ATE545647T1 - 5,6,7,8-tetrahydro-imidazoä1,5-aüpyrazinderivat - Google Patents
5,6,7,8-tetrahydro-imidazoä1,5-aüpyrazinderivatInfo
- Publication number
- ATE545647T1 ATE545647T1 AT07859469T AT07859469T ATE545647T1 AT E545647 T1 ATE545647 T1 AT E545647T1 AT 07859469 T AT07859469 T AT 07859469T AT 07859469 T AT07859469 T AT 07859469T AT E545647 T1 ATE545647 T1 AT E545647T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- tetrahydro
- alkoxy
- halogen
- imidazoä1
- Prior art date
Links
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
- WROMFHICINADER-UHFFFAOYSA-N 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine Chemical class C1NCCN2C=NC=C21 WROMFHICINADER-UHFFFAOYSA-N 0.000 abstract 1
- 229940123730 Orexin receptor antagonist Drugs 0.000 abstract 1
- 125000004849 alkoxymethyl group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- -1 cyano, hydroxymethyl Chemical group 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Addiction (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2006055019 | 2006-12-22 | ||
| PCT/IB2007/055245 WO2008078291A1 (en) | 2006-12-22 | 2007-12-20 | 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE545647T1 true ATE545647T1 (de) | 2012-03-15 |
Family
ID=39273168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07859469T ATE545647T1 (de) | 2006-12-22 | 2007-12-20 | 5,6,7,8-tetrahydro-imidazoä1,5-aüpyrazinderivat |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8188082B2 (de) |
| EP (1) | EP2125823B1 (de) |
| JP (1) | JP2010513466A (de) |
| KR (1) | KR20090106538A (de) |
| CN (1) | CN101568542B (de) |
| AT (1) | ATE545647T1 (de) |
| AU (1) | AU2007337659A1 (de) |
| BR (1) | BRPI0720522A2 (de) |
| CA (1) | CA2669561A1 (de) |
| ES (1) | ES2380391T3 (de) |
| MA (1) | MA31002B1 (de) |
| MX (1) | MX2009006553A (de) |
| NO (1) | NO20092715L (de) |
| RU (1) | RU2009127842A (de) |
| WO (1) | WO2008078291A1 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2380391T3 (es) | 2006-12-22 | 2012-05-11 | Actelion Pharmaceuticals Ltd. | Derivados de 5,6,7,8-tetrahidro-imidazo[1,5-a]pirazina |
| US7775298B2 (en) | 2007-10-29 | 2010-08-17 | Abergeldie Holdings Pty Ltd/Abergeldie Plant Pty Ltd | Drilling assemblies and methods of drilling |
| CN101468988A (zh) * | 2007-12-26 | 2009-07-01 | 上海恒瑞医药有限公司 | 哌嗪类衍生物,其制备方法及其在医药上的应用 |
| US20110105514A1 (en) * | 2008-06-25 | 2011-05-05 | Hamed Aissaoui | 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine compounds |
| ES2585806T3 (es) | 2009-10-23 | 2016-10-10 | Janssen Pharmaceutica N.V. | Octahidropirrolo [3,4-c] pirroles disustituidos como moduladores de receptores de orexina |
| CN102258508A (zh) * | 2011-04-14 | 2011-11-30 | 威海迪素制药有限公司 | 芳基丙烯酸衍生物抗癫痫的用途 |
| US9440982B2 (en) | 2012-02-07 | 2016-09-13 | Eolas Therapeutics, Inc. | Substituted prolines/piperidines as orexin receptor antagonists |
| WO2013119639A1 (en) | 2012-02-07 | 2013-08-15 | Eolas Therapeutics, Inc. | Substituted prolines / piperidines as orexin receptor antagonists |
| CN103980281B (zh) * | 2014-05-27 | 2016-06-08 | 天津市斯芬克司药物研发有限公司 | 一种咪唑吡嗪化合物及其制备方法 |
| TW201613902A (en) | 2014-08-13 | 2016-04-16 | Eolas Therapeutics Inc | Difluoropyrrolidines as orexin receptor modulators |
| LT3414241T (lt) | 2016-02-12 | 2022-08-25 | Astrazeneca Ab | Halogenu pakeisti piperidinai kaip oreksino receptoriaus moduliatoriai |
| HRP20220642T1 (hr) | 2016-03-10 | 2022-06-24 | Janssen Pharmaceutica Nv | Postupci za liječenje depresije uporabom antagonista receptora oreksina 2 |
| CN105753788A (zh) * | 2016-04-08 | 2016-07-13 | 西南科技大学 | 一种1-取代-2-苯基-4-碘咪唑的制备方法 |
| WO2017194548A1 (en) | 2016-05-10 | 2017-11-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases |
| DK3682881T3 (da) | 2017-09-14 | 2026-05-11 | Daiichi Sankyo Co Limited | Forbindelse med cyklisk struktur |
| CN108101930B (zh) * | 2017-12-22 | 2020-10-30 | 武汉大学 | 一类含有苯并噻二唑并噻吩单元的小分子受体材料及其制备方法与应用 |
| AU2019245403B2 (en) * | 2018-03-29 | 2025-02-06 | Board Of Regents, The University Of Texas System | Imidazopiperazine inhibitors of transcription activating proteins |
| WO2019195846A1 (en) | 2018-04-06 | 2019-10-10 | Board Of Regents, The University Of Texas System | Imidazopiperazinone inhibitors of transcription activating proteins |
| GB201908511D0 (en) | 2019-06-13 | 2019-07-31 | Adorx Therapeutics Ltd | Hydroxamate compounds |
| CN116348112A (zh) * | 2020-10-02 | 2023-06-27 | 德州大学系统董事会 | 转录激活蛋白的咪唑并哌嗪抑制剂 |
| JP2023544173A (ja) | 2020-10-02 | 2023-10-20 | ボード オブ レジェンツ，ザ ユニバーシティ オブ テキサス システム | 転写活性化タンパク質のイミダゾピペラジン阻害剤 |
| KR102910851B1 (ko) * | 2021-04-21 | 2026-01-09 | 장춘 진사이언스 파마슈티컬 씨오., 엘티디. | 이미다졸 함유 축합고리계 유도체, 이의 제조방법 및 이의 의약적 용도 |
| EP4574826A4 (de) * | 2022-10-19 | 2025-12-10 | Changchun Genescience Pharmaceutical Co Ltd | Kristallform eines nk3r-antagonisten und herstellungsverfahren dafür und verwendung davon |
| WO2025224168A1 (en) | 2024-04-24 | 2025-10-30 | Idorsia Pharmaceuticals Ltd | Aryl sulfone and sulfanone derivatives as orexin receptor modulators |
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| AU6011301A (en) * | 2000-03-14 | 2001-09-24 | Actelion Pharmaceuticals Ltd | 1,2,3,4-tetrahydroisoquinoline derivatives |
| CA2408343A1 (en) | 2000-05-11 | 2002-11-07 | Banyu Pharmaceutical Co., Ltd. | N-acyltetrahydroisoquinoline derivatives |
| WO2002051232A2 (en) | 2000-12-27 | 2002-07-04 | Actelion Pharmaceuticals Ltd. | Novel benzazepines and related heterocyclic derivatives |
| GB0124463D0 (en) * | 2001-10-11 | 2001-12-05 | Smithkline Beecham Plc | Compounds |
| MXPA04002269A (es) | 2002-07-09 | 2004-06-29 | Actelion Pharmaceuticals Ltd | Derivados de 7,8,9,10-tetrahidro-6h-azepino,6,7,8,9-tetrahidro-pirido y 2,3-dihidro-2h-pirrolo[2,1-b]-quinazolinona. |
| CA2494636A1 (en) * | 2002-08-07 | 2004-02-19 | Novartis Ag | Organic compounds as agents for the treatment of aldosterone mediated conditions |
| AU2004224156B2 (en) | 2003-03-26 | 2010-08-12 | Actelion Pharmaceuticals Ltd. | Tetrahydroisoquinolyl acetamide derivatives for use as orexin receptor antagonists |
| CA2540196C (en) * | 2003-09-26 | 2012-03-20 | Actelion Pharmaceuticals Ltd | Pyridine derivatives and use thereof as urotensin ii antagonists |
| JP4094050B2 (ja) | 2004-03-01 | 2008-06-04 | アクテリオン ファーマシューティカルズ リミテッド | 置換１，２，３，４−テトラヒドロイソキノリン誘導体 |
| EP1998774A1 (de) | 2006-03-15 | 2008-12-10 | Actelion Pharmaceuticals Ltd. | Tetrahydroisochinolin-derivate zur verstärkung der gedächtnisfunktion |
| ATE496051T1 (de) | 2006-04-26 | 2011-02-15 | Actelion Pharmaceuticals Ltd | Pyrazolotetrahydropyridinderivate als orexinrezeptorantagonisten |
| WO2008026149A1 (en) * | 2006-08-28 | 2008-03-06 | Actelion Pharmaceuticals Ltd | 1,4,5,6, 7,8-hexahydro-i^1s-triaza-azulene derivatives as orexin receptor antagonists |
| ES2380391T3 (es) | 2006-12-22 | 2012-05-11 | Actelion Pharmaceuticals Ltd. | Derivados de 5,6,7,8-tetrahidro-imidazo[1,5-a]pirazina |
| PE20091010A1 (es) | 2007-10-10 | 2009-08-08 | Actelion Pharmaceuticals Ltd | Derivados de tetrahidroquinolina |
| US20110105514A1 (en) * | 2008-06-25 | 2011-05-05 | Hamed Aissaoui | 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine compounds |
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- 2007-12-20 AT AT07859469T patent/ATE545647T1/de active
- 2007-12-20 MX MX2009006553A patent/MX2009006553A/es not_active Application Discontinuation
- 2007-12-20 AU AU2007337659A patent/AU2007337659A1/en not_active Abandoned
- 2007-12-20 JP JP2009542373A patent/JP2010513466A/ja active Pending
- 2007-12-20 WO PCT/IB2007/055245 patent/WO2008078291A1/en not_active Ceased
- 2007-12-20 CA CA002669561A patent/CA2669561A1/en not_active Abandoned
- 2007-12-20 BR BRPI0720522-8A patent/BRPI0720522A2/pt not_active IP Right Cessation
- 2007-12-20 KR KR1020097015261A patent/KR20090106538A/ko not_active Ceased
- 2007-12-20 RU RU2009127842/04A patent/RU2009127842A/ru not_active Application Discontinuation
- 2007-12-20 US US12/520,693 patent/US8188082B2/en not_active Expired - Fee Related
- 2007-12-20 CN CN2007800478100A patent/CN101568542B/zh not_active Expired - Fee Related
- 2007-12-20 EP EP07859469A patent/EP2125823B1/de active Active
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2009
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- 2009-07-20 NO NO20092715A patent/NO20092715L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MA31002B1 (fr) | 2009-12-01 |
| AU2007337659A1 (en) | 2008-07-03 |
| WO2008078291A1 (en) | 2008-07-03 |
| KR20090106538A (ko) | 2009-10-09 |
| CN101568542A (zh) | 2009-10-28 |
| BRPI0720522A2 (pt) | 2014-01-07 |
| EP2125823A1 (de) | 2009-12-02 |
| CA2669561A1 (en) | 2008-07-03 |
| MX2009006553A (es) | 2009-06-26 |
| JP2010513466A (ja) | 2010-04-30 |
| CN101568542B (zh) | 2013-03-27 |
| RU2009127842A (ru) | 2011-01-27 |
| ES2380391T3 (es) | 2012-05-11 |
| NO20092715L (no) | 2009-07-20 |
| US20100093740A1 (en) | 2010-04-15 |
| EP2125823B1 (de) | 2012-02-15 |
| US8188082B2 (en) | 2012-05-29 |
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