NO20092715L - 5,6,7,8-tetrahydro-imidazo[1,5-A]pyrazinderivater - Google Patents

5,6,7,8-tetrahydro-imidazo[1,5-A]pyrazinderivater

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Publication number
NO20092715L
NO20092715L NO20092715A NO20092715A NO20092715L NO 20092715 L NO20092715 L NO 20092715L NO 20092715 A NO20092715 A NO 20092715A NO 20092715 A NO20092715 A NO 20092715A NO 20092715 L NO20092715 L NO 20092715L
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NO
Norway
Prior art keywords
alkyl
imidazo
tetrahydro
alkoxy
halogen
Prior art date
Application number
NO20092715A
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English (en)
Inventor
Hamed Aissaoui
Christoph Boss
Markus Gude
Ralf Koberstein
Thierry Sifferlen
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Actelion Pharmaceuticals Ltd
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Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of NO20092715L publication Critical patent/NO20092715L/no

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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings

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Abstract

Oppfinnelsen vedrører 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazinderivater med formel (I) hvori X representerer CH2 eller O; R1 representerer en fenylgruppe, hvilken gruppe er uavhengig mono-, di- eller trisubstituert hvori substituentene er uavhengig valgt fra gruppen bestående av (C1-4)alkyl, (C1-4)alkoksy, halogen, cyano, trifluormetoksy og trifluormetyl; R2 representerer (C1-4)alkyl, (C1-4)alkoksy, (C2-4)alkenyl, halogen, cyano, hydroksymetyl, trifluormetyl, C(O)NR5R6 eller cyklopropyl; R3 representerer (C1-4)alkyl, (C1-4)alkoksy-metyl eller halogen; R4 representerer (C1-4)alkyl; R5 representerer hydrogen eller (C1-4)alkyl, og R6 representerer hydrogen eller (C1-4)alkyl. Oppfinnelsen vedrører også farmasøytisk akseptable salter av slike forbindelser; og anvendelsen av slike forbindelser som medikamenter; spesielt som oreksinreseptor-antagonister.
NO20092715A 2006-12-22 2009-07-20 5,6,7,8-tetrahydro-imidazo[1,5-A]pyrazinderivater NO20092715L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2006055019 2006-12-22
PCT/IB2007/055245 WO2008078291A1 (en) 2006-12-22 2007-12-20 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives

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NO20092715L true NO20092715L (no) 2009-07-20

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US (1) US8188082B2 (no)
EP (1) EP2125823B1 (no)
JP (1) JP2010513466A (no)
KR (1) KR20090106538A (no)
CN (1) CN101568542B (no)
AT (1) ATE545647T1 (no)
AU (1) AU2007337659A1 (no)
BR (1) BRPI0720522A2 (no)
CA (1) CA2669561A1 (no)
ES (1) ES2380391T3 (no)
MA (1) MA31002B1 (no)
MX (1) MX2009006553A (no)
NO (1) NO20092715L (no)
RU (1) RU2009127842A (no)
WO (1) WO2008078291A1 (no)

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WO2017194548A1 (en) 2016-05-10 2017-11-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases
KR102616949B1 (ko) 2017-09-14 2023-12-22 다이이찌 산쿄 가부시키가이샤 고리형 구조를 갖는 화합물
CN108101930B (zh) * 2017-12-22 2020-10-30 武汉大学 一类含有苯并噻二唑并噻吩单元的小分子受体材料及其制备方法与应用
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WO2019195846A1 (en) 2018-04-06 2019-10-10 Board Of Regents, The University Of Texas System Imidazopiperazinone inhibitors of transcription activating proteins
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WO2022072647A1 (en) * 2020-10-02 2022-04-07 Board Of Regents, The University Of Texas System Imidazopiperazine inhibitors of transcription activating proteins
AU2021355480A1 (en) * 2020-10-02 2023-05-04 Board Of Regents, The University Of Texas System Imidazopiperazine inhibitors of transcription activating proteins
CA3214215A1 (en) * 2021-04-21 2022-10-27 Yunlong Song Imidazole-containing condensed ring derivative, preparation method therefor, and application thereof in medicine

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CN101568542B (zh) 2013-03-27
ES2380391T3 (es) 2012-05-11
EP2125823B1 (en) 2012-02-15
CN101568542A (zh) 2009-10-28
KR20090106538A (ko) 2009-10-09
MA31002B1 (fr) 2009-12-01
WO2008078291A1 (en) 2008-07-03
JP2010513466A (ja) 2010-04-30
CA2669561A1 (en) 2008-07-03
RU2009127842A (ru) 2011-01-27
US8188082B2 (en) 2012-05-29
ATE545647T1 (de) 2012-03-15
EP2125823A1 (en) 2009-12-02
US20100093740A1 (en) 2010-04-15
BRPI0720522A2 (pt) 2014-01-07
AU2007337659A1 (en) 2008-07-03

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