DE69425453T2 - Wirkstoffabgabevorrichtung mit gesteuerter Freigabe - Google Patents

Wirkstoffabgabevorrichtung mit gesteuerter Freigabe

Info

Publication number
DE69425453T2
DE69425453T2 DE69425453T DE69425453T DE69425453T2 DE 69425453 T2 DE69425453 T2 DE 69425453T2 DE 69425453 T DE69425453 T DE 69425453T DE 69425453 T DE69425453 T DE 69425453T DE 69425453 T2 DE69425453 T2 DE 69425453T2
Authority
DE
Germany
Prior art keywords
delivery device
drug delivery
coated
controlled release
active agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69425453T
Other languages
English (en)
Other versions
DE69425453D1 (de
Inventor
Louis Savastano
James Carr
Elizabeth Quadros
Shailesh Shah
Satish Chandra Khanna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Pharma GmbH
Novartis AG
Original Assignee
Novartis Erfindungen Verwaltungs GmbH
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Erfindungen Verwaltungs GmbH, Novartis AG filed Critical Novartis Erfindungen Verwaltungs GmbH
Application granted granted Critical
Publication of DE69425453D1 publication Critical patent/DE69425453D1/de
Publication of DE69425453T2 publication Critical patent/DE69425453T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
DE69425453T 1993-04-23 1994-04-14 Wirkstoffabgabevorrichtung mit gesteuerter Freigabe Expired - Lifetime DE69425453T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5243593A 1993-04-23 1993-04-23
US16543793A 1993-12-10 1993-12-10

Publications (2)

Publication Number Publication Date
DE69425453D1 DE69425453D1 (de) 2000-09-14
DE69425453T2 true DE69425453T2 (de) 2001-04-12

Family

ID=26730596

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69425453T Expired - Lifetime DE69425453T2 (de) 1993-04-23 1994-04-14 Wirkstoffabgabevorrichtung mit gesteuerter Freigabe

Country Status (15)

Country Link
US (1) US5681584A (de)
EP (1) EP0621032B1 (de)
JP (2) JP3943144B2 (de)
KR (1) KR100354644B1 (de)
AT (1) ATE195252T1 (de)
AU (1) AU687784B2 (de)
CA (1) CA2121870C (de)
CY (1) CY2252B1 (de)
DE (1) DE69425453T2 (de)
DK (1) DK0621032T3 (de)
ES (1) ES2149250T3 (de)
GR (1) GR3034571T3 (de)
IL (1) IL109338A (de)
NZ (1) NZ260365A (de)
PT (1) PT621032E (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10653631B2 (en) 2011-09-07 2020-05-19 Roland SAUR-BROSCH Optimal colon targeting technology
US10799460B2 (en) 2011-09-07 2020-10-13 Roland SAUR-BROSCH Formulation for the controlled release of one or several substances in the digestive tract of a mammal

Families Citing this family (206)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5478577A (en) * 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
CA2144077C (en) * 1992-09-18 2005-05-24 Kazuhiro Sako Hydrogel-type sustained-release preparation
US5686105A (en) * 1993-10-19 1997-11-11 The Procter & Gamble Company Pharmaceutical dosage form with multiple enteric polymer coatings for colonic delivery
ATE195252T1 (de) * 1993-04-23 2000-08-15 Novartis Erfind Verwalt Gmbh Wirkstoffabgabevorrichtung mit gesteuerter freigabe
US6440457B1 (en) 1993-05-27 2002-08-27 Alza Corporation Method of administering antidepressant dosage form
DE4332394A1 (de) * 1993-09-23 1995-03-30 Falk Pharma Gmbh Budesonid-Pellets mit kontrolliertem Freigabeprofil und Verfahren zu ihrer Herstellung
US6210714B1 (en) 1993-11-23 2001-04-03 Euro-Celtique S.A. Immediate release tablet cores of acetaminophen having sustained-release coating
US5500227A (en) * 1993-11-23 1996-03-19 Euro-Celtique, S.A. Immediate release tablet cores of insoluble drugs having sustained-release coating
GB9412394D0 (en) 1994-06-21 1994-08-10 Danbiosyst Uk Colonic drug delivery composition
JPH0940561A (ja) * 1995-08-02 1997-02-10 Fujitsukusu Kk 瀉下剤
AU3909597A (en) * 1996-08-16 1998-03-06 Alza Corporation Dosage form for providing ascending dose of drug
US6919373B1 (en) 1996-11-12 2005-07-19 Alza Corporation Methods and devices for providing prolonged drug therapy
US5788987A (en) 1997-01-29 1998-08-04 Poli Industria Chimica Spa Methods for treating early morning pathologies
AU7706598A (en) * 1997-05-30 1998-12-30 Laboratorios Phoenix U.S.A., Inc. Multi-layered osmotic device
ATE282407T1 (de) 1997-09-09 2004-12-15 Alza Corp Arzneimittel-überzugszubereitung und verfahren zu ihrer anwendung
EP1035834B1 (de) * 1997-12-05 2002-04-17 Alza Corporation Osmotische darreichungsform mit zwei mantelschichten
US6598603B1 (en) * 1997-12-31 2003-07-29 Astra Aktiebolag Method for treating respiratory diseases
US8524277B2 (en) 1998-03-06 2013-09-03 Alza Corporation Extended release dosage form
US6245357B1 (en) * 1998-03-06 2001-06-12 Alza Corporation Extended release dosage form
US6224907B1 (en) * 1998-03-06 2001-05-01 Alza Corporation Anti-asthma therapy
US6099859A (en) 1998-03-20 2000-08-08 Andrx Pharmaceuticals, Inc. Controlled release oral tablet having a unitary core
US6551613B1 (en) * 1998-09-08 2003-04-22 Alza Corporation Dosage form comprising therapeutic formulation
ATE286725T1 (de) * 1998-10-01 2005-01-15 Novartis Pharma Gmbh Neue oral anzuwendende arzneizubereitungen für rivastigmine mit kontrollierter wirkstoffabgabe
DE19845358A1 (de) * 1998-10-02 2000-04-06 Roehm Gmbh Überzogene Arzneiformen mit kontrollierter Wirkstoffabgabe
JP2000119181A (ja) * 1998-10-06 2000-04-25 Kureha Chem Ind Co Ltd エスクレチン及びその誘導体の放出制御経口製剤
UA67802C2 (uk) * 1998-10-23 2004-07-15 Пфайзер Рісьоч Енд Дівелепмент Компані, Н.В./С.А. Фармацевтична композиція з контрольованим вивільненням інгібітора цгмф фде-5 (варіанти), спосіб її одержання та спосіб лікування еректильної дисфункції
US6033686A (en) * 1998-10-30 2000-03-07 Pharma Pass Llc Controlled release tablet of bupropion hydrochloride
US6096341A (en) * 1998-10-30 2000-08-01 Pharma Pass Llc Delayed release tablet of bupropion hydrochloride
US20060240105A1 (en) * 1998-11-02 2006-10-26 Elan Corporation, Plc Multiparticulate modified release composition
CN100444830C (zh) 1998-11-02 2008-12-24 伊兰公司，Plc 多颗粒改进释放组合物
US20090297597A1 (en) * 1998-11-02 2009-12-03 Gary Liversidge Modified Release Ticlopidine Compositions
US20090149479A1 (en) * 1998-11-02 2009-06-11 Elan Pharma International Limited Dosing regimen
US20070122481A1 (en) * 1998-11-02 2007-05-31 Elan Corporation Plc Modified Release Compositions Comprising a Fluorocytidine Derivative for the Treatment of Cancer
JP5558648B2 (ja) 1998-11-23 2014-07-23 デイビス、ボニー アセチルコリンエステラーゼ阻害剤のための投与製剤
US8895064B2 (en) 1999-06-14 2014-11-25 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
JP4790950B2 (ja) * 1999-06-14 2011-10-12 コスモ・テクノロジーズ・リミテッド 制御放出および味感遮蔽経口医薬組成物
US6458383B2 (en) * 1999-08-17 2002-10-01 Lipocine, Inc. Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin
US6251432B1 (en) * 1999-07-01 2001-06-26 Abbott Laboratories Sustained release dosage form unit having latex coating and method of making the same
GB9923045D0 (en) * 1999-09-29 1999-12-01 Novartis Ag New oral formulations
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
KR101216270B1 (ko) 1999-10-29 2012-12-31 유로-셀티크 소시에떼 아노뉨 서방성 하이드로코돈 제형
AU1592901A (en) * 1999-11-11 2001-06-06 Eli Lilly And Company Oncolytic combinations for the treatment of cancer
US6936275B2 (en) * 1999-12-20 2005-08-30 Scolr, Inc. Amino acid modulated extended release dosage form
KR100523127B1 (ko) * 1999-12-23 2005-10-20 화이자 프로덕츠 인코포레이티드 하이드로겔계 약물 투여 형태
JP2003518487A (ja) 1999-12-23 2003-06-10 ファイザー・プロダクツ・インク ヒドロゲル駆動型積層薬物製剤
US6391048B1 (en) 2000-01-05 2002-05-21 Integrated Vascular Systems, Inc. Integrated vascular device with puncture site closure component and sealant and methods of use
US7842068B2 (en) 2000-12-07 2010-11-30 Integrated Vascular Systems, Inc. Apparatus and methods for providing tactile feedback while delivering a closure device
US6461364B1 (en) 2000-01-05 2002-10-08 Integrated Vascular Systems, Inc. Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use
US9579091B2 (en) 2000-01-05 2017-02-28 Integrated Vascular Systems, Inc. Closure system and methods of use
US8758400B2 (en) 2000-01-05 2014-06-24 Integrated Vascular Systems, Inc. Closure system and methods of use
US6491949B2 (en) * 2000-01-14 2002-12-10 Osmotica Corp. Osmotic device within an osmotic device
US6352721B1 (en) * 2000-01-14 2002-03-05 Osmotica Corp. Combined diffusion/osmotic pumping drug delivery system
AR026148A1 (es) * 2000-01-21 2003-01-29 Osmotica Argentina S A Dispositivo osmotico con pasaje preformado que aumenta de tamano
US7220430B2 (en) * 2000-01-27 2007-05-22 Tanabe Seiyaku Co., Ltd. Sustained-release preparation and process for producing the same
US6420473B1 (en) * 2000-02-10 2002-07-16 Bpsi Holdings, Inc. Acrylic enteric coating compositions
US7223421B2 (en) * 2000-06-30 2007-05-29 Mcneil-Ppc, Inc. Teste masked pharmaceutical particles
US6500457B1 (en) 2000-08-14 2002-12-31 Peirce Management, Llc Oral pharmaceutical dosage forms for pulsatile delivery of an antiarrhythmic agent
US6616686B2 (en) 2000-09-08 2003-09-09 James Coleman Surgical staples and methods for stapling
US6626918B1 (en) 2000-10-06 2003-09-30 Medical Technology Group Apparatus and methods for positioning a vascular sheath
AU2002227383B2 (en) 2000-10-30 2004-07-08 Euro-Celtique S.A. Controlled release hydrocodone formulations
CA2359812C (en) 2000-11-20 2004-02-10 The Procter & Gamble Company Pharmaceutical dosage form with multiple coatings for reduced impact of coating fractures
US6623510B2 (en) 2000-12-07 2003-09-23 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US7211101B2 (en) 2000-12-07 2007-05-01 Abbott Vascular Devices Methods for manufacturing a clip and clip
US7905900B2 (en) 2003-01-30 2011-03-15 Integrated Vascular Systems, Inc. Clip applier and methods of use
US8690910B2 (en) 2000-12-07 2014-04-08 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US20020119196A1 (en) * 2000-12-21 2002-08-29 Narendra Parikh Texture masked particles containing an active ingredient
SE0100200D0 (sv) 2001-01-24 2001-01-24 Astrazeneca Ab New film coating
KR200249057Y1 (ko) * 2001-03-22 2001-10-19 김진환 뚜껑, 받침대에 합체된 하수역류. 악취방지 장치
US20030070584A1 (en) 2001-05-15 2003-04-17 Cynthia Gulian Dip coating compositions containing cellulose ethers
US6838093B2 (en) * 2001-06-01 2005-01-04 Shire Laboratories, Inc. System for osmotic delivery of pharmaceutically active agents
IES20010547A2 (en) 2001-06-07 2002-12-11 Christy Cummins Surgical Staple
CA2448558A1 (en) * 2001-07-10 2003-01-23 Teva Pharmaceutical Industries, Ltd. Drug delivery system for zero order, zero order-biphasic, ascending or descending drug delivery
GB0120835D0 (en) * 2001-08-28 2001-10-17 Smithkline Beecham Plc Process
US8309118B2 (en) 2001-09-28 2012-11-13 Mcneil-Ppc, Inc. Film forming compositions containing sucralose
US6982094B2 (en) * 2001-09-28 2006-01-03 Mcneil-Ppc, Inc. Systems, methods and apparatuses for manufacturing dosage forms
US7122143B2 (en) * 2001-09-28 2006-10-17 Mcneil-Ppc, Inc. Methods for manufacturing dosage forms
US7323192B2 (en) * 2001-09-28 2008-01-29 Mcneil-Ppc, Inc. Immediate release tablet
US6837696B2 (en) * 2001-09-28 2005-01-04 Mcneil-Ppc, Inc. Apparatus for manufacturing dosage forms
US7838026B2 (en) 2001-09-28 2010-11-23 Mcneil-Ppc, Inc. Burst-release polymer composition and dosage forms comprising the same
MXPA04002979A (es) 2001-09-28 2005-06-20 Johnson & Johnson Formas de dosificacion de liberacion modificada.
US7217381B2 (en) * 2001-09-28 2007-05-15 Mcneil-Ppc, Inc. Systems, methods and apparatuses for manufacturing dosage forms
US9308220B2 (en) 2001-12-11 2016-04-12 Cosmo Technologies Limited Pharmaceutical compositions for the oral administration of heparin or derivatives thereof
ITMI20012599A1 (it) 2001-12-11 2003-06-11 Cosmo Spa Composizioni farmaceutiche per la somministrazione orale di eparina osuoi derivati, utili per la terapia di malattie infiammatorie dell'int
IL156998A0 (en) 2001-12-19 2004-02-08 Astrazeneca Ab New film coating
GB0203296D0 (en) * 2002-02-12 2002-03-27 Glaxo Group Ltd Novel composition
US6749621B2 (en) 2002-02-21 2004-06-15 Integrated Vascular Systems, Inc. Sheath apparatus and methods for delivering a closure device
MXPA04009701A (es) * 2002-04-05 2005-05-27 Penwest Pharmaceuticals Co Formulaciones de metoprolol de liberacion sostenida.
AU2003269744A1 (en) * 2002-05-15 2003-12-02 Sun Pharmaceutical Industries Limited Oral osmotic controlled drug delivery system
DE60325355D1 (de) 2002-06-04 2009-01-29 Abbott Vascular Inc Chirurgische klemme und anbringungsvorrichtung zur gefässwundverschliessung
US20050232995A1 (en) 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
MXPA05002899A (es) * 2002-09-16 2005-05-27 Wyeth Corp Formulaciones de liberacion controlada para administracion oral de un agente terapeutico polipeptido y sus metodos de uso.
US9060941B2 (en) * 2002-09-20 2015-06-23 Actavis, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US7785627B2 (en) * 2002-09-20 2010-08-31 Watson Pharmaceuticals, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US8084058B2 (en) 2002-09-20 2011-12-27 Watson Pharmaceuticals, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US7959946B2 (en) 2002-09-20 2011-06-14 Watson Pharmaceuticals, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US7807197B2 (en) * 2002-09-28 2010-10-05 Mcneil-Ppc, Inc. Composite dosage forms having an inlaid portion
US20080220074A1 (en) * 2002-10-04 2008-09-11 Elan Corporation Plc Gamma radiation sterilized nanoparticulate docetaxel compositions and methods of making same
AU2003287301A1 (en) * 2002-10-31 2004-06-07 Alza Corporation Dosage form providing ascending release of liquid formulation
US20040097484A1 (en) * 2002-11-14 2004-05-20 Marc Cantillion Once a day galantamine pharmaceutical compositions and methods of use
US20070077301A1 (en) * 2002-12-23 2007-04-05 Meyer Glenn A Venlafaxine osmotic device formulation
US8758398B2 (en) 2006-09-08 2014-06-24 Integrated Vascular Systems, Inc. Apparatus and method for delivering a closure element
US8202293B2 (en) 2003-01-30 2012-06-19 Integrated Vascular Systems, Inc. Clip applier and methods of use
US8905937B2 (en) 2009-02-26 2014-12-09 Integrated Vascular Systems, Inc. Methods and apparatus for locating a surface of a body lumen
US8398656B2 (en) 2003-01-30 2013-03-19 Integrated Vascular Systems, Inc. Clip applier and methods of use
US8821534B2 (en) 2010-12-06 2014-09-02 Integrated Vascular Systems, Inc. Clip applier having improved hemostasis and methods of use
US20060177507A1 (en) * 2003-05-22 2006-08-10 Joaquina Faour Controlled release device containing lercanidipine
UY28326A1 (es) * 2003-05-22 2004-06-30 Osmotica Argentina S A Dispositivo de ruptura de liberacion controlada con un pasaje preformado
US8029822B2 (en) * 2003-05-22 2011-10-04 Osmotica Kereskedelmi és Seolgáltató KFT Rupturing controlled release device having a preformed passageway
KR100601249B1 (ko) * 2003-08-21 2006-07-13 한국화학연구원 경구용 약물 전달 기구용 서방형 다공성 막 형성 조성물
EP1643978A1 (de) * 2003-07-04 2006-04-12 Nycomed Danmark A/S Nebenschilddrüsenhormon (pth) mit pharmazeutischen zusammensetzungen zur oralen anwendung
US7314640B2 (en) * 2003-07-11 2008-01-01 Mongkol Sriwongjanya Formulation and process for drug loaded cores
JP2005075826A (ja) * 2003-08-29 2005-03-24 Boehringer Ingelheim Internatl Gmbh 多孔質シリカ担体を含有する徐放性製剤
US7737133B2 (en) * 2003-09-03 2010-06-15 Agi Therapeutics Ltd. Formulations and methods of treating inflammatory bowel disease
US7825106B2 (en) * 2003-09-03 2010-11-02 Agi Therapeutics Ltd. Modified release formulations and methods of treating inflammatory bowel disease
CN1856299B (zh) * 2003-09-19 2013-09-04 太阳医药工业有限公司 口服药物释出系统
US10213387B2 (en) 2003-09-19 2019-02-26 Sun Pharma Advanced Research Company Ltd. Oral drug delivery system
US10226428B2 (en) 2003-09-19 2019-03-12 Sun Pharma Advanced Research Company Ltd. Oral drug delivery system
US20050074514A1 (en) * 2003-10-02 2005-04-07 Anderson Oliver B. Zero cycle molding systems, methods and apparatuses for manufacturing dosage forms
US7498018B2 (en) * 2003-10-03 2009-03-03 Bracco Diagnostics Inc. Contrast media for use in medical and diagnostic procedures and methods of using the same
US20050129764A1 (en) * 2003-12-11 2005-06-16 Vergez Juan A. Osmotic device containing licofelone
EP1699442A2 (de) * 2003-12-31 2006-09-13 Genzyme Corporation Aliphatische amin-polymer-gallensäure-sequestriermittel mit magensaftresistentem überzug
US20050215561A1 (en) * 2004-03-19 2005-09-29 Krishnendu Ghosh Pharmaceutical dosage forms and compositions
US7404970B2 (en) * 2004-04-13 2008-07-29 Konec, Inc. Pain relief composition, method to form same, and method to use same
IES20040368A2 (en) 2004-05-25 2005-11-30 James E Coleman Surgical stapler
DE14172398T1 (de) * 2004-10-08 2015-01-08 Forward Pharma A/S Gesteuerte Freisetzung von pharmazeutischen Zusammensetzungen mit Fumarinsäureester
EP1811975A2 (de) * 2004-10-19 2007-08-01 The State of Oregon Acting by and Magensaftresistente zusammensetzungen, die wirkstoff(e) in magenflüssigkeit und darmflüssigkeit freisetzen
US20060099262A1 (en) * 2004-11-08 2006-05-11 Biokey, Inc. Methods and formulations for making controlled release oral dosage form
US8586085B2 (en) * 2004-11-08 2013-11-19 Biokey, Inc. Methods and formulations for making pharmaceutical compositions containing bupropion
US20060121112A1 (en) * 2004-12-08 2006-06-08 Elan Corporation, Plc Topiramate pharmaceutical composition
KR100670798B1 (ko) 2004-12-17 2007-01-17 한국전자통신연구원 데이터베이스 캐시 시스템
US20070298098A1 (en) * 2005-02-16 2007-12-27 Elan Pharma International Limited Controlled Release Compositions Comprising Levetiracetam
US8673352B2 (en) 2005-04-15 2014-03-18 Mcneil-Ppc, Inc. Modified release dosage form
WO2007037790A2 (en) * 2005-06-08 2007-04-05 Elan Corporation, Plc Modified release famciclovir compositions
US8926633B2 (en) 2005-06-24 2015-01-06 Abbott Laboratories Apparatus and method for delivering a closure element
US8313497B2 (en) 2005-07-01 2012-11-20 Abbott Laboratories Clip applier and methods of use
WO2007019393A2 (en) * 2005-08-04 2007-02-15 Alza Corporation Osmotic dosage forms comprising semipermeable membranes with polymer blends providing improved properties
US20070053983A1 (en) * 2005-09-06 2007-03-08 Girish Jain Extended release compositions of metoprolol succinate
BRPI0620863A8 (pt) * 2005-12-29 2018-01-16 Osmotica Kereskedelmi Es Szolgaltato Kft comprimido em camadas com combinação de liberação tripla
US20070231390A1 (en) * 2006-03-29 2007-10-04 Andrx Labs, Llc Formulations including hygroscopic compounds
US8808310B2 (en) 2006-04-20 2014-08-19 Integrated Vascular Systems, Inc. Resettable clip applier and reset tools
NZ573174A (en) * 2006-06-01 2012-01-12 Msd Consumer Care Inc Sustained release pharmaceutical dosage form containing phenylephrine
JP5175278B2 (ja) * 2006-06-01 2013-04-03 エムエスディー コンシューマー ケア， インコーポレイテッド 結腸吸収のためのフェニレフリン薬学的製剤および組成物
US8556930B2 (en) 2006-06-28 2013-10-15 Abbott Laboratories Vessel closure device
US20080260823A1 (en) * 2007-04-20 2008-10-23 Sciele Pharma, Inc. Orally disintegrating tablet comprising glycopyrrolate for treating sialorrhea
US8637080B2 (en) * 2007-06-28 2014-01-28 Osmotica Kereskedelmi és Szolgáltató, KFT Rupturing controlled release device comprising a subcoat
US20090036414A1 (en) * 2007-08-02 2009-02-05 Mutual Pharmaceutical Company, Inc. Mesalamine Formulations
US20090157101A1 (en) 2007-12-17 2009-06-18 Abbott Laboratories Tissue closure system and methods of use
US8893947B2 (en) 2007-12-17 2014-11-25 Abbott Laboratories Clip applier and methods of use
US7841502B2 (en) 2007-12-18 2010-11-30 Abbott Laboratories Modular clip applier
KR20100136967A (ko) * 2008-02-15 2010-12-29 썬 파마 어드밴스트 리서치 컴패니 리미티드 파열 효과가 감소된 방출 제어 경구 정제
GB0808537D0 (en) * 2008-05-12 2008-06-18 Archimedes Dev Ltd Compositions
US9282965B2 (en) 2008-05-16 2016-03-15 Abbott Laboratories Apparatus and methods for engaging tissue
US8398676B2 (en) 2008-10-30 2013-03-19 Abbott Vascular Inc. Closure device
US8323312B2 (en) 2008-12-22 2012-12-04 Abbott Laboratories Closure device
US8858594B2 (en) 2008-12-22 2014-10-14 Abbott Laboratories Curved closure device
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
UA125896C2 (uk) 2009-01-09 2022-07-06 Фвп Іп Апс Фармацевтичний склад, що містить в матриці, яка піддається ерозії, один або більше ефірів фумарової кислоти
US9414820B2 (en) 2009-01-09 2016-08-16 Abbott Vascular Inc. Closure devices, systems, and methods
US9173644B2 (en) 2009-01-09 2015-11-03 Abbott Vascular Inc. Closure devices, systems, and methods
US20100179589A1 (en) * 2009-01-09 2010-07-15 Abbott Vascular Inc. Rapidly eroding anchor
US9486191B2 (en) 2009-01-09 2016-11-08 Abbott Vascular, Inc. Closure devices
US9089311B2 (en) 2009-01-09 2015-07-28 Abbott Vascular Inc. Vessel closure devices and methods
US20100185234A1 (en) 2009-01-16 2010-07-22 Abbott Vascular Inc. Closure devices, systems, and methods
EP2416782A1 (de) * 2009-04-09 2012-02-15 Alkermes Pharma Ireland Limited Clozapinzusammensetzungen mit verzögerter freisetzung
CH701000A1 (de) * 2009-04-30 2010-11-15 U Nica Technology Ag Bacteriorhodopsin enthaltende Mikrokapseln und Verfahren zu deren Herstellung.
US20110054492A1 (en) 2009-08-26 2011-03-03 Abbott Laboratories Medical device for repairing a fistula
AU2011230778A1 (en) * 2010-03-23 2012-08-02 Aska Pharmaceutical Co., Ltd. Solid preparation
US8758399B2 (en) 2010-08-02 2014-06-24 Abbott Cardiovascular Systems, Inc. Expandable bioabsorbable plug apparatus and method
US8603116B2 (en) 2010-08-04 2013-12-10 Abbott Cardiovascular Systems, Inc. Closure device with long tines
HUE030062T2 (en) 2010-11-08 2017-04-28 Albireo Ab IBAT inhibitors for the treatment of liver diseases
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
US9149276B2 (en) 2011-03-21 2015-10-06 Abbott Cardiovascular Systems, Inc. Clip and deployment apparatus for tissue closure
US20140227293A1 (en) 2011-06-30 2014-08-14 Trustees Of Boston University Method for controlling tumor growth, angiogenesis and metastasis using immunoglobulin containing and proline rich receptor-1 (igpr-1)
US10154964B2 (en) 2011-09-07 2018-12-18 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
US9332976B2 (en) 2011-11-30 2016-05-10 Abbott Cardiovascular Systems, Inc. Tissue closure device
US9872982B2 (en) * 2012-01-10 2018-01-23 University of Pittsburgh—of the Commonwealth System of Higher Education Electroosmotic convection-enhanced delivery system
CA3107450A1 (en) 2012-03-29 2013-10-03 Therabiome, Llc Gastrointestinal site-specific oral vaccination formulations active on the ileum and appendix
US9364209B2 (en) 2012-12-21 2016-06-14 Abbott Cardiovascular Systems, Inc. Articulating suturing device
US9907755B2 (en) 2013-03-14 2018-03-06 Therabiome, Llc Targeted gastrointestinal tract delivery of probiotic organisms and/or therapeutic agents
RU2669407C2 (ru) 2013-03-15 2018-10-11 ТАРИС Биомедикал ЛЛК Устройства для доставки лекарственных средств и способы доставки лекарственных средств
JP6041823B2 (ja) * 2013-03-16 2016-12-14 ファイザー・インク トファシチニブの経口持続放出剤形
LT3069733T (lt) * 2013-11-13 2022-11-25 National Defense Education And Research Foundation Nauja acetaminofeno junginio sudėtis be šalutinio poveikio kepenims
US10709755B2 (en) 2014-06-25 2020-07-14 Elobix Ab Solid formulation and method for preventing or reducing coloration thereof
WO2016033549A2 (en) 2014-08-28 2016-03-03 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
US9498485B2 (en) 2014-08-28 2016-11-22 Lipocine Inc. Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters
EP3012252A1 (de) 2014-10-24 2016-04-27 Ferring BV Kristalline Form von elobixibat
CA3011565C (en) * 2016-02-09 2024-01-02 Albireo Ab Oral cholestyramine formulation and use thereof
US10441605B2 (en) 2016-02-09 2019-10-15 Albireo Ab Oral cholestyramine formulation and use thereof
US10786529B2 (en) 2016-02-09 2020-09-29 Albireo Ab Oral cholestyramine formulation and use thereof
WO2017138876A1 (en) * 2016-02-09 2017-08-17 Albireo Ab Cholestyramine pellets and methods for preparation thereof
US10441604B2 (en) 2016-02-09 2019-10-15 Albireo Ab Cholestyramine pellets and methods for preparation thereof
JP2020503269A (ja) 2016-11-28 2020-01-30 リポカイン インコーポレーテッド 経口ウンデカン酸テストステロン療法
HUE054587T2 (hu) 2017-02-01 2021-09-28 Taris Biomedical Llc In vivo gyógyszerbejuttató eszközök
EP3664781A1 (de) 2017-08-09 2020-06-17 Albireo AB Cholestyramingranulate, orale cholestyraminformulierungen und ihre verwendung
JP6858729B2 (ja) * 2018-05-25 2021-04-14 ▲財▼▲団▼法人国防教育研究基金会Ｎａｔｉｏｎａｌ Ｄｅｆｅｎｓｅ Ｅｄｕｃａｔｉｏｎ Ａｎｄ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ 肝臓に対する副作用がない、新しいアセトアミノフェン複合組成
US10793534B2 (en) 2018-06-05 2020-10-06 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
AU2019290337B2 (en) 2018-06-20 2023-01-12 Albireo Ab Crystal modifications of odevixibat
WO2020006278A1 (en) 2018-06-27 2020-01-02 Kashiv Biosciences, Llc Self-regulating osmotic gastroretentive drug delivery systems
US11549878B2 (en) 2018-08-09 2023-01-10 Albireo Ab In vitro method for determining the adsorbing capacity of an insoluble adsorbant
US10722457B2 (en) 2018-08-09 2020-07-28 Albireo Ab Oral cholestyramine formulation and use thereof
US11007142B2 (en) 2018-08-09 2021-05-18 Albireo Ab Oral cholestyramine formulation and use thereof
US11964048B2 (en) 2020-12-18 2024-04-23 Amneal Complex Products Research Llc Sustained release compositions comprising liothyronine
US11896719B2 (en) 2022-01-24 2024-02-13 Calliditas Therapeutics Ab Pharmaceutical compositions

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB155898A (en) * 1919-09-22 1920-12-22 Thomas Edwin O Dell Improvements in and connected with tool holders for use on lathes, drilling and similar machines
US3845770A (en) * 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
ZA825384B (en) * 1981-07-31 1983-05-25 Tillott J B Ltd Orally administrable pharmaceutical compositions
JPS58109413A (ja) * 1981-12-23 1983-06-29 Eisai Co Ltd 耐衝撃性腸溶錠
JPS5920219A (ja) * 1982-07-26 1984-02-01 Shin Etsu Chem Co Ltd 腸溶性コ−テイング製剤の製造方法
SE457505B (sv) * 1984-01-10 1989-01-09 Lejus Medical Ab Laminatbelagd oral farmaceutisk komposition och foerfarande foer dess framstaellning
US4705515A (en) * 1984-10-26 1987-11-10 Alza Corporation Dosage form for administering drug of the colon
US4627851A (en) * 1984-10-26 1986-12-09 Alza Corporation Colonic-therapeutic delivery system
US4693895A (en) * 1984-10-26 1987-09-15 Alza Corporation Colon delivery system
GB2189698A (en) * 1986-04-30 1987-11-04 Haessle Ab Coated omeprazole tablets
CH668187A5 (de) * 1986-08-07 1988-12-15 Ciba Geigy Ag Therapeutisches system mit systemischer wirkung.
US4891223A (en) * 1987-09-03 1990-01-02 Air Products And Chemicals, Inc. Controlled release delivery coating formulation for bioactive substances
US4946686A (en) * 1987-09-24 1990-08-07 Merck & Co., Inc. Solubility modulated drug delivery system
US4904474A (en) * 1988-01-25 1990-02-27 Alza Corporation Delivery of drug to colon by oral disage form
US4861223A (en) * 1988-02-09 1989-08-29 Cascade Corporation Automatic load push-pull slipsheet handler
US4892739A (en) * 1988-04-25 1990-01-09 Ciba-Geigy Corporation Osmotic continuous dispensing oral delivery system containing a pharmaceutically acceptable active agent having a improved core membrane adhesion properties
IT1230576B (it) * 1988-10-20 1991-10-28 Angeli Inst Spa Formulazioni farmaceutiche per via orale a liberazione selettiva nel colon
ATE109973T1 (de) * 1989-05-11 1994-09-15 Chugai Pharmaceutical Co Ltd Mundzubereitung zur verabreichung an bestimmter stelle des darmes.
GB8926639D0 (en) * 1989-11-24 1990-01-17 Agricultural & Food Res Delayed release formulations
US5156850A (en) * 1990-08-31 1992-10-20 Alza Corporation Dosage form for time-varying patterns of drug delivery
JPH04346930A (ja) * 1991-05-25 1992-12-02 Sumitomo Pharmaceut Co Ltd 安定なアスピリン腸溶錠
ATE195252T1 (de) * 1993-04-23 2000-08-15 Novartis Erfind Verwalt Gmbh Wirkstoffabgabevorrichtung mit gesteuerter freigabe
KR0170268B1 (ko) * 1994-08-31 1999-03-30 김광호 데드타임 발생회로

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10653631B2 (en) 2011-09-07 2020-05-19 Roland SAUR-BROSCH Optimal colon targeting technology
US10799460B2 (en) 2011-09-07 2020-10-13 Roland SAUR-BROSCH Formulation for the controlled release of one or several substances in the digestive tract of a mammal

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EP0621032A1 (de) 1994-10-26
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CA2121870C (en) 2005-05-17
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US5681584A (en) 1997-10-28
PT621032E (pt) 2001-01-31
CY2252B1 (en) 2003-07-04
NZ260365A (en) 1994-08-26
JP3943144B2 (ja) 2007-07-11
KR100354644B1 (ko) 2002-12-28
JPH072648A (ja) 1995-01-06
GR3034571T3 (en) 2001-01-31
ATE195252T1 (de) 2000-08-15
CA2121870A1 (en) 1994-10-24
DE69425453D1 (de) 2000-09-14
EP0621032B1 (de) 2000-08-09
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AU687784B2 (en) 1998-03-05
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