MX2009006553A - Derivados de 5,6,7,8-tetrahidro-imidazo[1,5-a]pirazina. - Google Patents

Derivados de 5,6,7,8-tetrahidro-imidazo[1,5-a]pirazina.

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Publication number
MX2009006553A
MX2009006553A MX2009006553A MX2009006553A MX2009006553A MX 2009006553 A MX2009006553 A MX 2009006553A MX 2009006553 A MX2009006553 A MX 2009006553A MX 2009006553 A MX2009006553 A MX 2009006553A MX 2009006553 A MX2009006553 A MX 2009006553A
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MX
Mexico
Prior art keywords
sup
alkyl
imidazo
tetrahydro
alkoxy
Prior art date
Application number
MX2009006553A
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English (en)
Inventor
Ralf Koberstein
Thierry Sifferlen
Hamed Aissaoui
Christoph Boss
Markus Gude
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Actelion Pharmaceuticals Ltd
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Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of MX2009006553A publication Critical patent/MX2009006553A/es

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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings

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Abstract

La presente invención se refiere a derivados de 5,6,7,8-tetrahidro-imidazo[1,5-a]pirazina de fórmula (I), en donde X representa CH2 u O; R1 representa un grupo fenilo, en el cual el grupo es independientemente mono, di o tri sustituido, en donde los sustituyentes son seleccionados independientemente del grupo que consiste de alquilo (C1-4), alcoxi (C1-4), halógeno, ciano, trifluorometoxi y trifluorometilo; R2 representa alquilo (C1-4), alcoxi (C1-4), alquenilo (C2-4), halógeno, ciano, hidroximetilo, trifluorometilo, C(O)NR5R6 o ciclopropilo; R3 representa alquilo (C1-4), alcoxi-metilo (C1-4) o halógeno; R4 representa alquilo (C1-4); R5 representa hidrógeno o alquilo (C1-4); y R6 representa hidrógeno o alquilo (C1-4). La invención también se refiere a sales farmacéuticamente aceptables de tales compuestos; y al uso de tales compuestos como medicamentos; especialmente como antagonistas del receptor de orexina.
MX2009006553A 2006-12-22 2007-12-20 Derivados de 5,6,7,8-tetrahidro-imidazo[1,5-a]pirazina. MX2009006553A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2006055019 2006-12-22
PCT/IB2007/055245 WO2008078291A1 (en) 2006-12-22 2007-12-20 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives

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Publication Number Publication Date
MX2009006553A true MX2009006553A (es) 2009-06-26

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MX2009006553A MX2009006553A (es) 2006-12-22 2007-12-20 Derivados de 5,6,7,8-tetrahidro-imidazo[1,5-a]pirazina.

Country Status (15)

Country Link
US (1) US8188082B2 (es)
EP (1) EP2125823B1 (es)
JP (1) JP2010513466A (es)
KR (1) KR20090106538A (es)
CN (1) CN101568542B (es)
AT (1) ATE545647T1 (es)
AU (1) AU2007337659A1 (es)
BR (1) BRPI0720522A2 (es)
CA (1) CA2669561A1 (es)
ES (1) ES2380391T3 (es)
MA (1) MA31002B1 (es)
MX (1) MX2009006553A (es)
NO (1) NO20092715L (es)
RU (1) RU2009127842A (es)
WO (1) WO2008078291A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8188082B2 (en) 2006-12-22 2012-05-29 Actelion Pharmaceuticals Ltd. 5,6,7,8-tetrahydro-imidazo[1,5-α]pyrazine derivatives
US7775298B2 (en) 2007-10-29 2010-08-17 Abergeldie Holdings Pty Ltd/Abergeldie Plant Pty Ltd Drilling assemblies and methods of drilling
CN101468988A (zh) * 2007-12-26 2009-07-01 上海恒瑞医药有限公司 哌嗪类衍生物,其制备方法及其在医药上的应用
JP2011525910A (ja) * 2008-06-25 2011-09-29 アクテリオン ファーマシューティカルズ リミテッド ５，６，７，８−テトラヒドロ−イミダゾ［１，５−ａ］ピラジン化合物
EP2491038B1 (en) 2009-10-23 2016-04-06 Janssen Pharmaceutica N.V. Disubstituted octahy - dropyrrolo [3,4-c]pyrroles as orexin receptor modulators
CN102258508A (zh) * 2011-04-14 2011-11-30 威海迪素制药有限公司 芳基丙烯酸衍生物抗癫痫的用途
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
EP2811997B1 (en) 2012-02-07 2018-04-11 Eolas Therapeutics Inc. Substituted prolines/piperidines as orexin receptor antagonists
CN103980281B (zh) * 2014-05-27 2016-06-08 天津市斯芬克司药物研发有限公司 一种咪唑吡嗪化合物及其制备方法
EP3180332B1 (en) 2014-08-13 2021-10-27 Eolas Therapeutics Inc. Difluoropyrrolidines as orexin receptor modulators
KR20180107232A (ko) 2016-02-12 2018-10-01 아스트라제네카 아베 오렉신 수용체 조정제로서의 할로-치환된 피페리딘
MY197558A (en) 2016-03-10 2023-06-23 Janssen Pharmaceutica Nv Methods of treating depression using orexin-2 receptor antagonists
CN105753788A (zh) * 2016-04-08 2016-07-13 西南科技大学 一种1-取代-2-苯基-4-碘咪唑的制备方法
WO2017194548A1 (en) 2016-05-10 2017-11-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases
MX2020002944A (es) 2017-09-14 2020-09-28 Daiichi Sankyo Co Ltd Compuesto que tiene estructura ciclica.
CN108101930B (zh) * 2017-12-22 2020-10-30 武汉大学 一类含有苯并噻二唑并噻吩单元的小分子受体材料及其制备方法与应用
EP3773587A4 (en) * 2018-03-29 2021-09-29 Board of Regents, The University of Texas System IMIDAZOPIPERAZINE INHIBITORS OF TRANSCRIPTION ACTIVATION PROTEINS
US10899769B2 (en) 2018-04-06 2021-01-26 Board Of Regents, The University Of Texas System Imidazopiperazinone inhibitors of transcription activating proteins
GB201908511D0 (en) 2019-06-13 2019-07-31 Adorx Therapeutics Ltd Hydroxamate compounds
JP2023544732A (ja) * 2020-10-02 2023-10-25 ボード オブ レジェンツ，ザ ユニバーシティ オブ テキサス システム 転写活性化タンパク質のイミダゾピペラジン阻害剤
WO2022072648A1 (en) * 2020-10-02 2022-04-07 Board Of Regents, The University Of Texas System Imidazopiperazine inhibitors of transcription activating proteins
JP2024514007A (ja) * 2021-04-21 2024-03-27 長春金賽薬業有限責任公司 イミダゾール含有縮合環系誘導体、その調製方法及びその医薬上の応用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100393703C (zh) 2000-03-14 2008-06-11 埃科特莱茵药品有限公司 1,2,3,4-四氢异喹啉的衍生物
CA2408343A1 (en) 2000-05-11 2002-11-07 Banyu Pharmaceutical Co., Ltd. N-acyltetrahydroisoquinoline derivatives
WO2002051232A2 (en) 2000-12-27 2002-07-04 Actelion Pharmaceuticals Ltd. Novel benzazepines and related heterocyclic derivatives
GB0124463D0 (en) * 2001-10-11 2001-12-05 Smithkline Beecham Plc Compounds
RU2005103398A (ru) 2002-07-09 2006-06-27 Актелион Фармасьютикалз Лтд. (Ch) Производные 7,8,9,10-тетрагидро-6h-азепино-, 6,7,8,9-тетрагидропиридо-и 2,3-дигидро-2h-пирроло-[2,1-b]-хиназолинона
EP1537114B8 (en) * 2002-08-07 2007-10-03 Novartis AG Organic compounds as agents for the treatment of aldosterone mediated conditions
US20060178515A1 (en) 2003-03-26 2006-08-10 Hamed Aissaoui Tetrahydroisoquinolyl acetamide derivatives for use as orexin receptor antagonists
RU2006113948A (ru) 2003-09-26 2007-11-10 Актелион Фармасьютиклз Лтд. (Ch) Производные пиридина и их применение в качестве антагонистов уротензина ii
EP1751111B1 (en) 2004-03-01 2014-12-31 Actelion Pharmaceuticals Ltd. Substituted 1,2,3,4-tetrahydroisoquinoline derivatives
MX2008011647A (es) 2006-03-15 2008-09-22 Actelion Pharmaceuticals Ltd Derivados de tetrahidroisoquinolina para mejorar la funcion de la memoria.
EP2013209B1 (en) 2006-04-26 2011-01-19 Actelion Pharmaceuticals Ltd. Pyrazolo-tetrahydropyridine derivatives as orexin receptor antagonists
WO2008026149A1 (en) 2006-08-28 2008-03-06 Actelion Pharmaceuticals Ltd 1,4,5,6, 7,8-hexahydro-i^1s-triaza-azulene derivatives as orexin receptor antagonists
US8188082B2 (en) 2006-12-22 2012-05-29 Actelion Pharmaceuticals Ltd. 5,6,7,8-tetrahydro-imidazo[1,5-α]pyrazine derivatives
PE20091010A1 (es) 2007-10-10 2009-08-08 Actelion Pharmaceuticals Ltd Derivados de tetrahidroquinolina
JP2011525910A (ja) 2008-06-25 2011-09-29 アクテリオン ファーマシューティカルズ リミテッド ５，６，７，８−テトラヒドロ−イミダゾ［１，５−ａ］ピラジン化合物

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KR20090106538A (ko) 2009-10-09
RU2009127842A (ru) 2011-01-27
EP2125823A1 (en) 2009-12-02
BRPI0720522A2 (pt) 2014-01-07
CN101568542A (zh) 2009-10-28
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US8188082B2 (en) 2012-05-29
CA2669561A1 (en) 2008-07-03
CN101568542B (zh) 2013-03-27
WO2008078291A1 (en) 2008-07-03
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