NO324932B1 - 1,2,3,4-Tetrahydroisokinolin-derivater, fremgangsmate for fremstilling av slike, farmasoytiske preparater inneholdende slike samt slike forbindelser anvendt til fremstilling av medikament for behandling av sykdommer - Google Patents

1,2,3,4-Tetrahydroisokinolin-derivater, fremgangsmate for fremstilling av slike, farmasoytiske preparater inneholdende slike samt slike forbindelser anvendt til fremstilling av medikament for behandling av sykdommer Download PDF

Info

Publication number
NO324932B1
NO324932B1 NO20024339A NO20024339A NO324932B1 NO 324932 B1 NO324932 B1 NO 324932B1 NO 20024339 A NO20024339 A NO 20024339A NO 20024339 A NO20024339 A NO 20024339A NO 324932 B1 NO324932 B1 NO 324932B1
Authority
NO
Norway
Prior art keywords
benzyl
dimethoxy
acetamide
dihydro
isoquinolin
Prior art date
Application number
NO20024339A
Other languages
English (en)
Norwegian (no)
Other versions
NO20024339L (no
NO20024339D0 (no
Inventor
Martine Clozel
Walter Fischli
Hamed Aissaoui
Michael Cappi
Ralf Koberstein
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of NO20024339L publication Critical patent/NO20024339L/no
Publication of NO20024339D0 publication Critical patent/NO20024339D0/no
Publication of NO324932B1 publication Critical patent/NO324932B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
NO20024339A 2000-03-14 2002-09-11 1,2,3,4-Tetrahydroisokinolin-derivater, fremgangsmate for fremstilling av slike, farmasoytiske preparater inneholdende slike samt slike forbindelser anvendt til fremstilling av medikament for behandling av sykdommer NO324932B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP0002245 2000-03-14
PCT/EP2001/002733 WO2001068609A1 (en) 2000-03-14 2001-03-12 1,2,3,4-tetrahydroisoquinoline derivatives

Publications (3)

Publication Number Publication Date
NO20024339L NO20024339L (no) 2002-09-11
NO20024339D0 NO20024339D0 (no) 2002-09-11
NO324932B1 true NO324932B1 (no) 2008-01-07

Family

ID=8163870

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20024339A NO324932B1 (no) 2000-03-14 2002-09-11 1,2,3,4-Tetrahydroisokinolin-derivater, fremgangsmate for fremstilling av slike, farmasoytiske preparater inneholdende slike samt slike forbindelser anvendt til fremstilling av medikament for behandling av sykdommer

Country Status (18)

Country Link
US (1) US6703392B2 (xx)
JP (1) JP4009460B2 (xx)
KR (2) KR20070087103A (xx)
CN (1) CN100393703C (xx)
AT (1) ATE286500T1 (xx)
AU (2) AU2001260113B2 (xx)
BR (1) BRPI0109200B8 (xx)
CA (1) CA2402431C (xx)
DE (1) DE60108236T2 (xx)
ES (1) ES2234840T3 (xx)
HU (1) HU227811B1 (xx)
IL (2) IL150986A0 (xx)
MX (1) MXPA02008797A (xx)
NO (1) NO324932B1 (xx)
NZ (1) NZ520624A (xx)
PT (1) PT1274687E (xx)
WO (1) WO2001068609A1 (xx)
ZA (1) ZA200206467B (xx)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002044172A1 (en) * 2000-11-28 2002-06-06 Smithkline Beecham P.L.C. Morpholine derivatives as antagonists of orexin receptors
GB0126292D0 (en) 2001-11-01 2002-01-02 Smithkline Beecham Plc Compounds
GB0130388D0 (en) * 2001-12-19 2002-02-06 Smithkline Beecham Plc Compounds
US7105526B2 (en) 2002-06-28 2006-09-12 Banyu Pharmaceuticals Co., Ltd. Benzimidazole derivatives
WO2004033418A2 (en) * 2002-10-11 2004-04-22 Actelion Pharmaceuticals Ltd. Sulfonylamino-acetic derivatives and their use as orexin receptor antagonists
GB0225884D0 (en) * 2002-11-06 2002-12-11 Glaxo Group Ltd Novel compounds
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
WO2004076411A2 (en) * 2003-02-24 2004-09-10 Merck & Co., Inc. Aminocyclopentyl fused heterotricylicamide modulators of chemokine receptor activity
KR20050114242A (ko) * 2003-03-26 2005-12-05 액테리온 파마슈티칼 리미티드 오렉신 수용체 길항제로서 이용되는테트라하이드로이소퀴놀릴 아세트아마이드 유도체
US7321065B2 (en) * 2003-04-18 2008-01-22 The Regents Of The University Of California Thyronamine derivatives and analogs and methods of use thereof
DE602004011204T2 (de) * 2003-04-28 2008-12-24 Actelion Pharmaceuticals Ltd. Quinoxalin-3-on-verdindungen als orexin-rezeptor antagonisten.
US7547693B2 (en) 2003-09-22 2009-06-16 Banyu Pharmaceutical Co. Ltd. Piperidine derivative
WO2005073214A2 (en) * 2004-01-23 2005-08-11 Janssen Pharmaceutica, N.V. Novel inhibitors of chymase
US20100048513A1 (en) 2008-08-20 2010-02-25 Hawkins Michael J Novel inhibitors of chymase
NZ550216A (en) 2004-03-01 2009-08-28 Actelion Pharmaceuticals Ltd Substituted 1,2,3,4-tetrahydroisoquinoline derivatives
US20080125403A1 (en) 2004-04-02 2008-05-29 Merck & Co., Inc. Method of Treating Men with Metabolic and Anthropometric Disorders
EP2286840A3 (en) 2004-11-01 2013-09-04 Amylin Pharmaceuticals, LLC Treatment of obesity and related diseases
WO2006081522A2 (en) * 2005-01-26 2006-08-03 The Regents Of The Unversity Of California Modulation of nmda receptor currents via orexin receptor and/or crf receptor
US20090286723A1 (en) 2005-02-11 2009-11-19 Amylin Pharmaceuticals, Inc. Hybrid Polypeptides with Selectable Properties
US7501395B2 (en) 2005-04-25 2009-03-10 Eisai R & D Management Co., Ltd. Method of screening for antianxiety drugs
US7737155B2 (en) 2005-05-17 2010-06-15 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
US8138206B2 (en) 2005-05-30 2012-03-20 Msd. K.K. Piperidine derivative
WO2007018248A1 (ja) 2005-08-10 2007-02-15 Banyu Pharmaceutical Co., Ltd. ピリドン化合物
BRPI0614649A2 (pt) 2005-08-11 2011-04-12 Amylin Pharmaceuticals Inc polipeptìdeos hìbridos com propriedades selecionáveis
WO2007024004A1 (ja) 2005-08-24 2007-03-01 Banyu Pharmaceutical Co., Ltd. フェニルピリドン誘導体
JPWO2007029847A1 (ja) 2005-09-07 2009-03-19 萬有製薬株式会社 二環性芳香族置換ピリドン誘導体
KR20080048502A (ko) 2005-09-29 2008-06-02 머크 앤드 캄파니 인코포레이티드 멜라노코르틴-4 수용체 조절제로서의 아실화스피로피페리딘 유도체
WO2007048027A2 (en) 2005-10-21 2007-04-26 Novartis Ag Combination of a renin-inhibitor and an anti-dyslipidemic agent and/or an antiobesity agent
US8163770B2 (en) 2005-10-27 2012-04-24 Msd. K. K. Benzoxathiin derivative
WO2007055418A1 (ja) 2005-11-10 2007-05-18 Banyu Pharmaceutical Co., Ltd. アザ置換スピロ誘導体
JP2009524643A (ja) * 2006-01-26 2009-07-02 アクテリオン ファーマシューティカルズ リミテッド テトラヒドロピラン抗生物質
EA015256B1 (ru) * 2006-03-15 2011-06-30 Актелион Фармасьютикалз Лтд. Производные тетрагидроизохинолина для повышения функции памяти
AU2007238755B2 (en) 2006-04-12 2012-07-12 Merck Sharp & Dohme Llc Pyridyl amide T-type calcium channel antagonists
DE602007012072D1 (de) 2006-04-26 2011-03-03 Actelion Pharmaceuticals Ltd Orantagonisten
JP2009543785A (ja) 2006-07-14 2009-12-10 メルク エンド カムパニー インコーポレーテッド 架橋ジアゼパンオレキシン受容体アンタゴニスト
ES2339822T3 (es) * 2006-08-28 2010-05-25 Actelion Pharmaceuticals Ltd. Derivados de 1,4,5,6,7,8-hexahidro-1,2,5-triaza-azuleno como antagonistas del receptor de orexina.
WO2008039327A2 (en) 2006-09-22 2008-04-03 Merck & Co., Inc. Method of treatment using fatty acid synthesis inhibitors
AU2007301126A1 (en) 2006-09-28 2008-04-03 Banyu Pharmaceutical Co., Ltd. Diaryl ketimine derivative
PE20081229A1 (es) 2006-12-01 2008-08-28 Merck & Co Inc Antagonistas de receptor de orexina de diazepam sustituido
MX2009006553A (es) 2006-12-22 2009-06-26 Actelion Pharmaceuticals Ltd Derivados de 5,6,7,8-tetrahidro-imidazo[1,5-a]pirazina.
JP5319518B2 (ja) 2007-04-02 2013-10-16 Ｍｓｄ株式会社 インドールジオン誘導体
WO2008122513A1 (en) * 2007-04-04 2008-10-16 F. Hoffmann-La Roche Ag Heterocycles as orexin antagonists
JP2010527924A (ja) 2007-05-18 2010-08-19 メルク・シャープ・エンド・ドーム・コーポレイション オキソ架橋ジアゼパンオレキシン受容体アンタゴニスト
PL2152690T3 (pl) 2007-05-23 2012-06-29 Merck Sharp & Dohme Pirydylo piperydynowi antagoniści receptora oreksyny
CA2687230A1 (en) 2007-05-23 2008-12-11 Merck & Co., Inc. Cyclopropyl pyrrolidine orexin receptor antagonists
ES2393885T7 (es) 2007-06-04 2014-01-30 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
PE20091010A1 (es) * 2007-10-10 2009-08-08 Actelion Pharmaceuticals Ltd Derivados de tetrahidroquinolina
RU2010120671A (ru) * 2007-10-24 2011-11-27 Мерк Шарп Энд Домэ Корп. (Us) Гетероциклические фениламидные антагонисты кальциевых каналов т-типа
CN102083796B (zh) 2007-12-28 2013-06-05 埃科特莱茵药品有限公司 三取代3,4-二氢-1h-异喹啉化合物，其制备方法，及其用途
JPWO2009110510A1 (ja) 2008-03-06 2011-07-14 Ｍｓｄ株式会社 アルキルアミノピリジン誘導体
CN101981025A (zh) 2008-03-28 2011-02-23 万有制药株式会社 具有黑色素浓缩激素受体拮抗作用的二芳基甲基酰胺衍生物
KR101717145B1 (ko) 2008-05-20 2017-03-16 노이로제스엑스, 인코포레이티드 간보호제 아세트아미노펜 공통 프로드러그
AU2009261248A1 (en) 2008-06-19 2009-12-23 Banyu Pharmaceutical Co., Ltd. Spirodiamine-diarylketoxime derivative
KR20110036069A (ko) * 2008-06-25 2011-04-06 액테리온 파마슈티칼 리미티드 5,6,7,8-테트라히드로-이미다조[1,5-ａ]피라진 화합물
AU2009270833B2 (en) 2008-07-16 2015-02-19 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
WO2010013595A1 (ja) 2008-07-30 2010-02-04 萬有製薬株式会社 ５員－５員又は５員－６員縮環シクロアルキルアミン誘導体
EP2161266A1 (en) 2008-08-22 2010-03-10 EVOTEC Neurosciences GmbH Benzofuran derivatives as orexin receptor antagonists
MX2011004258A (es) 2008-10-22 2011-06-01 Merck Sharp & Dohme Derivados de bencimidazol ciclicos novedosos utiles como agentes anti-diabeticos.
CA2741672A1 (en) 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
WO2010064212A1 (en) 2008-12-05 2010-06-10 Actelion Pharmaceuticals Ltd Method for obtaining an optically pure 1,2,3,4 tetrahydro-isoquinoline derivative
EP2379547A1 (en) 2008-12-16 2011-10-26 Schering Corporation Pyridopyrimidine derivatives and methods of use thereof
US20110243940A1 (en) 2008-12-16 2011-10-06 Schering Corporation Bicyclic pyranone derivatives and methods of use thereof
WO2011061318A1 (en) 2009-11-23 2011-05-26 N.V. Organon Heterocylic compounds as antagonists of the orexin receptors
CA2786314A1 (en) 2010-02-25 2011-09-01 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
WO2011138265A2 (en) 2010-05-03 2011-11-10 Evotec Ag Indole and indazole derivatives as orexin receptor antagonists
WO2011138266A1 (en) 2010-05-03 2011-11-10 Evotec Ag Indolizine and imidazopyridine derivatives as orexin receptor antagonists
EP2402322A1 (en) 2010-07-02 2012-01-04 Actelion Pharmaceuticals Ltd. 1,2,3,4-tetrahydroisoquinoline derivative and its use as orexin receptor antagonist
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
KR101668514B1 (ko) 2011-02-25 2016-10-21 머크 샤프 앤드 돔 코포레이션 항당뇨병제로서 유용한 신규 시클릭 아자벤즈이미다졸 유도체
CN103957919B (zh) 2011-09-19 2018-10-16 瑞士苏黎世联邦理工学院 RORγ调节剂
AR088352A1 (es) 2011-10-19 2014-05-28 Merck Sharp & Dohme Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
WO2013078413A1 (en) * 2011-11-22 2013-05-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Modulators of lipid storage
JP2015525782A (ja) 2012-08-02 2015-09-07 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． 抗糖尿病性三環式化合物
JP6678455B2 (ja) 2012-12-21 2020-04-08 エピザイム，インコーポレイティド Ｐｒｍｔ５阻害剤およびその使用
RU2015140066A (ru) 2013-02-22 2017-03-30 Мерк Шарп И Доум Корп. Противодиабетические бициклические соединения
US9650375B2 (en) 2013-03-14 2017-05-16 Merck Sharp & Dohme Corp. Indole derivatives useful as anti-diabetic agents
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
EP2781217A1 (en) 2013-03-18 2014-09-24 ETH Zurich ROR gamma modulators
US10011637B2 (en) 2013-06-05 2018-07-03 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase C, method of making and using same
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
MX2017002610A (es) 2014-08-29 2017-10-11 Tes Pharma S R L INHIBIDORES DE ACIDO A-AMINO-ß-CARBOXIMUCONICO SEMIALDEHIDO DESCARBOXILASA.
CN105198809A (zh) * 2015-09-24 2015-12-30 绍兴文理学院 一种2-（1-酰亚胺基甲基）-1,2,3,4-四氢异喹啉衍生物及其合成方法与应用
CN105418498A (zh) * 2015-12-30 2016-03-23 绍兴文理学院 一种1,2,3,4-四氢异喹啉衍生物及其合成方法与应用
EP3454857A1 (en) 2016-05-10 2019-03-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases
US20180134667A1 (en) 2016-10-14 2018-05-17 TES Pharma S.r.I. Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
WO2018106518A1 (en) 2016-12-06 2018-06-14 Merck Sharp & Dohme Corp. Antidiabetic heterocyclic compounds
US10968232B2 (en) 2016-12-20 2021-04-06 Merck Sharp & Dohme Corp. Antidiabetic spirochroman compounds
MX2021005904A (es) 2018-11-20 2021-09-08 Tes Pharma S R L Inhibidores de la ácido alfa-amino-beta-carboximucónico semialdehído descarboxilasa.
CN112538100B (zh) * 2020-12-16 2022-06-24 河南中医药大学 一种从黄柏中提取的具有抗炎活性的异喹啉生物碱苷类化合物及其制备方法与应用
TW202342433A (zh) * 2022-02-25 2023-11-01 比利時魯汶大學 用於抑制ｙａｐ／ｔａｚ—ｔｅａｄ之二氫喹唑啉酮及相關類似物

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE258817C (xx)
CA205079A (en) * 1920-10-26 Nelson Lionel Gas producer
DE204917C (xx)
DE261158C (xx)
CA110459A (en) * 1907-12-09 1908-02-25 Charles Albert Keller Electric furnace
CA173523A (en) * 1916-04-01 1916-11-28 Raymond B. Price Textile material
CA170679A (en) * 1916-05-26 1916-07-11 Edwin W. Webb Car brake
US3480714A (en) * 1966-02-07 1969-11-25 Ciba Geigy Corp N-substituted isoquinolines as antiprotozoal agents
DD204917A1 (de) * 1981-12-31 1983-12-14 Gerhard Kempter Verfahren zur herstellung phenylsubstituierter und benzkondensierter cycloalkylaminoacetanilide
JPS6153268A (ja) * 1984-08-24 1986-03-17 Hokuriku Seiyaku Co Ltd アントラニルアミド誘導体
DD261158A1 (de) * 1987-01-08 1988-10-19 Univ Halle Wittenberg Verfahren zur herstellung von 2-aminoalkyl-3,4-dihydro-4-oxo-7h-pyrrolo 2.3-d pyrimidinen
DD258817A1 (de) * 1987-01-19 1988-08-03 Univ Halle Wittenberg Verfahren zur herstellung von 2-(aminoalkyl) -pyrimido-4,5'-5,4 pyrrolo 3,2-f 1,4 thiazepinderivaten
CZ283038B6 (cs) 1991-01-11 1997-12-17 Laboratoires Glaxo Sa Akridinové deriváty, způsob výroby a farmaceutické prostředky s jejich obsahem
RO117377B1 (ro) * 1993-06-22 2002-02-28 Boots Co Plc Derivati de tetrahidroizochinolina, procedeu de preparare, compozitie farmaceutica care ii contine si metoda de tratament
JPH07267961A (ja) * 1994-03-30 1995-10-17 Taisho Pharmaceut Co Ltd ベンゾフロ［３，２−ｄピリミジン−４−オン誘導体
JPH1095766A (ja) * 1996-09-19 1998-04-14 Sanwa Kagaku Kenkyusho Co Ltd アセトアミド誘導体、及びその用途
SK65499A3 (en) * 1996-11-27 2001-05-10 Pfizer Apo b-secretion/mtp inhibitory amides
AR016817A1 (es) 1997-08-14 2001-08-01 Smithkline Beecham Plc Derivados de fenilurea o feniltiourea, procedimiento para su preparacion, coleccion de compuestos, compuestos intermediarios, composicion farmaceutica,metodo de tratamiento y uso de dichos compuestos para la manufactura de un medicamento
AU4037799A (en) * 1998-05-08 1999-11-29 Smithkline Beecham Plc Phenylurea and phenylthio urea derivatives
WO2000029399A1 (en) 1998-11-12 2000-05-25 Boehringer Ingelheim (Canada) Ltd. Antiherpes compounds
GB9827467D0 (en) 1998-12-15 1999-02-10 Zeneca Ltd Chemical compounds
GB9914015D0 (en) 1999-06-17 1999-08-18 Zeneca Ltd Chemical compounds
GB9914025D0 (en) 1999-06-17 1999-08-18 Zeneca Ltd Chemical compounds
AU6073300A (en) 1999-07-06 2001-01-22 Vertex Pharmaceuticals Incorporated N-heterocyclic derivatives with neuronal activity

Also Published As

Publication number Publication date
CN1416420A (zh) 2003-05-07
WO2001068609A1 (en) 2001-09-20
IL150986A (en) 2007-07-04
DE60108236D1 (de) 2005-02-10
MXPA02008797A (es) 2005-09-08
AU6011301A (en) 2001-09-24
HU227811B1 (en) 2012-03-28
ES2234840T3 (es) 2005-07-01
CA2402431C (en) 2009-10-06
NZ520624A (en) 2004-02-27
JP2003527374A (ja) 2003-09-16
ATE286500T1 (de) 2005-01-15
JP4009460B2 (ja) 2007-11-14
WO2001068609B1 (en) 2002-02-21
PT1274687E (pt) 2005-04-29
CA2402431A1 (en) 2001-09-20
KR100842698B1 (ko) 2008-07-01
AU2001260113B2 (en) 2006-04-06
BRPI0109200B1 (pt) 2015-08-11
NO20024339L (no) 2002-09-11
KR20070087103A (ko) 2007-08-27
DE60108236T2 (de) 2005-12-22
CN100393703C (zh) 2008-06-11
US6703392B2 (en) 2004-03-09
BRPI0109200B8 (pt) 2021-05-25
ZA200206467B (en) 2003-11-13
BR0109200A (pt) 2003-06-03
HUP0300207A3 (en) 2005-07-28
IL150986A0 (en) 2003-02-12
KR20020080465A (ko) 2002-10-23
NO20024339D0 (no) 2002-09-11
US20030176415A1 (en) 2003-09-18
HUP0300207A2 (en) 2003-05-28

Similar Documents

Publication Publication Date Title
NO324932B1 (no) 1,2,3,4-Tetrahydroisokinolin-derivater, fremgangsmate for fremstilling av slike, farmasoytiske preparater inneholdende slike samt slike forbindelser anvendt til fremstilling av medikament for behandling av sykdommer
AU2001260113A1 (en) 1,2,3,4-tetrahydroisoquinoline derivatives
RU2378257C2 (ru) Замещенные производные 1,2,3,4-тетрагидроизохинолина
US7192950B2 (en) Benzazepines and related heterocyclic derivatives which are useful as orexin receptor antagonists
US20060178515A1 (en) Tetrahydroisoquinolyl acetamide derivatives for use as orexin receptor antagonists
ZA200500026B (en) 7,8,9,10-tetrahydro-6H-azepino, 6,7,8,9-tetrahydo-pyrido and 2,3-dihydro-2H-pyrroloÄ2,1-bÜ-quinazolinone derivatives.
US7538109B2 (en) Quinoxalin-3-one derivatives as orexin receptor antagonists
EP1274687B1 (en) 1,2,3,4- tetrahydroisoquinoline derivatives
US20060040977A1 (en) 5-HT7 receptor ligands
EP1620409B1 (en) Quinoxalin-3-one derivatives as orexin receptor antagonists
MXPA06009833A (en) Substituted 1,2,3,4-tetrahydroisoquinoline derivatives

Legal Events

Date Code Title Description
MK1K Patent expired