NO312811B1 - Preparat av hydrogeltype med forlenget frigivelse - Google Patents
Preparat av hydrogeltype med forlenget frigivelse Download PDFInfo
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- NO312811B1 NO312811B1 NO19951036A NO951036A NO312811B1 NO 312811 B1 NO312811 B1 NO 312811B1 NO 19951036 A NO19951036 A NO 19951036A NO 951036 A NO951036 A NO 951036A NO 312811 B1 NO312811 B1 NO 312811B1
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- drug
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- hydrogel
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27497992 | 1992-09-18 | ||
| JP16526393 | 1993-06-08 | ||
| PCT/JP1993/001297 WO1994006414A1 (en) | 1992-09-18 | 1993-09-10 | Sustained-release hydrogel preparation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO951036D0 NO951036D0 (no) | 1995-03-17 |
| NO951036L NO951036L (no) | 1995-03-17 |
| NO312811B1 true NO312811B1 (no) | 2002-07-08 |
Family
ID=26490061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19951036A NO312811B1 (no) | 1992-09-18 | 1995-03-17 | Preparat av hydrogeltype med forlenget frigivelse |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US6436441B1 (de) |
| EP (1) | EP0661045B1 (de) |
| JP (1) | JP3140465B2 (de) |
| KR (1) | KR100355130B1 (de) |
| CN (1) | CN1048397C (de) |
| AT (1) | ATE219933T1 (de) |
| AU (1) | AU682827B2 (de) |
| BG (1) | BG61861B1 (de) |
| CA (1) | CA2144077C (de) |
| CZ (1) | CZ291495B6 (de) |
| DE (1) | DE69332081T2 (de) |
| DK (1) | DK0661045T3 (de) |
| ES (1) | ES2179829T3 (de) |
| FI (1) | FI115697B (de) |
| HU (1) | HU226456B1 (de) |
| NO (1) | NO312811B1 (de) |
| NZ (1) | NZ255579A (de) |
| PL (1) | PL175026B1 (de) |
| PT (1) | PT661045E (de) |
| RO (1) | RO112991B1 (de) |
| RU (1) | RU2121830C1 (de) |
| SK (1) | SK281042B6 (de) |
| WO (1) | WO1994006414A1 (de) |
Families Citing this family (161)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0661045T3 (da) * | 1992-09-18 | 2002-10-28 | Yamanouchi Pharma Co Ltd | Hydrogelpræparat med forsinket frigivelse |
| DE19509807A1 (de) * | 1995-03-21 | 1996-09-26 | Basf Ag | Verfahren zur Herstellung von Wirkstoffzubereitungen in Form einer festen Lösung des Wirkstoffs in einer Polymermatrix sowie mit diesem Verfahren hergestellte Wirkstoffzubereitungen |
| US5945125A (en) * | 1995-02-28 | 1999-08-31 | Temple University | Controlled release tablet |
| US6166024A (en) * | 1995-03-30 | 2000-12-26 | Mayo Foundation For Medical Education And Research | Use of topical azathioprine and thioguanine to treat colorectal adenomas |
| EP0761209A3 (de) * | 1995-09-01 | 1998-02-04 | J.B. Chemicals & Pharmaceuticals Ltd. | Ranitidinformulierungen mit gesteuerter Freisetzung |
| ES2325046T3 (es) * | 1996-06-26 | 2009-08-24 | The Board Of Regents, The University Of Texas System | Formulacion farmaceutica extruible por fusion en caliente. |
| ZA976189B (en) * | 1996-07-12 | 1999-01-11 | Novartis Consumer Health Sa | Oral pharmaceutical combinations |
| GB9720797D0 (en) * | 1997-09-30 | 1997-12-03 | Rhodes John | Pharmaceutical composition for the treatment of inflammatory bowel disease and irritable bowel syndrome |
| US20040029962A1 (en) * | 1997-12-12 | 2004-02-12 | Chih-Ming Chen | HMG-COA reductase inhibitor extended release formulation |
| US20060141036A1 (en) * | 1997-12-12 | 2006-06-29 | Andrx Labs Llc | HMG-CoA reductase inhibitor extended release formulation |
| SE9704869D0 (sv) * | 1997-12-22 | 1997-12-22 | Astra Ab | New pharmaceutical formulaton II |
| DE19901040A1 (de) * | 1999-01-14 | 2000-07-20 | Knoll Ag | Arzneiformen mit gesteuerter Freisetzung, enthaltend gut wasserlösliche Wirkstoffe |
| EG23951A (en) | 1999-03-25 | 2008-01-29 | Otsuka Pharma Co Ltd | Cilostazol preparation |
| WO2000074650A2 (en) * | 1999-06-04 | 2000-12-14 | Alza Corporation | Implantable gel compositions and method of manufacture |
| US6562375B1 (en) | 1999-08-04 | 2003-05-13 | Yamanouchi Pharmaceuticals, Co., Ltd. | Stable pharmaceutical composition for oral use |
| US20020015731A1 (en) * | 1999-12-23 | 2002-02-07 | Appel Leah E. | Hydrogel-Driven Drug Dosage Form |
| JPWO2001078681A1 (ja) * | 2000-04-17 | 2004-01-08 | 山之内製薬株式会社 | 薬物動態学的な薬物相互作用を回避する薬物送達システム及びその方法 |
| US20020028240A1 (en) * | 2000-04-17 | 2002-03-07 | Toyohiro Sawada | Timed-release compression-coated solid composition for oral administration |
| US6419954B1 (en) * | 2000-05-19 | 2002-07-16 | Yamanouchi Pharmaceutical Co., Ltd. | Tablets and methods for modified release of hydrophilic and other active agents |
| US20030068375A1 (en) | 2001-08-06 | 2003-04-10 | Curtis Wright | Pharmaceutical formulation containing gelling agent |
| PE20030527A1 (es) | 2001-10-24 | 2003-07-26 | Gruenenthal Chemie | Formulacion farmaceutica con liberacion retardada que contiene 3-(3-dimetilamino-1-etil-2-metil-propil) fenol o una sal farmaceuticamente aceptable del mismo y tabletas para administracion oral que la contienen |
| US20030152622A1 (en) * | 2001-10-25 | 2003-08-14 | Jenny Louie-Helm | Formulation of an erodible, gastric retentive oral diuretic |
| US20030091630A1 (en) * | 2001-10-25 | 2003-05-15 | Jenny Louie-Helm | Formulation of an erodible, gastric retentive oral dosage form using in vitro disintegration test data |
| KR101016619B1 (ko) * | 2001-11-13 | 2011-02-23 | 아스텔라스세이야쿠 가부시키가이샤 | 용해성 약물 지속 방출 시스템 |
| CA2474838C (en) * | 2002-02-01 | 2009-01-06 | Pfizer Products Inc. | Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials |
| AU2003211267A1 (en) * | 2002-02-27 | 2003-09-09 | Shionogi And Co., Ltd. | Solid preparations with improved absorbability of hardly water-soluble drug |
| NZ519363A (en) * | 2002-06-05 | 2004-02-27 | Agres Ltd | A novel drug dosing regimen |
| US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
| MY142204A (en) | 2002-07-25 | 2010-10-29 | Pharmacia Corp | Pramipexole once-daily dosage form |
| US20060039974A1 (en) | 2002-09-11 | 2006-02-23 | Takeda Pharmaceutical Company Limited | Sustained release preparation |
| MY148805A (en) * | 2002-10-16 | 2013-05-31 | Takeda Pharmaceutical | Controlled release preparation |
| JP4459543B2 (ja) | 2003-03-17 | 2010-04-28 | 株式会社メドジェル | 徐放性ハイドロゲル製剤 |
| WO2005011635A2 (en) | 2003-08-04 | 2005-02-10 | Pfizer Products Inc. | Pharmaceutical compositions of adsorbates of amorphous drugs and lipophilic microphase-forming materials |
| DE102004032051A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
| US8075872B2 (en) | 2003-08-06 | 2011-12-13 | Gruenenthal Gmbh | Abuse-proofed dosage form |
| US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
| DE10361596A1 (de) * | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
| DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
| DE102004020220A1 (de) * | 2004-04-22 | 2005-11-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
| US8128958B2 (en) | 2003-11-10 | 2012-03-06 | Astellas Pharma Inc. | Sustained release pharmaceutical composition |
| US8197846B2 (en) | 2003-11-10 | 2012-06-12 | Astellas Pharma Inc. | Sustained release pharmaceutical composition |
| US20050171248A1 (en) * | 2004-02-02 | 2005-08-04 | Yanmei Li | Hydrogel for use in downhole seal applications |
| WO2005079752A2 (en) * | 2004-02-11 | 2005-09-01 | Rubicon Research Private Limited | Controlled release pharmaceutical compositions with improved bioavailability |
| SI1765292T1 (en) | 2004-06-12 | 2018-04-30 | Collegium Pharmaceutical, Inc. | Formulations of medicines to discourage abuse |
| DE102004032049A1 (de) * | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
| WO2006015277A1 (en) * | 2004-07-30 | 2006-02-09 | Baker Hughes Incorporated | Downhole inflow control device with shut-off feature |
| EP1781260B2 (de) | 2004-08-13 | 2014-04-02 | Boehringer Ingelheim International GmbH | Tablettenformulierung mit verlängerter freisetzung enthaltend pramipexol oder ein pharmazeutisch annehmbares salz, die herstellungsmethode und die verwendung der tabletten |
| MX2007001850A (es) | 2004-08-13 | 2007-03-28 | Boehringer Ingelheim Int | Formulacion de pildora de liberacion prolongada que contiene pramipexol o una sal farmaceuticamente aceptable del mismo, metodo para fabricarlo y uso del mismo. |
| US20060074182A1 (en) | 2004-09-30 | 2006-04-06 | Depuy Products, Inc. | Hydrogel composition and methods for making the same |
| CA2582615A1 (en) * | 2004-10-05 | 2006-04-13 | Astellas Pharma Inc. | Pharmaceutical composition for treatment of tear and salivary fluid drying |
| JP2008523143A (ja) * | 2004-12-13 | 2008-07-03 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | 月経困難症の治療のためのα−アドレナリン遮断剤の使用 |
| DE102005005449A1 (de) * | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| US20060239956A1 (en) * | 2005-04-26 | 2006-10-26 | Lulu Henson | Preparation and use of hydrogels |
| KR20080055797A (ko) * | 2005-08-23 | 2008-06-19 | 닛산 가가쿠 고교 가부시키 가이샤 | 서방성 제제 |
| WO2007055329A1 (ja) * | 2005-11-11 | 2007-05-18 | Asahi Kasei Chemicals Corporation | 徐放性固形製剤 |
| GB0607534D0 (en) * | 2006-04-13 | 2006-05-24 | Univ London Pharmacy | Colonic drug delivery formulation |
| EP2026766A1 (de) | 2006-05-17 | 2009-02-25 | Synthon B.V. | Tabletten-zusammensetzung mit verlängerter freisetzung von tamsulosin |
| SA07280459B1 (ar) | 2006-08-25 | 2011-07-20 | بيورديو فارما إل. بي. | أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني |
| EP2090298A4 (de) * | 2006-11-13 | 2014-02-26 | Kyorin Seiyaku Kk | Verfahren zur herstellung einer tablette mit verzögerter freisetzung |
| WO2008081829A1 (ja) | 2006-12-27 | 2008-07-10 | Astellas Pharma Inc. | 難水溶性薬物の溶解性維持用アミノアルキルメタアクリレートコポリマーｅ |
| KR100885029B1 (ko) * | 2007-02-07 | 2009-02-23 | 지엘팜텍 주식회사 | 경구투여용 서방성 삼중정제 |
| DE102007011485A1 (de) | 2007-03-07 | 2008-09-11 | Grünenthal GmbH | Darreichungsform mit erschwertem Missbrauch |
| US20090036414A1 (en) * | 2007-08-02 | 2009-02-05 | Mutual Pharmaceutical Company, Inc. | Mesalamine Formulations |
| US8312931B2 (en) * | 2007-10-12 | 2012-11-20 | Baker Hughes Incorporated | Flow restriction device |
| US7942206B2 (en) | 2007-10-12 | 2011-05-17 | Baker Hughes Incorporated | In-flow control device utilizing a water sensitive media |
| EP2047847A1 (de) | 2007-10-12 | 2009-04-15 | KRKA, tovarna zdravil, d.d., Novo mesto | Feste pharmazeutische Zusammensetzung mit Tamsulosin |
| US8096351B2 (en) * | 2007-10-19 | 2012-01-17 | Baker Hughes Incorporated | Water sensing adaptable in-flow control device and method of use |
| US8069921B2 (en) * | 2007-10-19 | 2011-12-06 | Baker Hughes Incorporated | Adjustable flow control devices for use in hydrocarbon production |
| US7775271B2 (en) | 2007-10-19 | 2010-08-17 | Baker Hughes Incorporated | Device and system for well completion and control and method for completing and controlling a well |
| US7784543B2 (en) * | 2007-10-19 | 2010-08-31 | Baker Hughes Incorporated | Device and system for well completion and control and method for completing and controlling a well |
| US7918272B2 (en) * | 2007-10-19 | 2011-04-05 | Baker Hughes Incorporated | Permeable medium flow control devices for use in hydrocarbon production |
| US7913755B2 (en) | 2007-10-19 | 2011-03-29 | Baker Hughes Incorporated | Device and system for well completion and control and method for completing and controlling a well |
| US20090101354A1 (en) * | 2007-10-19 | 2009-04-23 | Baker Hughes Incorporated | Water Sensing Devices and Methods Utilizing Same to Control Flow of Subsurface Fluids |
| US7891430B2 (en) | 2007-10-19 | 2011-02-22 | Baker Hughes Incorporated | Water control device using electromagnetics |
| US7775277B2 (en) * | 2007-10-19 | 2010-08-17 | Baker Hughes Incorporated | Device and system for well completion and control and method for completing and controlling a well |
| US7913765B2 (en) * | 2007-10-19 | 2011-03-29 | Baker Hughes Incorporated | Water absorbing or dissolving materials used as an in-flow control device and method of use |
| US7793714B2 (en) | 2007-10-19 | 2010-09-14 | Baker Hughes Incorporated | Device and system for well completion and control and method for completing and controlling a well |
| US7789139B2 (en) | 2007-10-19 | 2010-09-07 | Baker Hughes Incorporated | Device and system for well completion and control and method for completing and controlling a well |
| US8544548B2 (en) * | 2007-10-19 | 2013-10-01 | Baker Hughes Incorporated | Water dissolvable materials for activating inflow control devices that control flow of subsurface fluids |
| US20090101344A1 (en) * | 2007-10-22 | 2009-04-23 | Baker Hughes Incorporated | Water Dissolvable Released Material Used as Inflow Control Device |
| US7918275B2 (en) * | 2007-11-27 | 2011-04-05 | Baker Hughes Incorporated | Water sensitive adaptive inflow control using couette flow to actuate a valve |
| US8383152B2 (en) | 2008-01-25 | 2013-02-26 | Gruenenthal Gmbh | Pharmaceutical dosage form |
| US7597150B2 (en) | 2008-02-01 | 2009-10-06 | Baker Hughes Incorporated | Water sensitive adaptive inflow control using cavitations to actuate a valve |
| US8839849B2 (en) * | 2008-03-18 | 2014-09-23 | Baker Hughes Incorporated | Water sensitive variable counterweight device driven by osmosis |
| US7992637B2 (en) * | 2008-04-02 | 2011-08-09 | Baker Hughes Incorporated | Reverse flow in-flow control device |
| DE102008022520A1 (de) * | 2008-05-07 | 2009-11-12 | Bayer Animal Health Gmbh | Feste Arzneimittelformulierung mit verzögerter Freisetzung |
| US8931570B2 (en) * | 2008-05-08 | 2015-01-13 | Baker Hughes Incorporated | Reactive in-flow control device for subterranean wellbores |
| HUE030803T2 (en) | 2008-05-09 | 2017-06-28 | Gruenenthal Gmbh | Process for the preparation of an intermediate powder formulation and a final solid dosage form using a spraying step \ t |
| US7789152B2 (en) | 2008-05-13 | 2010-09-07 | Baker Hughes Incorporated | Plug protection system and method |
| US8171999B2 (en) * | 2008-05-13 | 2012-05-08 | Baker Huges Incorporated | Downhole flow control device and method |
| US8555958B2 (en) | 2008-05-13 | 2013-10-15 | Baker Hughes Incorporated | Pipeless steam assisted gravity drainage system and method |
| US8113292B2 (en) | 2008-05-13 | 2012-02-14 | Baker Hughes Incorporated | Strokable liner hanger and method |
| US7762341B2 (en) * | 2008-05-13 | 2010-07-27 | Baker Hughes Incorporated | Flow control device utilizing a reactive media |
| EP2161019A1 (de) | 2008-09-05 | 2010-03-10 | KRKA, D.D., Novo Mesto | Verlängerte Freisetzung von einer pharmazeutischen Mehrteilchenzusammensetzung mit Paliperidon |
| TWI478712B (zh) | 2008-09-30 | 2015-04-01 | Astellas Pharma Inc | 釋控性醫藥組成物 |
| US8465770B2 (en) | 2008-12-24 | 2013-06-18 | Synthon Bv | Low dose controlled release tablet |
| CN102307579B (zh) | 2009-02-04 | 2013-10-16 | 安斯泰来制药株式会社 | 经口给药用医药组合物 |
| EP2255793A1 (de) | 2009-05-28 | 2010-12-01 | Krka Tovarna Zdravil, D.D., Novo Mesto | Pharmazeutische Zusammensetzung mit Tamsulosin |
| US8056627B2 (en) * | 2009-06-02 | 2011-11-15 | Baker Hughes Incorporated | Permeability flow balancing within integral screen joints and method |
| US20100300674A1 (en) * | 2009-06-02 | 2010-12-02 | Baker Hughes Incorporated | Permeability flow balancing within integral screen joints |
| US8132624B2 (en) * | 2009-06-02 | 2012-03-13 | Baker Hughes Incorporated | Permeability flow balancing within integral screen joints and method |
| US20100300675A1 (en) * | 2009-06-02 | 2010-12-02 | Baker Hughes Incorporated | Permeability flow balancing within integral screen joints |
| US8151881B2 (en) * | 2009-06-02 | 2012-04-10 | Baker Hughes Incorporated | Permeability flow balancing within integral screen joints |
| EP2456427B1 (de) | 2009-07-22 | 2015-03-04 | Grünenthal GmbH | Heißschmelzextrudierte retardierte pharmazeutische Darreichungsform |
| AR077420A1 (es) | 2009-07-22 | 2011-08-24 | Gruenenthal Gmbh | Forma de dosificacion resistente a la manipulacion para opiaceos sensibles a la oxidacion |
| CA2780294C (en) | 2009-11-09 | 2018-01-16 | Spotlight Technology Partners Llc | Polysaccharide based hydrogels |
| WO2011057133A1 (en) | 2009-11-09 | 2011-05-12 | Spotlight Technology Partners Llc | Fragmented hydrogels |
| US10668060B2 (en) | 2009-12-10 | 2020-06-02 | Collegium Pharmaceutical, Inc. | Tamper-resistant pharmaceutical compositions of opioids and other drugs |
| EP2531176B1 (de) | 2010-02-03 | 2016-09-07 | Grünenthal GmbH | Herstellung einer pulverförmigen pharmazeutischen zusammensetzung mittels eines extruders |
| CA2788659C (en) * | 2010-02-24 | 2015-05-05 | Pfizer Inc. | Veterinary compositions |
| JP5849946B2 (ja) * | 2010-03-29 | 2016-02-03 | アステラス製薬株式会社 | 放出制御医薬組成物 |
| PL2554168T3 (pl) | 2010-03-29 | 2018-05-30 | Astellas Pharma Inc. | Kompozycja farmaceutyczna do kontrolowanego uwalniania |
| JP5933553B2 (ja) | 2010-09-02 | 2016-06-15 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | アニオン性ポリマーを含む不正使用抵抗性剤形 |
| ES2486791T3 (es) | 2010-09-02 | 2014-08-19 | Grünenthal GmbH | Forma de dosificación resistente a la manipulación que comprende una sal inorgánica |
| US9011912B2 (en) | 2010-10-07 | 2015-04-21 | Abon Pharmaceuticals, Llc | Extended-release oral dosage forms for poorly soluble amine drugs |
| EA032906B1 (ru) | 2010-12-22 | 2019-08-30 | Пэдью Фарма Л.П. | Твердая лекарственная форма с контролируемым высвобождением и способы ее получения и применения |
| KR101458334B1 (ko) | 2010-12-23 | 2014-11-04 | 퍼듀 퍼머 엘피 | 탬퍼 저항성 고체 경구 투여 형태 |
| KR102027912B1 (ko) | 2011-02-15 | 2019-10-02 | 지엘팜텍주식회사 | 경구투여용 탐술로신 또는 이의 약제학적으로 허용되는 염을 포함하는 서방성 삼중정제 |
| RU2451680C1 (ru) | 2011-02-21 | 2012-05-27 | Общество С Ограниченной Ответственностью "Научно-Исследовательская Компания "Медбиофарм" | Клатратный комплекс циклодекстрина или арабиногалактана с 9-фенил-симм-октагидроселеноксантеном, способ его получения (варианты), фармацевтическая композиция и лекарственное средство |
| KR101992449B1 (ko) * | 2011-06-07 | 2019-06-24 | 젤레시스 엘엘씨 | 하이드로겔 생성 방법 |
| LT2736495T (lt) | 2011-07-29 | 2017-11-10 | Grünenthal GmbH | Sugadinimui atspari tabletė, pasižyminti greitu vaisto atpalaidavimu |
| RS56527B1 (sr) | 2011-07-29 | 2018-02-28 | Gruenenthal Gmbh | Tableta za trenutno oslobađanje leka rezistentna na zloupotrebu |
| CA2852417A1 (en) * | 2011-10-21 | 2013-04-25 | Takeda Pharmaceutical Company Limited | Sustained-release preparation |
| US20130143867A1 (en) | 2011-12-02 | 2013-06-06 | Sychroneuron Inc. | Acamprosate formulations, methods of using the same, and combinations comprising the same |
| CA2864949A1 (en) | 2012-02-28 | 2013-09-06 | Grunenthal Gmbh | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
| JP6123795B2 (ja) * | 2012-03-30 | 2017-05-10 | アステラス製薬株式会社 | 放出制御医薬組成物 |
| EP2838512B1 (de) | 2012-04-18 | 2018-08-22 | Grünenthal GmbH | Fälschungssichere und dose dumping sichere pharmazeutische darreichungsform |
| US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
| WO2014096181A1 (en) * | 2012-12-21 | 2014-06-26 | Nestec S.A. | Device for producing milk foam |
| US8999393B1 (en) | 2013-01-09 | 2015-04-07 | Edgemont Pharmaceuticals Llc | Sustained release formulations of lorazepam |
| CN105120846B (zh) | 2013-02-05 | 2019-10-18 | 普渡制药公司 | 抗篡改的药物制剂 |
| US10751287B2 (en) | 2013-03-15 | 2020-08-25 | Purdue Pharma L.P. | Tamper resistant pharmaceutical formulations |
| MX371432B (es) | 2013-05-29 | 2020-01-30 | Gruenenthal Gmbh | Forma de dosificacion resistente al uso indebido que contiene una o mas particulas. |
| JP6466417B2 (ja) | 2013-05-29 | 2019-02-06 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 二峰性放出プロファイルを有する改変防止（ｔａｍｐｅｒ−ｒｅｓｉｓｔａｎｔ）剤形 |
| EP3003297A4 (de) | 2013-06-05 | 2017-04-19 | Synchroneuron Inc. | Acamprosat-formulierungen, verfahren zur verwendung davon und kombinationen damit |
| MX368846B (es) | 2013-07-12 | 2019-10-18 | Gruenenthal Gmbh | Forma de dosificación resistente a la alteración que contiene polímero de acetato de etilen-vinilo. |
| EP3073994A1 (de) | 2013-11-26 | 2016-10-05 | Grünenthal GmbH | Herstellung einer pulverförmigen pharmazeutischen zusammensetzung mittels kryogenen mahlens |
| EP3142646A1 (de) | 2014-05-12 | 2017-03-22 | Grünenthal GmbH | Manipulationssichere kapselformulierung mit tapentadol mit unmittelbarer freisetzung |
| AU2015266117A1 (en) | 2014-05-26 | 2016-11-24 | Grunenthal Gmbh | Multiparticles safeguarded against ethanolic dose-dumping |
| JP6726109B2 (ja) | 2014-06-20 | 2020-07-22 | ジェレシス，エルエルシー | 過体重または肥満を治療するための組成物 |
| ES2858517T3 (es) | 2014-11-07 | 2021-09-30 | Sublimity Therapeutics Ltd | Composiciones que comprenden ciclosporina |
| MX2017009805A (es) | 2015-01-29 | 2018-05-07 | Gelesis Llc | Método para la producción de hidrogeles que juntan alto módulo elástico y absorbancia. |
| WO2016123482A2 (en) | 2015-01-30 | 2016-08-04 | Mylan, Inc. | Sustained-release oral dosage forms for low aqueous solubility compounds |
| EA035434B1 (ru) | 2015-04-24 | 2020-06-15 | Грюненталь Гмбх | Защищенная от применения не по назначению лекарственная форма с немедленным высвобождением и устойчивостью к экстракции растворителями |
| TWI722988B (zh) * | 2015-06-05 | 2021-04-01 | 瑩碩生技醫藥股份有限公司 | 緩釋性醫藥組合物及其製備方法 |
| JP2018526414A (ja) | 2015-09-10 | 2018-09-13 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 乱用抑止性の即放性製剤を用いた経口過剰摂取に対する保護 |
| US9687475B1 (en) | 2016-03-24 | 2017-06-27 | Ezra Pharma Llc | Extended release pharmaceutical formulations with controlled impurity levels |
| US9675585B1 (en) | 2016-03-24 | 2017-06-13 | Ezra Pharma | Extended release pharmaceutical formulations |
| CN105770866A (zh) * | 2016-04-08 | 2016-07-20 | 王夕花 | 一种缓释型降糖药物组合物及其制备方法 |
| US10543174B2 (en) | 2016-04-25 | 2020-01-28 | Synthon B.V. | Modified release tablet composition comprising mirabegron |
| WO2017189422A1 (en) | 2016-04-25 | 2017-11-02 | Gelesis, Llc. | Method for treating constipation |
| US20190307696A1 (en) | 2016-04-25 | 2019-10-10 | Synthon B.V. | Tablets comprising mirabegron and solifenacin |
| US9737530B1 (en) | 2016-06-23 | 2017-08-22 | Collegium Pharmaceutical, Inc. | Process of making stable abuse-deterrent oral formulations |
| EP3292864A1 (de) | 2017-10-12 | 2018-03-14 | Synthon B.V. | Tablettenzusammensetzung aus mirabegron mit modifizierter freisetzung |
| WO2019072404A1 (en) | 2017-10-12 | 2019-04-18 | Synthon B.V. | MODIFIED RELEASE COMPRESSED COMPOSITION COMPRISING MIRABEGRON |
| US10478399B2 (en) | 2017-10-12 | 2019-11-19 | Synthon B.V. | Modified release tablet composition comprising mirabegron |
| EP4035660A1 (de) | 2017-10-17 | 2022-08-03 | Synthon B.V. | Tabletten mit tamsulosin und solifenacin |
| TW202140010A (zh) * | 2020-01-31 | 2021-11-01 | 日商日本新藥股份有限公司 | 控釋組合物 |
| WO2022117594A1 (en) | 2020-12-01 | 2022-06-09 | Adamed Pharma S.A. | Orally-administered preparation containing solifenacin and tamsulosin |
| JP2023553202A (ja) | 2020-12-08 | 2023-12-20 | ルミナント バイオテク コーポレーション リミテッド | 動物に物質を送達するための装置および方法の改善 |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3065143A (en) * | 1960-04-19 | 1962-11-20 | Richardson Merrell Inc | Sustained release tablet |
| BR6570825D0 (pt) * | 1964-07-04 | 1973-08-16 | Shiryo Kogyo Co Inc Nippon | Processo para produzir granulos cristalizados a partir de solucoes de acucares e outros cristaloides |
| US3458622A (en) * | 1967-04-07 | 1969-07-29 | Squibb & Sons Inc | Controlled release tablet |
| US3619292A (en) * | 1968-07-15 | 1971-11-09 | Penick & Ford Ltd | Tablets and method of forming |
| JPS51135900A (en) * | 1975-05-19 | 1976-11-25 | Kao Corp | Method for prod uction of the stable sodium percarbonate |
| US4126672A (en) * | 1976-02-04 | 1978-11-21 | Hoffmann-La Roche Inc. | Sustained release pharmaceutical capsules |
| US4111201A (en) * | 1976-11-22 | 1978-09-05 | Alza Corporation | Osmotic system for delivering selected beneficial agents having varying degrees of solubility |
| GB1579818A (en) * | 1977-06-07 | 1980-11-26 | Yamanouchi Pharma Co Ltd | Nifedipine-containing solid preparation composition |
| CA1146866A (en) | 1979-07-05 | 1983-05-24 | Yamanouchi Pharmaceutical Co. Ltd. | Process for the production of sustained release pharmaceutical composition of solid medical material |
| JPS5649314A (en) | 1979-07-05 | 1981-05-02 | Yamanouchi Pharmaceut Co Ltd | Lasting pharmaceutical composition having prolonged action and its preparation |
| GB2108517B (en) | 1981-06-12 | 1985-06-12 | Nat Res Dev | Hydrogels |
| JPS58189121A (ja) * | 1982-04-30 | 1983-11-04 | Ajinomoto Co Inc | インシユリン投与賦活剤 |
| US4571333A (en) * | 1983-06-14 | 1986-02-18 | Syntex (U.S.A.) Inc. | Controlled release naproxen and naproxen sodium tablets |
| US5002776A (en) * | 1983-12-22 | 1991-03-26 | Elan Corporation, Plc | Controlled absorption diltiazem formulations |
| US4629621A (en) * | 1984-07-23 | 1986-12-16 | Zetachron, Inc. | Erodible matrix for sustained release bioactive composition |
| US4704285A (en) * | 1985-11-18 | 1987-11-03 | The Dow Chemical Company | Sustained release compositions comprising hydroxypropyl cellulose ethers |
| IE63321B1 (en) * | 1986-02-03 | 1995-04-05 | Elan Corp Plc | Drug delivery system |
| US4764378A (en) * | 1986-02-10 | 1988-08-16 | Zetachron, Inc. | Buccal drug dosage form |
| SE8601624D0 (sv) | 1986-04-11 | 1986-04-11 | Haessle Ab | New pharmaceutical preparations |
| US4940580A (en) | 1986-11-03 | 1990-07-10 | Schering Corporation | Sustained release labetalol tablets |
| ATE71833T1 (de) | 1986-11-03 | 1992-02-15 | Schering Corp | Labetalol tablette mit verzoegerter wirkstoffabgabe. |
| JPS63151353A (ja) * | 1986-12-15 | 1988-06-23 | Oogawara Kakoki Kk | ワツクスコ−テイングマイクロカプセルの製造方法 |
| US5026560A (en) * | 1987-01-29 | 1991-06-25 | Takeda Chemical Industries, Ltd. | Spherical granules having core and their production |
| US5015479A (en) * | 1987-02-02 | 1991-05-14 | Seamus Mulligan | Sustained release capsule or tablet formulation comprising a pharmaceutically acceptable dihydropyridine |
| US4968508A (en) | 1987-02-27 | 1990-11-06 | Eli Lilly And Company | Sustained release matrix |
| US4904474A (en) * | 1988-01-25 | 1990-02-27 | Alza Corporation | Delivery of drug to colon by oral disage form |
| JPH0283316A (ja) | 1988-09-20 | 1990-03-23 | Shin Etsu Chem Co Ltd | 徐放性錠剤 |
| IT1230576B (it) * | 1988-10-20 | 1991-10-28 | Angeli Inst Spa | Formulazioni farmaceutiche per via orale a liberazione selettiva nel colon |
| US5128132A (en) * | 1988-11-22 | 1992-07-07 | Parnell Pharmaceuticals, Inc. | Eriodictyon compositions and methods for treating internal mucous membranes |
| IL92966A (en) * | 1989-01-12 | 1995-07-31 | Pfizer | Hydrogel-operated release devices |
| KR900011455A (ko) | 1989-01-31 | 1990-08-01 | 호르스트 카베리쯔 | 활성제의 서방형 제제 및 그 제조방법 |
| HU203041B (en) | 1989-03-14 | 1991-05-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing pharmaceutical compositions of controlled releasing factor containing nifedipin |
| PT93637A (pt) * | 1989-04-20 | 1990-11-20 | Procter & Gamble | Metodo para o tratamento de desordens funcionais intestinais/colonicas, especialmente o sindrome de irritacao intestinal |
| JPH0334927A (ja) * | 1989-06-29 | 1991-02-14 | Teikoku Seiyaku Kk | 潰瘍性大腸炎およびクローン病治療用経口投与組成物 |
| US5000962A (en) * | 1989-08-25 | 1991-03-19 | Schering Corporation | Long acting diltiazem formulation |
| US5178866A (en) * | 1990-03-23 | 1993-01-12 | Alza Corporation | Dosage form for delivering drug to the intestine |
| US5252318A (en) | 1990-06-15 | 1993-10-12 | Allergan, Inc. | Reversible gelation compositions and methods of use |
| US5156850A (en) * | 1990-08-31 | 1992-10-20 | Alza Corporation | Dosage form for time-varying patterns of drug delivery |
| SE9003904D0 (sv) | 1990-12-07 | 1990-12-07 | Astra Ab | Method for the manufacture of a pharmaceutical dosage form |
| US5273758A (en) * | 1991-03-18 | 1993-12-28 | Sandoz Ltd. | Directly compressible polyethylene oxide vehicle for preparing therapeutic dosage forms |
| JP2916290B2 (ja) * | 1991-03-22 | 1999-07-05 | 帝國製薬株式会社 | 生理活性ポリペプチド含有大腸崩壊経口製剤 |
| JPH05255125A (ja) * | 1992-02-29 | 1993-10-05 | Upjohn Co:The | 徐放性製剤およびその製法 |
| JPH05262767A (ja) | 1992-03-19 | 1993-10-12 | Takeda Chem Ind Ltd | 持続性製剤 |
| JPH08502082A (ja) | 1992-07-02 | 1996-03-05 | コラーゲン コーポレイション | 生体適合性ポリマー結合体 |
| DE4226753A1 (de) | 1992-08-13 | 1994-02-17 | Basf Ag | Wirkstoffe enthaltende Zubereitungen in Form fester Teilchen |
| DK0661045T3 (da) * | 1992-09-18 | 2002-10-28 | Yamanouchi Pharma Co Ltd | Hydrogelpræparat med forsinket frigivelse |
| DE69425453T2 (de) * | 1993-04-23 | 2001-04-12 | Novartis Ag | Wirkstoffabgabevorrichtung mit gesteuerter Freigabe |
| TWI478712B (zh) * | 2008-09-30 | 2015-04-01 | Astellas Pharma Inc | 釋控性醫藥組成物 |
-
1993
- 1993-09-10 DK DK93919648T patent/DK0661045T3/da active
- 1993-09-10 AU AU49838/93A patent/AU682827B2/en not_active Expired
- 1993-09-10 JP JP06507964A patent/JP3140465B2/ja not_active Expired - Lifetime
- 1993-09-10 SK SK338-95A patent/SK281042B6/sk not_active IP Right Cessation
- 1993-09-10 PT PT93919648T patent/PT661045E/pt unknown
- 1993-09-10 HU HU9500808A patent/HU226456B1/hu unknown
- 1993-09-10 WO PCT/JP1993/001297 patent/WO1994006414A1/ja active IP Right Grant
- 1993-09-10 NZ NZ255579A patent/NZ255579A/en not_active IP Right Cessation
- 1993-09-10 AT AT93919648T patent/ATE219933T1/de active
- 1993-09-10 ES ES93919648T patent/ES2179829T3/es not_active Expired - Lifetime
- 1993-09-10 KR KR1019950701051A patent/KR100355130B1/ko not_active IP Right Cessation
- 1993-09-10 US US08/403,752 patent/US6436441B1/en not_active Expired - Fee Related
- 1993-09-10 PL PL93308137A patent/PL175026B1/pl unknown
- 1993-09-10 DE DE69332081T patent/DE69332081T2/de not_active Expired - Lifetime
- 1993-09-10 EP EP93919648A patent/EP0661045B1/de not_active Expired - Lifetime
- 1993-09-10 CZ CZ1995679A patent/CZ291495B6/cs not_active IP Right Cessation
- 1993-09-10 CA CA002144077A patent/CA2144077C/en not_active Expired - Lifetime
- 1993-09-10 RU RU95109153/14A patent/RU2121830C1/ru active
- 1993-09-10 RO RO95-00542A patent/RO112991B1/ro unknown
- 1993-09-18 CN CN93117868A patent/CN1048397C/zh not_active Expired - Lifetime
-
1995
- 1995-03-15 BG BG99503A patent/BG61861B1/bg unknown
- 1995-03-16 FI FI951226A patent/FI115697B/fi not_active IP Right Cessation
- 1995-03-17 NO NO19951036A patent/NO312811B1/no not_active IP Right Cessation
-
2000
- 2000-11-01 US US09/702,880 patent/US6699503B1/en not_active Expired - Fee Related
-
2002
- 2002-12-20 US US10/323,810 patent/US20030203024A1/en not_active Abandoned
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