ATE545647T1 - 5,6,7,8-tetrahydro-imidazoä1,5-aüpyrazinderivat - Google Patents

5,6,7,8-tetrahydro-imidazoä1,5-aüpyrazinderivat

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Publication number
ATE545647T1
ATE545647T1 AT07859469T AT07859469T ATE545647T1 AT E545647 T1 ATE545647 T1 AT E545647T1 AT 07859469 T AT07859469 T AT 07859469T AT 07859469 T AT07859469 T AT 07859469T AT E545647 T1 ATE545647 T1 AT E545647T1
Authority
AT
Austria
Prior art keywords
alkyl
tetrahydro
alkoxy
halogen
imidazoä1
Prior art date
Application number
AT07859469T
Other languages
English (en)
Inventor
Hamed Aissaoui
Christoph Boss
Markus Gude
Ralf Koberstein
Thierry Sifferlen
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Application granted granted Critical
Publication of ATE545647T1 publication Critical patent/ATE545647T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Gynecology & Obstetrics (AREA)
AT07859469T 2006-12-22 2007-12-20 5,6,7,8-tetrahydro-imidazoä1,5-aüpyrazinderivat ATE545647T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2006055019 2006-12-22
PCT/IB2007/055245 WO2008078291A1 (en) 2006-12-22 2007-12-20 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives

Publications (1)

Publication Number Publication Date
ATE545647T1 true ATE545647T1 (de) 2012-03-15

Family

ID=39273168

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07859469T ATE545647T1 (de) 2006-12-22 2007-12-20 5,6,7,8-tetrahydro-imidazoä1,5-aüpyrazinderivat

Country Status (15)

Country Link
US (1) US8188082B2 (de)
EP (1) EP2125823B1 (de)
JP (1) JP2010513466A (de)
KR (1) KR20090106538A (de)
CN (1) CN101568542B (de)
AT (1) ATE545647T1 (de)
AU (1) AU2007337659A1 (de)
BR (1) BRPI0720522A2 (de)
CA (1) CA2669561A1 (de)
ES (1) ES2380391T3 (de)
MA (1) MA31002B1 (de)
MX (1) MX2009006553A (de)
NO (1) NO20092715L (de)
RU (1) RU2009127842A (de)
WO (1) WO2008078291A1 (de)

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US8188082B2 (en) 2006-12-22 2012-05-29 Actelion Pharmaceuticals Ltd. 5,6,7,8-tetrahydro-imidazo[1,5-α]pyrazine derivatives
US7775298B2 (en) 2007-10-29 2010-08-17 Abergeldie Holdings Pty Ltd/Abergeldie Plant Pty Ltd Drilling assemblies and methods of drilling
CN101468988A (zh) * 2007-12-26 2009-07-01 上海恒瑞医药有限公司 哌嗪类衍生物,其制备方法及其在医药上的应用
US20110105514A1 (en) * 2008-06-25 2011-05-05 Hamed Aissaoui 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine compounds
TR201910327T4 (tr) 2009-10-23 2019-07-22 Janssen Pharmaceutica Nv Oreksin reseptör modülatörleri olarak di-ornatılmış oktahidropirrolo [3,4-c]pirroller.
CN102258508A (zh) * 2011-04-14 2011-11-30 威海迪素制药有限公司 芳基丙烯酸衍生物抗癫痫的用途
WO2013119639A1 (en) 2012-02-07 2013-08-15 Eolas Therapeutics, Inc. Substituted prolines / piperidines as orexin receptor antagonists
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
CN103980281B (zh) * 2014-05-27 2016-06-08 天津市斯芬克司药物研发有限公司 一种咪唑吡嗪化合物及其制备方法
JP6663909B2 (ja) 2014-08-13 2020-03-13 エオラス セラピューティクス， インコーポレイテッド オレキシンレセプターモジュレーターとしてのジフルオロピロリジン
EP3414241B1 (de) 2016-02-12 2022-05-04 Astrazeneca AB Halo-substituierte piperidine als orexinrezeptormodulatoren
SI3426251T1 (sl) 2016-03-10 2022-07-29 Janssen Pharmaceutica Nv Postopki za zdravljenje depresije z antagonisti receptorja oreksina-2
CN105753788A (zh) * 2016-04-08 2016-07-13 西南科技大学 一种1-取代-2-苯基-4-碘咪唑的制备方法
US20190151304A1 (en) 2016-05-10 2019-05-23 Inserm (Institut National De La Santé Et De La Rechercjae Médicale Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory
KR102616949B1 (ko) 2017-09-14 2023-12-22 다이이찌 산쿄 가부시키가이샤 고리형 구조를 갖는 화합물
CN108101930B (zh) * 2017-12-22 2020-10-30 武汉大学 一类含有苯并噻二唑并噻吩单元的小分子受体材料及其制备方法与应用
CN112165944B (zh) 2018-03-29 2024-04-09 德州大学系统董事会 转录激活蛋白的咪唑并哌嗪抑制剂
WO2019195846A1 (en) 2018-04-06 2019-10-10 Board Of Regents, The University Of Texas System Imidazopiperazinone inhibitors of transcription activating proteins
GB201908511D0 (en) 2019-06-13 2019-07-31 Adorx Therapeutics Ltd Hydroxamate compounds
EP4221708A1 (de) * 2020-10-02 2023-08-09 Board of Regents, The University of Texas System Imidazopiperazinhemmer von transkriptionsaktivierenden proteinen
CN116261454A (zh) * 2020-10-02 2023-06-13 德州大学系统董事会 转录激活蛋白的咪唑并哌嗪抑制剂
KR20230146639A (ko) * 2021-04-21 2023-10-19 장춘 진사이언스 파마슈티컬 씨오., 엘티디. 이미다졸 함유 축합고리계 유도체, 이의 제조방법 및 이의 의약적 용도

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BRPI0109200B8 (pt) * 2000-03-14 2021-05-25 Actelion Pharmaceuticals Ltd compostos e composições farmacêuticas
EP1288202A4 (de) 2000-05-11 2003-07-02 Banyu Pharma Co Ltd N-acyltetrahydroisochinolin-derivate
WO2002051232A2 (en) 2000-12-27 2002-07-04 Actelion Pharmaceuticals Ltd. Novel benzazepines and related heterocyclic derivatives
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EP2125823B1 (de) 2012-02-15
ES2380391T3 (es) 2012-05-11
MX2009006553A (es) 2009-06-26
US20100093740A1 (en) 2010-04-15
EP2125823A1 (de) 2009-12-02
RU2009127842A (ru) 2011-01-27
MA31002B1 (fr) 2009-12-01
NO20092715L (no) 2009-07-20
JP2010513466A (ja) 2010-04-30
WO2008078291A1 (en) 2008-07-03
US8188082B2 (en) 2012-05-29
AU2007337659A1 (en) 2008-07-03
CA2669561A1 (en) 2008-07-03
CN101568542B (zh) 2013-03-27
KR20090106538A (ko) 2009-10-09
CN101568542A (zh) 2009-10-28

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