ATE545647T1 - 5,6,7,8-tetrahydro-imidazoä1,5-aüpyrazinderivat - Google Patents
5,6,7,8-tetrahydro-imidazoä1,5-aüpyrazinderivatInfo
- Publication number
- ATE545647T1 ATE545647T1 AT07859469T AT07859469T ATE545647T1 AT E545647 T1 ATE545647 T1 AT E545647T1 AT 07859469 T AT07859469 T AT 07859469T AT 07859469 T AT07859469 T AT 07859469T AT E545647 T1 ATE545647 T1 AT E545647T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- tetrahydro
- alkoxy
- halogen
- imidazoä1
- Prior art date
Links
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
- WROMFHICINADER-UHFFFAOYSA-N 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine Chemical class C1NCCN2C=NC=C21 WROMFHICINADER-UHFFFAOYSA-N 0.000 abstract 1
- 229940123730 Orexin receptor antagonist Drugs 0.000 abstract 1
- 125000004849 alkoxymethyl group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- -1 cyano, hydroxymethyl Chemical group 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Gynecology & Obstetrics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2006055019 | 2006-12-22 | ||
| PCT/IB2007/055245 WO2008078291A1 (en) | 2006-12-22 | 2007-12-20 | 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE545647T1 true ATE545647T1 (de) | 2012-03-15 |
Family
ID=39273168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07859469T ATE545647T1 (de) | 2006-12-22 | 2007-12-20 | 5,6,7,8-tetrahydro-imidazoä1,5-aüpyrazinderivat |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8188082B2 (de) |
| EP (1) | EP2125823B1 (de) |
| JP (1) | JP2010513466A (de) |
| KR (1) | KR20090106538A (de) |
| CN (1) | CN101568542B (de) |
| AT (1) | ATE545647T1 (de) |
| AU (1) | AU2007337659A1 (de) |
| BR (1) | BRPI0720522A2 (de) |
| CA (1) | CA2669561A1 (de) |
| ES (1) | ES2380391T3 (de) |
| MA (1) | MA31002B1 (de) |
| MX (1) | MX2009006553A (de) |
| NO (1) | NO20092715L (de) |
| RU (1) | RU2009127842A (de) |
| WO (1) | WO2008078291A1 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0720522A2 (pt) | 2006-12-22 | 2014-01-07 | Actelion Pharmaceuticals Ltd | Composto derivado de 5,6,7,8-tetra-hidroimidazo [1,5-a] pirazina e uso deste ou de um de seus sais farmaceuticamente aceitáveis. |
| US7775298B2 (en) | 2007-10-29 | 2010-08-17 | Abergeldie Holdings Pty Ltd/Abergeldie Plant Pty Ltd | Drilling assemblies and methods of drilling |
| CN101468988A (zh) * | 2007-12-26 | 2009-07-01 | 上海恒瑞医药有限公司 | 哌嗪类衍生物,其制备方法及其在医药上的应用 |
| EP2307417A2 (de) * | 2008-06-25 | 2011-04-13 | Actelion Pharmaceuticals Ltd. | 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazinverbindungen |
| US8653263B2 (en) | 2009-10-23 | 2014-02-18 | Janssen Pharmaceutica | Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators |
| CN102258508A (zh) * | 2011-04-14 | 2011-11-30 | 威海迪素制药有限公司 | 芳基丙烯酸衍生物抗癫痫的用途 |
| US9440982B2 (en) | 2012-02-07 | 2016-09-13 | Eolas Therapeutics, Inc. | Substituted prolines/piperidines as orexin receptor antagonists |
| ES2672732T3 (es) | 2012-02-07 | 2018-06-15 | Eolas Therapeutics Inc. | Prolinas/piperidinas sustituidas como antagonistas del receptor de orexina |
| CN103980281B (zh) * | 2014-05-27 | 2016-06-08 | 天津市斯芬克司药物研发有限公司 | 一种咪唑吡嗪化合物及其制备方法 |
| UY36272A (es) | 2014-08-13 | 2016-02-29 | Eolas Therapeutics Inc | Difluoropirrolidinas como moduladores de los receptores de orexinas |
| TWI710557B (zh) | 2016-02-12 | 2020-11-21 | 美商伊歐拉斯治療學公司 | 作為食慾素受體調節劑之經鹵素取代之六氫吡啶 |
| BR112018067906A2 (pt) | 2016-03-10 | 2019-01-29 | Janssen Pharmaceutica Nv | métodos de tratamento de depressão usando antagonistas do receptor de orexina-2 |
| CN105753788A (zh) * | 2016-04-08 | 2016-07-13 | 西南科技大学 | 一种1-取代-2-苯基-4-碘咪唑的制备方法 |
| WO2017194548A1 (en) | 2016-05-10 | 2017-11-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases |
| EP3682881A4 (de) | 2017-09-14 | 2021-08-11 | Daiichi Sankyo Company, Limited | Verbindung mit zyklischer struktur |
| CN108101930B (zh) * | 2017-12-22 | 2020-10-30 | 武汉大学 | 一类含有苯并噻二唑并噻吩单元的小分子受体材料及其制备方法与应用 |
| JP7387627B2 (ja) | 2018-03-29 | 2023-11-28 | ボード オブ レジェンツ，ザ ユニバーシティ オブ テキサス システム | 転写活性化タンパク質のイミダゾピペラジン阻害剤 |
| US10899769B2 (en) | 2018-04-06 | 2021-01-26 | Board Of Regents, The University Of Texas System | Imidazopiperazinone inhibitors of transcription activating proteins |
| GB201908511D0 (en) | 2019-06-13 | 2019-07-31 | Adorx Therapeutics Ltd | Hydroxamate compounds |
| EP4221708A4 (de) * | 2020-10-02 | 2024-11-06 | Board of Regents, The University of Texas System | Imidazopiperazinhemmer von transkriptionsaktivierenden proteinen |
| CA3193745A1 (en) * | 2020-10-02 | 2022-04-07 | Kang Le | Imidazopiperazine inhibitors of transcription activating proteins |
| KR20230146639A (ko) * | 2021-04-21 | 2023-10-19 | 장춘 진사이언스 파마슈티컬 씨오., 엘티디. | 이미다졸 함유 축합고리계 유도체, 이의 제조방법 및 이의 의약적 용도 |
| TW202428579A (zh) * | 2022-10-19 | 2024-07-16 | 大陸商長春金賽藥業有限責任公司 | Ｎｋ３ｒ拮抗劑的晶型及其製備方法和用途 |
| WO2025224168A1 (en) | 2024-04-24 | 2025-10-30 | Idorsia Pharmaceuticals Ltd | Aryl sulfone and sulfanone derivatives as orexin receptor modulators |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA02008797A (es) | 2000-03-14 | 2005-09-08 | Actelion Pharmaceuticals Ltd | Derivados de 1,2,3,4-tetrahidroisoquinolina. |
| WO2001085693A1 (en) | 2000-05-11 | 2001-11-15 | Banyu Pharmaceutical Co., Ltd. | N-acyltetrahydroisoquinoline derivatives |
| WO2002051232A2 (en) | 2000-12-27 | 2002-07-04 | Actelion Pharmaceuticals Ltd. | Novel benzazepines and related heterocyclic derivatives |
| GB0124463D0 (en) * | 2001-10-11 | 2001-12-05 | Smithkline Beecham Plc | Compounds |
| CN1556705B (zh) | 2002-07-09 | 2010-04-28 | 埃科特莱茵药品有限公司 | 7,8,9,10-四氢-6H-氮杂卓并、6,7,8,9-四氢-吡啶并和2,3-二氢-2H-吡咯并[2,1-b]-喹唑啉酮衍生物 |
| ES2270143T3 (es) * | 2002-08-07 | 2007-04-01 | Novartis Ag | Compuestos organicos como agentes para el tratamiento de condiciones mediadas por aldosterona. |
| CN100432056C (zh) | 2003-03-26 | 2008-11-12 | 埃科特莱茵药品有限公司 | 四氢异喹啉基乙酰胺衍生物作为阿立新受体拮抗剂的应用 |
| EP1670470B1 (de) * | 2003-09-26 | 2009-04-08 | Actelion Pharmaceuticals Ltd. | Pyridin-derivate und ihre verwendung als urotensin ii antagonisten |
| PT1751111E (pt) * | 2004-03-01 | 2015-04-01 | Actelion Pharmaceuticals Ltd | Derivados de 1,2,3,4-tetrahidroisoquinolina substituída |
| US20090082394A1 (en) | 2006-03-15 | 2009-03-26 | Actelion Pharmaceuticals, Ltd. | Tetrahydroisoquinoline Derivatives to Enhance Memory Function |
| CN101432285A (zh) | 2006-04-26 | 2009-05-13 | 埃科特莱茵药品有限公司 | 作为食欲素受体拮抗剂的吡唑并-四氢吡啶衍生物 |
| DE602007004999D1 (de) * | 2006-08-28 | 2010-04-08 | Actelion Pharmaceuticals Ltd | 1,4,5,6,7,8-hexahydro-1,2,5-triaza-azulen-derivate als orexinrezeptor-antagonisten |
| BRPI0720522A2 (pt) | 2006-12-22 | 2014-01-07 | Actelion Pharmaceuticals Ltd | Composto derivado de 5,6,7,8-tetra-hidroimidazo [1,5-a] pirazina e uso deste ou de um de seus sais farmaceuticamente aceitáveis. |
| PE20091010A1 (es) | 2007-10-10 | 2009-08-08 | Actelion Pharmaceuticals Ltd | Derivados de tetrahidroquinolina |
| EP2307417A2 (de) * | 2008-06-25 | 2011-04-13 | Actelion Pharmaceuticals Ltd. | 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazinverbindungen |
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2007
- 2007-12-20 BR BRPI0720522-8A patent/BRPI0720522A2/pt not_active IP Right Cessation
- 2007-12-20 WO PCT/IB2007/055245 patent/WO2008078291A1/en not_active Ceased
- 2007-12-20 CN CN2007800478100A patent/CN101568542B/zh not_active Expired - Fee Related
- 2007-12-20 KR KR1020097015261A patent/KR20090106538A/ko not_active Ceased
- 2007-12-20 AU AU2007337659A patent/AU2007337659A1/en not_active Abandoned
- 2007-12-20 RU RU2009127842/04A patent/RU2009127842A/ru not_active Application Discontinuation
- 2007-12-20 EP EP07859469A patent/EP2125823B1/de active Active
- 2007-12-20 MX MX2009006553A patent/MX2009006553A/es not_active Application Discontinuation
- 2007-12-20 ES ES07859469T patent/ES2380391T3/es active Active
- 2007-12-20 AT AT07859469T patent/ATE545647T1/de active
- 2007-12-20 JP JP2009542373A patent/JP2010513466A/ja active Pending
- 2007-12-20 US US12/520,693 patent/US8188082B2/en not_active Expired - Fee Related
- 2007-12-20 CA CA002669561A patent/CA2669561A1/en not_active Abandoned
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2009
- 2009-06-17 MA MA32006A patent/MA31002B1/fr unknown
- 2009-07-20 NO NO20092715A patent/NO20092715L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20092715L (no) | 2009-07-20 |
| JP2010513466A (ja) | 2010-04-30 |
| ES2380391T3 (es) | 2012-05-11 |
| MA31002B1 (fr) | 2009-12-01 |
| RU2009127842A (ru) | 2011-01-27 |
| EP2125823B1 (de) | 2012-02-15 |
| BRPI0720522A2 (pt) | 2014-01-07 |
| KR20090106538A (ko) | 2009-10-09 |
| WO2008078291A1 (en) | 2008-07-03 |
| MX2009006553A (es) | 2009-06-26 |
| CN101568542B (zh) | 2013-03-27 |
| CN101568542A (zh) | 2009-10-28 |
| AU2007337659A1 (en) | 2008-07-03 |
| US8188082B2 (en) | 2012-05-29 |
| US20100093740A1 (en) | 2010-04-15 |
| CA2669561A1 (en) | 2008-07-03 |
| EP2125823A1 (de) | 2009-12-02 |
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