) 1981-08-01
KR850000873B1 (ko) 1985-06-22
ES8306119A1 (es) 1983-05-16
CA1175431A (en) 1984-10-02
KR850000883B1 (ko) 1985-06-26
KR850002752A (ko) 1985-05-15
ES514584A0 (es) 1983-05-16
KR850002747A (ko) 1985-05-15
ES8306122A1 (es) 1983-05-16
ES514585A0 (es) 1983-07-01
ES8306121A1 (es) 1983-05-16
KR850000890B1 (ko) 1985-06-26
PL237001A1 (en) 1983-02-28
GR75287B (enExample) 1984-07-13
ES504257A0 (es) 1982-12-01
IL63410A (en) 1986-04-29
KR850000891B1 (ko) 1985-06-26
PL237005A1 (en) 1983-02-28
KR850000886B1 (ko) 1985-06-26
ES8306124A1 (es) 1983-05-16
ATE17349T1 (de) 1986-01-15
ES8306120A1 (es) 1983-05-16
SU1205764A3 (ru) 1986-01-15
KR830006230A (ko) 1983-09-20
KR850000892B1 (ko) 1985-06-26
FI812326A7 (fi) 1982-01-26
ES8307245A1 (es) 1983-07-01
KR850000888B1 (ko) 1985-06-26
KR850000884B1 (ko) 1985-06-26
ES8306123A1 (es) 1983-05-16
GB2080805A (en) 1982-02-10
KR850000885B1 (ko) 1985-06-26
PT73424B (en) 1983-06-20
PL237003A1 (en) 1983-02-28
AU5655586A (en) 1986-09-11
PL237000A1 (en) 1983-02-28
EP0045081A2 (de) 1982-02-03
KR850000911B1 (ko) 1985-06-27
FI812326L (fi) 1982-01-26
KR850002748A (ko) 1985-05-15
PL135822B1 (en) 1985-12-31
SU1235454A3 (ru) 1986-05-30
DD201677A5 (de) 1983-08-03
IL63410A0 (en) 1981-10-30
KR850002746A (ko) 1985-05-15
SU1169534A3 (ru) 1985-07-23
SU1227112A3 (ru) 1986-04-23
DE3173434D1 (en) 1986-02-20
PL236997A1 (en) 1983-01-03
SU1145928A3 (ru) 1985-03-15
ES8301472A1 (es) 1982-12-01
PL237004A1 (en) 1983-02-28
ES514581A0 (es) 1983-05-16
KR850000887B1 (ko) 1985-06-26
PL232352A1 (enExample) 1982-12-20
IE811680L (en) 1982-01-25
ES514579A0 (es) 1983-05-16
KR850002753A (ko) 1985-05-15
ES514583A0 (es) 1983-05-16
SU1138023A3 (ru) 1985-01-30
ZA815078B (en) 1982-07-28
DK331881A (da) 1982-01-26
KR850002750A (ko) 1985-05-15
SU1152520A3 (en) 1985-04-23
KR850002755A (ko) 1985-05-15
ES514580A0 (es) 1983-05-16
KR850002744A (ko) 1985-05-15
JPS5756466A (en) 1982-04-05
KR850001064B1 (ko) 1985-07-25
EP0045081A3 (en) 1982-04-07

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