WO1998026767A3 - Site-specific controlled release dosage formulation for mesalamine - Google Patents

Site-specific controlled release dosage formulation for mesalamine Download PDF

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Publication number
WO1998026767A3
WO1998026767A3 PCT/IB1997/001652 IB9701652W WO9826767A3 WO 1998026767 A3 WO1998026767 A3 WO 1998026767A3 IB 9701652 W IB9701652 W IB 9701652W WO 9826767 A3 WO9826767 A3 WO 9826767A3
Authority
WO
WIPO (PCT)
Prior art keywords
mesalamine
site
coating layer
controlled release
release dosage
Prior art date
Application number
PCT/IB1997/001652
Other languages
French (fr)
Other versions
WO1998026767A2 (en
Inventor
Cesare Busetti
Tiziano Crimella
Vincenzo Olgiati
Original Assignee
Poli Ind Chimica Spa
Cesare Busetti
Tiziano Crimella
Vincenzo Olgiati
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Poli Ind Chimica Spa, Cesare Busetti, Tiziano Crimella, Vincenzo Olgiati filed Critical Poli Ind Chimica Spa
Priority to AU57753/98A priority Critical patent/AU5775398A/en
Publication of WO1998026767A2 publication Critical patent/WO1998026767A2/en
Publication of WO1998026767A3 publication Critical patent/WO1998026767A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil

Abstract

Pharmaceutical formulation for the site-specific delivery of mesalamine in the colon is disclosed. The formulation includes (a) a core comprising mesalamine in an amount effective to produce a therapeutic anti-inflammatory effect; (b) a swellable polymeric coating layer substantially surrounding the core which inhibits the release of mesalamine for a predetermined period of time dependent upon the thickness of the swellable polymeric coating layer, and (c) an outer enteric coating layer substantially surrounding the swellable polymeric coating layer. Methods of achieving the site-specific delivery of mesalamine in the colon are also disclosed.
PCT/IB1997/001652 1996-12-17 1997-12-16 Site-specific controlled release dosage formulation for mesalamine WO1998026767A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU57753/98A AU5775398A (en) 1996-12-17 1997-12-16 Site-specific controlled release dosage formulation for mesalamine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76798096A 1996-12-17 1996-12-17
US08/767,980 1996-12-17

Publications (2)

Publication Number Publication Date
WO1998026767A2 WO1998026767A2 (en) 1998-06-25
WO1998026767A3 true WO1998026767A3 (en) 1998-09-03

Family

ID=25081155

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1997/001652 WO1998026767A2 (en) 1996-12-17 1997-12-16 Site-specific controlled release dosage formulation for mesalamine

Country Status (2)

Country Link
AU (1) AU5775398A (en)
WO (1) WO1998026767A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6733789B1 (en) 1999-01-21 2004-05-11 Biovail Laboratories, Inc. Multiparticulate bisoprolol formulation
US6417227B1 (en) * 1999-04-28 2002-07-09 Cg And Associates Methods of delivery of cetyl myristoleate
ITMI991316A1 (en) * 1999-06-14 2000-12-14 Cip Ninety Two 92 S A ORAL PHARMACEUTICAL COMPOSITIONS WITH MODIFIED RELEASE OF MESALAZINE
EP1210071A1 (en) * 1999-09-06 2002-06-05 Günther Beisel Method for improving and maintaining bowel function as well as a method for the production thereof
CA2359812C (en) 2000-11-20 2004-02-10 The Procter & Gamble Company Pharmaceutical dosage form with multiple coatings for reduced impact of coating fractures
US8282955B2 (en) 2001-10-15 2012-10-09 Ferring B.V. Method for the preparation of a pharmaceutical composition comprising 5-aminosalicylic acid for use in treatment of ulcerative colitis and Crohn's disease
US20070042143A1 (en) 2003-04-23 2007-02-22 Ferring B.V. Sachet for a pharmaceutical composition
EP1547601A1 (en) 2003-12-23 2005-06-29 Ferring B.V. Coating method
WO2009047801A1 (en) * 2007-10-10 2009-04-16 Lupin Limited Therapeutic combinations and compositions for the treatment of gastrointestinal disorders
CN102365083A (en) * 2009-03-18 2012-02-29 赢创罗姆有限公司 Controlled release pharmaceutical composition with resistance against the influence of ethanol employing a coating comprising a polymer mixture and excipients
US9463163B2 (en) * 2009-10-16 2016-10-11 Sun Pharmaceutical Industries Limited Delayed release pharmaceutical composition of mesalamine
EP2425826A1 (en) 2010-09-01 2012-03-07 Disphar International B.V. Mesalazine tablet having improved dissolution
US20140105956A1 (en) * 2012-10-11 2014-04-17 Rupak BANERJEE Biodegradable polymer based microimplant for ocular drug delivery
IN2014MU00097A (en) * 2014-01-10 2015-08-21 Cadila Healthcare Ltd
TR201722039A2 (en) * 2017-12-27 2019-07-22 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi SOLID ORAL PHARMACEUTICAL COMPOSITIONS OF MESALAZINE
EP3662895A1 (en) 2018-12-07 2020-06-10 Tillotts Pharma AG A process for manufacturing reducing sugar-free 5-asa tablet cores
IT201900018041A1 (en) 2019-10-07 2021-04-07 Sara Pellegrino POLYETHYLENIMMIN WITH N-ACYLATE HYDROXYPYRIDONIC FUNCTION, THEIR SYNTHESIS AND THERAPEUTIC USE
WO2022066110A1 (en) * 2020-09-25 2022-03-31 Pharmacti̇ve İlaç Sanayi̇ Ve Ti̇caret A.Ş. Pharmaceutical compositions comprising mesalamin and relevant excipients

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0453001A1 (en) * 1990-04-17 1991-10-23 GIULIANI S.p.A. Pharmaceutical composition for the targeted controlled release of an active principle within the intestine, and particularly within the colon
GB2245492A (en) * 1990-07-04 1992-01-08 Zambon Spa Programmed release oral solid pharmaceutical dosage form
EP0527942A1 (en) * 1990-05-04 1993-02-24 Perio Products Limited Colonic drug delivery system
EP0671167A1 (en) * 1994-02-10 1995-09-13 Tanabe Seiyaku Co., Ltd. Pharmaceutical preparation controlled to release medicinal active ingredient at targeted site in intestinal tract
EP0673645A2 (en) * 1994-03-23 1995-09-27 F. Hoffmann-La Roche AG Pharmaceutical composition
WO1995028963A1 (en) * 1994-04-22 1995-11-02 Yamanouchi Pharmaceutical Co., Ltd. Colon-specific drug release system

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0453001A1 (en) * 1990-04-17 1991-10-23 GIULIANI S.p.A. Pharmaceutical composition for the targeted controlled release of an active principle within the intestine, and particularly within the colon
EP0527942A1 (en) * 1990-05-04 1993-02-24 Perio Products Limited Colonic drug delivery system
GB2245492A (en) * 1990-07-04 1992-01-08 Zambon Spa Programmed release oral solid pharmaceutical dosage form
EP0671167A1 (en) * 1994-02-10 1995-09-13 Tanabe Seiyaku Co., Ltd. Pharmaceutical preparation controlled to release medicinal active ingredient at targeted site in intestinal tract
EP0673645A2 (en) * 1994-03-23 1995-09-27 F. Hoffmann-La Roche AG Pharmaceutical composition
WO1995028963A1 (en) * 1994-04-22 1995-11-02 Yamanouchi Pharmaceutical Co., Ltd. Colon-specific drug release system
EP0759303A1 (en) * 1994-04-22 1997-02-26 Yamanouchi Pharmaceutical Co. Ltd. Colon-specific drug release system

Also Published As

Publication number Publication date
WO1998026767A2 (en) 1998-06-25
AU5775398A (en) 1998-07-15

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